NO20076076L - Bicykliske 6-alkyliden-penems som klasse-D beta-laktamase inhibitorer - Google Patents

Bicykliske 6-alkyliden-penems som klasse-D beta-laktamase inhibitorer

Info

Publication number
NO20076076L
NO20076076L NO20076076A NO20076076A NO20076076L NO 20076076 L NO20076076 L NO 20076076L NO 20076076 A NO20076076 A NO 20076076A NO 20076076 A NO20076076 A NO 20076076A NO 20076076 L NO20076076 L NO 20076076L
Authority
NO
Norway
Prior art keywords
class
present
bicyclic
beta
compounds
Prior art date
Application number
NO20076076A
Other languages
English (en)
Inventor
Aranapakam Mudumbai Venkatesan
Tarek Suhayl Mansour
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20076076L publication Critical patent/NO20076076L/no

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Foreliggende oppfinnelse angår visse bisykliske 6-alkyliden-penemer som virker som en inhibitor av klasse-D enzymer. ??laktamaser hydrolyserer ?-laktam- antibiotika og tjener som sådanne som den primære årsak til bakteriell resistens. Forbindelsene ifølge foreliggende oppfinnelse når kombinert med ??laktam-antibiotika vil gi en effektiv behandling mot livstruende bakterieinfeksjoner. I henhold til foreliggende oppfinnelse er det gitt forbindelser med den generelle formel I eller et farmasøytisk akseptabelt salt eller in vivo hydrolyserbar ester R5 derav: hvor: én av A og B betyr hydrogen og den andre en eventuelt substituert kondensert bisyklisk heteroarylgruppe; og X=O eller S. (I)
NO20076076A 2005-06-01 2007-11-27 Bicykliske 6-alkyliden-penems som klasse-D beta-laktamase inhibitorer NO20076076L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68634705P 2005-06-01 2005-06-01
PCT/US2006/020891 WO2006130588A1 (en) 2005-06-01 2006-05-26 Bicyclic 6-alkylidene-penems as class-d beta-lactamases inhibitors

Publications (1)

Publication Number Publication Date
NO20076076L true NO20076076L (no) 2008-02-27

Family

ID=36992759

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20076076A NO20076076L (no) 2005-06-01 2007-11-27 Bicykliske 6-alkyliden-penems som klasse-D beta-laktamase inhibitorer

Country Status (17)

Country Link
US (1) US20060276445A1 (no)
EP (1) EP1885357A1 (no)
JP (1) JP2008545747A (no)
KR (1) KR20080016676A (no)
CN (1) CN101217955A (no)
AR (1) AR058795A1 (no)
AU (1) AU2006252604A1 (no)
BR (1) BRPI0610957A2 (no)
CA (1) CA2609428A1 (no)
GT (1) GT200600236A (no)
IL (1) IL187694A0 (no)
MX (1) MX2007015172A (no)
NO (1) NO20076076L (no)
PE (1) PE20070080A1 (no)
RU (1) RU2007145594A (no)
TW (1) TW200716102A (no)
WO (1) WO2006130588A1 (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
US20090018332A1 (en) * 2007-06-28 2009-01-15 Wyeth Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors
CN101998858A (zh) * 2008-03-18 2011-03-30 亚历山大·弗拉基米罗维奇·季科夫斯基 抗生素和益生元的药物组合物用于预防和治疗抗生素治疗中的微生态失调
CN102020659B (zh) * 2009-09-11 2013-07-03 中国中化股份有限公司 一种甲缩醛青霉烯中间体的制备方法
CA2910759C (en) 2013-05-02 2018-01-16 Pfizer Inc. Imidazo-triazine derivatives as pde10 inhibitors
CN103435617B (zh) * 2013-08-22 2016-04-27 南京华安药业有限公司 一种6,7-二氢-5H-吡咯并[1,2-a]咪唑-2-甲醛的合成方法
US10323042B2 (en) 2016-02-23 2019-06-18 Pfizer Inc. 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
ES2938615T3 (es) 2016-08-15 2023-04-13 Bayer Cropscience Ag Derivados del heterociclo bicíclico condensado como agentes de control de plagas
CN114990241B (zh) * 2022-06-07 2025-04-18 天津金匙医学科技有限公司 用于预测鲍曼不动杆菌对抗生素药敏表型的特征基因组合、试剂盒及测序方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8518416D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
GB9222700D0 (en) * 1992-10-29 1992-12-09 Smithkline Beecham Plc Chemical compounds
GB9326248D0 (en) * 1993-12-23 1994-02-23 Smithkline Beecham Plc Pharmaceutical formulations
MX9605149A (es) * 1994-04-25 1997-12-31 Smithkline Beecham Plc Formulaciones farmaceuticas que contienen una penema inhibidora de beta-lactamasa en combinacion con un antibiotico de beta-lactama y su uso en el tratamiento de infecciones bacterianas.
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
WO2003094839A2 (en) * 2002-05-09 2003-11-20 Cytokinetics, Inc. Pyrimidinone compounds, compositions and methods
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
CA2615886A1 (en) * 2005-07-27 2007-02-08 Wyeth Bicyclic 6-alkylidene-penem beta-lactamase inhibitors and beta-lactam antibiotic combination: a broad spectrum antibiotic

Also Published As

Publication number Publication date
CA2609428A1 (en) 2006-12-07
TW200716102A (en) 2007-05-01
RU2007145594A (ru) 2009-07-20
BRPI0610957A2 (pt) 2010-08-03
AU2006252604A1 (en) 2006-12-07
US20060276445A1 (en) 2006-12-07
IL187694A0 (en) 2008-11-03
KR20080016676A (ko) 2008-02-21
JP2008545747A (ja) 2008-12-18
PE20070080A1 (es) 2007-01-24
AR058795A1 (es) 2008-02-27
GT200600236A (es) 2007-03-29
EP1885357A1 (en) 2008-02-13
MX2007015172A (es) 2008-02-19
CN101217955A (zh) 2008-07-09
WO2006130588A1 (en) 2006-12-07

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