NO20083739L - Tieno-pyridinderivater som MEK-inhibitorer - Google Patents

Tieno-pyridinderivater som MEK-inhibitorer

Info

Publication number
NO20083739L
NO20083739L NO20083739A NO20083739A NO20083739L NO 20083739 L NO20083739 L NO 20083739L NO 20083739 A NO20083739 A NO 20083739A NO 20083739 A NO20083739 A NO 20083739A NO 20083739 L NO20083739 L NO 20083739L
Authority
NO
Norway
Prior art keywords
tienopyridine
derivatives
mek inhibitors
enzymes
mek
Prior art date
Application number
NO20083739A
Other languages
English (en)
Other versions
NO341064B1 (no
Inventor
Martin Clive Hutchings
Sarah Catherine Archibald
Daniel Christopher Brookings
Jeremy Martin Davis
James Andrew Johnson
Barry John Langham
Judi Charlotte Neuss
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Publication of NO20083739L publication Critical patent/NO20083739L/no
Publication of NO341064B1 publication Critical patent/NO341064B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

En klasse tieno[2,3-b]pyridinderivater som i 2 stillingen er substituert med en substituert anilindel, og som er selektive inhibitorer av MEK-enzymer (MAPKK)-enzyrner. De er følgelig gunstige innenfor medisinen, for eksempel ved behandling av skadelige, inflammatoriske, autoimmune, kardiovaskulære, proliferative (inklusive onkologiske) og nociceptive tilstander.
NO20083739A 2006-01-31 2008-08-29 Tieno-pyridinderivater eller et farmasøytisk akseptabelt salt, solvat eller N-oksyd derav, og deres anvendelse i terapi, og til fremstilling av et medikament, samt et farmasøytisk preparat derav. NO341064B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0601962.4A GB0601962D0 (en) 2006-01-31 2006-01-31 Therapeutic agents
PCT/GB2007/000310 WO2007088345A1 (en) 2006-01-31 2007-01-30 Thieno-pyridine derivatives as mek inhibitors

Publications (2)

Publication Number Publication Date
NO20083739L true NO20083739L (no) 2008-08-29
NO341064B1 NO341064B1 (no) 2017-08-14

Family

ID=36100789

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083739A NO341064B1 (no) 2006-01-31 2008-08-29 Tieno-pyridinderivater eller et farmasøytisk akseptabelt salt, solvat eller N-oksyd derav, og deres anvendelse i terapi, og til fremstilling av et medikament, samt et farmasøytisk preparat derav.

Country Status (26)

Country Link
US (3) US8283359B2 (no)
EP (1) EP1981892B1 (no)
JP (1) JP5249787B2 (no)
KR (1) KR101446919B1 (no)
CN (1) CN101379067B (no)
AU (1) AU2007211377B2 (no)
BR (1) BRPI0708016B1 (no)
CA (1) CA2640594C (no)
CY (1) CY1115404T1 (no)
DK (1) DK1981892T3 (no)
EA (1) EA016128B1 (no)
EC (1) ECSP088704A (no)
ES (1) ES2471970T3 (no)
GB (1) GB0601962D0 (no)
HR (1) HRP20140503T1 (no)
IL (1) IL192603A (no)
MY (1) MY146387A (no)
NO (1) NO341064B1 (no)
NZ (1) NZ569638A (no)
PL (1) PL1981892T3 (no)
PT (1) PT1981892E (no)
RS (1) RS53342B (no)
SI (1) SI1981892T1 (no)
UA (1) UA95939C2 (no)
WO (1) WO2007088345A1 (no)
ZA (1) ZA200807447B (no)

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EP3249054A1 (en) 2012-12-20 2017-11-29 Biomatrica, INC. Formulations and methods for stabilizing pcr reagents
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JP6604942B2 (ja) 2013-06-13 2019-11-13 バイオマトリカ，インク． 細胞安定化
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US20190008859A1 (en) 2015-08-21 2019-01-10 Acerta Pharma B.V. Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor
KR102589056B1 (ko) 2015-12-08 2023-10-12 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
CA3063535A1 (en) 2017-05-19 2018-11-22 Nflection Therapeutics, Inc. Fused heteroaromatic-aniline compounds for treatment of dermal disorders
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CA3120351A1 (en) * 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Aryl-aniline and heteroaryl-aniline compounds for treatment of skin cancers
MA55141A (fr) 2018-11-20 2021-09-29 Nflection Therapeutics Inc Composés cyanoaryl-aniline pour le traitement d'affections de la peau
JP7546297B2 (ja) 2018-11-20 2024-09-06 エヌフレクション セラピューティクス インコーポレイテッド 皮膚障害の処置のためのチエニル－アニリン化合物
US12378240B2 (en) 2018-11-20 2025-08-05 Nflection Therapeutics, Inc. Naphthyridinone-aniline compounds for treatment of dermal disorders
EP3942045A1 (en) 2019-03-21 2022-01-26 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
EP4054579A1 (en) 2019-11-08 2022-09-14 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
CN111138449B (zh) * 2020-01-15 2022-11-29 四川大学华西医院 双靶向erk1和erk5抑制剂的制备及其抗肿瘤应用
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2022251193A1 (en) 2021-05-27 2022-12-01 Mirati Therapeutics, Inc. Combination therapies
IL312977A (en) 2021-11-23 2024-07-01 Nflection Therapeutics Inc Formulations of pyrrolopyridine-aniline compounds
GB202205203D0 (en) 2022-04-08 2022-05-25 UCB Biopharma SRL Combination with inhibitor
WO2025073765A1 (en) 2023-10-03 2025-04-10 Institut National de la Santé et de la Recherche Médicale Methods of prognosis and treatment of patients suffering from melanoma

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Also Published As

Publication number Publication date
AU2007211377A1 (en) 2007-08-09
GB0601962D0 (en) 2006-03-15
JP5249787B2 (ja) 2013-07-31
EA200801684A1 (ru) 2009-04-28
CN101379067B (zh) 2011-03-23
EP1981892B1 (en) 2014-03-12
CA2640594C (en) 2014-12-23
KR101446919B1 (ko) 2014-10-07
PL1981892T3 (pl) 2014-08-29
BRPI0708016A2 (pt) 2011-05-17
WO2007088345A1 (en) 2007-08-09
PT1981892E (pt) 2014-06-23
CY1115404T1 (el) 2017-01-04
ZA200807447B (en) 2009-11-25
HK1125924A1 (en) 2009-08-21
AU2007211377B2 (en) 2012-03-01
US20130150573A1 (en) 2013-06-13
IL192603A0 (en) 2009-02-11
US20090149437A1 (en) 2009-06-11
SI1981892T1 (sl) 2014-07-31
US8604051B2 (en) 2013-12-10
DK1981892T3 (da) 2014-06-23
MY146387A (en) 2012-08-15
ECSP088704A (es) 2008-09-29
RS53342B (sr) 2014-10-31
NO341064B1 (no) 2017-08-14
HRP20140503T1 (hr) 2014-07-04
IL192603A (en) 2013-12-31
EP1981892A1 (en) 2008-10-22
US8394822B2 (en) 2013-03-12
JP2009525317A (ja) 2009-07-09
EA016128B1 (ru) 2012-02-28
UA95939C2 (en) 2011-09-26
ES2471970T3 (es) 2014-06-27
KR20080095870A (ko) 2008-10-29
NZ569638A (en) 2010-08-27
BRPI0708016B1 (pt) 2021-07-06
CA2640594A1 (en) 2007-08-09
US20120329774A1 (en) 2012-12-27
US8283359B2 (en) 2012-10-09
CN101379067A (zh) 2009-03-04

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Owner name: UCB BIOPHARMA SRL, BE