NO20082733L - Indol-3-yl-karbonyl-spiro-piperidinderivater - Google Patents

Indol-3-yl-karbonyl-spiro-piperidinderivater

Info

Publication number: NO20082733L
Authority: NO; Norway
Prior art keywords: indol; carbonyl; spiropiperidine; spiro; relates
Prior art date: 2006-01-05

Application number

NO20082733A

Other languages

English (en)

Norwegian (no)

Inventor

Patrick Schnider

Hasane Ratni

Caterina Bissantz

Christophe Grundschober

Mark Rogers-Evans

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-01-05

Filing date

2008-06-18

Publication date

2008-10-02

2008-06-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2008-10-02 Publication of NO20082733L publication Critical patent/NO20082733L/no

Links

JUXAVSAMVBLDKO-UHFFFAOYSA-N 1-(1-azabicyclo[2.2.2]octan-3-yl)-3-[3-(1h-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]urea Chemical compound C1N(CC2)CCC2C1NC(=O)NC(C(=O)N1CCC2(C3=CC=CC=C3CC2)CC1)CC1=CNC2=CC=CC=C12 JUXAVSAMVBLDKO-UHFFFAOYSA-N 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010007558 Cardiac failure chronic Diseases 0.000 abstract 1
208000020401 Depressive disease Diseases 0.000 abstract 1
208000005171 Dysmenorrhea Diseases 0.000 abstract 1
206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
206010029164 Nephrotic syndrome Diseases 0.000 abstract 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 abstract 1
102000002852 Vasopressins Human genes 0.000 abstract 1
108010004977 Vasopressins Proteins 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 abstract 1
208000019425 cirrhosis of liver Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
229960003726 vasopressin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Gastroenterology & Hepatology (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20082733A 2006-01-05 2008-06-18 Indol-3-yl-karbonyl-spiro-piperidinderivater NO20082733L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06100118		2006-01-05
PCT/EP2006/069897 WO2007077122A1 (en)	2006-01-05	2006-12-19	Indol-3-yl-carbonyl-spiro-piperidine derivatives

Publications (1)

Publication Number	Publication Date
NO20082733L true NO20082733L (no)	2008-10-02

Family

ID=37989141

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20082733A NO20082733L (no)	2006-01-05	2008-06-18	Indol-3-yl-karbonyl-spiro-piperidinderivater

Country Status (15)

Country	Link
US (1)	US7351706B2 (pt)
EP (1)	EP1973913A1 (pt)
JP (1)	JP2009522318A (pt)
KR (1)	KR101121349B1 (pt)
CN (1)	CN101356174B (pt)
AR (1)	AR059136A1 (pt)
AU (1)	AU2006334423B2 (pt)
BR (1)	BRPI0620951A2 (pt)
CA (1)	CA2634120A1 (pt)
IL (1)	IL192401A0 (pt)
NO (1)	NO20082733L (pt)
RU (1)	RU2420529C2 (pt)
TW (1)	TW200734343A (pt)
WO (1)	WO2007077122A1 (pt)
ZA (1)	ZA200805574B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6374762B1 (en) *	1997-10-27	2002-04-23	Correct Craft, Inc.	Water sport towing apparatus
US7786141B2 (en) *	2004-08-19	2010-08-31	Vertex Pharmaceuticals Incorporated	Dihydrospiroindene modulators of muscarinic receptors
EP2374455A3 (en)	2004-08-19	2012-03-28	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
RU2007124373A (ru) *	2004-11-29	2009-01-10	Вертекс Фармасьютикалз Инкорпорейтед (Us)	Модуляторы мускариновых рецептеров
KR101018934B1 (ko) *	2005-09-28	2011-03-02	에프. 호프만-라 로슈 아게	바소프레신 수용체 길항물질로서인돌-3-일-카보닐-아자스피로 유도체
AU2006330866A1 (en) *	2005-12-22	2007-07-05	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
AU2007221214A1 (en)	2006-02-22	2007-09-07	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
AU2007284548A1 (en) *	2006-08-15	2008-02-21	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
CA2660974A1 (en) *	2006-08-18	2008-02-21	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
DE602007006989D1 (en) *	2006-12-07	2010-07-15	Hoffmann La Roche	Spiropiperidinderivate
JP2010540640A (ja) *	2007-10-03	2010-12-24	バーテックスファーマシューティカルズインコーポレイテッド	ムスカリン作用性レセプターのモジュレーター
WO2012170098A2 (en) *	2011-03-31	2012-12-13	The Regents Of The University Of Michigan	Arbovirus inhibitors and uses thereof
CN104203951B (zh)	2012-03-16	2016-11-02	生命医药公司	肝x受体调节剂
WO2013138568A1 (en)	2012-03-16	2013-09-19	Vitae Pharmaceuticals, Inc.	Liver x reception modulators
EA029167B1 (ru)	2013-12-19	2018-02-28	Ф. Хоффманн-Ля Рош Аг	Спиро-оксазолоны
EP3679043B9 (en) *	2017-09-05	2023-09-27	Neumora Therapeutics, Inc.	Vasopressin receptor antagonists and products and methods related thereto
WO2020048830A1 (en)	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds
WO2020048829A1 (en)	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	3,9-diazaspiro[5.5]undecane compounds
WO2020048828A1 (en)	2018-09-03	2020-03-12	Bayer Pharma Aktiengesellschaft	5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds
WO2020048826A1 (en)	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	5-substituted 1-oxa-3,9-diazaspiro[5.5]undecan-2-one compounds
WO2020048831A1 (en)	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4349549A (en) *	1981-05-18	1982-09-14	Syntex (U.S.A.) Inc.	Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s
FR2740136B1 (fr) *	1995-10-24	1998-01-09	Sanofi Sa	Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant
EP1009405A4 (en)	1997-08-28	2001-05-09	Merck & Co Inc	PAYRROLIDINE AND PIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
US6013652A (en) *	1997-12-04	2000-01-11	Merck & Co., Inc.	Spiro-substituted azacycles as neurokinin antagonists
AU7716600A (en)	1999-09-30	2001-04-30	Merck & Co., Inc.	Spiro[bicyclic -azacycloalkyl and -cycloalkyl] derivatives and uses thereof
GB0003397D0 (en) *	2000-02-14	2000-04-05	Merck Sharp & Dohme	Therapeutic agents
PL375149A1 (en) *	2002-10-03	2005-11-28	F.Hoffmann-La Roche Ag	Indole-3-carboxamides as glucokinase (gk) activators
CA2615726C (en)	2005-07-14	2014-05-27	Caterina Bissantz	Indol-3-yl-carbonyl-spiro-piperidine derivatives as v1a receptor antagonists

2006
- 2006-12-18 US US11/640,739 patent/US7351706B2/en not_active Expired - Fee Related
- 2006-12-19 EP EP06841445A patent/EP1973913A1/en not_active Withdrawn
- 2006-12-19 CA CA002634120A patent/CA2634120A1/en not_active Abandoned
- 2006-12-19 RU RU2008125813/04A patent/RU2420529C2/ru not_active IP Right Cessation
- 2006-12-19 AU AU2006334423A patent/AU2006334423B2/en not_active Ceased
- 2006-12-19 CN CN2006800504473A patent/CN101356174B/zh not_active Expired - Fee Related
- 2006-12-19 BR BRPI0620951-3A patent/BRPI0620951A2/pt not_active IP Right Cessation
- 2006-12-19 KR KR1020087016220A patent/KR101121349B1/ko not_active Expired - Fee Related
- 2006-12-19 JP JP2008548964A patent/JP2009522318A/ja not_active Ceased
- 2006-12-19 WO PCT/EP2006/069897 patent/WO2007077122A1/en not_active Ceased
2007
- 2007-01-02 TW TW096100068A patent/TW200734343A/zh unknown
- 2007-01-04 AR ARP070100032A patent/AR059136A1/es not_active Application Discontinuation
2008
- 2008-06-18 NO NO20082733A patent/NO20082733L/no not_active Application Discontinuation
- 2008-06-23 IL IL192401A patent/IL192401A0/en unknown
- 2008-06-25 ZA ZA200805574A patent/ZA200805574B/xx unknown

Also Published As

Publication number	Publication date
US7351706B2 (en)	2008-04-01
WO2007077122A1 (en)	2007-07-12
KR20080073364A (ko)	2008-08-08
AU2006334423B2 (en)	2011-09-22
CN101356174B (zh)	2011-11-23
BRPI0620951A2 (pt)	2011-11-29
JP2009522318A (ja)	2009-06-11
CA2634120A1 (en)	2007-07-12
IL192401A0 (en)	2008-12-29
ZA200805574B (en)	2009-12-30
AR059136A1 (es)	2008-03-12
CN101356174A (zh)	2009-01-28
AU2006334423A1 (en)	2007-07-12
US20070155761A1 (en)	2007-07-05
TW200734343A (en)	2007-09-16
KR101121349B1 (ko)	2012-03-09
RU2008125813A (ru)	2010-02-10
RU2420529C2 (ru)	2011-06-10
EP1973913A1 (en)	2008-10-01

Legal Events

Date	Code	Title	Description
2013-07-29	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20082733L (no)	2008-10-02	Indol-3-yl-karbonyl-spiro-piperidinderivater
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NO20083909L (no)	2008-12-15	Bisykliske benzimidazolforbindelser, og deres anvendelse som metabotropiske glutamatreseptorforsterkere
WO2006021213A3 (en)	2006-08-17	Vasopressin v1a antagonists
NO20064579L (no)	2006-11-08	Bifenylforbindelser anvendelige som muskariniske receptorantagonister
EP3925614A3 (en)	2022-03-23	Melanocortin receptor ligands
MA32812B1 (fr)	2011-11-01	Composition pharmaceutique d'un inhibiteur puissant du vhc pour une administration orale
UA92670C2 (ru)	2010-11-25	Пиразолиновые соединения и их фармацевтическое применение, композиция на их основе
WO2008125600A3 (en)	2009-01-22	Pyrazole derivatives as p2x7 modulators
MY143581A (en)	2011-05-31	Carboxamide derivatives as muscarinic receptor antagonists
WO2008099072A3 (fr)	2008-11-13	Nouveaux derives de 2, 4-dianilinopyrimidines, leur preparation, a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
WO2007136689A3 (en)	2008-01-10	Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-ht2a serotonin receptor
WO2007020213A3 (en)	2007-04-12	Thiazolyl piperidine derivatives useful as h3 receptor modulators
AR077534A1 (es)	2011-09-07	Derivados de isoxazol, un proceso para su obtencion, composiciones farmaceuticas que los contienen y su uso en el tratamiento de enfermedades relacionadas con el receptor gaba aalfa5
MXPA05004507A (es)	2005-10-18	4-amino-1-(piridilmetil)piperidina sustituida como antagonista del receptor muscarinico.
JP4973191B2 (ja)	2012-07-11	含窒素複素環化合物およびその医薬用途
NO20063597L (no)	2006-10-10	Acetylinske piperazinforbindelser og deres anvendelse som metabotrofiske glutamatreseptorantagonister
NO20091831L (no)	2009-07-07	Indoler
TW200640863A (en)	2006-12-01	Compounds which potentiate glutamate receptor and uses thereof in medicine
NO20091832L (no)	2009-07-07	Indoler som virker via reseptorantagonister