NO20072741L - Stabiliserte, individuelt belagte ramiprilpartikler, sammensetninger og fremgangsmater - Google Patents

Stabiliserte, individuelt belagte ramiprilpartikler, sammensetninger og fremgangsmater

Info

Publication number
NO20072741L
NO20072741L NO20072741A NO20072741A NO20072741L NO 20072741 L NO20072741 L NO 20072741L NO 20072741 A NO20072741 A NO 20072741A NO 20072741 A NO20072741 A NO 20072741A NO 20072741 L NO20072741 L NO 20072741L
Authority
NO
Norway
Prior art keywords
ramipril
bioavailability
stabilized
pharmaceutical
particles
Prior art date
Application number
NO20072741A
Other languages
English (en)
Inventor
Edward Wilson
Martin W Beasley
Original Assignee
King Pharmaceuticals Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by King Pharmaceuticals Res & Dev filed Critical King Pharmaceuticals Res & Dev
Publication of NO20072741L publication Critical patent/NO20072741L/no

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

Det beskrives nye krystallinske ramiprilpartikler med forbedret stabilitet og biotilgjengelighet.Det gjelder mer spesielt individuelt belagte, krystallinske ramipril enkeltpartikler for farmasøytiske og biofarmasøytiske anvendelser i oral terapi som er stabilisert mot dekomponering til nedbrytningsproduktene, nemlig ramipril-DKP og ramipril-disyre, under formulerings- og lagringsbetingelser.Det beskrives videre farmasøytiske, stabiliserte ramiprilpreparater, nye, vannfrie ramiprilpulvere av farmasøytisk kvalitet, metoder for å forbedre biotilgjengeligheten til rarnipril samt metoder for fremstilling og stabilisering av ramiprilformuleringer.De nye, vannfrie ramiprilpulvere av farmasøytisk kvalitet og ramiprilpreparater og doseringsformer som oppnås ved dette, er nyttige ved behandling av kardiovaskulære forstyrrelser og har fordelen av at de gir større stabilitet mot dekomponering til ramiprilDKP'er og ramipril-disyrer under formulerings- og lagringsbetingelser.I tillegg beholder de konsistent angitt ramiprilpotens over utstrakt lagringstid og gir redusert. in vivo-variasjon i biotilgjengeligheten for ramipril hos individer ved oral administrering.
NO20072741A 2004-11-05 2007-05-30 Stabiliserte, individuelt belagte ramiprilpartikler, sammensetninger og fremgangsmater NO20072741L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62527004P 2004-11-05 2004-11-05
PCT/US2005/040429 WO2006050533A2 (en) 2004-11-05 2005-11-07 Stabilized individually coated ramipril particles, compositions and methods

Publications (1)

Publication Number Publication Date
NO20072741L true NO20072741L (no) 2007-08-03

Family

ID=36319833

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20072739A NO20072739L (no) 2004-11-05 2007-05-30 Stabiliserte ramiprilsammensetninger og fremgangsmater for fremstilling
NO20072741A NO20072741L (no) 2004-11-05 2007-05-30 Stabiliserte, individuelt belagte ramiprilpartikler, sammensetninger og fremgangsmater

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20072739A NO20072739L (no) 2004-11-05 2007-05-30 Stabiliserte ramiprilsammensetninger og fremgangsmater for fremstilling

Country Status (14)

Country Link
US (2) US20060159742A1 (no)
EP (2) EP1824451A2 (no)
JP (2) JP2008519062A (no)
KR (2) KR20070085759A (no)
CN (2) CN101098679A (no)
AU (2) AU2005304664A1 (no)
BR (2) BRPI0517663A (no)
CA (2) CA2586760A1 (no)
IL (2) IL183017A0 (no)
MX (2) MX2007005377A (no)
NO (2) NO20072739L (no)
RU (2) RU2007120821A (no)
WO (2) WO2006052968A2 (no)
ZA (2) ZA200704768B (no)

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Also Published As

Publication number Publication date
AU2005304664A1 (en) 2006-05-18
NO20072739L (no) 2007-07-24
WO2006050533A2 (en) 2006-05-11
WO2006050533A3 (en) 2006-09-14
WO2006052968A3 (en) 2006-10-12
CN101098679A (zh) 2008-01-02
BRPI0517662A (pt) 2008-10-14
KR20070085754A (ko) 2007-08-27
JP2008519062A (ja) 2008-06-05
CA2586760A1 (en) 2006-05-18
IL183018A0 (en) 2007-09-20
CN101098681A (zh) 2008-01-02
BRPI0517663A (pt) 2008-10-14
EP1824451A2 (en) 2007-08-29
IL183017A0 (en) 2007-09-20
US20060159742A1 (en) 2006-07-20
CA2586547A1 (en) 2006-05-11
US20060134213A1 (en) 2006-06-22
MX2007005377A (es) 2008-01-11
JP2008519063A (ja) 2008-06-05
RU2007120817A (ru) 2008-12-10
RU2007120821A (ru) 2008-12-10
KR20070085759A (ko) 2007-08-27
MX2007005373A (es) 2007-08-14
ZA200704768B (en) 2008-08-27
AU2005301989A1 (en) 2006-05-11
EP1817007A2 (en) 2007-08-15
ZA200704767B (en) 2008-08-27
WO2006052968A2 (en) 2006-05-18

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