NO20083059L - Pyrimidinderivater - Google Patents

Pyrimidinderivater

Info

Publication number
NO20083059L
NO20083059L NO20083059A NO20083059A NO20083059L NO 20083059 L NO20083059 L NO 20083059L NO 20083059 A NO20083059 A NO 20083059A NO 20083059 A NO20083059 A NO 20083059A NO 20083059 L NO20083059 L NO 20083059L
Authority
NO
Norway
Prior art keywords
relates
compounds
pyrimidine
ephb4
epha2
Prior art date
Application number
NO20083059A
Other languages
English (en)
Inventor
Jason Grant Kettle
Jon Read
Andrew Leach
Bernard Christope Barlaam
Richard Ducray
Christine Marie Paul La Brempt
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38229185&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20083059(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20083059L publication Critical patent/NO20083059L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Oppfinnelsen angår benzamidforbindelser med formel I eller et farmasøytisk akseptabelt salt derav, hvor R1, ring A, n, R3 og R4 er som definert i beskrivelsen. Foreliggende oppfinnelse angår også fremgangsmåter for fremstilling av slike forbindelser, farmasøytiske preparater inneholdende dem og anvendelse av dem ved fremstilling av et medikament for anvendelse som et antiproliferativt middel for forebygging eller behandling av tumorer eller andre proliferative tilstander som er sensitive for hemning av EphB4 og/eller EphA2 og/eller Src kinaser.
NO20083059A 2006-01-26 2008-07-09 Pyrimidinderivater NO20083059L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76238706P 2006-01-26 2006-01-26
PCT/GB2007/000251 WO2007085833A2 (en) 2006-01-26 2007-01-25 Pyrimidine derivatives

Publications (1)

Publication Number Publication Date
NO20083059L true NO20083059L (no) 2008-10-22

Family

ID=38229185

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083059A NO20083059L (no) 2006-01-26 2008-07-09 Pyrimidinderivater

Country Status (16)

Country Link
US (1) US20110046108A1 (no)
EP (1) EP1981856A2 (no)
JP (1) JP2009524632A (no)
KR (1) KR20080089504A (no)
CN (1) CN101374818A (no)
AR (1) AR059218A1 (no)
AU (1) AU2007209126B2 (no)
BR (1) BRPI0707284A2 (no)
CA (1) CA2640375A1 (no)
IL (1) IL192610A0 (no)
NO (1) NO20083059L (no)
NZ (1) NZ569763A (no)
TW (1) TW200736232A (no)
UY (1) UY30107A1 (no)
WO (1) WO2007085833A2 (no)
ZA (1) ZA200806153B (no)

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BRPI0413018B8 (pt) 2003-07-30 2021-05-25 Rigel Pharmaceuticals Inc composto, e, uso de um composto
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ES2439948T3 (es) 2006-02-17 2014-01-27 Rigel Pharmaceuticals, Inc. Compuestos de 2,4-pirimidindiamina para el tratamiento o la prevención de enfermedades autoinmunitarias
EP2089369B1 (en) 2006-10-19 2011-02-02 Rigel Pharmaceuticals, Inc. 2,4 -pyrimidinediamine derivatives as inhibitors of jak kinases for the treatment of autoimmune diseases
CN101535276B (zh) 2006-10-23 2013-08-28 赛福伦公司 作为ALK和c-MET抑制剂的2,4-二氨基嘧啶稠合双环衍生物
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EP2183242A2 (en) 2007-07-16 2010-05-12 AstraZeneca AB Pyrimidine derivatives 934
WO2009010794A1 (en) * 2007-07-19 2009-01-22 Astrazeneca Ab 2,4-diamino-pyrimidine derivatives
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CN101659659B (zh) * 2008-08-29 2013-01-02 和记黄埔医药（上海）有限公司 嘧啶衍生物及其医药用途
WO2010072155A1 (zh) * 2008-12-26 2010-07-01 复旦大学 一种嘧啶类衍生物及其制备方法和用途
KR101705158B1 (ko) 2009-05-05 2017-02-09 다나-파버 캔서 인스티튜트 인크. Ｅｇｆｒ 억제제 및 질환 치료방법
NZ620174A (en) 2009-09-16 2016-08-26 Celgene Avilomics Res Inc Protein kinase conjugates and inhibitors
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EP2536696A1 (en) 2010-02-18 2012-12-26 Concert Pharmaceuticals Inc. Pyrimidine derivatives
EP2552211A4 (en) * 2010-03-26 2013-10-23 Glaxo Group Ltd INDAZOLYL-PYRIMIDINE AS KINASEHEMMER
US8927547B2 (en) 2010-05-21 2015-01-06 Noviga Research Ab Pyrimidine derivatives
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CN105566229A (zh) 2010-08-10 2016-05-11 西建阿维拉米斯研究公司 Btk抑制剂的苯磺酸盐及其用途和制备方法
EP2635285B1 (en) 2010-11-01 2017-05-03 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
MX382354B (es) 2010-11-01 2025-03-13 Celgene Car Llc Compuestos heterocíclicos y usos de los mismos.
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AR088570A1 (es) 2011-10-28 2014-06-18 Celgene Avilomics Res Inc Metodos para tratar una enfermedad o trastorno relacionado con la tirosina quinasa de bruton
KR102081042B1 (ko) 2012-03-15 2020-02-26 셀젠 카르 엘엘씨 상피 성장 인자 수용체 키나제 억제제의 고체 형태
PL2825042T3 (pl) 2012-03-15 2019-02-28 Celgene Car Llc Sole inhibitora kinazy receptora czynnika wzrostu naskórka
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EP2711365A1 (en) 2012-09-21 2014-03-26 Chemilia AB 4-Indazolylamino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer
BR112015010221B1 (pt) * 2012-11-06 2022-09-13 Shanghai Fochon Pharmaceutical Co., Ltd. Inibidores de quinase alk, seus usos, composição farmacêutica, e método para fabricação de medicamento
US9126950B2 (en) 2012-12-21 2015-09-08 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
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US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
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HUE064145T2 (hu) * 2016-04-15 2024-03-28 Epizyme Inc Amin-szubsztituált aril- vagy heteroaril vegyületek, mint EHMT1 és EHMT2 inhibitorok
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CN111234067B (zh) * 2018-11-29 2021-08-03 中国石油化工股份有限公司 用于烯烃聚合的固体催化剂组分和催化剂及其应用
CN113801108B (zh) * 2020-06-16 2024-02-27 中国药科大学 蛋白激酶抑制剂及其衍生物，制备方法、药物组合物和应用
JP7801084B2 (ja) * 2020-09-22 2026-01-16 ベイジーン リミテッド Ｅｇｆｒ阻害剤としてのインドリン化合物及び誘導体
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CN117794914A (zh) * 2021-07-13 2024-03-29 韩国化学研究院 新型嘧啶-2，4-二胺衍生物、其制备方法及包含其作为活性成分的用于预防或治疗癌症的药物组合物
WO2024071415A1 (ja) * 2022-09-30 2024-04-04 日本ポリケム株式会社 化合物、金属錯体、オレフィン重合用触媒組成物、オレフィン重合用触媒、及び、オレフィン系重合体の製造方法
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Also Published As

Publication number Publication date
KR20080089504A (ko) 2008-10-06
TW200736232A (en) 2007-10-01
AU2007209126A1 (en) 2007-08-02
WO2007085833A3 (en) 2007-09-27
IL192610A0 (en) 2009-08-03
CA2640375A1 (en) 2007-08-02
BRPI0707284A2 (pt) 2011-04-26
NZ569763A (en) 2012-06-29
CN101374818A (zh) 2009-02-25
AU2007209126B2 (en) 2012-01-19
ZA200806153B (en) 2009-07-29
WO2007085833A2 (en) 2007-08-02
AR059218A1 (es) 2008-03-19
EP1981856A2 (en) 2008-10-22
US20110046108A1 (en) 2011-02-24
UY30107A1 (es) 2007-08-31
JP2009524632A (ja) 2009-07-02

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