NO20082511L - Nye pyridopyraziner og deres anvendelse som kinasemodulatorer - Google Patents

Nye pyridopyraziner og deres anvendelse som kinasemodulatorer

Info

Publication number
NO20082511L
NO20082511L NO20082511A NO20082511A NO20082511L NO 20082511 L NO20082511 L NO 20082511L NO 20082511 A NO20082511 A NO 20082511A NO 20082511 A NO20082511 A NO 20082511A NO 20082511 L NO20082511 L NO 20082511L
Authority
NO
Norway
Prior art keywords
kinase modulators
pyridopyrazines
novel
novel pyridopyrazines
malignant
Prior art date
Application number
NO20082511A
Other languages
English (en)
Inventor
Eckhard Guenther
Emmanuel Polymeropoulos
Irene Seipelt
Eckhard Claus
Michael Czech
Tilmann Schuster
Original Assignee
Aeterna Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05024693A external-priority patent/EP1785423A1/de
Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Publication of NO20082511L publication Critical patent/NO20082511L/no

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Diabetes (AREA)
  • Cardiology (AREA)
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  • Neurology (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

Det beskrives nye pyrido[2,3-b]pyrazinderivater med den generelle formel (I) og (II), deres fremstilling samt deres anvendelse som medikamenter. De finner særlig anvendelse for behandling av maligne og andre forstyrrelser som involverer patologisk celleproliferering.
NO20082511A 2005-11-11 2008-06-03 Nye pyridopyraziner og deres anvendelse som kinasemodulatorer NO20082511L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73569805P 2005-11-11 2005-11-11
EP05024693A EP1785423A1 (de) 2005-11-11 2005-11-11 Neue Pyridopyrazine und deren Verwendung als Modulatoren von Kinasen
US84976106P 2006-10-06 2006-10-06
PCT/EP2006/068322 WO2007054556A1 (de) 2005-11-11 2006-11-10 Neue pyridopyrazine und deren verwendung als modulatoren von kinasen

Publications (1)

Publication Number Publication Date
NO20082511L true NO20082511L (no) 2008-06-24

Family

ID=37654792

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082511A NO20082511L (no) 2005-11-11 2008-06-03 Nye pyridopyraziner og deres anvendelse som kinasemodulatorer

Country Status (9)

Country Link
EP (1) EP1957487A1 (no)
JP (1) JP5527972B2 (no)
KR (1) KR101400905B1 (no)
AR (1) AR060010A1 (no)
AU (1) AU2006313701B2 (no)
CA (1) CA2628039A1 (no)
IL (1) IL191139A0 (no)
NO (1) NO20082511L (no)
WO (1) WO2007054556A1 (no)

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US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
EP1790342A1 (de) 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
EP1990342A1 (en) * 2007-05-10 2008-11-12 AEterna Zentaris GmbH Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof
US20100130597A1 (en) * 2007-07-06 2010-05-27 The United State Of America, As Represented By The Secretary Of The Dept Of Health And Human Service Dna-pkcs modulates energy regulation and brain function
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
US8846723B2 (en) 2010-07-29 2014-09-30 Eastman Chemical Company Esters of O-substituted hydroxy carboxylic acids and preparations thereof
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
EP2508184A1 (en) 2011-04-06 2012-10-10 Æterna Zentaris GmbH Pyridopyrazine derivatives and their use
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
HRP20210319T1 (hr) 2014-03-26 2021-04-30 Astex Therapeutics Ltd. Kombinacije inhibitora fgfr i inhibitora igf1r
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
RU2715236C2 (ru) 2014-03-26 2020-02-26 Астекс Терапьютикс Лтд Комбинации
TWI719960B (zh) 2015-02-10 2021-03-01 英商阿斯迪克治療公司 新穎組成物
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
EP3353164B1 (en) 2015-09-23 2021-11-03 Janssen Pharmaceutica, N.V. Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
US11155555B2 (en) 2015-09-23 2021-10-26 Janssen Pharmaceutica Nv Compounds

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Also Published As

Publication number Publication date
AU2006313701B2 (en) 2012-05-31
HK1126474A1 (en) 2009-09-04
WO2007054556A1 (de) 2007-05-18
JP5527972B2 (ja) 2014-06-25
CA2628039A1 (en) 2007-05-18
JP2009515853A (ja) 2009-04-16
IL191139A0 (en) 2008-12-29
AU2006313701A1 (en) 2007-05-18
EP1957487A1 (de) 2008-08-20
KR20080068117A (ko) 2008-07-22
AR060010A1 (es) 2008-05-21
KR101400905B1 (ko) 2014-05-29

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