NO20065863L - 3-[4-(6-(4,5-dihydroisoksazol-3-yl]pyridin-3-yl)-3-fenyl]-5-(1 H,1,2,3-triazol-1-yl-metyl)-1,3-oksazolidin-2-oner som antibakterielle midler - Google Patents

3-[4-(6-(4,5-dihydroisoksazol-3-yl]pyridin-3-yl)-3-fenyl]-5-(1 H,1,2,3-triazol-1-yl-metyl)-1,3-oksazolidin-2-oner som antibakterielle midler

Info

Publication number
NO20065863L
NO20065863L NO20065863A NO20065863A NO20065863L NO 20065863 L NO20065863 L NO 20065863L NO 20065863 A NO20065863 A NO 20065863A NO 20065863 A NO20065863 A NO 20065863A NO 20065863 L NO20065863 L NO 20065863L
Authority
NO
Norway
Prior art keywords
methyl
optionally substituted
antibacterial agents
dihydroisoxazol
oxazolidin
Prior art date
Application number
NO20065863A
Other languages
English (en)
Inventor
Daniel Robert Carcanague
Michael Barry Gravenstock
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0411594A external-priority patent/GB0411594D0/en
Priority claimed from GB0500055A external-priority patent/GB0500055D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20065863L publication Critical patent/NO20065863L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Det tilveiebringes forbindelser med formel (I) eller et farmasøytisk akseptabelt salt eller prodrug derav der R1 er valgt for eksempel blant hydrogen, halogen, eventuelt substituert metyl; R2 og R3 uavhengig er valgt blant hydrogen, fluor, klor og trifluormetyl; R4 og R5 uavhengig for eksempel er valgt blant hydrogen, metyl, eventuelt substituert (C2-4)alkyl, -C(O)R6, eller R4 og R5 sammen med nitrogenatomet hvortil de er bundet danner en eventuelt substituert 5- eller 6-leddet, mettet eller partielt umettet heterocyklyl ring eller en eventuelt substituert imidazol ring. Det beskrives videre metoder for fremstilling av forbindelser med formel (I), preparater som inneholder forbindelsene og deres anvendelse som antibaktericide midler.
NO20065863A 2004-05-25 2006-12-19 3-[4-(6-(4,5-dihydroisoksazol-3-yl]pyridin-3-yl)-3-fenyl]-5-(1 H,1,2,3-triazol-1-yl-metyl)-1,3-oksazolidin-2-oner som antibakterielle midler NO20065863L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0411594A GB0411594D0 (en) 2004-05-25 2004-05-25 Chemical compounds
GB0500055A GB0500055D0 (en) 2005-01-05 2005-01-05 Chemical compounds
PCT/GB2005/002040 WO2005116021A1 (en) 2004-05-25 2005-05-24 3-[4-(6-{4,5-dihydroisoxazol-3-yl}pyridin-3-yl)-3-phenyl]-5-(1h-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-ones as antibacterial agents

Publications (1)

Publication Number Publication Date
NO20065863L true NO20065863L (no) 2007-02-20

Family

ID=34968779

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20065863A NO20065863L (no) 2004-05-25 2006-12-19 3-[4-(6-(4,5-dihydroisoksazol-3-yl]pyridin-3-yl)-3-fenyl]-5-(1 H,1,2,3-triazol-1-yl-metyl)-1,3-oksazolidin-2-oner som antibakterielle midler

Country Status (14)

Country Link
US (1) US20080064689A1 (no)
EP (1) EP1753756A1 (no)
JP (1) JP2008500315A (no)
KR (1) KR20070027614A (no)
AR (1) AR049121A1 (no)
AU (1) AU2005247663A1 (no)
BR (1) BRPI0511554A (no)
CA (1) CA2567454A1 (no)
IL (1) IL179348A0 (no)
MX (1) MXPA06013539A (no)
NO (1) NO20065863L (no)
TW (1) TW200604185A (no)
UY (1) UY28924A1 (no)
WO (1) WO2005116021A1 (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
KR100848232B1 (ko) * 2007-04-12 2008-07-24 일동제약주식회사 신규 헤테로 고리 또는 알콕시아미노메틸 옥사졸리디논 및그 제조방법
WO2010042887A2 (en) 2008-10-10 2010-04-15 Trius Therapeutics Methods for preparing oxazolidinones and compositions containing them
CN102224151A (zh) 2008-11-20 2011-10-19 万能药生物有限公司 新的抗微生物剂
BRPI1008829A2 (pt) 2009-02-03 2016-03-15 Trius Therapeutics forma cristalina de dihidrogenofosfato de (r)-3-(4-(2-(2-metiltetrazol-5-il) piridin-5-il)-3-fluorofenil)-5-hidroximetil oxazolidin-2-ona
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
MX2012000231A (es) 2009-06-26 2012-03-07 Panacea Biotec Ltd Nuevos aza-biciclo-hexanos.
WO2011130419A2 (en) * 2010-04-13 2011-10-20 The Regents Of The University Of California Broad spectrum antiviral and antiparasitic agents
CA2977919A1 (en) * 2015-02-27 2016-09-01 Op Bio Factory Co., Ltd. Method for producing kakeromycin and derivatives thereof
CN111471041B (zh) * 2019-01-23 2022-09-20 中国科学院上海药物研究所 一种噁唑烷酮类抗菌药物中间体的合成方法
WO2021000297A1 (en) 2019-07-03 2021-01-07 Merck Sharp & Dohme Corp. Compounds and methods of use thereof as antibacterial agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1427711E (pt) * 2001-09-11 2005-11-30 Astrazeneca Ab Derivados de oxazolidinona e/ou isoxazolina como agentes antibacterianos
GB0227701D0 (en) * 2002-11-28 2003-01-08 Astrazeneca Ab Chemical compounds
JP2006508192A (ja) * 2002-11-28 2006-03-09 アストラゼネカ アクチボラグ 抗細菌薬としてのオキサゾリジノンおよび／またはイソオキサゾリン誘導体
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds

Also Published As

Publication number Publication date
CA2567454A1 (en) 2005-12-08
AR049121A1 (es) 2006-06-28
EP1753756A1 (en) 2007-02-21
UY28924A1 (es) 2005-12-30
TW200604185A (en) 2006-02-01
AU2005247663A1 (en) 2005-12-08
US20080064689A1 (en) 2008-03-13
JP2008500315A (ja) 2008-01-10
WO2005116021A1 (en) 2005-12-08
KR20070027614A (ko) 2007-03-09
MXPA06013539A (es) 2007-01-26
BRPI0511554A (pt) 2008-01-02
IL179348A0 (en) 2007-03-08

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