NO20072755L - Fremgangsmate for fremstilling av 4-(6-klor-2-metylendioksyanilino)-7-2-(4-metylpiperazin-1-yl)etoksy]-5-tetrahydropyran-4-yloksykinazolin, deres mellomprodukter og krystallinske salter derav - Google Patents

Fremgangsmate for fremstilling av 4-(6-klor-2-metylendioksyanilino)-7-2-(4-metylpiperazin-1-yl)etoksy]-5-tetrahydropyran-4-yloksykinazolin, deres mellomprodukter og krystallinske salter derav

Info

Publication number: NO20072755L
Authority: NO; Norway
Prior art keywords: preparation; intermediates; yloxyquinazoline; methylenedioxyanilino; methylpiperazin
Prior art date: 2004-12-17

Application number

NO20072755A

Other languages

English (en)

Norwegian (no)

Inventor

Mark Purdie

James Mccabe

James Gair Ford

Anne O'kearney-Mcmullan

Phillip O'keefe

Simon Mark Pointon

Lyn Powell

Jane Withnall

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-17

Filing date

2007-05-30

Publication date

2007-07-02

2007-05-30 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2007-07-02 Publication of NO20072755L publication Critical patent/NO20072755L/no

Links

239000000543 intermediate Substances 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title abstract 2
125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 title 1
-1 6-Chloro-2-methylenedioxyanilino Chemical group 0.000 title 1
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
OUKYUETWWIPKQR-UHFFFAOYSA-N saracatinib Chemical compound C1CN(C)CCN1CCOC1=CC(OC2CCOCC2)=C(C(NC=2C(=CC=C3OCOC3=2)Cl)=NC=N2)C2=C1 OUKYUETWWIPKQR-UHFFFAOYSA-N 0.000 abstract 2
238000001311 chemical methods and process Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229950009919 saracatinib Drugs 0.000 abstract 1
150000004684 trihydrates Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO20072755A 2004-12-17 2007-05-30 Fremgangsmate for fremstilling av 4-(6-klor-2-metylendioksyanilino)-7-2-(4-metylpiperazin-1-yl)etoksy]-5-tetrahydropyran-4-yloksykinazolin, deres mellomprodukter og krystallinske salter derav NO20072755L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0427697.8A GB0427697D0 (en)	2004-12-17	2004-12-17	Chemical process
PCT/GB2005/004807 WO2006064217A2 (en)	2004-12-17	2005-12-14	PROCESS FOR THE PREPARATION OF 4-(6-CHLORO-2, 3-METHYLENEDIOXYANILINO)-7-[2-(4-METHYLPIPERAZIN-l-YL) ETHOXY]-5-TETRAHYDROPYRAN-4-YLOXYQUINAZOLINE , THEIR INTERMEDIATES AND CRYSTALLINE SALTS THEREOF

Publications (1)

Publication Number	Publication Date
NO20072755L true NO20072755L (no)	2007-07-02

Family

ID=34090249

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20072755A NO20072755L (no)	2004-12-17	2007-05-30	Fremgangsmate for fremstilling av 4-(6-klor-2-metylendioksyanilino)-7-2-(4-metylpiperazin-1-yl)etoksy]-5-tetrahydropyran-4-yloksykinazolin, deres mellomprodukter og krystallinske salter derav

Country Status (16)

Country	Link
US (1)	US8304417B2 (pt)
EP (1)	EP1871769B1 (pt)
JP (2)	JP5161584B2 (pt)
KR (6)	KR20070090004A (pt)
CN (1)	CN101115744B (pt)
AU (2)	AU2005315458B2 (pt)
BR (1)	BRPI0519085A2 (pt)
CA (2)	CA2590735C (pt)
ES (1)	ES2622480T3 (pt)
GB (1)	GB0427697D0 (pt)
IL (1)	IL183525A0 (pt)
MX (1)	MX2007007210A (pt)
NO (1)	NO20072755L (pt)
NZ (1)	NZ555468A (pt)
WO (1)	WO2006064217A2 (pt)
ZA (1)	ZA200704532B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0412074D0 (en) *	2004-05-29	2004-06-30	Astrazeneca Ab	Combination product
WO2009068906A2 (en) *	2007-11-26	2009-06-04	Astrazeneca Ab	Combinations comprising zd4054 and a src family kinase inhibitor 172
CN103275072B (zh) *	2013-05-22	2016-01-20	苏州明锐医药科技有限公司	塞卡替尼的制备方法
US10660957B2 (en) *	2013-06-13	2020-05-26	Yale University	Compositions and methods for treating an Aβ-modulated disease or disorder or improving cognition in a subject
US11241434B2 (en)	2013-06-13	2022-02-08	Yale Uninversity	Compositions and methods for improving cognition in a subject
WO2016130897A1 (en)	2015-02-13	2016-08-18	Yu Paul B	Methods and compositions for the treatment or prevention of abnormal bone formation in a soft tissue
FI3930715T3 (fi)	2019-02-27	2024-08-05	Astrazeneca Ab	Sarakatinibi käytettäväksi idiopaattisen keuhkofibroosin hoidossa
CN116332789A (zh) *	2023-03-10	2023-06-27	上海康鹏科技股份有限公司	一种4-氨基-2-氟苯甲酰胺的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA73993C2 (uk) *	2000-06-06	2005-10-17	Астразенека Аб	Хіназолінові похідні для лікування пухлин та фармацевтична композиція
AU2001278609B2 (en)	2000-08-21	2005-04-14	Astrazeneca Ab	Quinazoline derivatives
ATE409185T1 (de)	2001-04-19	2008-10-15	Astrazeneca Ab	Chinazolin derivate
RU2350618C2 (ru) *	2002-11-04	2009-03-27	Астразенека Аб	ПРОИЗВОДНЫЕ ХИНАЗОЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ Src ТИРОЗИНКИНАЗЫ
GB0226434D0 (en)	2002-11-13	2002-12-18	Astrazeneca Ab	Combination product
GB0307333D0 (en)	2003-03-29	2003-05-07	Astrazeneca Ab	Therapeutic agent
GB0309850D0 (en) *	2003-04-30	2003-06-04	Astrazeneca Ab	Quinazoline derivatives
GB0310401D0 (en) *	2003-05-07	2003-06-11	Astrazeneca Ab	Therapeutic agent

2004
- 2004-12-17 GB GBGB0427697.8A patent/GB0427697D0/en not_active Ceased
2005
- 2005-12-14 KR KR1020077015972A patent/KR20070090004A/ko not_active Ceased
- 2005-12-14 WO PCT/GB2005/004807 patent/WO2006064217A2/en not_active Ceased
- 2005-12-14 CA CA002590735A patent/CA2590735C/en not_active Expired - Lifetime
- 2005-12-14 NZ NZ555468A patent/NZ555468A/en not_active IP Right Cessation
- 2005-12-14 ES ES05818127.2T patent/ES2622480T3/es not_active Expired - Lifetime
- 2005-12-14 MX MX2007007210A patent/MX2007007210A/es not_active Application Discontinuation
- 2005-12-14 CA CA002675642A patent/CA2675642A1/en not_active Abandoned
- 2005-12-14 AU AU2005315458A patent/AU2005315458B2/en not_active Expired
- 2005-12-14 US US11/793,064 patent/US8304417B2/en active Active
- 2005-12-14 KR KR1020087023973A patent/KR20080094849A/ko not_active Withdrawn
- 2005-12-14 BR BRPI0519085-1A patent/BRPI0519085A2/pt not_active IP Right Cessation
- 2005-12-14 EP EP05818127.2A patent/EP1871769B1/en not_active Expired - Lifetime
- 2005-12-14 JP JP2007546172A patent/JP5161584B2/ja not_active Expired - Lifetime
- 2005-12-14 CN CN2005800476248A patent/CN101115744B/zh not_active Expired - Lifetime
- 2005-12-14 KR KR1020087023969A patent/KR20080094846A/ko not_active Withdrawn
- 2005-12-14 KR KR1020087023972A patent/KR20080094848A/ko not_active Withdrawn
- 2005-12-14 KR KR1020087023971A patent/KR20080094847A/ko not_active Withdrawn
- 2005-12-14 KR KR1020117022793A patent/KR20110114727A/ko not_active Ceased
2007
- 2007-05-29 IL IL183525A patent/IL183525A0/en unknown
- 2007-05-30 NO NO20072755A patent/NO20072755L/no not_active Application Discontinuation
- 2007-05-31 ZA ZA200704532A patent/ZA200704532B/en unknown
2008
- 2008-12-15 JP JP2008318186A patent/JP2009143920A/ja active Pending
2009
- 2009-02-18 AU AU2009200622A patent/AU2009200622A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2009200622A1 (en)	2009-03-12
US8304417B2 (en)	2012-11-06
US20090099196A1 (en)	2009-04-16
KR20080094847A (ko)	2008-10-24
JP2008524183A (ja)	2008-07-10
ZA200704532B (en)	2008-07-30
KR20070090004A (ko)	2007-09-04
MX2007007210A (es)	2007-11-07
EP1871769B1 (en)	2017-02-22
NZ555468A (en)	2010-12-24
JP5161584B2 (ja)	2013-03-13
EP1871769A2 (en)	2008-01-02
KR20110114727A (ko)	2011-10-19
CN101115744A (zh)	2008-01-30
AU2005315458B2 (en)	2009-03-12
KR20080094846A (ko)	2008-10-24
KR20080094849A (ko)	2008-10-24
WO2006064217A3 (en)	2006-12-21
WO2006064217A8 (en)	2007-07-05
CN101115744B (zh)	2012-02-01
IL183525A0 (en)	2007-09-20
BRPI0519085A2 (pt)	2008-12-23
WO2006064217A2 (en)	2006-06-22
ES2622480T3 (es)	2017-07-06
CA2590735A1 (en)	2006-06-22
KR20080094848A (ko)	2008-10-24
GB0427697D0 (en)	2005-01-19
JP2009143920A (ja)	2009-07-02
CA2590735C (en)	2009-11-10
CA2675642A1 (en)	2006-06-22
AU2005315458A1 (en)	2006-06-22

Legal Events

Date	Code	Title	Description
2013-07-29	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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