NO20080498L - Fluorsubstituerte 2-okso-azepanderivater - Google Patents
Fluorsubstituerte 2-okso-azepanderivaterInfo
- Publication number
- NO20080498L NO20080498L NO20080498A NO20080498A NO20080498L NO 20080498 L NO20080498 L NO 20080498L NO 20080498 A NO20080498 A NO 20080498A NO 20080498 A NO20080498 A NO 20080498A NO 20080498 L NO20080498 L NO 20080498L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- halogen
- lower alkyl
- fluorine
- heteroaryl
- Prior art date
Links
- -1 Fluorine-substituted 2-oxo-azepane Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000002439 beta secretase inhibitor Substances 0.000 abstract 1
- 208000019065 cervical carcinoma Diseases 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000000777 hematopoietic system Anatomy 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Oppfinnelsen angår forbindelser med den generelle formel I hvor R1 er lavere alkyl substituert med halogen eller er aryl eller heteroaryl, usubstituert eller substituert med halogen; R2 er heterosykloalkyl, aryl eller heteroaryl, som er usubstituert eller substituert med én eller flere substituenter, valgt fra gruppen bestående av halogen, lavere alkyloksy, lavere alkyl substituert med halogen, O-lavere alkyl substituert med halogen eller er substituert med C(O)-NR''2, (CR2)m-C(O)-R', heteroaryl eller S(O)2-lavere alkyl; R3/R3', R4/R4' og R5/R5' uavhengig av hverandre er hydrogen eller fluor, hvor minst én av R4/R4' eller R5/R5' alltid er fluor; R' er aryl eller hydroksy; R'' er hydrogen, sykloalkyl eller heterosykloalkyl; R er hydrogen eller lavere alkyl; m er 0, 1, 2 eller 3; samt farmasøytisk egnede syreaddisjonssalter, optisk rene enantiomerer, racemater eller diastereomere blandinger derav. Det er funnet at forbindelsene med den generelle formel I er ?-sekretaseinhibitorer og de beslektede forbindelsene kan være anvendelige ved behandling av Alzheimers sykdom eller vanlige kreftformer omfattende, men ikke begrenset til, karsinomer i livmorhalsen og brystkarsinomer og ondartede sykdommer i det hematopoetiske systemet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05107455 | 2005-08-12 | ||
| PCT/EP2006/064935 WO2007020190A1 (en) | 2005-08-12 | 2006-08-02 | Fluoro substituted 2-oxo azepan derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20080498L true NO20080498L (no) | 2008-03-07 |
Family
ID=37102441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20080498A NO20080498L (no) | 2005-08-12 | 2008-01-28 | Fluorsubstituerte 2-okso-azepanderivater |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7501406B2 (no) |
| EP (1) | EP1915345B1 (no) |
| JP (1) | JP4885958B2 (no) |
| KR (1) | KR101020397B1 (no) |
| CN (1) | CN101238106B (no) |
| AR (1) | AR055370A1 (no) |
| AT (1) | ATE492536T1 (no) |
| AU (1) | AU2006281493A1 (no) |
| BR (1) | BRPI0614566A2 (no) |
| CA (1) | CA2619223A1 (no) |
| DE (1) | DE602006019103D1 (no) |
| ES (1) | ES2355581T3 (no) |
| IL (1) | IL189026A0 (no) |
| MX (1) | MX2008001833A (no) |
| NO (1) | NO20080498L (no) |
| RU (1) | RU2419611C2 (no) |
| TW (1) | TWI325421B (no) |
| WO (1) | WO2007020190A1 (no) |
| ZA (1) | ZA200800930B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2667802A1 (en) * | 2006-11-03 | 2008-05-29 | Northwestern University | Multiple sclerosis therapy |
| FR2913886B1 (fr) | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
| GB201009603D0 (en) | 2010-06-08 | 2010-07-21 | Cambridge Entpr Ltd | Anti-inflammatory agent |
| WO2012014127A1 (en) | 2010-07-30 | 2012-02-02 | Ranbaxy Laboratories Limited | 5-lipoxygenase inhibitors |
| AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2793246B1 (fr) * | 1999-05-03 | 2001-06-29 | Adir | Nouveaux derives de 1-aza-2-alkyl-6-aryl-cycloalcanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP2004508289A (ja) * | 2000-04-03 | 2004-03-18 | デュポン ファーマシューティカルズ カンパニー | Ａβタンパク質産生の阻害剤としての環状ラクタム |
| CN102146053A (zh) * | 2003-03-24 | 2011-08-10 | 阿克西金药品公司 | 治疗哮喘及其它炎症或免疫性疾病的具有ccr3拮抗活性的2-苯氧基-和2-苯基磺酰胺衍生物 |
| RU2364587C2 (ru) * | 2003-10-29 | 2009-08-20 | Элан Фармасьютикалз, Инк. | N-замещенные бензолсульфонамиды |
| KR100880972B1 (ko) * | 2004-07-13 | 2009-02-03 | 에프. 호프만-라 로슈 아게 | 설폰아마이드 유도체 |
-
2006
- 2006-08-02 EP EP06792637A patent/EP1915345B1/en not_active Not-in-force
- 2006-08-02 JP JP2008525543A patent/JP4885958B2/ja not_active Expired - Fee Related
- 2006-08-02 CN CN2006800285175A patent/CN101238106B/zh not_active Expired - Fee Related
- 2006-08-02 RU RU2008103452/04A patent/RU2419611C2/ru not_active IP Right Cessation
- 2006-08-02 AU AU2006281493A patent/AU2006281493A1/en not_active Abandoned
- 2006-08-02 BR BRPI0614566-3A patent/BRPI0614566A2/pt not_active IP Right Cessation
- 2006-08-02 WO PCT/EP2006/064935 patent/WO2007020190A1/en not_active Ceased
- 2006-08-02 CA CA002619223A patent/CA2619223A1/en not_active Abandoned
- 2006-08-02 KR KR1020087003293A patent/KR101020397B1/ko not_active Expired - Fee Related
- 2006-08-02 ES ES06792637T patent/ES2355581T3/es active Active
- 2006-08-02 DE DE602006019103T patent/DE602006019103D1/de active Active
- 2006-08-02 AT AT06792637T patent/ATE492536T1/de active
- 2006-08-02 MX MX2008001833A patent/MX2008001833A/es active IP Right Grant
- 2006-08-08 US US11/500,662 patent/US7501406B2/en not_active Expired - Fee Related
- 2006-08-08 TW TW095129018A patent/TWI325421B/zh not_active IP Right Cessation
- 2006-08-10 AR ARP060103496A patent/AR055370A1/es not_active Application Discontinuation
-
2008
- 2008-01-24 IL IL189026A patent/IL189026A0/en unknown
- 2008-01-28 NO NO20080498A patent/NO20080498L/no not_active Application Discontinuation
- 2008-01-29 ZA ZA200800930A patent/ZA200800930B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2008103452A (ru) | 2009-09-20 |
| JP2009504600A (ja) | 2009-02-05 |
| CN101238106A (zh) | 2008-08-06 |
| DE602006019103D1 (de) | 2011-02-03 |
| US20070037789A1 (en) | 2007-02-15 |
| AU2006281493A1 (en) | 2007-02-22 |
| ZA200800930B (en) | 2009-02-25 |
| EP1915345A1 (en) | 2008-04-30 |
| ES2355581T3 (es) | 2011-03-29 |
| WO2007020190A1 (en) | 2007-02-22 |
| JP4885958B2 (ja) | 2012-02-29 |
| TWI325421B (en) | 2010-06-01 |
| TW200734308A (en) | 2007-09-16 |
| KR101020397B1 (ko) | 2011-03-08 |
| RU2419611C2 (ru) | 2011-05-27 |
| EP1915345B1 (en) | 2010-12-22 |
| US7501406B2 (en) | 2009-03-10 |
| MX2008001833A (es) | 2008-04-09 |
| IL189026A0 (en) | 2008-08-07 |
| CN101238106B (zh) | 2011-02-16 |
| CA2619223A1 (en) | 2007-02-22 |
| BRPI0614566A2 (pt) | 2009-08-04 |
| KR20080027936A (ko) | 2008-03-28 |
| AR055370A1 (es) | 2007-08-22 |
| ATE492536T1 (de) | 2011-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |