NO20083573L - Amfifile polymerer for opploseliggjoring og malrettet avgivelse av legemidler - Google Patents

Amfifile polymerer for opploseliggjoring og malrettet avgivelse av legemidler

Info

Publication number
NO20083573L
NO20083573L NO20083573A NO20083573A NO20083573L NO 20083573 L NO20083573 L NO 20083573L NO 20083573 A NO20083573 A NO 20083573A NO 20083573 A NO20083573 A NO 20083573A NO 20083573 L NO20083573 L NO 20083573L
Authority
NO
Norway
Prior art keywords
solubilization
drug delivery
drugs
targeted drug
amphiphilic polymers
Prior art date
Application number
NO20083573A
Other languages
English (en)
Other versions
NO338835B1 (no
Inventor
Anil Diwan
Ann Louise Onton
Jayant G Tatake
Original Assignee
Allexcell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allexcell Inc filed Critical Allexcell Inc
Publication of NO20083573L publication Critical patent/NO20083573L/no
Publication of NO338835B1 publication Critical patent/NO338835B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/34—Introducing sulfur atoms or sulfur-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/48—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G75/00—Macromolecular compounds obtained by reactions forming a linkage containing sulfur with or without nitrogen, oxygen, or carbon in the main chain of the macromolecule
    • C08G75/02—Polythioethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/05—Alcohols; Metal alcoholates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Amfifile bionedbrytbare kopolymerer omfattende en hydrofil ryggrad med alifatiske sidegrupper som den hydrofobe komponent. I vandige omgivelser danner polymerene molekylaggregater i nanoskala med en hydrofob indre del som kan oppløseliggjøre uløselige organiske forbindelser som legemidler, vitaminer, fargestoffer og bildegivende midler. Polymerene har eventuelt reaktive funksjonelle grupper som gir bindingspunkter for antistoffer, ligander og andre målrettende grupper som er anvendelige for målrettende avlevering av legemidler og bildegivende midler.
NO20083573A 2006-01-19 2008-08-18 Amfifile polymerer for oppløseliggjøring og målrettet avgivelse av legemidler NO338835B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2006/001820 WO2007084126A1 (en) 2006-01-19 2006-01-19 Solubilization and targeted delivery of drugs with self-assembling amphiphilic polymers

Publications (2)

Publication Number Publication Date
NO20083573L true NO20083573L (no) 2008-10-17
NO338835B1 NO338835B1 (no) 2016-10-24

Family

ID=38287941

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083573A NO338835B1 (no) 2006-01-19 2008-08-18 Amfifile polymerer for oppløseliggjøring og målrettet avgivelse av legemidler

Country Status (20)

Country Link
US (1) US8173764B2 (no)
EP (1) EP1979407B1 (no)
JP (1) JP5027157B2 (no)
KR (1) KR101263057B1 (no)
CN (1) CN101400730B (no)
AP (1) AP2570A (no)
AU (1) AU2006336311B2 (no)
BR (1) BRPI0621291A2 (no)
CA (1) CA2637560C (no)
CY (1) CY1115715T1 (no)
DK (1) DK1979407T5 (no)
EA (1) EA025295B1 (no)
ES (1) ES2523431T3 (no)
IL (2) IL192869A (no)
NO (1) NO338835B1 (no)
NZ (1) NZ570484A (no)
PL (1) PL1979407T3 (no)
PT (1) PT1979407E (no)
SI (1) SI1979407T1 (no)
WO (1) WO2007084126A1 (no)

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US7897170B2 (en) * 2006-08-25 2011-03-01 Boston Scientific Scimed, Inc. Medical devices having improved mechanical performance
HUE034416T2 (en) * 2007-01-22 2018-02-28 Allexcel Inc Self-organized amphiphilic polymers as antiviral agents
CN101795695B (zh) * 2007-07-19 2016-01-06 阿列克斯塞尔公司 作为抗癌剂的自组装的两亲性聚合物
EP2344134B1 (en) 2008-09-23 2017-11-08 The Regents of The University of California Nanocarriers for drug delivery
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EP2637779A2 (en) 2010-11-10 2013-09-18 Battelle Memorial Institute Self-assembling polymer particle release system
US8496946B2 (en) 2011-03-10 2013-07-30 International Business Machines Corporation Antimicrobial hydrogels, methods of preparation thereof, and articles therefrom
US9642916B2 (en) 2012-12-12 2017-05-09 The Regents Of The University Of California Porphyrin modified telodendrimers
CN103254442B (zh) * 2013-04-28 2015-01-14 天津大学 二硫键键接的聚酯梳型接枝共聚物及其制备方法和应用
US10780175B2 (en) 2015-04-18 2020-09-22 The Texas A&M University System Polymer systems and their applications in diagnostics and drug delivery
WO2017193294A1 (zh) * 2016-05-10 2017-11-16 苏州大学张家港工业技术研究院 基于聚氨基酸的功能性生物可降解纳米粒子的制备方法
CN110392583B (zh) 2016-09-15 2023-01-03 加利福尼亚大学董事会 改进的杂化的末端树枝状聚合物
EP3577179B1 (en) 2017-01-31 2024-06-19 The Regents of The University of California Multi-arm block-copolymers for multifunctional self-assembled systems
US12527880B2 (en) 2018-08-31 2026-01-20 The Regents Of The University Of California Cyanine-based telodendrimers and uses for treating cancer
CN110423355B (zh) * 2019-08-29 2021-09-14 武汉轻工大学 羧甲基化莲藕多糖-曲古霉素a轭合物的制备方法
CN113082219B (zh) * 2021-04-07 2023-02-17 中国科学院大学温州研究院(温州生物材料与工程研究所) 一种基于π-π作用的疏水药物的增溶方法
WO2022271183A1 (en) * 2021-06-25 2022-12-29 Allexcel Inc. Self-assembling amphphlic polymers as anti-covid-19 agents
EP4688158A1 (en) * 2023-03-30 2026-02-11 Freie Universität Berlin Heteromultivalent polymers and antiviral applications thereof
CN120938965B (zh) * 2025-10-10 2026-02-03 浙江大学医学院附属第一医院(浙江省第一医院) 纳米金担载ns9283靶向长效镇痛药物及制备方法

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Also Published As

Publication number Publication date
CA2637560A1 (en) 2007-07-26
BRPI0621291A2 (pt) 2011-12-06
JP5027157B2 (ja) 2012-09-19
KR101263057B1 (ko) 2013-05-09
US8173764B2 (en) 2012-05-08
NZ570484A (en) 2011-02-25
HK1127490A1 (zh) 2009-09-25
CA2637560C (en) 2013-11-26
SI1979407T1 (sl) 2015-01-30
EP1979407B1 (en) 2014-08-06
IL192869A0 (en) 2009-02-11
EP1979407A4 (en) 2010-05-26
EA200801729A1 (ru) 2009-02-27
KR20080098373A (ko) 2008-11-07
PT1979407E (pt) 2014-10-16
AP2008004573A0 (en) 2008-08-31
EP1979407A1 (en) 2008-10-15
DK1979407T3 (en) 2014-11-03
CN101400730B (zh) 2012-10-17
AU2006336311B2 (en) 2013-01-24
US20100260743A1 (en) 2010-10-14
PL1979407T3 (pl) 2015-03-31
WO2007084126A1 (en) 2007-07-26
JP2009528394A (ja) 2009-08-06
EA025295B1 (ru) 2016-12-30
CY1115715T1 (el) 2017-01-25
ES2523431T3 (es) 2014-11-25
CN101400730A (zh) 2009-04-01
IL192869A (en) 2013-04-30
IL225205A (en) 2017-03-30
AU2006336311A1 (en) 2007-07-26
AP2570A (en) 2013-01-23
DK1979407T5 (en) 2014-12-01
NO338835B1 (no) 2016-10-24

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