NO20084631L - Fremgangsmate for dannelsen av pyrazolylaminoquinazolin deivater inneholdende en fosfat gruppe - Google Patents

Fremgangsmate for dannelsen av pyrazolylaminoquinazolin deivater inneholdende en fosfat gruppe

Info

Publication number: NO20084631L
Authority: NO; Norway
Prior art keywords: pyrazolylaminoquinazoline; formation; phosphate group; derivatives containing; amino
Prior art date: 2006-05-16

Application number

NO20084631A

Other languages

English (en)

Norwegian (no)

Inventor

John David Pittam

George Joseph Sependa

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-05-16

Filing date

2008-11-04

Publication date

2008-12-03

2008-11-04 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2008-12-03 Publication of NO20084631L publication Critical patent/NO20084631L/no

Links

230000015572 biosynthetic process Effects 0.000 title 1
ZOLMXQVLFGWBPK-UHFFFAOYSA-N n-(1h-pyrazol-5-yl)quinazolin-2-amine Chemical class N=1C=C2C=CC=CC2=NC=1NC=1C=CNN=1 ZOLMXQVLFGWBPK-UHFFFAOYSA-N 0.000 title 1
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 title 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO20084631A 2006-05-16 2008-11-04 Fremgangsmate for dannelsen av pyrazolylaminoquinazolin deivater inneholdende en fosfat gruppe NO20084631L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0609617.6A GB0609617D0 (en)	2006-05-16	2006-05-16	Process & intermediate
PCT/GB2007/001748 WO2007132210A1 (en)	2006-05-16	2007-05-14	Process for the preparation of pyrazolylaminoquinazoline derivatives comprising a phosphate group

Publications (1)

Publication Number	Publication Date
NO20084631L true NO20084631L (no)	2008-12-03

Family

ID=36637525

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20084631A NO20084631L (no)	2006-05-16	2008-11-04	Fremgangsmate for dannelsen av pyrazolylaminoquinazolin deivater inneholdende en fosfat gruppe

Country Status (18)

Country	Link
US (1)	US8063210B2 (pt)
EP (1)	EP2019832B1 (pt)
JP (1)	JP5249927B2 (pt)
KR (1)	KR101463633B1 (pt)
CN (1)	CN101443339B (pt)
AR (1)	AR060962A1 (pt)
AU (1)	AU2007251395B2 (pt)
BR (1)	BRPI0712787A2 (pt)
CA (1)	CA2650518C (pt)
ES (1)	ES2392996T3 (pt)
GB (1)	GB0609617D0 (pt)
IL (1)	IL194861A0 (pt)
MX (1)	MX2008014551A (pt)
NO (1)	NO20084631L (pt)
NZ (1)	NZ572204A (pt)
TW (1)	TWI387601B (pt)
WO (1)	WO2007132210A1 (pt)
ZA (1)	ZA200809171B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003055491A1 (en) *	2001-12-24	2003-07-10	Astrazeneca Ab	Substituted quinazoline derivatives as inhibitors of aurora kinases
CA2526285A1 (en) *	2003-05-15	2004-12-23	Arqule, Inc.	Inhibitors of p38 and methods of using the same
EP2258704A1 (en) *	2004-10-19	2010-12-08	ArQule, Inc.	Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
WO2007123892A2 (en) *	2006-04-17	2007-11-01	Arqule Inc.	Raf inhibitors and their uses
EP2361254A1 (en) *	2008-12-05	2011-08-31	ArQule, Inc.	Raf inhibitors and their uses
CN103664797A (zh) *	2012-09-25	2014-03-26	杨子娇	一类治疗房角狭窄的化合物及其用途
CN103435598B (zh) *	2013-07-25	2015-08-05	苏州明锐医药科技有限公司	巴拉塞替的制备方法
RS60093B1 (sr)	2013-09-16	2020-05-29	Astrazeneca Ab	Terapeutske polimerne nanočestice i postupci njihove pripreme i primene

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003055491A1 (en)	2001-12-24	2003-07-10	Astrazeneca Ab	Substituted quinazoline derivatives as inhibitors of aurora kinases
US7022667B2 (en) *	2002-07-03	2006-04-04	Bristol-Myers Squibb Company	O-derivatized nocathiacin derivatives
SI1847539T1 (sl)	2002-12-24	2010-01-29	Astrazeneca Ab	Kinazolinski derivati
MXPA05006920A (es) *	2002-12-24	2006-02-10	Astrazeneca Ab	Compuestos de quinazolina.
UA86470C2 (ru) *	2002-12-24	2009-04-27	Астразенека Аб	Производные фосфонооксихиназолина и их фармацевтическое применение
KR20060003351A (ko) *	2003-04-16	2006-01-10	아스트라제네카 아베	화합물
ATE401080T1 (de)	2003-06-02	2008-08-15	Astrazeneca Ab	(3-((chinazolin-4-yl)amino)-1h-pyrazol-1- yl)acetamid derivate und verwandte verbindungen als aurora kinase inhibitoren zur behandlung von proliferativen erkrankungen wie krebs
GB0609619D0 (en) *	2006-05-16	2006-06-21	Astrazeneca Ab	Combination

2006
- 2006-05-16 GB GBGB0609617.6A patent/GB0609617D0/en not_active Ceased
2007
- 2007-05-14 CN CN2007800176933A patent/CN101443339B/zh not_active Expired - Fee Related
- 2007-05-14 JP JP2009510529A patent/JP5249927B2/ja not_active Expired - Fee Related
- 2007-05-14 CA CA2650518A patent/CA2650518C/en not_active Expired - Fee Related
- 2007-05-14 EP EP07732773A patent/EP2019832B1/en active Active
- 2007-05-14 MX MX2008014551A patent/MX2008014551A/es active IP Right Grant
- 2007-05-14 NZ NZ572204A patent/NZ572204A/en not_active IP Right Cessation
- 2007-05-14 WO PCT/GB2007/001748 patent/WO2007132210A1/en not_active Ceased
- 2007-05-14 AU AU2007251395A patent/AU2007251395B2/en not_active Ceased
- 2007-05-14 BR BRPI0712787-1A patent/BRPI0712787A2/pt not_active IP Right Cessation
- 2007-05-14 ES ES07732773T patent/ES2392996T3/es active Active
- 2007-05-14 KR KR1020087029568A patent/KR101463633B1/ko not_active Expired - Fee Related
- 2007-05-15 US US11/748,655 patent/US8063210B2/en not_active Expired - Fee Related
- 2007-05-16 TW TW096117466A patent/TWI387601B/zh not_active IP Right Cessation
- 2007-05-16 AR ARP070102120A patent/AR060962A1/es unknown
2008
- 2008-10-23 IL IL194861A patent/IL194861A0/en not_active IP Right Cessation
- 2008-10-24 ZA ZA200809171A patent/ZA200809171B/xx unknown
- 2008-11-04 NO NO20084631A patent/NO20084631L/no unknown

Also Published As

Publication number	Publication date
MX2008014551A (es)	2008-11-27
HK1126221A1 (en)	2009-08-28
CN101443339B (zh)	2012-07-04
BRPI0712787A2 (pt)	2012-09-11
EP2019832A1 (en)	2009-02-04
IL194861A0 (en)	2009-08-03
NZ572204A (en)	2011-09-30
US20070270384A1 (en)	2007-11-22
WO2007132210A1 (en)	2007-11-22
CA2650518A1 (en)	2007-11-22
KR20090008450A (ko)	2009-01-21
CN101443339A (zh)	2009-05-27
GB0609617D0 (en)	2006-06-21
ZA200809171B (en)	2009-11-25
AU2007251395A1 (en)	2007-11-22
JP5249927B2 (ja)	2013-07-31
JP2009537496A (ja)	2009-10-29
AR060962A1 (es)	2008-07-23
AU2007251395B2 (en)	2011-01-06
US8063210B2 (en)	2011-11-22
TW200813080A (en)	2008-03-16
KR101463633B1 (ko)	2014-11-19
ES2392996T3 (es)	2012-12-17
CA2650518C (en)	2014-12-02
TWI387601B (zh)	2013-03-01
EP2019832B1 (en)	2012-09-12

Publication	Publication Date	Title
NO20084631L (no)	2008-12-03	Fremgangsmate for dannelsen av pyrazolylaminoquinazolin deivater inneholdende en fosfat gruppe
EA200970090A1 (ru)	2009-06-30	Модуляторы метаболизма и лечение связанных с ним расстройств
NO20091626L (no)	2009-05-04	MGLUR5-modulatorer
SI2091948T1 (sl)	2012-07-31	Novi inhibitorji glutaminil ciklaze
NO20091599L (no)	2009-07-21	Kjemiske forbindelser
NO20063501L (no)	2006-09-28	Kinolinintermediater av reseptor-Tyrosin-Kinase-inhibitorer og deres syntese
CY1119827T1 (el)	2018-06-27	Ακυλαμινο-υποκατεστημενα συντηγμενα παραγωγα κυκλοπεντανο καρβοξυλικου οξεος και η χρηση αυτων ως φαρμακευτικων ουσιων
EA200970680A1 (ru)	2010-02-26	N-замещенные производные глицина: ингибиторы гидроксилаз
NO20084302L (no)	2008-12-03	2-(syklisk amino)-pyrimidonderivater som TPK1-inhibitorer
EA200970050A1 (ru)	2009-06-30	Ингибиторы пролилгидроксилаз
EA200701756A1 (ru)	2008-02-28	Соль производного пролина, её сольват и способ её получения
NO20085169L (no)	2009-01-20	Krystallinske solvater og komplekser av (1S)-1,5-anhydro-L-C- (3-((fenyl)metyl)fenyl)-D-glucitol derivater med aminosyrer som SGLT2-inhibitorer for behandling av diabetes
NO20083918L (no)	2008-11-12	Dihydridiazepiner anvendelige som inhibitorer av proteinkinaser
IL198979A (en)	2013-09-30	Enzyme inhibitors diacylglycerol o-acetyltransferase type 1
NO20091596L (no)	2009-06-30	Benzoylamino-heterocykliske forbindelser som Glucokinase-(GLK)-activatorer
WO2008005569A3 (en)	2008-04-10	Modulators of metabolism and the treatment of disorders related thereto
NO20073791L (no)	2007-08-30	Pyrazolylaminopyridinderivater anvendbare som kinaseinhibitorer
ECSP088890A (es)	2008-12-30	Co-cristal de maleato de azd1152
MX2009005048A (es)	2009-05-25	Nuevo proceso para la preparacion de derivados de 2-imino-tiazolidin-4-ona.
TW200801027A (en)	2008-01-01	Processes for production of 4-(biphenylyl)azetidin-2-one phosphonic acids
NO20073701L (no)	2007-09-03	Nye fremgangsmater for fremstilling av et 2H-kromen
EA200970604A1 (ru)	2009-10-30	Новое промежуточное соединение и способ, используемый для получения {2-[1-(3,5-бис-трифторметилбензил)-5-пиридин-4-ил-1н-[1,2,3]триазол-4-ил]пиридин-3-ил}-(2-хлорфенил)метанона
WO2008053334A3 (en)	2008-07-03	An improved process for preparing rosuvastatin calcium
WO2008036316A3 (en)	2008-11-06	Piperidine and pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease
UA92354C2 (en)	2010-10-25	Amino acid salts of rosiglitazone