NO20081654L - Stabiliserte GLP-1-analoger - Google Patents

Stabiliserte GLP-1-analoger

Info

Publication number: NO20081654L
Authority: NO; Norway
Prior art keywords: amino acid; glp; analogs; base sequence; side groups
Prior art date: 2005-09-08

Application number

NO20081654A

Other languages

English (en)

Norwegian (no)

Inventor

William W Bachovchin

David George Sanford

Original Assignee

Tufts College

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-08

Filing date

2008-04-03

Publication date

2008-04-03

2008-04-03 Application filed by Tufts College filed Critical Tufts College

2008-04-03 Publication of NO20081654L publication Critical patent/NO20081654L/no

Links

DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 title abstract 6
150000001413 amino acids Chemical class 0.000 abstract 9
101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 3
102400000322 Glucagon-like peptide 1 Human genes 0.000 abstract 3
229920001184 polypeptide Polymers 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
102000007446 Glucagon-Like Peptide-1 Receptor Human genes 0.000 abstract 1
108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Zoology (AREA)
Physical Education & Sports Medicine (AREA)
Ophthalmology & Optometry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Emergency Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Child & Adolescent Psychology (AREA)

NO20081654A 2005-09-08 2008-04-03 Stabiliserte GLP-1-analoger NO20081654L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US71532205P	2005-09-08	2005-09-08
PCT/US2006/034685 WO2007030519A2 (en)	2005-09-08	2006-09-07	Stabilized glp-1 analogs

Publications (1)

Publication Number	Publication Date
NO20081654L true NO20081654L (no)	2008-04-03

Family

ID=37836409

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20081654A NO20081654L (no)	2005-09-08	2008-04-03	Stabiliserte GLP-1-analoger

Country Status (11)

Country	Link
US (1)	US8318668B2 (pt)
EP (2)	EP1940438A4 (pt)
JP (1)	JP2009507844A (pt)
KR (1)	KR20080052649A (pt)
CN (1)	CN101262874A (pt)
AU (1)	AU2006287562B2 (pt)
BR (1)	BRPI0615573A2 (pt)
CA (1)	CA2621699A1 (pt)
IL (1)	IL189996A0 (pt)
NO (1)	NO20081654L (pt)
WO (1)	WO2007030519A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7259234B2 (en) *	2003-05-15	2007-08-21	Trustees Of Tufts College	Stable analogs of peptide and polypeptide therapeutics
WO2009149148A2 (en) *	2008-06-03	2009-12-10	Trustees Of Tufts College	Long-acting glp-1 derivatives, and methods of treating cardiac dysfunction
CA2797095A1 (en)	2010-05-13	2011-11-17	Indiana University Research And Technology Corporation	Glucagon superfamily peptides exhibiting nuclear hormone receptor activity
BR112012029248B1 (pt) *	2010-05-17	2021-09-28	Betta Pharmaceuticals Co., Ltd	Análogo de glp-1 de fórmula i ou a sua composição, análogo de glp-1 de fórmula viii ou um sal farmaceuticamente aceitável ou a composição do mesmo, composição farmacêutica e uso de um composto
CA2796894A1 (en)	2010-06-24	2011-12-29	Indiana University Research And Technology Corporation	Amide based glucagon superfamily peptide prodrugs
CN102363633B (zh) *	2011-11-16	2013-11-20	天津拓飞生物科技有限公司	胰高血糖素样肽-1突变体多肽及其制备方法、药物组合物和其应用
CN103957927B (zh)	2011-11-17	2016-11-09	印第安纳大学研究及科技有限公司	呈现糖皮质激素受体活性的胰高血糖素超家族肽
EP2630965A1 (en) *	2012-02-24	2013-08-28	Curatis Pharma GmbH	A polypeptide for the protection from neurodegeneration in patients with amyotrophic lateral sclerosis (ALS)
AU2014359894B2 (en)	2013-12-06	2020-09-17	Baikang (Suzhou) Co., Ltd	Bioreversable promoieties for nitrogen-containing and hydroxyl-containing drugs
JP5910901B1 (ja) *	2015-03-27	2016-04-27	株式会社東洋新薬	Ｇｌｐ−１分泌促進剤
TWI726889B (zh) *	2015-06-10	2021-05-11	英商梅迪繆思有限公司	蛋白酶抗性之脂化肽
DK4122954T3 (da)	2018-04-05	2024-06-10	Sun Pharmaceutical Ind Ltd	Novel GLP-1-analoger
WO2020087305A1 (zh) *	2018-10-30	2020-05-07	刘建宁	具有glp-1受体激动剂活性的glp-1多肽及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3773919A (en)	1969-10-23	1973-11-20	Du Pont	Polylactide-drug mixtures
IE52535B1 (en)	1981-02-16	1987-12-09	Ici Plc	Continuous release pharmaceutical compositions
US5545618A (en)	1990-01-24	1996-08-13	Buckley; Douglas I.	GLP-1 analogs useful for diabetes treatment
EP0636032A1 (en)	1992-03-25	1995-02-01	Mallinckrodt Medical, Inc.	Method of intraoperatively detecting and locating tumoral tissues
EP0678018B1 (en)	1993-01-06	2003-04-09	Kinerton Limited	Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
US6890905B2 (en) *	2001-04-02	2005-05-10	Prosidion Limited	Methods for improving islet signaling in diabetes mellitus and for its prevention
EP1411968B1 (en) *	2001-07-31	2008-09-17	THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES	Glp-1 exendin-4 peptide analogs and uses thereof
WO2003020201A2 (en)	2001-08-28	2003-03-13	Eli Lilly And Company	Pre-mixes of glp-1 and basal insulin
MXPA04003553A (es) *	2001-10-18	2004-07-22	Bristol Myers Squibb Co	Mimeticos del peptido-1 similares aglucagon humano y su uso en tratamiento de diabetes y condiciones relacionadas.
US7238671B2 (en) *	2001-10-18	2007-07-03	Bristol-Myers Squibb Company	Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
US7259234B2 (en) *	2003-05-15	2007-08-21	Trustees Of Tufts College	Stable analogs of peptide and polypeptide therapeutics

2006
- 2006-09-07 EP EP06814219A patent/EP1940438A4/en not_active Withdrawn
- 2006-09-07 KR KR1020087008178A patent/KR20080052649A/ko not_active Ceased
- 2006-09-07 EP EP11194831A patent/EP2497781A1/en not_active Withdrawn
- 2006-09-07 BR BRPI0615573-1A patent/BRPI0615573A2/pt not_active Application Discontinuation
- 2006-09-07 US US12/066,324 patent/US8318668B2/en active Active
- 2006-09-07 JP JP2008530161A patent/JP2009507844A/ja not_active Ceased
- 2006-09-07 WO PCT/US2006/034685 patent/WO2007030519A2/en not_active Ceased
- 2006-09-07 AU AU2006287562A patent/AU2006287562B2/en not_active Ceased
- 2006-09-07 CA CA002621699A patent/CA2621699A1/en not_active Abandoned
- 2006-09-07 CN CNA2006800331050A patent/CN101262874A/zh active Pending
2008
- 2008-03-06 IL IL189996A patent/IL189996A0/en unknown
- 2008-04-03 NO NO20081654A patent/NO20081654L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP1940438A4 (en)	2009-10-21
US20090306338A1 (en)	2009-12-10
IL189996A0 (en)	2008-08-07
BRPI0615573A2 (pt)	2011-05-24
WO2007030519A2 (en)	2007-03-15
CA2621699A1 (en)	2007-03-15
KR20080052649A (ko)	2008-06-11
JP2009507844A (ja)	2009-02-26
CN101262874A (zh)	2008-09-10
US8318668B2 (en)	2012-11-27
EP1940438A2 (en)	2008-07-09
AU2006287562A1 (en)	2007-03-15
EP2497781A1 (en)	2012-09-12
AU2006287562B2 (en)	2012-05-10
WO2007030519A3 (en)	2007-11-29

Legal Events

Date	Code	Title	Description
2013-04-22	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20081654L (no)	2008-04-03	Stabiliserte GLP-1-analoger
SA521430398B1 (ar)	2024-05-14	Ph20 تركيبة صيدلانية، تشمل متغير ودواء هيالورونيداز البشرى، للحقن تحت الجلد
DK1877435T3 (da)	2011-06-06	Glucagon-lignende peptid 2 (GLP-2)-analoger
CY1110397T1 (el)	2015-04-29	Πολυπεπτιδιο που εχει βελτιωμενη δραστικοτητα αποαμινασης κυτοσινης
PE20130615A1 (es)	2013-07-01	Polipeptidos del receptor de activina variante y uso de los mismos
DE602005020165D1 (de)	2010-05-06	Verfahren zur herstellung von l-arginin, l-ornithin oder l-citrullin
RU2010147076A (ru)	2012-05-27	Аналоги инсулина специфичные к изоформам
EA201170878A1 (ru)	2012-01-30	Полипептиды с ксиланазной активностью
NO20061026L (no)	2006-03-02	Nye insulinderivater
WO2007115837B1 (en)	2008-03-27	Combination of an anti-edb fibronectin domain antibody/ il2 fusion protein and a further small molecule
DK2231860T3 (da)	2011-12-05	Polypeptid afledt protein A og i stand til at binde PDGF
PE20120358A1 (es)	2012-04-26	Mutantes fgf21 y usos de los mismos
MY206268A (en)	2024-12-06	Modified s1 subunit of the coronavirus spike protein
DK1755634T3 (da)	2009-02-16	Oligopeptider til formindskelse af forhöjet blodurinstofkoncentration
MXPA06010347A (es)	2007-06-19	Agonistas de receptor selectivo de y2 para intervenciones terapeuticas.
WO2011038900A3 (en)	2011-06-23	Peptide analogues of glucagon for diabetes therapy
BRPI0715331B8 (pt)	2021-05-25	polipeptídeo que compreende uma porção n-terminal e uma porção c-terminal, e uso do mesmo
MX2021013702A (es)	2021-12-10	Subunidad s2 modificada de la proteina de espicula de coronavirus.
MX2015016560A (es)	2017-06-01	Proteina analgesica aislada de la secrecion de la rana trachycephalous venulosus.
NO20083576L (no)	2008-12-10	Peptider av regulatoriske eller hjelpeproteiner av HIV, samt sammensetninger og anvendelser derav
NO20082864L (no)	2008-09-25	Nytt polypeptid med esteraseaktivitet og rekombinant esterase samt anvendelse derav
DE602005025989D1 (de)	2011-03-03	Von 2',3'-didesoxynucleosiden und 2',3'-didehydro-2',3'-didesoxynucleosiden
CA2722618A1 (en)	2009-10-01	Method of treating degenerative diseases
TH98389B (th)	2009-09-24	อานาลอกใหม่ของเพปไทด์ของลำไส้ที่ออกฤทธิ์กับเส้นเลือด