NO20084583L - Makrosykliske kinase-inhibitorer - Google Patents

Makrosykliske kinase-inhibitorer

Info

Publication number
NO20084583L
NO20084583L NO20084583A NO20084583A NO20084583L NO 20084583 L NO20084583 L NO 20084583L NO 20084583 A NO20084583 A NO 20084583A NO 20084583 A NO20084583 A NO 20084583A NO 20084583 L NO20084583 L NO 20084583L
Authority
NO
Norway
Prior art keywords
kinase inhibitors
macrocyclic kinase
macrocyclic
useful
compound
Prior art date
Application number
NO20084583A
Other languages
English (en)
Norwegian (no)
Inventor
Hong Fu
Yue Chen
Daniel V Santi
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Publication of NO20084583L publication Critical patent/NO20084583L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
NO20084583A 2006-05-11 2008-11-03 Makrosykliske kinase-inhibitorer NO20084583L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US79978606P 2006-05-11 2006-05-11
US81726006P 2006-06-28 2006-06-28
US11/729,327 US7601852B2 (en) 2006-05-11 2007-03-27 Macrocyclic kinase inhibitors
PCT/US2007/008591 WO2007133352A2 (fr) 2006-05-11 2007-04-05 Inhibiteurs de kinase macrocycliques

Publications (1)

Publication Number Publication Date
NO20084583L true NO20084583L (no) 2008-12-04

Family

ID=38685942

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084583A NO20084583L (no) 2006-05-11 2008-11-03 Makrosykliske kinase-inhibitorer

Country Status (6)

Country Link
US (1) US7601852B2 (fr)
EP (1) EP2015745A4 (fr)
JP (1) JP2009536946A (fr)
CN (1) CN101489547B (fr)
NO (1) NO20084583L (fr)
WO (1) WO2007133352A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8546404B2 (en) * 2005-12-13 2013-10-01 Merck Sharp & Dohme Compounds that are ERK inhibitors
JP2009528280A (ja) * 2006-02-16 2009-08-06 シェーリング コーポレイション Ｅｒｋインヒビターとしてのピロリジン誘導体
MX2010005960A (es) * 2007-11-30 2010-06-11 Schering Corp Biomarcadores de braf.
US8716483B2 (en) * 2008-02-21 2014-05-06 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
US9556426B2 (en) 2009-09-16 2017-01-31 Celgene Avilomics Research, Inc. Protein kinase conjugates and inhibitors
AU2010299835A1 (en) * 2009-09-28 2012-04-05 Centre National De La Recherche Scientifique Irreversible inhibitors useful for the treatment of kinase-related pathologies
JP2013516422A (ja) 2009-12-30 2013-05-13 アビラ セラピューティクス， インコーポレイテッド タンパク質のリガンド−指向性共有的修飾
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
CN103173529B (zh) * 2011-12-23 2015-04-29 上海吉凯基因化学技术有限公司 人nlk基因相关的用途及其相关药物
GB201212690D0 (en) * 2012-07-16 2012-08-29 Cancer Res Inst Royal Materials and methods for treating pten mutated or deficient cancer
CN104342440A (zh) * 2013-07-30 2015-02-11 上海交通大学医学院附属新华医院 CDKL1基因及其siRNA和应用
EP3247378B8 (fr) 2015-01-09 2023-08-23 Revolution Medicines, Inc. Composés macrocycliques participant à une liaison coopérative et leurs utilisations médicales
EP4242304A3 (fr) 2015-10-01 2024-02-07 Revolution Medicines, Inc. Procédés et réactifs pour l'analyse d'interfaces protéine-protéine
CN108379583B (zh) * 2018-03-27 2021-08-17 北京大学 一种肿瘤转移药物治疗的靶标及其应用
BR112021012057A2 (pt) * 2018-12-21 2021-10-19 Revolution Medicines, Inc. Compostos que participam de ligação cooperativa e usos dos mesmos
AU2020377925A1 (en) 2019-11-04 2022-05-05 Revolution Medicines, Inc. Ras inhibitors
IL322454A (en) 2019-11-04 2025-09-01 Revolution Medicines Inc ras inhibitors
TW202132316A (zh) 2019-11-04 2021-09-01 美商銳新醫藥公司 Ｒａｓ抑制劑
CA3194067A1 (fr) 2020-09-15 2022-03-24 Revolution Medicines, Inc. Derives d'indole servant d'inhibiteurs dans le traitement du cancer
KR20240017811A (ko) 2021-05-05 2024-02-08 레볼루션 메디슨즈, 인크. 암의 치료를 위한 ras 억제제
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9225396D0 (en) 1992-12-04 1993-01-27 Sandoz Ltd Improvements in or relating to organic compounds
JPH0840893A (ja) 1993-08-31 1996-02-13 Takeda Chem Ind Ltd インターロイキン−１産生抑制剤
US5795910A (en) * 1994-10-28 1998-08-18 Cor Therapeutics, Inc. Method and compositions for inhibiting protein kinases
GB2323845A (en) * 1997-03-31 1998-10-07 Merck & Co Inc MEK inhibiting lactones
WO2000038674A1 (fr) * 1998-12-24 2000-07-06 Novation Pharmaceuticals Inc. COMPOSES MODIFIANT LA STABILITE DE L'ARNm ET UTILISATIONS DE CES COMPOSES
JP2001294527A (ja) 2000-04-14 2001-10-23 Ajinomoto Co Inc Ｔｈ２反応に特異的な免疫寛容誘導剤
JP2004292315A (ja) 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd Ｔａｋ１阻害剤
JP2004292314A (ja) 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd ケラチノサイト増殖抑制剤
EP1450784A4 (fr) * 2001-11-09 2005-02-09 Conforma Therapeutics Corp Composes de zearalanol inhibant hsp90 et leurs procedes de production et d'utilisation
US7915306B2 (en) * 2002-03-08 2011-03-29 Eisai Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
CN1653059A (zh) * 2002-03-08 2005-08-10 卫材株式会社 用作医药品的大环化合物
CA2482940A1 (fr) * 2002-04-17 2003-10-23 Taisho Pharmaceuticals Co., Ltd. Produit tonique pour la pousse de cheveux
WO2004004644A2 (fr) * 2002-07-05 2004-01-15 Beth Israel Deaconess Medical Center Association d'un inhibiteur de cible mammalienne de rapamycine (mtor) et d'un inhibiteur de la tyrosine kinase aux fins du de traitement de neoplasmes
JP2008514635A (ja) * 2004-09-27 2008-05-08 コーザン バイオサイエンシス インコーポレイテッド 特異的キナーゼ阻害剤
CN100548827C (zh) * 2004-09-29 2009-10-14 发明家快递私人有限公司 饮料运载器

Also Published As

Publication number Publication date
JP2009536946A (ja) 2009-10-22
US20070265333A1 (en) 2007-11-15
CN101489547B (zh) 2012-08-08
WO2007133352A2 (fr) 2007-11-22
EP2015745A4 (fr) 2011-03-09
US7601852B2 (en) 2009-10-13
WO2007133352A3 (fr) 2008-03-13
EP2015745A2 (fr) 2009-01-21
CN101489547A (zh) 2009-07-22

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Legal Events

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