NO20074447L - Sykloheksylamider som dopamin D3, D2 og 5HT1A-antagonister - Google Patents

Sykloheksylamider som dopamin D3, D2 og 5HT1A-antagonister

Info

Publication number
NO20074447L
NO20074447L NO20074447A NO20074447A NO20074447L NO 20074447 L NO20074447 L NO 20074447L NO 20074447 A NO20074447 A NO 20074447A NO 20074447 A NO20074447 A NO 20074447A NO 20074447 L NO20074447 L NO 20074447L
Authority
NO
Norway
Prior art keywords
dopamine
heteroaryl
cycloalkyl
alkenyl
aryl
Prior art date
Application number
NO20074447A
Other languages
English (en)
Inventor
Bela Kiss
Gyorgy Domany
Janos Galambos
Katalin Saghy
Eva Againe Csongor
Eva Schmidt
Istvan Gyertyan
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of NO20074447L publication Critical patent/NO20074447L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Foreliggende oppfinnelse angår nye dopamin D3- og D2- og serotonin 5-HTxA-reseptor-subtype-foretrekkende ligander av formel (I); hvori A betegner alkyl, alkenyl, aryl, heteroaryl, sykloalkyl eller en gruppe av formel -NR1R2, hvori Ri og R2 betegner uavhengig en substi-tuent valgt fra hydrogen, alkyl, alkenyl, aryl, heteroaryl eller sykloalkyl, eller Ri og R2 danner sammen med det tilstøtende nitro-genatom og eventuelt med ytterligere heteroatomer en heterosyk-lisk ring; m er et helt tall på 0 til 1; n er et helt tall på 1 til 2, og/eller geometriske isomerer og/eller stereoisomerer og/eller diastereomerer og/eller salter og/eller hydrater og/eller solvater derav, fremgangsmåter for fremstilling av disse, farmasøytiske preparater inneholdende disse, og deres anvendelse innen terapi og/eller forhindring av en tilstand som krever modulering av dopamin og/eller 5-HTiA-reseptorer.
NO20074447A 2005-02-03 2007-08-31 Sykloheksylamider som dopamin D3, D2 og 5HT1A-antagonister NO20074447L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0500170A HUP0500170A3 (en) 2005-02-03 2005-02-03 Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
PCT/HU2006/000012 WO2006082456A1 (en) 2005-02-03 2006-02-02 Cyclohexylamides as dopamine d3 , d2 and 5ht1a antagonists

Publications (1)

Publication Number Publication Date
NO20074447L true NO20074447L (no) 2007-10-18

Family

ID=89985795

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074447A NO20074447L (no) 2005-02-03 2007-08-31 Sykloheksylamider som dopamin D3, D2 og 5HT1A-antagonister

Country Status (19)

Country Link
US (1) US7705003B2 (no)
EP (1) EP1844030A1 (no)
JP (1) JP2008528674A (no)
KR (1) KR20070101265A (no)
CN (1) CN101107236A (no)
AU (1) AU2006211002A1 (no)
BR (1) BRPI0606895A2 (no)
CA (1) CA2594845A1 (no)
EA (1) EA200701640A1 (no)
HU (1) HUP0500170A3 (no)
IL (1) IL183740A0 (no)
MA (1) MA29250B1 (no)
MX (1) MX2007009353A (no)
MY (1) MY139750A (no)
NO (1) NO20074447L (no)
TN (1) TNSN07255A1 (no)
TW (1) TWI311990B (no)
WO (1) WO2006082456A1 (no)
ZA (1) ZA200705839B (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1870405A1 (en) * 2006-06-22 2007-12-26 Bioprojet Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands
HU230748B1 (hu) * 2007-05-11 2018-02-28 Richter Gedeon Nyrt Új piperazin só és előállítási eljárása
HUP0700353A2 (en) 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
CN101815519B (zh) * 2007-08-03 2013-08-21 吉瑞工厂 包含多巴胺受体配体的药物组合物和使用多巴胺受体配体的治疗方法
US7875610B2 (en) 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
PL2317852T3 (pl) 2008-07-16 2015-05-29 Richter Gedeon Nyrt Preparaty farmaceutyczne zawierające ligandy receptora dopaminy
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
US8586579B2 (en) * 2010-06-21 2013-11-19 Hoffmann-La Roche Inc. Anellated pyridine compounds
US8470828B2 (en) * 2010-07-06 2013-06-25 Hoffmann-La Roche Inc. Anellated pyridine compounds
US8877778B2 (en) 2010-12-15 2014-11-04 Hoffmann-La Roche Inc. Benzofurane compounds
US8722683B2 (en) * 2011-02-17 2014-05-13 Hoffmann La-Roche Inc. Benzodioxole piperazine compounds
US8921397B2 (en) 2011-05-04 2014-12-30 Hoffmann-La Roche Inc. Benzofurane-piperidine compounds
US9376396B2 (en) 2012-10-22 2016-06-28 AbbVie Deutschland GmbH & Co. KG Acylaminocycloalkyl compounds suitable for treating disorders that respond to modulation of dopamine D3 receptor
UY35420A (es) 2013-03-15 2014-10-31 Abbvie Inc Compuestos de acilaminocicloalquilo apropiados para tratar trastornos que responden a la modulación del receptor de dopamina d3
AR095264A1 (es) 2013-03-15 2015-09-30 Abbvie Deutschland Compuestos de acilaminocicloalquilo apropiados para tratar trastornos que responden a la modulación del receptor de dopamina d3
CN104140421B (zh) * 2013-05-08 2017-04-05 上海医药工业研究院 苯并异噻唑类化合物及在制备抗精神分裂症药物中的应用
WO2017045599A1 (zh) * 2015-09-15 2017-03-23 浙江京新药业股份有限公司 环己烷衍生物或其立体异构体或盐及其制备与应用
CN106518841B (zh) 2015-09-15 2019-03-05 浙江京新药业股份有限公司 环己烷衍生物或其立体异构体或盐及其制备与应用
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
EP3495363B1 (en) 2016-07-28 2023-08-23 Shionogi & Co., Ltd Nitrogen-containing condensed ring compounds having dopamine d3 receptor antagonistic effect
US12319659B2 (en) 2017-02-24 2025-06-03 Shenzhen Linglan Bio-Pharmaceutical Technology Co., Ltd Selective ligand for dopamine D3 receptor, preparation method therefor, and pharmaceutical application thereof
JP7250405B2 (ja) 2018-01-26 2023-04-03 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する環式化合物
EP3744721B1 (en) 2018-01-26 2025-07-02 Shionogi & Co., Ltd. Condensed ring compounds having dopamine d3 receptor antagonistic effect
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
JP7810643B2 (ja) * 2019-11-05 2026-02-03 上▲海▼翰森生物医▲薬▼科技有限公司 ベンゾチオフェン誘導体レギュレーター、その調製法及び使用
CN114634479B (zh) * 2020-12-16 2025-02-07 北京盈科瑞创新药物研究有限公司 一种派嗪衍生物、其制备方法及应用
EP4594294A1 (en) * 2022-09-30 2025-08-06 The United States of America, as represented by the Secretary, Department of Health and Human Services Dopamine d3/d2 receptor partial agonists for the treatment of neuropsychiatric disorders
CN119874636A (zh) * 2025-01-16 2025-04-25 鲁南制药集团股份有限公司 一种卡利拉嗪的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763609A (en) 1996-03-21 1998-06-09 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands
US5703083A (en) 1996-04-15 1997-12-30 Neurogen Corporation N-aminoalkyl-1-biphenylenyl-2-carboxamides; new dopamine receptor subtype specific ligands
US5703237A (en) 1996-04-18 1997-12-30 Neurogen Corporation N-Aminoalkyl-2-anthraquinonecarboxamides; new dopamine receptor subtype specific ligands
JPH10152470A (ja) 1996-09-25 1998-06-09 Yoshitomi Pharmaceut Ind Ltd ピペラジン化合物
EP1009052B1 (en) * 1998-06-02 2012-02-15 Panasonic Corporation Polymer electrolyte fuel cell and method of manufacture thereof
SE9802208D0 (sv) 1998-06-22 1998-06-22 Astra Pharma Inc Novel compounds
JP4156859B2 (ja) 2001-06-20 2008-09-24 コスモ石油株式会社 軽油の水素化処理触媒及びその製造方法並びに軽油の水素化処理方法
HU227543B1 (en) 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
HUP0103987A3 (en) 2001-09-28 2004-11-29 Richter Gedeon Vegyeszet Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates

Also Published As

Publication number Publication date
HUP0500170A2 (en) 2006-11-28
CN101107236A (zh) 2008-01-16
US20080103140A1 (en) 2008-05-01
EA200701640A1 (ru) 2008-02-28
TW200639158A (en) 2006-11-16
ZA200705839B (en) 2009-05-27
TNSN07255A1 (en) 2008-12-31
HU0500170D0 (en) 2005-04-28
WO2006082456A1 (en) 2006-08-10
AU2006211002A1 (en) 2006-08-10
HUP0500170A3 (en) 2007-11-28
JP2008528674A (ja) 2008-07-31
KR20070101265A (ko) 2007-10-16
EP1844030A1 (en) 2007-10-17
IL183740A0 (en) 2007-09-20
CA2594845A1 (en) 2006-08-10
US7705003B2 (en) 2010-04-27
MA29250B1 (fr) 2008-02-01
MY139750A (en) 2009-10-30
MX2007009353A (es) 2007-09-21
BRPI0606895A2 (pt) 2009-07-21
TWI311990B (en) 2009-07-11

Similar Documents

Publication Publication Date Title
NO20074447L (no) Sykloheksylamider som dopamin D3, D2 og 5HT1A-antagonister
NO20061076L (no) (Tio)karbamoylsykloheksanderivater som D3/D2 -reseptorantagonister
MX2017002241A (es) Compuestos de aminopirimidina como inhibidores de jak.
NO341631B1 (no) Hydroksybenzamidderivater og deres anvendelse, fremgangsmåte for fremstilling og farmasøytiske sammensetninger
NO20073729L (no) Heterocykliske forbindelser som CCR2B-antagonister
AR070130A1 (es) Compuestos moduladores de beta-amiloide, un proceso para su obtencion, el uso del compuesto para la fabricacion de un medicamento y dicho medicamento
SG162805A1 (en) Pyrazine derivatives useful as adenosine receptor antagonists
NO20072632L (no) Oksadiazolderivater som DGAT-inhibitorer
ZA201008012B (en) Spirocyclic derivatives as histone deacetylase inhibitors
AR080878A1 (es) Derivados heterociclicos de ariletinilo, composiciones farmaceuticas que los contienen, metodo para prepararlos y uso de los mismos en el tratamiento de la esquizofrenia y trastornos cognitivos.
NO20063469L (no) Polyeheterosykliske forbindelser og deres anvendelse som metabotrofe glutamat reseptorantagonister
PE20140610A1 (es) Derivados de la piperidina 3-espirociclica como agonistas de receptores de la ghrelina
MX2009012885A (es) Nuevo derivado de 1,2,3,4-tetrahidroquinoxalina que tiene, como sustituyente, grupo fenilo que tiene estructura de ester de acido sulfonico o estructura de amida de acido sulfonico introducida en este, y tiene actividad de enlace al receptor de gluco
NO20076060L (no) Piperidin-4-yl-amidderivater og deres anvendelse som SST-reseptor subtype 5-antagonister
UA100669C2 (ru) Спироциклические нитрилы как ингибиторы протеазы, способ их получения (варианты) и лекарственное средство на их основе
ECSP14013296A (es) Derivados de etinilo
MY161403A (en) 5- (phenyl/pyridinyl-ethinyl) -2-pyridine/ 2-pyrimidine-carborxamides as mglur5 modulators
PH12022553296A1 (en) Spiro compounds as melanocortin 4 receptor antagonists and uses thereof
TN2009000386A1 (en) Pyrimidinyl-piperazines useful as dopamine d3 / d2 receptor ligands
NO20063597L (no) Acetylinske piperazinforbindelser og deres anvendelse som metabotrofiske glutamatreseptorantagonister
TW200800962A (en) Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
NO20076614L (no) Piperidinderivater
MX2010007929A (es) Imidazolinilmetil aril sulfonamidas novedosas.
CO5660263A2 (es) Derivados de imidazol heteroaril sustituidos como antagonistas del receptor de glutamato
NO20081862L (no) Alkylsulfoksidkinoliner som NK-3-reseptorligander

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application