NO20080823L - Fremgangsmate for fremstilling av nebivolol - Google Patents

Fremgangsmate for fremstilling av nebivolol

Info

Publication number
NO20080823L
NO20080823L NO20080823A NO20080823A NO20080823L NO 20080823 L NO20080823 L NO 20080823L NO 20080823 A NO20080823 A NO 20080823A NO 20080823 A NO20080823 A NO 20080823A NO 20080823 L NO20080823 L NO 20080823L
Authority
NO
Norway
Prior art keywords
nebivolol
preparation
separated
transphonation
cyanhydrins
Prior art date
Application number
NO20080823A
Other languages
English (en)
Inventor
Christian N Noe
Muhammed Jasic
Hermann Kollmann
Bodo Lachmann
Original Assignee
Pharmacon Forschung & Beratung Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacon Forschung & Beratung Gmbh filed Critical Pharmacon Forschung & Beratung Gmbh
Publication of NO20080823L publication Critical patent/NO20080823L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)

Abstract

Gjenstand for oppfinnelsen er en fremgangsmåte for fremstilling av det rasemiske virkestoffet nebivolol, hvorved fremstilles diastereomere cyanhydriner, disse skilles og de skilte diastereomerene koples med hverandre etter en transfonnasjon, fortrinnsvis en delvis eller fullstendig reduksjon av cyanogruppen eller en pinner-forsåpning.
NO20080823A 2005-07-19 2008-02-15 Fremgangsmate for fremstilling av nebivolol NO20080823L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0121405A AT502220A1 (de) 2005-07-19 2005-07-19 Verfahren zur herstellung von nebivolol
PCT/AT2006/000303 WO2007009143A2 (de) 2005-07-19 2006-07-17 Verfahren zur herstellung nebivolol

Publications (1)

Publication Number Publication Date
NO20080823L true NO20080823L (no) 2008-04-02

Family

ID=37450808

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080823A NO20080823L (no) 2005-07-19 2008-02-15 Fremgangsmate for fremstilling av nebivolol

Country Status (15)

Country Link
US (1) US20080221340A1 (no)
EP (1) EP1919888A2 (no)
JP (1) JP2009502750A (no)
KR (1) KR20080027368A (no)
CN (1) CN101243062A (no)
AT (1) AT502220A1 (no)
AU (1) AU2006272420A1 (no)
BR (1) BRPI0613610A2 (no)
CA (1) CA2615832A1 (no)
EA (1) EA200800364A1 (no)
IL (1) IL188777A0 (no)
MX (1) MX2008000747A (no)
NO (1) NO20080823L (no)
WO (1) WO2007009143A2 (no)
ZA (1) ZA200800963B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2163551B1 (en) 2008-09-08 2011-11-16 Cadila Pharmaceuticals Ltd. An improved process for the preparation of nebivolol hydrochloride
IT1395354B1 (it) * 2009-07-23 2012-09-14 Zach System Spa Processo di preparazione di nebivololo
DE102010005953A1 (de) 2010-01-27 2011-07-28 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Nebivolol
IT1397962B1 (it) * 2010-02-11 2013-02-04 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
CN102190647A (zh) * 2010-03-12 2011-09-21 浙江海翔药业股份有限公司 一种奈比洛尔的中间体的制备方法
US10526304B2 (en) 2015-05-19 2020-01-07 Zhejiang Ausun Pharmaceutical Co., Ltd. Nebivolol synthesis method and intermediate compound thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
CN100546987C (zh) * 2005-03-03 2009-10-07 浙江医药股份有限公司新昌制药厂 Dl-奈必洛尔及其盐酸盐的制备方法

Also Published As

Publication number Publication date
IL188777A0 (en) 2008-08-07
EA200800364A1 (ru) 2008-06-30
CA2615832A1 (en) 2007-01-25
BRPI0613610A2 (pt) 2011-01-18
AT502220A1 (de) 2007-02-15
JP2009502750A (ja) 2009-01-29
ZA200800963B (en) 2009-08-26
WO2007009143A2 (de) 2007-01-25
MX2008000747A (es) 2008-04-14
WO2007009143A3 (de) 2007-04-05
CN101243062A (zh) 2008-08-13
EP1919888A2 (de) 2008-05-14
US20080221340A1 (en) 2008-09-11
KR20080027368A (ko) 2008-03-26
AU2006272420A1 (en) 2007-01-25

Similar Documents

Publication Publication Date Title
NO20080823L (no) Fremgangsmate for fremstilling av nebivolol
CY1110337T1 (el) Παρασκευη πρεγκαμπαλινης και σχετικων ενωσεων
DK2207786T3 (da) 2´-Fluor-2´-deoxytetrahydrouridiner som cytidindeaminasehæmmere
NO20033913L (no) Systemarkitektur og beslektede fremgangsmater for dynamisk tilfoyelse av programkomponenter, for a utvide systemprosessers funksjonalitet
EA200700974A1 (ru) Способ получения хиральных 8-(3-аминопиперидин-1-ил)ксантинов
EP1828223A4 (en) Novel betulin derivatives, their preparation and their use
DK1896364T3 (da) Pulverformet kalksammensætning, fremgangsmåde til fremstilling deraf og anvendelse deraf
BRPI0822775A2 (pt) Método de obtenção de uma proteína heteróloga, purificada, biologicamente ativa.
CL2014000937A1 (es) Metodo de obtención de plantas madereras usando factores de transcripcion (divisional de la solicitud 3915-08).
WO2007128737A3 (en) Method and device to fractionate stem cells
ATE412649T1 (de) Substituierte heteroarylbenzofuransäuren
WO2007044950A3 (en) Crystalline forms of docetaxel and processes for their preparation
EP1506965A4 (en) PROPANOLAMINE DERIVATIVES, PROCESS FOR PREPARING 3-N-METHYLAMINO-1- (2-THIENYL) -1-PROPANOLS AND METHOD FOR PRODUCING PROPANOLAMINE DERIVATIVES
MA28366A1 (fr) Derives de piperidinylalkylcarbamates, leur preparation et leur application comme inhibiteurs de l'enzyme faah
EP2366691A4 (en) NITROPYRIDINYLETHYLENIMINE COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
EE200700050A (et) Meetod bensofuraani valmistamiseks ning vahehendid
DK1756049T3 (da) Fremgangsmåde til fremstilling af 1,4-diphenylazetidinon-derivater
WO2005123043A3 (en) Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
WO2006093860A3 (en) Method and composition for repairing heart tissue
DK1429795T3 (da) Fremgangsmåde til fremstilling af ekstrakter af Pelargonium sidoides og/eller Pelargonium reniforme
WO2009077635A3 (es) Composición antiinflamatoria, antiedematosa y antieritematosa, procedimiento de obtención y usos
FR2900403B1 (fr) Procede de preparation de derives organiques oxysulfures et fluores
BRPI0615207A2 (pt) método de remoção de material de bissulfito de uma composição que compreende material de bissulfito e uma enzima, e de remoção de bissulfito de uma composição contendo bissulfito e uma enzima, e, composição de enzima
EE200400009A (et) Meetod (-)-R-homosidrunhappe- ja (+)-S-homosidrunhappe laktoonide saamiseks
FI20051058L (fi) Menetelmä puhtaiden enantiomeerien valmistukseen

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application