NO20072440L - 2,6-substituert-4-monosubstituertamino-pyrimidin som prostaglanding D2 reseptor antagonister - Google Patents

2,6-substituert-4-monosubstituertamino-pyrimidin som prostaglanding D2 reseptor antagonister

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Publication number
NO20072440L
NO20072440L NO20072440A NO20072440A NO20072440L NO 20072440 L NO20072440 L NO 20072440L NO 20072440 A NO20072440 A NO 20072440A NO 20072440 A NO20072440 A NO 20072440A NO 20072440 L NO20072440 L NO 20072440L
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Norway
Prior art keywords
formula
urticaria
inflammation
itchy
effective amount
Prior art date
Application number
NO20072440A
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English (en)
Other versions
NO339772B1 (no
Inventor
Timothy Alan Gillespy
Sungtaek Lim
Keith John Harris
David Stefany
Charles J Gardner
Bin Cao
Ray Boffey
Joacy C Aguiar
Hazel J Hunt
Elsa Dechaux
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Aventis Pharma Inc
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Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of NO20072440L publication Critical patent/NO20072440L/no
Publication of NO339772B1 publication Critical patent/NO339772B1/no

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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Foreliggende oppfinnelse angår en forbindelse med formel (I) som definert heri, en farmasøytisk sammensetning som innbefatter en farmasøytisk effektiv mengde av en eller flere forbindelser av formel (I) sammenblandet med en farmastøysik akseptabel bærer, og en fremgangsmåte for behandling av en pasient som lider av en PGD2-mediert forstyrrelse, som inkluderer, men er ikke begrenset til, allergisk sykdom (slik som allergisk rinitt, allergisk konjuktivitt, atopisk dermatitt, bronkial astma og matallergi), systemisk mastocytose, forstyrrelser ledsaget av systemisk mastcelle aktivering, anafylaktisk sjokk, bronkokonstriksjon, bronkitt, urticaria, eksem, sykdommer ledsaget av kløe (slik som atopisk dermatitt og urticaria), sykdommer (slik som katarakt, retinal løsgjøring, inflammasjon, infeksjon og søvnforstyrrelser) som genereres sekundært som et resultat av oppførsel ledsaget av kløe (slik som skraping og bitin), inflammasjon, kronisk obstruktive lungesykdommer, ischemisk reperfusjonssakde, cerebrovaskulær ulykke, kronisk reumatoid artritt, pleurisi, ulcerativ kolitt og liknende ved å administrere til nevnte pasient en farmasøytisk effektiv mengde av en forbindelse ifølge formel (I).
NO20072440A 2004-10-15 2007-05-11 2,6-substituert-4-monosubstituert aminopyrimidin som prostaglandin D2 reseptorantagonister og farmasøytiske sammensetninger inneholdene disse, samt anvendelse av disse for fremstilling av et medikament NO339772B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61927204P 2004-10-15 2004-10-15
PCT/US2005/037148 WO2006044732A2 (en) 2004-10-15 2005-10-14 2, 6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin d2 receptor antagonists

Publications (2)

Publication Number Publication Date
NO20072440L true NO20072440L (no) 2007-07-03
NO339772B1 NO339772B1 (no) 2017-01-30

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NO20072440A NO339772B1 (no) 2004-10-15 2007-05-11 2,6-substituert-4-monosubstituert aminopyrimidin som prostaglandin D2 reseptorantagonister og farmasøytiske sammensetninger inneholdene disse, samt anvendelse av disse for fremstilling av et medikament

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US (2) US8193183B2 (no)
EP (1) EP1891019B1 (no)
JP (1) JP4970274B2 (no)
KR (1) KR101280268B1 (no)
CN (1) CN101039920B (no)
AR (1) AR053770A1 (no)
AU (1) AU2005295502B2 (no)
BR (1) BRPI0516482A (no)
CA (1) CA2583742C (no)
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NZ (1) NZ553919A (no)
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PE (1) PE20060936A1 (no)
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SI (1) SI1891019T1 (no)
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Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200600457A (es) * 2005-10-13 2007-04-27 Aventis Pharma Inc Sal de fosfato dihidrogeno como antagonistas del receptor de prostaglandina d2
DOP2007000068A (es) * 2006-04-12 2007-10-31 Sanofi Aventis Us Llc Compuestos de amino-pirimidina 2,6-sustituidos-4-monosustituidos como antagonistas del receptor de prostaglandina d2
WO2008039882A1 (en) * 2006-09-30 2008-04-03 Sanofi-Aventis U.S. Llc A combination of niacin and a prostaglandin d2 receptor antagonist
DK2142516T3 (da) * 2007-03-30 2013-04-15 Sanofi Sa Pyrimidinhydrazidforbindelser i ders egenskab af pgds-inhibitorer
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