NO20073390L - Phenylpiperazines with a combination of affinity for dopamine D2 receptors and serotonin reuptake sites - Google Patents

Phenylpiperazines with a combination of affinity for dopamine D2 receptors and serotonin reuptake sites

Info

Publication number
NO20073390L
NO20073390L NO20073390A NO20073390A NO20073390L NO 20073390 L NO20073390 L NO 20073390L NO 20073390 A NO20073390 A NO 20073390A NO 20073390 A NO20073390 A NO 20073390A NO 20073390 L NO20073390 L NO 20073390L
Authority
NO
Norway
Prior art keywords
dopamine
receptors
affinity
serotonin reuptake
phenylpiperazines
Prior art date
Application number
NO20073390A
Other languages
Norwegian (no)
Inventor
Cornelis G Kruse
Roelof Van Hes
Pieter Smid
Martinus Th M Tulp
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2005/056500 external-priority patent/WO2006061372A2/en
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of NO20073390L publication Critical patent/NO20073390L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oppfinnelsen vedrører en gruppe nye fenylpiperazinderivater med en todelt virkemåte: serotonin-reopptaksinhibisjon og affinitet for dopamin-D2-reseptorer, og fremgangsmåter for fremstilling av disse forbindelsene. Oppfinnelsen vedrører også anvendelse av en forbindelse som er beskrevet for fremstilling av et medikament som gir en fordelaktig effekt. Forbindelsene har den generelle formel (1), der symbolene har betydningene som er gitt i teksten.The invention relates to a group of novel phenylpiperazine derivatives having a two-part mode of action: serotonin reuptake inhibition and affinity for dopamine D2 receptors, and methods for preparing these compounds. The invention also relates to the use of a compound disclosed for the manufacture of a medicament which provides a beneficial effect. The compounds have the general formula (1), where the symbols have the meanings given in the text.

NO20073390A 2004-12-07 2007-07-02 Phenylpiperazines with a combination of affinity for dopamine D2 receptors and serotonin reuptake sites NO20073390L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63344904P 2004-12-07 2004-12-07
EP04106350 2004-12-07
PCT/EP2005/056500 WO2006061372A2 (en) 2004-12-07 2005-12-06 Phenylpiperazines with a combination of affinity for dopamine -d2 receptors and serotonin reuptake sites

Publications (1)

Publication Number Publication Date
NO20073390L true NO20073390L (en) 2007-07-05

Family

ID=36578274

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073390A NO20073390L (en) 2004-12-07 2007-07-02 Phenylpiperazines with a combination of affinity for dopamine D2 receptors and serotonin reuptake sites

Country Status (2)

Country Link
IL (1) IL183201A0 (en)
NO (1) NO20073390L (en)

Also Published As

Publication number Publication date
IL183201A0 (en) 2007-08-19

Similar Documents

Publication Publication Date Title
SI1881967T1 (en) Substituted benzo(d)isoxazol-3-yl amine compounds as analgesics
NO20082136L (en) 1,5-substituted indol-2-yl amide derivatives
PT1940839E (en) Pyridopyrimidinone inhibitors of pi3kalpha
MY148429A (en) Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with benzyl groups, method for producing drugs containing said compounds and use thereof
MXPA05009969A (en) Methods for isolating crystalline form i of 5-azacytidine.
NO20072969L (en) Phenylpiperazine derivatives with a combination of partial dopamine D2 receptor agonism and serotonin reuptake inhibition
MX2009012471A (en) 4' substituted compounds having 5-ht6 receptor affinity.
NO20073941L (en) Dihydroimidazotiazolderivater
IL176111A0 (en) 2-(1h-indolylsulfanyl)-benzyl amine derivatives as ssri
IN2012DN03844A (en)
MX2009008324A (en) 6' substituted compounds having 5-ht6 receptor affinity.
DE602005009977D1 (en) TETRALIN AND INDANDERIVATES AND THEIR APPLICATIONS AS 5-HT ANTAGONISTS
MX2007007027A (en) Piperazinyl pyridine derivatives as anti-obesity agents.
WO2007017728A3 (en) Novel heterocyclic compounds
MX2009005242A (en) 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives and therapeutic use thereof.
NO20073390L (en) Phenylpiperazines with a combination of affinity for dopamine D2 receptors and serotonin reuptake sites
TW200631952A (en) Benzdioxan piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
TW200633987A (en) Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
UA97370C2 (en) Phenylpentadienoyl derivatives and their use as par 1 antagonists
DE602006013828D1 (en) 4-aryloxy-chinolin-derivate als 5-ht6-modulatoren
NO20073387L (en) Benz dioxane piperazine derivatives with a combination of affinity for dopamine D2 receptors and serotonin reuptake sites
DE602007008947D1 (en) 4,5,6,7-tetrahydrothienoä2,3-cüpyridine als h3-modulatoren
TW200634009A (en) Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
NO20064410L (en) Process for the preparation of tryptase inhibitors
DE602005017663D1 (en) TETRALINE AND INDANDERIVATES AND APPLICATIONS THEREOF

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application