NO20075384L - Tiadiazolsubstituerte kumarinderivater og deres anvendelse som leukotrienbiosynteseinhibitorer. - Google Patents

Tiadiazolsubstituerte kumarinderivater og deres anvendelse som leukotrienbiosynteseinhibitorer.

Info

Publication number: NO20075384L
Authority: NO; Norway
Prior art keywords: biosynthesis inhibitors; tiadiazole; leukotriene biosynthesis; coumarin derivatives; substituted coumarin
Prior art date: 2005-03-23

Application number

NO20075384A

Other languages

English (en)

Norwegian (no)

Inventor

Richard Friesen

Erich Grimm

Sebastien Laliberte

Marc Blouin

Yves Gareau

Helene Juteau

Marc Gagnon

Bruce Mackay

Original Assignee

Merck Frosst Canada Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-23

Filing date

2007-10-22

Publication date

2007-11-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37023348&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20075384(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-10-22 Application filed by Merck Frosst Canada Ltd filed Critical Merck Frosst Canada Ltd

2007-11-30 Publication of NO20075384L publication Critical patent/NO20075384L/no

Links

230000015572 biosynthetic process Effects 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
150000002617 leukotrienes Chemical class 0.000 title abstract 2
150000001893 coumarin derivatives Chemical class 0.000 title 1
UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 2
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000003266 anti-allergic effect Effects 0.000 abstract 1
230000001088 anti-asthma Effects 0.000 abstract 1
230000000879 anti-atherosclerotic effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000000924 antiasthmatic agent Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000001120 cytoprotective effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Hematology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Toxicology (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Pregnancy & Childbirth (AREA)
Rheumatology (AREA)
Oncology (AREA)
Gynecology & Obstetrics (AREA)
Gastroenterology & Hepatology (AREA)
Ophthalmology & Optometry (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)

NO20075384A 2005-03-23 2007-10-22 Tiadiazolsubstituerte kumarinderivater og deres anvendelse som leukotrienbiosynteseinhibitorer. NO20075384L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US66431705P	2005-03-23	2005-03-23
PCT/CA2006/000432 WO2006099735A1 (en)	2005-03-23	2006-03-21	Thiadiazole substituted coumarin derivatives and their use as leukotriene biosynthesis inhibitor

Publications (1)

Publication Number	Publication Date
NO20075384L true NO20075384L (no)	2007-11-30

Family

ID=37023348

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20075384A NO20075384L (no)	2005-03-23	2007-10-22	Tiadiazolsubstituerte kumarinderivater og deres anvendelse som leukotrienbiosynteseinhibitorer.

Country Status (26)

Country	Link
US (3)	US7553973B2 (es)
EP (1)	EP1869031B1 (es)
JP (2)	JP4109316B1 (es)
KR (1)	KR20070113259A (es)
CN (2)	CN102627638A (es)
AR (1)	AR055041A1 (es)
AU (1)	AU2006227524B2 (es)
BR (1)	BRPI0609687A2 (es)
CA (1)	CA2600727C (es)
CR (1)	CR9442A (es)
DO (1)	DOP2006000069A (es)
EA (1)	EA012704B1 (es)
ES (1)	ES2394179T3 (es)
GT (1)	GT200600117A (es)
IL (1)	IL185724A0 (es)
MA (1)	MA29398B1 (es)
MX (1)	MX2007011638A (es)
MY (1)	MY142105A (es)
NI (1)	NI200700242A (es)
NO (1)	NO20075384L (es)
PA (1)	PA8667201A1 (es)
PE (1)	PE20061328A1 (es)
TN (1)	TNSN07348A1 (es)
TW (1)	TWI321130B (es)
WO (1)	WO2006099735A1 (es)
ZA (1)	ZA200707385B (es)

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AR055041A1 (es) *	2005-03-23	2007-08-01	Merck Frosst Canada Ltd	Tiadiazoles y oxadiazoles como inhibidores de la sintesis de leucotrienos. composiciones farmaceuticas.
CA2624294A1 (en) *	2005-10-05	2007-04-12	Merck Frosst Canada Ltd.	Substituted quinolines as inhibitors of leukotriene biosynthesis
AR065093A1 (es) *	2007-02-05	2009-05-13	Merck Frosst Canada Ltd	Compuestos farmacéuticos inhibidores de la biosintesis de leucotrienos
AR068498A1 (es) *	2007-09-27	2009-11-18	Merck & Co Inc	Compuestos de oxadiazol para inhibicion de biosintesis de leucotrienos
CN102574822A (zh)	2009-08-04	2012-07-11	阿米拉制药公司	作为溶血磷脂酸受体拮抗剂的化合物
GB2474120B (en)	2009-10-01	2011-12-21	Amira Pharmaceuticals Inc	Compounds as Lysophosphatidic acid receptor antagonists
CN103347510B (zh)	2010-12-07	2015-11-25	艾米拉医药股份有限公司	溶血磷脂酸受体拮抗剂及其在治疗纤维化中的用途
CN103596566B (zh)	2010-12-07	2017-08-25	阿米拉制药公司	多环lpa1拮抗剂及其使用
CN103596947A (zh)	2011-04-05	2014-02-19	艾米拉医药股份有限公司	用于治疗纤维化、疼痛、癌症和呼吸、过敏性、神经系统疾病或心血管疾病的基于3-或5-联苯-4-基异噁唑的化合物
US9260416B2 (en)	2011-05-27	2016-02-16	Amira Pharmaceuticals, Inc.	Heterocyclic autotaxin inhibitors and uses thereof
WO2014031586A2 (en) *	2012-08-20	2014-02-27	Tallikut Pharmaceuticals, Inc.	Methods for treating cardiovascular diseases
CN102924442B (zh) *	2012-11-15	2014-10-29	沈阳药科大学	含有噻唑环的色满类化合物及其类似物和医药用途
CN103304556B (zh) *	2013-06-21	2016-06-01	天津药物研究院有限公司	含有苯并吡喃的希夫碱类化合物、其制备方法和用途
WO2016144703A1 (en)	2015-03-06	2016-09-15	Pharmakea, Inc.	Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof
CA2999200C (en) *	2015-09-24	2021-03-30	Guizhou Bailing Group Pharmaceutical Co., Ltd.	4-substituted coumarin derivatives and preparation methods and uses thereof
MX2019002612A (es)	2016-09-07	2019-08-21	Pharmakea Inc	Usos de un inhibidor de lisil-oxidasa tipo 2.
MX390964B (es)	2016-09-07	2025-03-21	Pharmakea Inc	Formas cristalinas de un inhibidor tipo lisil oxidasa 2 y metodos de realizacion.
CN108658962B (zh) *	2017-03-30	2021-10-01	复旦大学	3-取代香豆素呋咱衍生物及其在制备抗多药耐药肿瘤药物中的用途
CN111116506B (zh) *	2019-12-31	2024-03-08	浙江大学衢州研究院	一种芳巯基二唑类衍生物的合成方法
CN113149979B (zh) *	2021-03-05	2022-11-25	朗捷睿(苏州)生物科技有限公司	一种8-(苯并噻唑酰胺)取代香豆素类化合物及其制备方法和应用

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DE3834860A1 (de) *	1988-10-13	1990-04-19	Basf Ag	Heterocyclisch substituierte alkoxycumarine, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
DE4235603A1 (de) *	1992-10-22	1994-04-28	Basf Ag	Arylalkoxythiocumarine, Verfahren zu ihrer Herstellung und diese enthaltende therapeutische Mittel
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EP0650964A1 (en)	1993-11-02	1995-05-03	Duphar International Research B.V	1 2H-1-benzopyran-2-one-8-yl -piperazine derivatives
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CN1802372B (zh) *	2003-06-11	2010-05-12	麦克弗罗斯特加拿大有限公司	7＇-(1,3-噻唑-2-基)-硫代香豆素及其作为白三烯生物合成抑制剂的应用
AR055041A1 (es) *	2005-03-23	2007-08-01	Merck Frosst Canada Ltd	Tiadiazoles y oxadiazoles como inhibidores de la sintesis de leucotrienos. composiciones farmaceuticas.

2006
- 2006-03-13 AR ARP060100953A patent/AR055041A1/es not_active Application Discontinuation
- 2006-03-15 TW TW095108809A patent/TWI321130B/zh not_active IP Right Cessation
- 2006-03-16 GT GT200600117A patent/GT200600117A/es unknown
- 2006-03-16 PE PE2006000290A patent/PE20061328A1/es not_active Application Discontinuation
- 2006-03-21 JP JP2008502204A patent/JP4109316B1/ja not_active Expired - Fee Related
- 2006-03-21 US US11/385,615 patent/US7553973B2/en not_active Expired - Lifetime
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- 2006-03-21 CA CA2600727A patent/CA2600727C/en not_active Expired - Fee Related
- 2006-03-21 KR KR1020077021981A patent/KR20070113259A/ko not_active Ceased
- 2006-03-21 ES ES06741360T patent/ES2394179T3/es not_active Expired - Lifetime
- 2006-03-21 MX MX2007011638A patent/MX2007011638A/es active IP Right Grant
- 2006-03-21 CN CN2012100528865A patent/CN102627638A/zh active Pending
- 2006-03-21 BR BRPI0609687-5A patent/BRPI0609687A2/pt not_active IP Right Cessation
- 2006-03-21 EA EA200702058A patent/EA012704B1/ru unknown
- 2006-03-21 WO PCT/CA2006/000432 patent/WO2006099735A1/en not_active Ceased
- 2006-03-21 AU AU2006227524A patent/AU2006227524B2/en not_active Ceased
- 2006-03-21 US US11/886,757 patent/US20090227638A1/en not_active Abandoned
- 2006-03-21 CN CNA2006800091517A patent/CN101146802A/zh active Pending
- 2006-03-22 MY MYPI20061254A patent/MY142105A/en unknown
- 2006-03-23 DO DO2006000069A patent/DOP2006000069A/es unknown
- 2006-03-23 PA PA20068667201A patent/PA8667201A1/es unknown
2007
- 2007-08-30 ZA ZA200707385A patent/ZA200707385B/xx unknown
- 2007-09-04 IL IL185724A patent/IL185724A0/en unknown
- 2007-09-14 TN TNP2007000348A patent/TNSN07348A1/en unknown
- 2007-09-20 NI NI200700242A patent/NI200700242A/es unknown
- 2007-10-16 CR CR9442A patent/CR9442A/es not_active Application Discontinuation
- 2007-10-17 MA MA30306A patent/MA29398B1/fr unknown
- 2007-10-22 NO NO20075384A patent/NO20075384L/no not_active Application Discontinuation
- 2007-11-20 JP JP2007300093A patent/JP5207711B2/ja not_active Expired - Fee Related
2008
- 2008-06-27 US US12/215,499 patent/US20090030048A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PE20061328A1 (es)	2007-01-13
DOP2006000069A (es)	2006-09-30
AR055041A1 (es)	2007-08-01
JP2008533179A (ja)	2008-08-21
JP2008101010A (ja)	2008-05-01
CN101146802A (zh)	2008-03-19
EP1869031B1 (en)	2012-08-08
JP4109316B1 (ja)	2008-07-02
EA012704B1 (ru)	2009-12-30
AU2006227524B2 (en)	2011-06-30
TNSN07348A1 (en)	2008-12-31
EA200702058A1 (ru)	2008-02-28
NI200700242A (es)	2008-05-13
CA2600727C (en)	2011-06-14
ES2394179T3 (es)	2013-01-23
IL185724A0 (en)	2008-01-06
EP1869031A1 (en)	2007-12-26
CA2600727A1 (en)	2006-09-28
KR20070113259A (ko)	2007-11-28
EP1869031A4 (en)	2011-02-09
CR9442A (es)	2008-01-21
TWI321130B (en)	2010-03-01
WO2006099735A1 (en)	2006-09-28
US20070149579A1 (en)	2007-06-28
CN102627638A (zh)	2012-08-08
US7553973B2 (en)	2009-06-30
BRPI0609687A2 (pt)	2010-04-20
TW200700414A (en)	2007-01-01
AU2006227524A1 (en)	2006-09-28
MA29398B1 (fr)	2008-04-01
MY142105A (en)	2010-09-15
US20090227638A1 (en)	2009-09-10
GT200600117A (es)	2007-01-19
JP5207711B2 (ja)	2013-06-12
ZA200707385B (en)	2010-01-27
US20090030048A1 (en)	2009-01-29
PA8667201A1 (es)	2006-10-13
MX2007011638A (es)	2007-11-14

Legal Events

Date	Code	Title	Description
2011-10-24	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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