NO20071953L - RNAi modulering av RSV, PIV og andre respiratoriske viruser og anvendelse derav - Google Patents
RNAi modulering av RSV, PIV og andre respiratoriske viruser og anvendelse deravInfo
- Publication number
- NO20071953L NO20071953L NO20071953A NO20071953A NO20071953L NO 20071953 L NO20071953 L NO 20071953L NO 20071953 A NO20071953 A NO 20071953A NO 20071953 A NO20071953 A NO 20071953A NO 20071953 L NO20071953 L NO 20071953L
- Authority
- NO
- Norway
- Prior art keywords
- rsv
- piv
- respiratory viruses
- findings
- present
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- 108091030071 RNAI Proteins 0.000 title abstract 2
- 230000009368 gene silencing by RNA Effects 0.000 title abstract 2
- 230000000241 respiratory effect Effects 0.000 title abstract 2
- 230000003612 virological effect Effects 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62155204P | 2004-10-22 | 2004-10-22 | |
| US11/151,893 US7592322B2 (en) | 2004-10-22 | 2005-06-14 | RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof |
| US11/151,976 US20060089324A1 (en) | 2004-10-22 | 2005-06-14 | RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof |
| PCT/US2005/038269 WO2006062596A2 (en) | 2004-10-22 | 2005-10-21 | RNAi MODULATION OF RSV, PIV AND OTHER RESPIRATORY VIRUSES AND USES THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20071953L true NO20071953L (no) | 2007-05-18 |
Family
ID=36578352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20071953A NO20071953L (no) | 2004-10-22 | 2007-04-17 | RNAi modulering av RSV, PIV og andre respiratoriske viruser og anvendelse derav |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20060089324A1 (pt) |
| EP (1) | EP1806968B1 (pt) |
| JP (1) | JP5037349B2 (pt) |
| KR (1) | KR101193825B1 (pt) |
| CN (1) | CN101087527B (pt) |
| AU (1) | AU2005314617B2 (pt) |
| BR (1) | BRPI0517286A (pt) |
| CA (1) | CA2584309A1 (pt) |
| MX (1) | MX2007004692A (pt) |
| NO (1) | NO20071953L (pt) |
| RU (1) | RU2494745C2 (pt) |
| WO (1) | WO2006062596A2 (pt) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3415625A1 (en) | 2002-02-01 | 2018-12-19 | Life Technologies Corporation | Double-stranded oligonucleotides |
| WO2003064621A2 (en) | 2002-02-01 | 2003-08-07 | Ambion, Inc. | HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
| US20060009409A1 (en) | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
| US8258288B2 (en) * | 2002-02-20 | 2012-09-04 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of respiratory syncytial virus (RSV) expression using short interfering nucleic acid (siNA) |
| US20080214437A1 (en) * | 2002-09-06 | 2008-09-04 | Mohapatra Shyam S | Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases |
| US7297786B2 (en) | 2004-07-09 | 2007-11-20 | University Of Iowa Research Foundation | RNA interference in respiratory epitheial cells |
| US7790878B2 (en) * | 2004-10-22 | 2010-09-07 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof |
| CN101119734B (zh) * | 2005-01-07 | 2012-05-09 | 阿尔尼拉姆医药品有限公司 | RSV的RNAi调节及其治疗应用 |
| SI2308514T1 (sl) | 2007-03-23 | 2013-09-30 | To-Bbb Holding B.V. | Konjugati za prenos zdravila preko krvno-moĹľganske pregrade |
| JP2010527914A (ja) * | 2007-04-26 | 2010-08-19 | クォーク ファーマシューティカルズ インコーポレーティッド | 呼吸器系への抑制性核酸分子の治療的送達 |
| WO2009055445A2 (en) * | 2007-10-22 | 2009-04-30 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF RESPIRATORY SYNCYTIAL VIRUS (RSV) EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| EP2229459B1 (en) * | 2007-12-13 | 2014-08-27 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for prevention or treatment of RSV infection |
| CA2732229C (en) * | 2008-07-25 | 2023-10-17 | Alnylam Pharmaceuticals, Inc. | Enhancement of sirna silencing activity using universal bases or mismatches in the sense strand |
| WO2010048590A1 (en) * | 2008-10-23 | 2010-04-29 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for prevention or treatment of rsv infection using modified duplex rna molecules |
| JP2013521771A (ja) * | 2010-03-08 | 2013-06-13 | ノバルティス アーゲー | 細胞内病原体について試験する方法 |
| WO2012118911A1 (en) * | 2011-03-03 | 2012-09-07 | Quark Pharmaceuticals, Inc. | Oligonucleotide modulators of the toll-like receptor pathway |
| US10184942B2 (en) | 2011-03-17 | 2019-01-22 | University Of South Florida | Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer |
| US8916352B2 (en) * | 2011-04-08 | 2014-12-23 | Bio-Rad Laboratories, Inc. | PCR reaction mixtures with decreased non-specific activity |
| US11163898B2 (en) * | 2013-09-11 | 2021-11-02 | Mimecast Services Ltd. | Sharing artifacts in permission-protected archives |
| WO2016037164A1 (en) | 2014-09-07 | 2016-03-10 | Selecta Biosciences, Inc. | Methods and compositions for attenuating gene expression modulating anti-viral transfer vector immune responses |
| AU2015320409B2 (en) | 2014-09-26 | 2019-03-28 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Virus-based expression vectors and uses thereof |
| MX2020003838A (es) | 2017-10-13 | 2020-08-06 | Selecta Biosciences Inc | Metodos y composiciones para atenuar las respuestas de inmunoglobulina m del vector de transferencia antiviral. |
| BR112021023594A2 (pt) | 2019-05-28 | 2022-02-08 | Selecta Biosciences Inc | Métodos e composições para resposta imune de vetor de transferência antiviral atenuada |
| US20250152599A1 (en) * | 2020-03-13 | 2025-05-15 | Nuo-Beta Pharmaceutical Technology (Shanghai) Co., Ltd | Anti-coronavirus effect and application of p14k inhibitor |
| EP4162050A1 (en) * | 2020-06-09 | 2023-04-12 | Alnylam Pharmaceuticals, Inc. | Rnai compositions and methods of use thereof for delivery by inhalation |
| US20230141563A1 (en) | 2021-10-12 | 2023-05-11 | Selecta Biosciences, Inc. | Methods and compositions for attenuating anti-viral transfer vector igm responses |
| US20230357437A1 (en) | 2022-03-09 | 2023-11-09 | Selecta Biosciences, Inc. | Immunosuppressants in combination with anti-igm agents and related dosing |
| EP4527927A1 (en) * | 2023-09-22 | 2025-03-26 | Medizinische Hochschule Hannover | Oligonucleotide-based strategies to combat respiratory viruses |
| WO2026063375A1 (ja) * | 2024-09-20 | 2026-03-26 | 東亞合成株式会社 | Ｒｓｖ ｐタンパク質 ｒｎａ配列に基づく新規二本鎖ｒｎａ及びその利用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4501729A (en) * | 1982-12-13 | 1985-02-26 | Research Corporation | Aerosolized amiloride treatment of retained pulmonary secretions |
| US5693532A (en) * | 1994-11-04 | 1997-12-02 | Ribozyme Pharmaceuticals, Inc. | Respiratory syncytial virus ribozymes |
| AU6848396A (en) * | 1995-10-17 | 1997-05-07 | Hybridon, Inc. | Oligonucleotides with anti-respiratory syncytial virus activity |
| US6214805B1 (en) * | 1996-02-15 | 2001-04-10 | The United States Of America As Represented By The Department Of Health And Human Services | RNase L activators and antisense oligonucleotides effective to treat RSV infections |
| US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| KR100872437B1 (ko) * | 2000-12-01 | 2008-12-05 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | Ｒｎａ 간섭을 매개하는 작은 ｒｎａ 분자 |
| US20030124513A1 (en) * | 2001-05-29 | 2003-07-03 | Mcswiggen James | Enzymatic nucleic acid treatment of diseases or conditions related to levels of HIV |
| US20030148928A1 (en) | 2001-07-20 | 2003-08-07 | Leonid Beigelman | Enzymatic nucleic acid peptide conjugates |
| US20030203356A1 (en) * | 2002-01-22 | 2003-10-30 | The Cleveland Clinic Foundation | RNase L activator-antisense complexes |
| US20030203868A1 (en) * | 2002-02-06 | 2003-10-30 | Bushman Frederic D. | Inhibition of pathogen replication by RNA interference |
| WO2004042002A2 (en) * | 2002-08-05 | 2004-05-21 | University Of Massachusetts | Compounds for modulating rna interference |
| JP2006512906A (ja) * | 2002-09-28 | 2006-04-20 | マサチューセッツ インスティチュート オブ テクノロジー | インフルエンザ治療剤 |
| US20040242518A1 (en) | 2002-09-28 | 2004-12-02 | Massachusetts Institute Of Technology | Influenza therapeutic |
| EP1562970A4 (en) * | 2002-11-01 | 2006-04-12 | Univ Pennsylvania | COMPOSITIONS AND METHODS FOR SIRNAIL INHIBITION OF HIF-1 ALPHA |
| ATE477337T1 (de) * | 2003-01-16 | 2010-08-15 | Univ Pennsylvania | Zusammensetzungen und verfahren zur sirna-hemmung von icam-1 |
| WO2004064737A2 (en) | 2003-01-17 | 2004-08-05 | Alnylam Pharmaceuticals | Therapeutics compositions |
| WO2004080406A2 (en) | 2003-03-07 | 2004-09-23 | Alnylam Pharmaceuticals | Therapeutic compositions |
| WO2004094345A2 (en) | 2003-04-17 | 2004-11-04 | Alnylam Pharmaceuticals Inc. | Protected monomers |
| JP4597976B2 (ja) | 2003-04-17 | 2010-12-15 | アルナイラム ファーマシューティカルズ インコーポレイテッド | 修飾ｉＲＮＡ剤 |
| WO2005056021A1 (en) * | 2003-12-04 | 2005-06-23 | University Of South Florida | Polynucleotides for reducing respiratory syncytial virus gene expression |
| US7297786B2 (en) | 2004-07-09 | 2007-11-20 | University Of Iowa Research Foundation | RNA interference in respiratory epitheial cells |
| CN101119734B (zh) * | 2005-01-07 | 2012-05-09 | 阿尔尼拉姆医药品有限公司 | RSV的RNAi调节及其治疗应用 |
-
2005
- 2005-06-14 US US11/151,976 patent/US20060089324A1/en not_active Abandoned
- 2005-06-14 US US11/151,893 patent/US7592322B2/en not_active Expired - Fee Related
- 2005-10-21 AU AU2005314617A patent/AU2005314617B2/en not_active Ceased
- 2005-10-21 JP JP2007538147A patent/JP5037349B2/ja not_active Expired - Fee Related
- 2005-10-21 RU RU2010139908/10A patent/RU2494745C2/ru not_active IP Right Cessation
- 2005-10-21 CN CN2005800444868A patent/CN101087527B/zh not_active Expired - Fee Related
- 2005-10-21 CA CA002584309A patent/CA2584309A1/en not_active Abandoned
- 2005-10-21 BR BRPI0517286-1A patent/BRPI0517286A/pt not_active IP Right Cessation
- 2005-10-21 MX MX2007004692A patent/MX2007004692A/es active IP Right Grant
- 2005-10-21 KR KR1020077011553A patent/KR101193825B1/ko not_active Expired - Fee Related
- 2005-10-21 WO PCT/US2005/038269 patent/WO2006062596A2/en not_active Ceased
- 2005-10-21 EP EP05815963A patent/EP1806968B1/en not_active Expired - Lifetime
-
2007
- 2007-04-17 NO NO20071953A patent/NO20071953L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101087527A (zh) | 2007-12-12 |
| CA2584309A1 (en) | 2006-06-15 |
| WO2006062596A3 (en) | 2007-05-18 |
| CN101087527B (zh) | 2012-01-18 |
| RU2494745C2 (ru) | 2013-10-10 |
| JP2008517940A (ja) | 2008-05-29 |
| EP1806968A2 (en) | 2007-07-18 |
| MX2007004692A (es) | 2007-09-07 |
| AU2005314617B2 (en) | 2011-05-26 |
| AU2005314617A1 (en) | 2006-06-15 |
| US20060089323A1 (en) | 2006-04-27 |
| KR20070106686A (ko) | 2007-11-05 |
| KR101193825B1 (ko) | 2012-10-23 |
| BRPI0517286A (pt) | 2008-10-07 |
| JP5037349B2 (ja) | 2012-09-26 |
| HK1114308A1 (en) | 2008-10-31 |
| RU2010139908A (ru) | 2012-04-10 |
| EP1806968B1 (en) | 2012-12-05 |
| US20060089324A1 (en) | 2006-04-27 |
| WO2006062596A2 (en) | 2006-06-15 |
| US7592322B2 (en) | 2009-09-22 |
| EP1806968A4 (en) | 2010-06-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |