NO20073389L - Tetrahydropyridln-4-yllndoler med en kombinasjon av affinitet for dopamin-D2-reseptorer og serotoningjenopptaksseter - Google Patents
Tetrahydropyridln-4-yllndoler med en kombinasjon av affinitet for dopamin-D2-reseptorer og serotoningjenopptaksseterInfo
- Publication number
- NO20073389L NO20073389L NO20073389A NO20073389A NO20073389L NO 20073389 L NO20073389 L NO 20073389L NO 20073389 A NO20073389 A NO 20073389A NO 20073389 A NO20073389 A NO 20073389A NO 20073389 L NO20073389 L NO 20073389L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- hydrogen
- tetrahydropyridin
- dopamine
- receptors
- Prior art date
Links
- 102000004980 Dopamine D2 Receptors Human genes 0.000 title abstract 2
- 108090001111 Dopamine D2 Receptors Proteins 0.000 title abstract 2
- 230000000697 serotonin reuptake Effects 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- XUDGCZURHPXFLU-UHFFFAOYSA-N 2-(1,2,3,4-tetrahydropyridin-4-yl)-1h-indole Chemical class C1=CNCCC1C1=CC2=CC=CC=C2N1 XUDGCZURHPXFLU-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Den foreliggende oppfinnelsen vedrører en gruppe nye tetrahydropyridin-4-yl-indoler med en todelt virkemåte: serotonin-reopptaksinhibisjon og affinitet for dopamin-D2 reseptorer, fremgangsmåter for fremstilling av disse forbindelsene og nye mellomprodukter som er nyttige ved syntesen av de nevnte tetrahydropyridin-4-yl-indolene. Oppfinnelsen vedrører også anvendelse av en forbindelse som her er beskrevet for fremstilling av et medikament som gir en fordelaktig effekt. Oppfinnelsen vedrører nye tetrahydropyridin-4-yl-indoler med formel (I). Og tautomerer, isomerer, prodrugs, N-oksider, farmakologisk akseptable salter, hydrater og solvater derav, der: - R1 er hydrogen, halogen, alkyl(C1-3) eller alkoksy(C1-3), CN eller CF3, - R2 er hydrogen eller alkyl(C1-3), R3 er hydrogen eller alkyl (C1-3), -Z er hydrogen eller alkyl (C1-3), alkoksy (C1-3) eller alkyltio(C1-3), - A er hydrogen eller alkyl (C1-3), eller -A og Z danner sammen en mettet eller (delvis) umettet 5- eller 6-leddet ring som kan være substituert med halogen, alkyl (C1-3) eller fenyl, der Z i ringen står for karbon, svovel eller nitrogen.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63343904P | 2004-12-07 | 2004-12-07 | |
| EP04106351 | 2004-12-07 | ||
| PCT/EP2005/056501 WO2006061373A2 (en) | 2004-12-07 | 2005-12-06 | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-d2 receptors and serotonin reuptake sites |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20073389L true NO20073389L (no) | 2007-07-05 |
Family
ID=36578275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20073389A NO20073389L (no) | 2004-12-07 | 2007-07-02 | Tetrahydropyridln-4-yllndoler med en kombinasjon av affinitet for dopamin-D2-reseptorer og serotoningjenopptaksseter |
Country Status (2)
| Country | Link |
|---|---|
| IL (1) | IL183202A0 (no) |
| NO (1) | NO20073389L (no) |
-
2007
- 2007-05-15 IL IL183202A patent/IL183202A0/en unknown
- 2007-07-02 NO NO20073389A patent/NO20073389L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL183202A0 (en) | 2007-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |