NO20084783L - Syntese av acylaminoalkenylenamider nyttige som substans P antagonister - Google Patents

Syntese av acylaminoalkenylenamider nyttige som substans P antagonister

Info

Publication number
NO20084783L
NO20084783L NO20084783A NO20084783A NO20084783L NO 20084783 L NO20084783 L NO 20084783L NO 20084783 A NO20084783 A NO 20084783A NO 20084783 A NO20084783 A NO 20084783A NO 20084783 L NO20084783 L NO 20084783L
Authority
NO
Norway
Prior art keywords
acylaminoalkenylenamides
antagonists
synthesis
substance
useful
Prior art date
Application number
NO20084783A
Other languages
English (en)
Norwegian (no)
Inventor
Robert Portmann
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0607532A external-priority patent/GB0607532D0/en
Priority claimed from GB0610244A external-priority patent/GB0610244D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20084783L publication Critical patent/NO20084783L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20084783A 2006-04-13 2008-11-12 Syntese av acylaminoalkenylenamider nyttige som substans P antagonister NO20084783L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0607532A GB0607532D0 (en) 2006-04-13 2006-04-13 Organic compounds
GB0610244A GB0610244D0 (en) 2006-05-23 2006-05-23 Organic compounds
PCT/EP2007/003213 WO2007118651A1 (en) 2006-04-13 2007-04-11 Synthesis of acylaminoalkenylene amides useful as substance p antagonists

Publications (1)

Publication Number Publication Date
NO20084783L true NO20084783L (no) 2008-11-12

Family

ID=38324102

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084783A NO20084783L (no) 2006-04-13 2008-11-12 Syntese av acylaminoalkenylenamider nyttige som substans P antagonister

Country Status (28)

Country Link
US (2) US8008479B2 (de)
EP (1) EP2010498B1 (de)
JP (1) JP5208917B2 (de)
KR (1) KR20080108291A (de)
AR (1) AR060506A1 (de)
AT (1) ATE486853T1 (de)
AU (1) AU2007237482B2 (de)
CA (1) CA2645362C (de)
CL (1) CL2007001040A1 (de)
CY (1) CY1111294T1 (de)
DE (1) DE602007010269D1 (de)
DK (1) DK2010498T3 (de)
EC (1) ECSP088820A (de)
GT (1) GT200800209A (de)
HR (1) HRP20110045T1 (de)
JO (1) JO2630B1 (de)
MA (1) MA30394B1 (de)
MX (1) MX2008013117A (de)
MY (1) MY145069A (de)
NO (1) NO20084783L (de)
NZ (1) NZ571142A (de)
PE (1) PE20071223A1 (de)
PL (1) PL2010498T3 (de)
PT (1) PT2010498E (de)
RU (1) RU2433122C2 (de)
SI (1) SI2010498T1 (de)
TW (1) TW200815358A (de)
WO (1) WO2007118651A1 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7790699B2 (en) 2004-10-12 2010-09-07 Fmc Biopolymer As Self-gelling alginate systems and uses thereof
CA2616383C (en) 2005-07-29 2015-06-09 Concert Pharmaceuticals Inc. Novel benzo[d][1,3]-dioxol derivatives
US8796267B2 (en) 2006-10-23 2014-08-05 Concert Pharmaceuticals, Inc. Oxazolidinone derivatives and methods of use
US8080549B2 (en) 2007-01-12 2011-12-20 Concert Pharmaceuticals, Inc. Endothelin receptor antagonists
WO2008088727A2 (en) 2007-01-12 2008-07-24 Concert Pharmaceuticals, Inc. Endothelin receptor antagonists
WO2008106125A2 (en) 2007-02-26 2008-09-04 Concert Pharmaceuticals, Inc. Deuterated derivatives of silodosin as alpha la-adrenoceptor antagonists
JP2010520291A (ja) 2007-03-07 2010-06-10 コンサート ファーマシューティカルズ インコーポレイテッド 抗狭心症化合物としての重水素化ピペラジン誘導体
EP2918578A1 (de) 2007-03-16 2015-09-16 Concert Pharmaceuticals, Inc. Hemmer des cholesterinestertransferproteins
US8198305B2 (en) 2007-04-13 2012-06-12 Concert Pharmaceuticals Inc. 1,2-benzisoxazol-3-yl compounds
EP2527336A1 (de) 2007-04-25 2012-11-28 Concert Pharmaceuticals Inc. Deuterium Analoga von Cilostazol
US8349817B2 (en) 2007-04-25 2013-01-08 Concert Pharmaceuticals, Inc. Analogues of cilostazol
US7973049B2 (en) 2007-05-01 2011-07-05 Concert Pharmaceuticals Inc. Morphinan compounds
FI3825306T3 (fi) 2007-05-01 2023-08-23 Concert Pharmaceuticals Inc Morfinaaniyhdisteitä
WO2008141021A1 (en) 2007-05-08 2008-11-20 Concert Pharmaceuticals, Inc. Deuterated derivatives of tetrahydrotriazolopyrazine compounds and their use as dpp-iv inhibitors
AR066972A1 (es) 2007-06-12 2009-09-23 Concert Pharmaceuticals Inc Derivados azapeptidicos
WO2009009531A2 (en) 2007-07-09 2009-01-15 Concert Pharmaceuticals Inc. Pyrimidinecarboxamide derivatives for the treatment of hiv infections
WO2009023233A1 (en) 2007-08-14 2009-02-19 Concert Pharmaceuticals, Inc. Substituted oxazolidinone derivatives
US8809521B2 (en) 2007-08-28 2014-08-19 Fmc Biopolymer As Delayed self-gelling alginate systems and uses thereof
MX2010002679A (es) 2007-09-12 2010-03-29 Concert Pharmaceuticals Inc Derivados de 4-oxoquinolina deuterados para el tratamiento de la infeccion por el virus de inmunodeficiencia humana.
CA2698808A1 (en) 2007-09-13 2009-03-19 Concert Pharmaceuticals, Inc. Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof
WO2009051782A1 (en) 2007-10-18 2009-04-23 Concert Pharmaceuticals Inc. Deuterated etravirine
US8592487B2 (en) 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
EP2231155A4 (de) 2007-12-18 2011-09-14 Concert Pharmaceuticals Inc Tetrahydroisochinolin-derivate
WO2009094210A1 (en) 2008-01-22 2009-07-30 Concert Pharmaceuticals Inc. Vandetanib derivatives
US7855204B2 (en) 2008-01-22 2010-12-21 Concert Pharmaceuticals Inc. Derivatives of gefitinib
KR20100121527A (ko) 2008-02-29 2010-11-17 콘서트 파마슈티컬즈, 인크. 치환된 잔틴 유도체
WO2009128947A1 (en) 2008-04-17 2009-10-22 Concert Pharmaceuticals, Inc. Piperazine derivatives
WO2009154754A2 (en) 2008-06-17 2009-12-23 Concert Pharmaceuticals, Inc. Synthesis of deuterated morpholine derivatives
CA2735549A1 (en) 2008-08-29 2010-03-04 Concert Pharmaceuticals, Inc. Substituted triazolo-pyridazine derivatives
WO2010033511A1 (en) 2008-09-16 2010-03-25 Concert Pharmaceuticals, Inc. Deuterated 2-amino-3-hydroxypropanoic acid derivatives
EP2334678B1 (de) 2008-09-19 2012-12-26 Concert Pharmaceuticals Inc. Morphinanverbindungen
US9045453B2 (en) 2008-11-14 2015-06-02 Concert Pharmaceuticals, Inc. Substituted dioxopiperidinyl phthalimide derivatives
EA201101207A1 (ru) * 2009-02-24 2012-04-30 Новартис Аг Применение антагонистов рецептора nk
US8263601B2 (en) 2009-02-27 2012-09-11 Concert Pharmaceuticals, Inc. Deuterium substituted xanthine derivatives
DE102009001446A1 (de) 2009-03-10 2010-09-23 Evonik Rohmax Additives Gmbh Verwendung von Kammpolymeren als Antifatigue-Additive
AP2909A (en) 2009-03-17 2014-05-31 Concert Pharmaceuticals Inc Pyrazinoisoquinoline Compounds
WO2010108103A1 (en) * 2009-03-19 2010-09-23 Concert Pharmaceuticals, Inc. Azepan-2-one derivatives
CA2759251C (en) 2009-04-23 2017-01-03 Concert Pharmaceuticals, Inc. 4-hydroxybutyric acid analogs
US8410082B2 (en) 2009-05-22 2013-04-02 Concert Pharmaceuticals, Inc. Fluorinated diaryl urea derivatives
EP3090999A1 (de) 2009-06-18 2016-11-09 Concert Pharmaceuticals Inc. Deuterierte isoindolin-1, 3-dion-derivate als pde4- und tfn-alpha-inhibitoren
US8501738B2 (en) 2009-06-23 2013-08-06 Concert Pharmaceuticals, Inc. Substituted triazolo-pyridazine derivatives
EP2464355A4 (de) 2009-08-14 2013-01-02 Concert Pharmaceuticals Inc Substituierte triazolphthalazinderivate
MX2012002704A (es) 2009-09-02 2012-03-21 Concert Pharmaceuticals Inc Derivados de xantina sustituidos.
WO2011028820A1 (en) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Substituted derivatives of bicyclic [4.3.0] heteroaryl compounds
US8278460B2 (en) 2009-10-15 2012-10-02 Concert Pharmaceuticals, Inc. Substituted benzimidazoles
US8471034B2 (en) 2009-11-18 2013-06-25 Concert Pharmaceuticals, Inc. Niacin prodrugs and deuterated versions thereof
DE102010001040A1 (de) 2010-01-20 2011-07-21 Evonik RohMax Additives GmbH, 64293 (Meth)acrylat-Polymere zur Verbesserung des Viskositätsindexes
US8575361B2 (en) 2010-03-02 2013-11-05 Concert Pharmaceuticals Inc. Tetrahydronaphthalene derivatives
US8513434B2 (en) 2010-03-02 2013-08-20 Concert Pharmaceuticals Inc. Tetrahydronaphthalene derivatives
US9226801B2 (en) * 2010-03-08 2016-01-05 Ibur, Llc Custom linkable imaging and multifunctional tray
WO2011116066A1 (en) 2010-03-17 2011-09-22 Concert Pharmaceuticals, Inc. Derivatives of dimethylcurcumin
WO2012009446A1 (en) 2010-07-16 2012-01-19 Concert Pharmaceuticals Inc. Novel pyrimidinecarboxamide derivatives
WO2012031073A1 (en) 2010-09-01 2012-03-08 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
WO2012031072A1 (en) 2010-09-01 2012-03-08 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
ES2804540T3 (es) 2011-02-14 2021-02-08 Concert Pharmaceuticals Inc Análogos deuterados de ácido 4–hidroxibutírico
US9145390B2 (en) 2011-03-03 2015-09-29 Concert Pharmaceuticals, Inc. Derivatives of pyrazole-substituted amino-heteroaryl compounds
US8889687B2 (en) 2011-03-04 2014-11-18 Concert Pharmaceuticals, Inc. Deuterated pyrazinoisoquinoline compounds
HUE047354T2 (hu) 2011-05-18 2020-04-28 Vertex Pharmaceuticals Europe Ltd Ivacaftor deuterizált származékai
IN2014DN08443A (de) 2012-04-13 2015-05-08 Concert Pharmaceuticals Inc
US9249093B2 (en) 2012-04-20 2016-02-02 Concert Pharmaceuticals, Inc. Deuterated rigosertib
AU2013274030B2 (en) 2012-06-15 2016-07-07 Sun Pharmaceutical Industries, Inc. Deuterated derivatives of ruxolitinib
US9181190B2 (en) 2012-07-04 2015-11-10 Concert Pharmaceuticals, Inc. Deuterated vercirnon
US10017445B2 (en) 2012-07-12 2018-07-10 Concert Pharmaceuticals, Inc. Deuterated idebenone
CN104507946A (zh) 2012-07-30 2015-04-08 康塞特医药品有限公司 氘代依鲁替尼
CA2880083A1 (en) 2012-08-17 2014-02-20 Concert Pharmaceuticals, Inc. Deuterated baricitinib
US9643950B2 (en) 2012-10-22 2017-05-09 Concert Pharmaceuticals, Inc. Solid forms of {s-3-(4-amino-1-oxo-isoindolin-2-yl)(piperidine-3,4,4,5,5-d5)-2,6-dione}
JP2016505015A (ja) 2013-01-09 2016-02-18 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化モメロチニブ（ｍｏｍｅｌｏｔｉｎｉｂ）
EP2968268B1 (de) 2013-03-15 2020-07-29 Concert Pharmaceuticals Inc. Inhibitoren des udp-glucose:n-acyl-sphingosin-glucosyltransferase enzyms
US8906951B1 (en) 2013-06-24 2014-12-09 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
US9198898B2 (en) 2013-06-24 2015-12-01 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
WO2015031741A1 (en) 2013-08-30 2015-03-05 Concert Pharmaceuticals, Inc. Deuterated derivatives of a thienotriazolodiazapine bromodomain-containing protein inhibitor
EP3105232B1 (de) 2014-02-10 2019-08-28 Concert Pharmaceuticals Inc. Substituierte triazolobenzodiazepine
EP3212656B1 (de) 2014-10-27 2019-06-05 Concert Pharmaceuticals Inc. Pyrimidinphosphonsäureester mit mindestens einem deuteriumatom
EP3277647A1 (de) 2015-03-31 2018-02-07 Vertex Pharmaceuticals (Europe) Limited Deuteriertes vx-661
US10683305B2 (en) 2015-04-27 2020-06-16 Concert Pharmaceuticals, Inc. Deuterated OTX-015
EP3352758A2 (de) 2015-09-25 2018-08-01 Vertex Pharmaceuticals (Europe) Limited Deuterierte cftr-potenziatoren
WO2017087795A1 (en) 2015-11-19 2017-05-26 Concert Pharmaceuticals, Inc. Deuterated epi-743
EP3416629A4 (de) 2016-02-16 2019-08-07 CoNCERT Pharmaceuticals, Inc. Deuteriertes gft-505
CN111491629A (zh) 2017-11-22 2020-08-04 康塞特医药品公司 D-丝氨酸的氘化类似物及其用途
MA51206A (fr) 2017-12-01 2020-10-07 Vertex Pharma Procédés pour préparer des modulateurs de régulateur de conductance transmembranaire de mucoviscidose
WO2020206367A1 (en) 2019-04-03 2020-10-08 Concert Pharmaceuticals, Inc. Processes for the preparation of deuterated d-serine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA002348B1 (ru) 1995-02-22 2002-04-25 Новартис Аг Соединения 1-арил-2-ациламиноэтана и их применение в качестве антагонистов нейрокинина, в частности нейрокинина 1
MY132550A (en) * 1996-08-22 2007-10-31 Novartis Ag Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists
GB0010958D0 (en) * 2000-05-05 2000-06-28 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
KR20080108291A (ko) 2008-12-12
DK2010498T3 (da) 2011-02-14
SI2010498T1 (sl) 2011-03-31
JP2009533369A (ja) 2009-09-17
US8008479B2 (en) 2011-08-30
JP5208917B2 (ja) 2013-06-12
RU2008145102A (ru) 2010-05-27
TW200815358A (en) 2008-04-01
EP2010498B1 (de) 2010-11-03
CY1111294T1 (el) 2015-08-05
MY145069A (en) 2011-12-15
JO2630B1 (en) 2012-06-17
HRP20110045T1 (hr) 2011-02-28
PT2010498E (pt) 2011-02-08
MX2008013117A (es) 2008-10-21
AU2007237482B2 (en) 2011-03-17
ATE486853T1 (de) 2010-11-15
AU2007237482A1 (en) 2007-10-25
US20090137797A1 (en) 2009-05-28
US20110282053A1 (en) 2011-11-17
WO2007118651A1 (en) 2007-10-25
PE20071223A1 (es) 2008-01-22
DE602007010269D1 (de) 2010-12-16
CA2645362C (en) 2013-07-16
NZ571142A (en) 2011-02-25
EP2010498A1 (de) 2009-01-07
GT200800209A (es) 2008-12-15
CL2007001040A1 (es) 2008-03-14
ECSP088820A (es) 2008-11-27
RU2433122C2 (ru) 2011-11-10
CA2645362A1 (en) 2007-10-25
HK1125640A1 (en) 2009-08-14
PL2010498T3 (pl) 2011-04-29
AR060506A1 (es) 2008-06-25
MA30394B1 (fr) 2009-05-04

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