NO20072208L - Syklopropylpiperidinglysintransportorinhibitorer. - Google Patents

Syklopropylpiperidinglysintransportorinhibitorer.

Info

Publication number: NO20072208L
Authority: NO; Norway
Prior art keywords: glycine transporter; transporter glyt1; syklopropylpiperidinglysintransportorinhibitorer; glycinergic; glutamatergic
Prior art date: 2004-09-30

Application number

NO20072208A

Other languages

English (en)

Norwegian (no)

Inventor

Craig W Lindsley

David D Wisnoski

Scott E Wolkenberg

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-09-30

Filing date

2007-04-27

Publication date

2007-04-27

2007-04-27 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2007-04-27 Publication of NO20072208L publication Critical patent/NO20072208L/no

Links

102000010726 Glycine Plasma Membrane Transport Proteins Human genes 0.000 abstract 2
108010063380 Glycine Plasma Membrane Transport Proteins Proteins 0.000 abstract 2
102100023145 Sodium- and chloride-dependent glycine transporter 1 Human genes 0.000 abstract 2
101710083171 Sodium- and chloride-dependent glycine transporter 1 Proteins 0.000 abstract 2
JUBXTBVKELTJEX-UHFFFAOYSA-N 1-cyclopropylpiperidine Chemical class C1CC1N1CCCCC1 JUBXTBVKELTJEX-UHFFFAOYSA-N 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000004064 dysfunction Effects 0.000 abstract 1
230000000926 neurological effect Effects 0.000 abstract 1
208000020016 psychiatric disease Diseases 0.000 abstract 1
230000024587 synaptic transmission, glutamatergic Effects 0.000 abstract 1
230000027682 synaptic transmission, glycinergic Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Psychology (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20072208A 2004-09-30 2007-04-27 Syklopropylpiperidinglysintransportorinhibitorer. NO20072208L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US61494204P	2004-09-30	2004-09-30
PCT/US2005/034301 WO2006039221A2 (en)	2004-09-30	2005-09-26	Cyclopropyl piperidine glycine transporter inhibitors

Publications (1)

Publication Number	Publication Date
NO20072208L true NO20072208L (no)	2007-04-27

Family

ID=36142986

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20072208A NO20072208L (no)	2004-09-30	2007-04-27	Syklopropylpiperidinglysintransportorinhibitorer.

Country Status (16)

Country	Link
US (1)	US7776886B2 (pt)
EP (1)	EP1797035B1 (pt)
JP (1)	JP4646984B2 (pt)
KR (1)	KR20070058565A (pt)
CN (1)	CN101031547A (pt)
AT (1)	ATE488501T1 (pt)
AU (1)	AU2005292323B2 (pt)
BR (1)	BRPI0515954A (pt)
CA (1)	CA2581582C (pt)
DE (1)	DE602005024838D1 (pt)
IL (1)	IL182253A0 (pt)
MX (1)	MX2007003816A (pt)
NO (1)	NO20072208L (pt)
RU (1)	RU2387644C2 (pt)
WO (1)	WO2006039221A2 (pt)
ZA (1)	ZA200701612B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20070105902A1 (en) *	2003-11-12	2007-05-10	Lindsley Craig W	4-Phenyl piperdine sulfonyl glycine transporter inhibitors
US7825135B2 (en) *	2004-03-24	2010-11-02	Merck Sharp & Dohme Limited	Heteroaryl piperidine glycine transporter inhibitors
JP2007535538A (ja) *	2004-04-29	2007-12-06	メルク　エンド　カムパニー　インコーポレーテッド	アゼチジングリシン輸送体インヒビター
US7576083B2 (en) *	2004-05-05	2009-08-18	Merck & Co., Inc.	Morpholinyl piperidine glycine transporter inhibitors
JP5055493B2 (ja) *	2004-12-21	2012-10-24	メルクシャープエンドドームリミテッド	Ｇｌｙｔ１阻害薬としてのピペリジンおよびアゼチジン誘導体
PE20061490A1 (es) *	2005-06-06	2007-02-09	Merck Sharp & Dohme	Derivados de ciclohexanosulfonilo como inhibidores del transportador de glicina glyt1
EP1899294B1 (en)	2005-06-13	2015-03-18	Merck Sharp & Dohme Limited	Therapeutic agents
AU2006309050B2 (en)	2005-10-28	2012-08-16	Merck Sharp & Dohme Corp.	Piperidine glycine transporter inhibitors
US8431700B2 (en)	2009-03-03	2013-04-30	Vanderbilt University	Alkylsulfonyl-2,3-dihydrospiro[indene-1,4′-piperidine] analogs as GlyT1 inhibitors, methods for making same, and use of same in treating psychiatric disorders
MA39888A (fr)	2014-04-24	2017-03-01	Dart Neuroscience Cayman Ltd	Composés de 2,4,5,6-tétrahydropyrrolo[3,4-c] pyrazole et 4,5,6,7-tétrahydro-2 h-pyrazolo [4,3-c] pyridine utilisés comme inhibiteurs de glyt1
TWI601712B (zh)	2014-11-05	2017-10-11	達特神經科學（開曼）有限責任公司	作為ｇｌｙｔ１抑制劑之經取代之氮雜環丁基化合物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5532237A (en)	1995-02-15	1996-07-02	Merck Frosst Canada, Inc.	Indole derivatives with affinity for the cannabinoid receptor
US6303637B1 (en)	1998-10-30	2001-10-16	Merck & Co., Inc.	Heterocyclic potassium channel inhibitors
ES2278729T3 (es) *	2000-03-06	2007-08-16	Acadia Pharmaceuticals Inc.	Compuestos azaciclicos para usar en el tratamiento de enfermedades relacionadas con la serotonina.
AU4929601A (en)	2000-03-23	2001-10-03	Merck & Co Inc	Substituted piperidines as melanocortin receptor agonists
US7507767B2 (en)	2001-02-08	2009-03-24	Schering Corporation	Cannabinoid receptor ligands
RU2004117907A (ru)	2001-11-14	2006-01-10	Шеринг Корпорейшн (US)	Лиганды каннабиноидных рецепторов
GB0130696D0 (en) *	2001-12-21	2002-02-06	Smithkline Beecham Plc	Chemical Compounds
TW200403058A (en)	2002-04-19	2004-03-01	Bristol Myers Squibb Co	Heterocyclo inhibitors of potassium channel function
US20070105902A1 (en) *	2003-11-12	2007-05-10	Lindsley Craig W	4-Phenyl piperdine sulfonyl glycine transporter inhibitors
US7825135B2 (en)	2004-03-24	2010-11-02	Merck Sharp & Dohme Limited	Heteroaryl piperidine glycine transporter inhibitors
JP2007535538A (ja) *	2004-04-29	2007-12-06	メルク　エンド　カムパニー　インコーポレーテッド	アゼチジングリシン輸送体インヒビター
US7576083B2 (en)	2004-05-05	2009-08-18	Merck & Co., Inc.	Morpholinyl piperidine glycine transporter inhibitors
JP5055493B2 (ja) *	2004-12-21	2012-10-24	メルクシャープエンドドームリミテッド	Ｇｌｙｔ１阻害薬としてのピペリジンおよびアゼチジン誘導体
PE20061490A1 (es)	2005-06-06	2007-02-09	Merck Sharp & Dohme	Derivados de ciclohexanosulfonilo como inhibidores del transportador de glicina glyt1
WO2007041025A2 (en)	2005-09-29	2007-04-12	Merck & Co., Inc.	Radiolabeled glycine transporter inhibitors
AU2006309050B2 (en)	2005-10-28	2012-08-16	Merck Sharp & Dohme Corp.	Piperidine glycine transporter inhibitors

2005
- 2005-09-26 JP JP2007534679A patent/JP4646984B2/ja not_active Expired - Fee Related
- 2005-09-26 AU AU2005292323A patent/AU2005292323B2/en not_active Ceased
- 2005-09-26 DE DE602005024838T patent/DE602005024838D1/de not_active Expired - Lifetime
- 2005-09-26 MX MX2007003816A patent/MX2007003816A/es active IP Right Grant
- 2005-09-26 CN CNA2005800331179A patent/CN101031547A/zh active Pending
- 2005-09-26 BR BRPI0515954-7A patent/BRPI0515954A/pt not_active IP Right Cessation
- 2005-09-26 CA CA2581582A patent/CA2581582C/en not_active Expired - Lifetime
- 2005-09-26 RU RU2007116165/04A patent/RU2387644C2/ru not_active IP Right Cessation
- 2005-09-26 US US11/664,190 patent/US7776886B2/en active Active
- 2005-09-26 KR KR1020077007362A patent/KR20070058565A/ko not_active Withdrawn
- 2005-09-26 WO PCT/US2005/034301 patent/WO2006039221A2/en not_active Ceased
- 2005-09-26 AT AT05801197T patent/ATE488501T1/de not_active IP Right Cessation
- 2005-09-26 EP EP05801197A patent/EP1797035B1/en not_active Expired - Lifetime
2007
- 2007-02-23 ZA ZA200701612A patent/ZA200701612B/xx unknown
- 2007-03-27 IL IL182253A patent/IL182253A0/en unknown
- 2007-04-27 NO NO20072208A patent/NO20072208L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ATE488501T1 (de)	2010-12-15
WO2006039221A2 (en)	2006-04-13
IL182253A0 (en)	2007-09-20
JP2008514705A (ja)	2008-05-08
US7776886B2 (en)	2010-08-17
WO2006039221A3 (en)	2006-09-08
BRPI0515954A (pt)	2008-08-12
ZA200701612B (en)	2009-05-27
JP4646984B2 (ja)	2011-03-09
CA2581582A1 (en)	2006-04-13
KR20070058565A (ko)	2007-06-08
US20080108663A1 (en)	2008-05-08
EP1797035A4 (en)	2009-08-05
EP1797035A2 (en)	2007-06-20
CN101031547A (zh)	2007-09-05
AU2005292323B2 (en)	2011-06-09
RU2387644C2 (ru)	2010-04-27
EP1797035B1 (en)	2010-11-17
CA2581582C (en)	2010-07-20
RU2007116165A (ru)	2008-11-10
DE602005024838D1 (en)	2010-12-30
AU2005292323A1 (en)	2006-04-13
MX2007003816A (es)	2007-04-24

Legal Events

Date	Code	Title	Description
2011-05-09	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20072208L (no)	2007-04-27	Syklopropylpiperidinglysintransportorinhibitorer.
WO2005046601A3 (en)	2005-08-18	4-phenyl piperdine sulfonyl glycine transporter inhibitors
DE602007008434D1 (de)	2010-09-23	Rezeptoren
EA200900098A1 (ru)	2009-06-30	Пептидные соединения для лечения расстройств, связанных с повышенной возбудимостью, и болезней, связанных с дисфункцией ионных каналов
ATE557021T1 (de)	2012-05-15	Zur behandlung von erkrankungen des zns geeignete derivate des 4-piperazin-1-yl-4-benzoäbüthiophens
EA201170624A1 (ru)	2011-12-30	Изоникотинамидные антагонисты рецепторов орексинов
WO2005094514A3 (en)	2006-04-20	Heteroaryl piperidine glycine transporter inhibitors
WO2007061763A3 (en)	2007-12-13	Indole orexin receptor antagonists
BRPI0506679A (pt)	2007-05-15	métodos de tratar osteoartrite com antagonistas de il-6
MA31451B1 (fr)	2010-06-01	Antagonistes des recepteurs de l'orexine de pyridyl piperidine.
CR9347A (es)	2007-12-17	Derivados de pirimidina para el tratamiento de trastornos hiperproliferativos
WO2008008551A3 (en)	2008-02-28	2-substituted proline bis-amide orexin receptor antagonists
NO20074961L (no)	2007-10-17	Imidazopyridazinforbindelser
WO2007025069A3 (en)	2007-10-18	Diazaspirodecane orexin receptor antagonists
EA200500007A1 (ru)	2006-06-30	Пролекарства возбуждающих аминокислот
ATE494890T1 (de)	2011-01-15	Alpha-aminoamid-derivate zur behandlung von suchtstörungen
EA200700909A1 (ru)	2007-12-28	Азаиндолкарбоксамиды
EA200801343A1 (ru)	2008-12-30	Иммуноглобулины, направленные против nogo
TW200724140A (en)	2007-07-01	Hydantoin compounds
WO2007053400A3 (en)	2007-09-20	Piperidine glycine transporter inhibitors
WO2005107469A3 (en)	2006-06-29	Morpholinyl piperidine glycine transporter inhibitors
ATE542535T1 (de)	2012-02-15	Verwendung von azapaullonen zur vorbeugung und behandlung pankreatischer autoimmunkrankheiten
EA200601871A1 (ru)	2007-04-27	Способы лечения аутоиммунных и воспалительных заболеваний
IL173886A0 (en)	2006-07-05	Alpha-aminoamide derivatives useful as anti-inflammatory agents
EA200702336A1 (ru)	2008-04-28	ПРИМЕНЕНИЕ 24-норУДХК