NO20083031L - Tiadiazolderivater som anti-diabetiske agenter - Google Patents

Tiadiazolderivater som anti-diabetiske agenter

Info

Publication number: NO20083031L
Authority: NO; Norway
Prior art keywords: compounds; inhibitors; prevention; formula; treatment
Prior art date: 2005-12-08

Application number

NO20083031A

Other languages

English (en)

Norwegian (no)

Inventor

Gary Mark Coppola

Thalaththani Ralalage Vedananda

James Richard Wareing

Travis Mathew Stams

Sidney Wolf Topiol

Gregory Raymond Bebernitz

David Barnes

Katsumasa Nakajima

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-08

Filing date

2008-07-04

Publication date

2008-08-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37950917&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20083031(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-07-04 Application filed by Novartis Ag filed Critical Novartis Ag

2008-08-28 Publication of NO20083031L publication Critical patent/NO20083031L/no

Links

239000003472 antidiabetic agent Substances 0.000 title 1
229940125708 antidiabetic agent Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
102000002727 Protein Tyrosine Phosphatase Human genes 0.000 abstract 3
108020000494 protein-tyrosine phosphatase Proteins 0.000 abstract 3
208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 3
206010022489 Insulin Resistance Diseases 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
239000003112 inhibitor Substances 0.000 abstract 2
230000002265 prevention Effects 0.000 abstract 2
201000001320 Atherosclerosis Diseases 0.000 abstract 1
201000009030 Carcinoma Diseases 0.000 abstract 1
208000035473 Communicable disease Diseases 0.000 abstract 1
208000032928 Dyslipidaemia Diseases 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
208000002705 Glucose Intolerance Diseases 0.000 abstract 1
206010018429 Glucose tolerance impaired Diseases 0.000 abstract 1
208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
206010033645 Pancreatitis Diseases 0.000 abstract 1
102000014400 SH2 domains Human genes 0.000 abstract 1
108050003452 SH2 domains Proteins 0.000 abstract 1
210000001789 adipocyte Anatomy 0.000 abstract 1
210000004204 blood vessel Anatomy 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
210000000987 immune system Anatomy 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
208000023589 ischemic disease Diseases 0.000 abstract 1
206010024627 liposarcoma Diseases 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1
230000000626 neurodegenerative effect Effects 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
DCWXELXMIBXGTH-UHFFFAOYSA-N phosphotyrosine Chemical compound OC(=O)C(N)CC1=CC=C(OP(O)(O)=O)C=C1 DCWXELXMIBXGTH-UHFFFAOYSA-N 0.000 abstract 1
208000037803 restenosis Diseases 0.000 abstract 1
230000002792 vascular Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Immunology (AREA)
Psychiatry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO20083031A 2005-12-08 2008-07-04 Tiadiazolderivater som anti-diabetiske agenter NO20083031L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US74857305P	2005-12-08	2005-12-08
PCT/US2006/046545 WO2007067615A2 (en)	2005-12-08	2006-12-06	Thiadiazole derivatives as antidiabetic agents

Publications (1)

Publication Number	Publication Date
NO20083031L true NO20083031L (no)	2008-08-28

Family

ID=37950917

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20083031A NO20083031L (no)	2005-12-08	2008-07-04	Tiadiazolderivater som anti-diabetiske agenter

Country Status (26)

Country	Link
US (1)	US7700633B2 (es)
EP (1)	EP1963292B1 (es)
JP (1)	JP2009519248A (es)
KR (1)	KR20080074969A (es)
CN (1)	CN101326173A (es)
AR (1)	AR056838A1 (es)
AT (1)	ATE546440T1 (es)
AU (1)	AU2006321905B2 (es)
BR (1)	BRPI0619600A2 (es)
CA (1)	CA2629857A1 (es)
CR (1)	CR10049A (es)
EC (1)	ECSP088506A (es)
ES (1)	ES2381280T3 (es)
IL (1)	IL191549A0 (es)
MA (1)	MA30202B1 (es)
NO (1)	NO20083031L (es)
NZ (1)	NZ568243A (es)
PE (2)	PE20100733A1 (es)
PL (1)	PL1963292T3 (es)
PT (1)	PT1963292E (es)
RU (1)	RU2008127254A (es)
TN (1)	TNSN08249A1 (es)
TW (1)	TW200732315A (es)
UA (1)	UA94724C2 (es)
WO (1)	WO2007067615A2 (es)
ZA (1)	ZA200804074B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA94921C2 (en)	2005-12-08	2011-06-25	Новартис Аг	1-orthofluorophenyl substituted 1, 2, 5-thiazolidinedione derivatives as ptp-as inhibitors
CN101312957A (zh) *	2005-12-08	2008-11-26	诺瓦提斯公司	用于治疗由蛋白酪氨酸磷酸酶介导的疾病(ptpase)的1,2,5-噻唑烷衍生物
CA2630448A1 (en) *	2005-12-08	2007-06-14	Novartis Ag	1,1,3-trioxo-1,2,5-thiadiazolidines and their use as ptp-ases inhibitors
WO2008067527A1 (en) *	2006-12-01	2008-06-05	Novartis Ag	Inhibitors of protein tyrosine phosphatase for the treatment of muscle atrophy and related disorders
AR066820A1 (es) *	2007-06-04	2009-09-16	Novartis Ag	Compuestos de tiadiazolidin-3 ona
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JP5809157B2 (ja)	2010-10-08	2015-11-10	持田製薬株式会社	環状アミド誘導体
AU2012248627A1 (en)	2011-04-28	2013-11-14	Mochida Pharmaceutical Co., Ltd.	Cyclic amide derivative
WO2018112545A1 (en) *	2016-12-23	2018-06-28	The University Of Queensland	Inhibitors of sox18 protein activity for treating angiogenesis- and/or lymphangiogenesis-related diseases
KR20250133466A (ko) *	2018-06-21	2025-09-05	칼리코 라이프 사이언시스 엘엘씨	단백질 타이로신 포스파타아제 억제제 및 그의 사용 방법
CN113365992B (zh) *	2018-12-21	2024-05-28	晶体制药独资有限公司	用于沃塞洛托的制备的方法和中间体
PE20252767A1 (es) *	2019-03-14	2025-12-22	Calico Life Sciences Llc	Inhibidores de la proteina tirosina fosfatasa y metodos para usarlos
GB201915094D0 (en) *	2019-10-18	2019-12-04	Balticgruppen Bio Ab	New formulations
US11691954B2 (en)	2019-10-18	2023-07-04	Betagenon Ab	Formulations
JP2023506227A (ja)	2019-12-12	2023-02-15	カムクワットバイオサイエンシーズインコーポレイテッド	免疫活性を強化するための組成物および方法
US20240383886A1 (en) *	2019-12-20	2024-11-21	Calico Life Sciences Llc	Protein Tyrosine Phosphatase Degraders and Methods of Use Thereof
CN117279913A (zh) *	2021-03-11	2023-12-22	金橘生物科技公司	杂环化合物及其用途
WO2022271727A1 (en) *	2021-06-21	2022-12-29	Calico Life Sciences Llc	Degrader compounds and uses thereof
WO2023086498A1 (en) *	2021-11-11	2023-05-19	Calico Life Sciences Llc	Protein tyrosine phosphatase inhibitors and methods of use thereof
CN119137117A (zh) *	2022-02-02	2024-12-13	耐瑞欧医疗公司	蛋白酪氨酸磷酸酶抑制剂及其用途
US20250134882A1 (en) *	2022-02-02	2025-05-01	Nerio Therapeutics, Inc.	Protein tyrosine phosphatase inhibitors and uses thereof
CR20240360A (es) *	2022-02-02	2024-10-01	Nerio Therapeutics Inc	Inhibidores de proteína tirosina fosfatasa y usos de estos
JP2025530135A (ja) *	2022-09-13	2025-09-11	カムクワットバイオサイエンシーズインコーポレイテッド	ベンゾ縮合ｎ－複素環及びその使用
WO2024067802A1 (zh) *	2022-09-30	2024-04-04	深圳众格生物科技有限公司	蛋白酪氨酸磷酸酶抑制剂及其制备方法和医药用途
WO2024141015A1 (en) *	2022-12-30	2024-07-04	Insilico Medicine Ip Limited	Protein tyrosine phosphatase inhibitors and uses thereof
CN118852335A (zh) *	2023-04-28	2024-10-29	中科中山药物创新研究院	噻二唑烷酮衍生物及其制备方法和应用
CN116496248B (zh) *	2023-05-06	2025-09-02	江苏艾科姆检测有限公司	一种溴氰虫酰胺杂质的合成方法
CN120981456A (zh)	2023-05-24	2025-11-18	金橘生物科技公司	杂环化合物及其用途
AU2024288616A1 (en) *	2023-07-11	2026-02-12	Shenzhen Zhongge Biological Technology Co., Ltd.	Protein tyrosine phosphatase inhibitor, composition comprising same, and medical use thereof
CN120004876B (zh) *	2023-11-16	2026-02-06	英矽智能科技(上海)有限公司	蛋白酪氨酸磷酸酶抑制剂及其应用
CN117343052B (zh) *	2023-12-04	2024-02-06	英矽智能科技(上海)有限公司	蛋白酪氨酸磷酸酶抑制剂及其应用
WO2025242216A1 (zh) *	2024-05-24	2025-11-27	杭州百新生物医药科技有限公司	吲哚啉类化合物及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL164262A0 (en) *	2002-04-03	2005-12-18	Novartis Ag	5-Substituted 1,1-dioxo-1,2,5-thiazolidine-3-one derivatives as ptpase 1b inhibitors
GB0225986D0 (en) *	2002-11-07	2002-12-11	Astrazeneca Ab	Chemical compounds
GB0227813D0 (en) *	2002-11-29	2003-01-08	Astrazeneca Ab	Chemical compounds
AU2003300447B2 (en) *	2002-12-30	2009-09-03	Vertex Pharmaceuticals Incorporated	Sulfhydantoins as phosphate isosteres for use as phosphatase inhibitors in the treatment of cancer and autoimmune disorders
US7141596B2 (en) *	2003-10-08	2006-11-28	Incyte Corporation	Inhibitors of proteins that bind phosphorylated molecules
CA2630448A1 (en) *	2005-12-08	2007-06-14	Novartis Ag	1,1,3-trioxo-1,2,5-thiadiazolidines and their use as ptp-ases inhibitors
CN101312957A (zh) *	2005-12-08	2008-11-26	诺瓦提斯公司	用于治疗由蛋白酪氨酸磷酸酶介导的疾病(ptpase)的1,2,5-噻唑烷衍生物
US8084448B2 (en) *	2006-03-31	2011-12-27	Novartis Ag	Organic compounds

2006
- 2006-06-12 UA UAA200807751A patent/UA94724C2/ru unknown
- 2006-12-06 CA CA002629857A patent/CA2629857A1/en not_active Abandoned
- 2006-12-06 JP JP2008544467A patent/JP2009519248A/ja active Pending
- 2006-12-06 US US12/096,439 patent/US7700633B2/en not_active Expired - Fee Related
- 2006-12-06 KR KR1020087013716A patent/KR20080074969A/ko not_active Ceased
- 2006-12-06 CN CNA2006800461637A patent/CN101326173A/zh active Pending
- 2006-12-06 ES ES06839094T patent/ES2381280T3/es active Active
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2008
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Also Published As

Publication number	Publication date
AR056838A1 (es)	2007-10-24
US7700633B2 (en)	2010-04-20
IL191549A0 (en)	2008-12-29
EP1963292B1 (en)	2012-02-22
PT1963292E (pt)	2012-05-10
AU2006321905A1 (en)	2007-06-14
KR20080074969A (ko)	2008-08-13
AU2006321905B2 (en)	2011-08-11
CR10049A (es)	2008-08-25
ZA200804074B (en)	2009-03-25
JP2009519248A (ja)	2009-05-14
EP1963292A2 (en)	2008-09-03
ECSP088506A (es)	2008-07-30
TW200732315A (en)	2007-09-01
WO2007067615A3 (en)	2007-11-15
RU2008127254A (ru)	2010-01-20
PE20071031A1 (es)	2007-11-15
PE20100733A1 (es)	2010-10-29
BRPI0619600A2 (pt)	2011-10-11
NZ568243A (en)	2011-07-29
TNSN08249A1 (en)	2009-10-30
ES2381280T3 (es)	2012-05-24
CN101326173A (zh)	2008-12-17
ATE546440T1 (de)	2012-03-15
US20080262050A1 (en)	2008-10-23
MA30202B1 (fr)	2009-02-02
CA2629857A1 (en)	2007-06-14
WO2007067615A2 (en)	2007-06-14
UA94724C2 (en)	2011-06-10
PL1963292T3 (pl)	2012-07-31

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2013-07-29	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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