NO20074697L - Ikke-aromatisk, nitrogenholdig heterosyklisk-1-karboksylatester-pyridylderivat - Google Patents

Ikke-aromatisk, nitrogenholdig heterosyklisk-1-karboksylatester-pyridylderivat

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Publication number
NO20074697L
NO20074697L NO20074697A NO20074697A NO20074697L NO 20074697 L NO20074697 L NO 20074697L NO 20074697 A NO20074697 A NO 20074697A NO 20074697 A NO20074697 A NO 20074697A NO 20074697 L NO20074697 L NO 20074697L
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NO
Norway
Prior art keywords
carboxylate ester
containing heterocyclic
derivative
pyridyl derivative
aromatic nitrogen
Prior art date
Application number
NO20074697A
Other languages
English (en)
Inventor
Takashi Sugane
Akio Kakefuda
Chikashi Saitoh
Takatoshi Kanayama
Jotarou Suzuki
Takahiro Ishii
Jun Maeda
Fumie Narazaki
Kentaro Sato
Tatsuhisa Takahashi
Chisato Kanai
Original Assignee
Astellas Pharma Inc
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Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of NO20074697L publication Critical patent/NO20074697L/no

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
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Abstract

Den foreliggende oppfinnelse til-veiebringer en forbindelse som kan anvendes for behandling av en sykdom assosiert med fettsyreamidhydrolase (FAAH), særlig pollakisuri/urininkonti-nens, overaktdv blære og/eller smerte. Det er blitt funnet at et nytt ikke-aromatisk, nitrogenholdig, hetero-syklisk 1-karboksylatesterpyridylderi-vat og et farmasøytisk akseptabelt salt derav har en potent FAAH-inhiberende aktivitet. Derivatet gir forbedret effektiv blærekapasitet, lindrer polla-kisuri og har antiallodynisk virkning. Derfor kan denne forbindelsen anvendes for behandling av pollakisuri/urin-inkontinens, overaktiv blære og/eller smerte.
NO20074697A 2005-02-17 2007-09-14 Ikke-aromatisk, nitrogenholdig heterosyklisk-1-karboksylatester-pyridylderivat NO20074697L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005040197 2005-02-17
JP2005303065 2005-10-18
PCT/JP2006/302698 WO2006088075A1 (ja) 2005-02-17 2006-02-16 ピリジル 非芳香族含窒素ヘテロ環－１－カルボン酸エステル誘導体

Publications (1)

Publication Number Publication Date
NO20074697L true NO20074697L (no) 2007-11-16

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NO20074697A NO20074697L (no) 2005-02-17 2007-09-14 Ikke-aromatisk, nitrogenholdig heterosyklisk-1-karboksylatester-pyridylderivat

Country Status (20)

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US (3) US7919495B2 (no)
EP (2) EP1849773B1 (no)
JP (1) JP4702361B2 (no)
KR (3) KR101063663B1 (no)
CN (1) CN101160287B (no)
AU (3) AU2006215080B2 (no)
BR (1) BRPI0608205B8 (no)
CA (1) CA2598294C (no)
CY (2) CY1114709T1 (no)
DK (2) DK1849773T3 (no)
ES (2) ES2433290T3 (no)
IL (1) IL184998A (no)
MX (1) MX2007010076A (no)
NO (1) NO20074697L (no)
PL (2) PL1849773T3 (no)
PT (2) PT2607362E (no)
RU (3) RU2376289C2 (no)
SI (2) SI1849773T1 (no)
TW (3) TWI385164B (no)
WO (1) WO2006088075A1 (no)

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