NO20073823L - Kinolinderivater for behandlingen av latent tuberkulose - Google Patents
Kinolinderivater for behandlingen av latent tuberkuloseInfo
- Publication number
- NO20073823L NO20073823L NO20073823A NO20073823A NO20073823L NO 20073823 L NO20073823 L NO 20073823L NO 20073823 A NO20073823 A NO 20073823A NO 20073823 A NO20073823 A NO 20073823A NO 20073823 L NO20073823 L NO 20073823L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- hydrogen
- het
- alkyloxy
- alkylthio
- Prior art date
Links
- 206010065048 Latent tuberculosis Diseases 0.000 title abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 cyano, hydroxy Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Anvendelse av en forbindelse med formel (Ia) eller (Ib) for fremstillingen av et medikament for behandlingen av latent tuberkulose, hvori forbindelsen med formel (Ia) eller (Ib) er (Ia) (Ib) et farmasøytisk akseptabelt salt, et kvaternært amin, et N-oksid, en tautomer form eller en stereokjemisk isomer form derav hvori R1 er hydrogen, halo, haloalkyl, cyano, hydroksy, Ar, Het, alkyl, alkyloksy, alkyltio, alkyloksyalkyl, alkyltioalkyl, Ar-alkyl eller di(Ar)alkyl; p er 1, 2, 3 eller 4; R2 er hydrogen, hydroksy, merkapto, alkyloksy, alkyloksyalkyloksy, alkyltio, mono eller di(alkyl)amino eller et radikal med formel ; R3 er alkyl, Ar, Ar-alkyl, Het eller Het-alkyl; q er null, 1, 2, 3 eller 4; R4 og R5 er hver uavhengig hydrogen, alkyl eller benzyl; eller R4 og R5 kan tas sammen inklusive N til hvilket de er bundet; R6 er hydrogen, halo, haloalkyl, hydroksy, Ar, alkyl, alkyloksy, alkyltio, alkyloksyalkyl, alkyltioalkyl, Ar-alkyl eller di(Ar)alkyl; eller to vicinale R6-radikaler kan tas sammen for å danne et bivalent radikal -CH=CH-CH=CH-; r er 1, 2, 3, 4 eller 5; R7 er hydrogen, alkyl, Ar eller Het; R8 er hydrogen eller alkyl; R9 er okso; eller R8 og R9 danner sammen radikalet =N-CH=CH- . ?? ?? ?? ?? 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04078529 | 2004-12-24 | ||
| EP05105008 | 2005-06-08 | ||
| PCT/EP2005/056594 WO2006067048A1 (en) | 2004-12-24 | 2005-12-08 | Quinoline derivatives for the treatment of latent tuberculosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20073823L true NO20073823L (no) | 2007-07-23 |
| NO340376B1 NO340376B1 (no) | 2017-04-10 |
Family
ID=35717702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20073823A NO340376B1 (no) | 2004-12-24 | 2007-07-23 | Kinolinderivater for behandlingen av latent tuberkulose |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US20060142279A1 (no) |
| EP (1) | EP1830850B1 (no) |
| CN (1) | CN103142595B (no) |
| AP (1) | AP2327A (no) |
| AR (1) | AR051790A1 (no) |
| AT (1) | ATE501721T1 (no) |
| AU (1) | AU2005242138B2 (no) |
| BR (1) | BRPI0506400B8 (no) |
| CA (1) | CA2529265C (no) |
| CR (1) | CR9267A (no) |
| CY (1) | CY1112247T1 (no) |
| DE (1) | DE602005026984D1 (no) |
| DK (1) | DK1830850T3 (no) |
| EE (1) | EE05394B1 (no) |
| HR (1) | HRP20110392T1 (no) |
| IL (1) | IL184123A (no) |
| LV (1) | LV13469B (no) |
| ME (1) | ME01207B (no) |
| MY (1) | MY145845A (no) |
| NI (1) | NI200700146A (no) |
| NO (1) | NO340376B1 (no) |
| NZ (1) | NZ555460A (no) |
| PA (1) | PA8654801A1 (no) |
| PL (1) | PL1830850T3 (no) |
| PT (1) | PT1830850E (no) |
| RS (1) | RS51730B (no) |
| SI (1) | SI1830850T1 (no) |
| TR (1) | TR200504892A1 (no) |
| TW (1) | TWI404535B (no) |
| WO (1) | WO2006067048A1 (no) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO342701B1 (no) * | 2005-06-28 | 2018-07-09 | Janssen Pharmaceutica Nv | Kinolinderivater som antibakterielle midler |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1527050T3 (da) * | 2002-07-25 | 2010-07-19 | Janssen Pharmaceutica Nv | Quinolin-derivater og deres anvendelse som mycobakterielle inhibitorer |
| JO3270B1 (ar) * | 2005-06-28 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات كوينولين بصفة عوامل مضادة للبكتيريا |
| AU2006263882B2 (en) * | 2005-06-28 | 2012-12-13 | Janssen Pharmaceutica N.V | Quinoline derivatives as antibacterial agents |
| JO2725B1 (en) * | 2006-12-06 | 2013-09-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2683B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2970B1 (en) * | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO3271B1 (ar) * | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
| CA2711912A1 (en) * | 2008-01-14 | 2009-07-23 | Jyoti Chattopadhyaya | Quinoline, naphthalene and conformationally constrained quinoline or naphthalene derivates as anti-mycobacterial agents |
| RU2404971C2 (ru) * | 2008-12-02 | 2010-11-27 | ЗАО "Фарм-Синтез" | Новые производные хинолина, способ их получения, их применение для лечения микобактериальных инфекций, фармацевтическая композиция на их основе |
| US8741917B2 (en) | 2009-01-15 | 2014-06-03 | Rutgers, The State University Of New Jersey | Benzo [C] phenanthridines as antimicrobial agents |
| US20120059026A1 (en) | 2009-04-30 | 2012-03-08 | University Of Medicine And Dentistry Of New Jersey | Antimicrobial agents |
| WO2011156626A1 (en) | 2010-06-09 | 2011-12-15 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| CA2803890A1 (en) * | 2010-06-25 | 2011-12-29 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| US9822108B2 (en) | 2012-01-13 | 2017-11-21 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| US9475783B2 (en) | 2012-03-21 | 2016-10-25 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| KR102110355B1 (ko) | 2012-04-27 | 2020-05-14 | 얀센 파마슈티카 엔.브이. | 항균성 퀴놀린 유도체 |
| CA2869453C (en) | 2012-04-27 | 2021-03-02 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
| US9458150B2 (en) | 2013-11-08 | 2016-10-04 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| LT3250182T (lt) | 2015-01-27 | 2023-07-10 | Janssen Pharmaceutica Nv | Dispersinės kompozicijos |
| WO2017147316A1 (en) | 2016-02-25 | 2017-08-31 | Taxis Pharmaceuticals, Inc. | Synthetic processes and intermediates |
| ES2934785T3 (es) * | 2016-03-07 | 2023-02-27 | Global Alliance For Tb Drug Development Inc | Compuestos antibacterianos y usos de los mismos |
| RU2629369C1 (ru) * | 2016-10-05 | 2017-08-29 | Федеральное Государственное Унитарное Предприятие "Государственный Ордена Трудового Красного Знамени Научно-Исследовательский Институт Химических Реактивов И Особо Чистых Химических Веществ" | Четвертичные аммонийные производные 2-аминотиофен-3-карбоксилатов, обладающие противотуберкулезной активностью |
| US10774093B2 (en) | 2017-03-30 | 2020-09-15 | Taxis Pharmaceuticals, Inc. | Synthetic processes and synthetic intermediates |
| JOP20200004B1 (ar) | 2017-07-14 | 2023-09-17 | Janssen Pharmaceutica Nv | تركيبات طويلة المفعول |
| RU2661151C1 (ru) * | 2017-12-14 | 2018-07-12 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Селективные ингибиторы глицеральдегид-3-фосфатдегидрогеназы микобактерий |
| WO2020144197A1 (en) | 2019-01-09 | 2020-07-16 | Janssen Pharmaceutica Nv | Combination in the treatment of nontuberculous mycobacterial diseases |
| JP2023532982A (ja) | 2020-07-09 | 2023-08-01 | ヤンセン ファーマシューティカ エヌ．ベー． | 長時間作用型配合物 |
| KR20230038521A (ko) | 2020-07-09 | 2023-03-20 | 얀센 파마슈티카 엔.브이. | 장기 작용 제형 |
| CN116406270A (zh) | 2020-11-12 | 2023-07-07 | 詹森药业有限公司 | 在治疗非结核分枝杆菌疾病时的贝达喹啉、乙胺丁醇和大环内酯的组合 |
| WO2023232838A1 (en) | 2022-05-31 | 2023-12-07 | Janssen Pharmaceutica Nv | Bedaquiline for use in the treatment of leprosy |
| WO2024068693A1 (en) | 2022-09-28 | 2024-04-04 | Janssen Pharmaceutica Nv | Long-acting formulations |
| WO2024068699A1 (en) | 2022-09-28 | 2024-04-04 | Janssen Pharmaceutica Nv | Long-acting formulations |
| WO2025068448A1 (en) | 2023-09-28 | 2025-04-03 | Janssen Pharmaceutica Nv | Atp synthase inhibitors for use in the treatment of non-tuberculosis mycobacteria |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR038536A1 (es) * | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| DK1527050T3 (da) * | 2002-07-25 | 2010-07-19 | Janssen Pharmaceutica Nv | Quinolin-derivater og deres anvendelse som mycobakterielle inhibitorer |
-
2005
- 2005-12-05 EE EEP200500033A patent/EE05394B1/xx unknown
- 2005-12-06 CA CA2529265A patent/CA2529265C/en not_active Expired - Lifetime
- 2005-12-07 PA PA20058654801A patent/PA8654801A1/es unknown
- 2005-12-07 AU AU2005242138A patent/AU2005242138B2/en not_active Expired
- 2005-12-07 MY MYPI20055732A patent/MY145845A/en unknown
- 2005-12-08 HR HR20110392T patent/HRP20110392T1/hr unknown
- 2005-12-08 US US11/296,992 patent/US20060142279A1/en not_active Abandoned
- 2005-12-08 ME MEP-2011-92A patent/ME01207B/me unknown
- 2005-12-08 DK DK05815816.3T patent/DK1830850T3/da active
- 2005-12-08 AT AT05815816T patent/ATE501721T1/de active
- 2005-12-08 RS RS20110221A patent/RS51730B/sr unknown
- 2005-12-08 SI SI200531294T patent/SI1830850T1/sl unknown
- 2005-12-08 AP AP2007004054A patent/AP2327A/xx active
- 2005-12-08 TR TR2005/04892A patent/TR200504892A1/xx unknown
- 2005-12-08 NZ NZ555460A patent/NZ555460A/en not_active IP Right Cessation
- 2005-12-08 BR BRPI0506400A patent/BRPI0506400B8/pt not_active IP Right Cessation
- 2005-12-08 TW TW094143290A patent/TWI404535B/zh active
- 2005-12-08 CN CN201210507318.XA patent/CN103142595B/zh not_active Expired - Fee Related
- 2005-12-08 PT PT05815816T patent/PT1830850E/pt unknown
- 2005-12-08 EP EP05815816A patent/EP1830850B1/en not_active Expired - Lifetime
- 2005-12-08 WO PCT/EP2005/056594 patent/WO2006067048A1/en not_active Ceased
- 2005-12-08 DE DE602005026984T patent/DE602005026984D1/de not_active Expired - Lifetime
- 2005-12-08 PL PL05815816T patent/PL1830850T3/pl unknown
- 2005-12-09 LV LVP-05-161A patent/LV13469B/lv unknown
- 2005-12-09 AR ARP050105140A patent/AR051790A1/es unknown
-
2007
- 2007-06-05 NI NI200700146A patent/NI200700146A/es unknown
- 2007-06-21 IL IL184123A patent/IL184123A/en active IP Right Grant
- 2007-07-20 CR CR9267A patent/CR9267A/es not_active Application Discontinuation
- 2007-07-23 NO NO20073823A patent/NO340376B1/no unknown
-
2011
- 2011-06-15 CY CY20111100563T patent/CY1112247T1/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO342701B1 (no) * | 2005-06-28 | 2018-07-09 | Janssen Pharmaceutica Nv | Kinolinderivater som antibakterielle midler |
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