NO20085399L - Regulering av genekspresjon av transformerende vekstfaktor-beta (TGF-β) i levende celler via anvendelse av spesifikke og selektive elektriske og magnetiske felter - Google Patents
Regulering av genekspresjon av transformerende vekstfaktor-beta (TGF-β) i levende celler via anvendelse av spesifikke og selektive elektriske og magnetiske felterInfo
- Publication number
- NO20085399L NO20085399L NO20085399A NO20085399A NO20085399L NO 20085399 L NO20085399 L NO 20085399L NO 20085399 A NO20085399 A NO 20085399A NO 20085399 A NO20085399 A NO 20085399A NO 20085399 L NO20085399 L NO 20085399L
- Authority
- NO
- Norway
- Prior art keywords
- tgf
- specific
- tissues
- gene expression
- selective
- Prior art date
Links
- 102000004887 Transforming Growth Factor beta Human genes 0.000 title 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 title 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title 2
- 230000014493 regulation of gene expression Effects 0.000 title 1
- 210000001519 tissue Anatomy 0.000 abstract 8
- 102000009618 Transforming Growth Factors Human genes 0.000 abstract 5
- 108010009583 Transforming Growth Factors Proteins 0.000 abstract 5
- 210000000988 bone and bone Anatomy 0.000 abstract 4
- 230000014509 gene expression Effects 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 abstract 3
- 102000011117 Transforming Growth Factor beta2 Human genes 0.000 abstract 3
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 abstract 3
- 101800000304 Transforming growth factor beta-2 Proteins 0.000 abstract 3
- 210000002449 bone cell Anatomy 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 208000010392 Bone Fractures Diseases 0.000 abstract 2
- 206010031264 Osteonecrosis Diseases 0.000 abstract 2
- 102000056172 Transforming growth factor beta-3 Human genes 0.000 abstract 2
- 108090000097 Transforming growth factor beta-3 Proteins 0.000 abstract 2
- 230000005684 electric field Effects 0.000 abstract 2
- 230000035876 healing Effects 0.000 abstract 2
- 208000030016 Avascular necrosis Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 230000033228 biological regulation Effects 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 230000003828 downregulation Effects 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000003827 upregulation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Radiology & Medical Imaging (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Electrotherapy Devices (AREA)
- Magnetic Treatment Devices (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Fremgangsmåter og innretninger er beskrevet for reguleringen av transformerende vekstfaktor (TGF)-ß1-, (TGF)-ß2- og/eller (TGF)-ß3-protein-genekspresjon i beinceller og andre vev via den kapasitive eller induktive kopling av spesifikke og selektive elektriske felt til beincellene eller andre vev, hvor de spesifikke og selektive elektriske felt genereres ved anvendelse av spesifikke og selektive elektriske og elektromagnetiske signaler til elektroder eller én eller flere spoler eller annen feltgenererende innretning som er anvendt med hensyn til beincellene eller andre vev for å lette behandling av sykt eller skadet bein og annet vev. Med genekspresjon menes opp- eller nedreguleringen av prosessen hvorved spesifikke deler (gener) av det humane genom (DNA) transkriberes til mRNA og deretter translateres til protein. Fremgangsmåter og innretninger er tilveiebrakt for den målrettete behandling av skadet eller sykt bein og annet vev, som inkluderer å generere spesifikke og selektive elektriske og elektromagnetiske signaler som genererer felter i målvevet som er optimaliserte for å øke TGF-ßl-, TGF-ß2- og/eller (TGF)-ß3-protein-genekspresjon og å eksponere bein og annet vev til feltene som genereres ved spesifikke og selektive signaler for å regulere TGF-ß1-, TGF-ß2- og/eller TGF-ß3-protein-genekspresjon i slikt vev. De resulterende fremgangsmåter og innretninger er anvendbare for den målrettete behandling av beinfrakturer, frakturer med risiko, forsinket tilheling, ufullstendig tilheling av fraktur, beindefekter, ryggradsfusjoner, osteonekrose eller avaskulær nekrose, som et tillegg til andre terapier i behandlingen av én eller alle av de ovenfor nevnte, i behandlingen av osteoporose og ved andre tilstander hvori TGF-ßl-, TGF-ß2- og/eller TGF- ß3-protein kan impliseres.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/444,179 US7465546B2 (en) | 2000-02-23 | 2006-05-31 | Regulation of transforming growth factor-beta (TGF-β) gene expression in living cells via the application of specific and selective electric and electromagnetic fields |
| PCT/US2007/012560 WO2007142901A1 (en) | 2006-05-31 | 2007-05-29 | REGULATION OF TRANSFORMING GROWTH FACTOR-BETA (TGF-β) GENE EXPRESSION IN LIVING CELLS VIA THE APPLICATION OF SPECIFIC AND SELECTIVE ELECTRIC AND ELECTROMAGNETIC FIELDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20085399L true NO20085399L (no) | 2009-02-27 |
Family
ID=38801791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20085399A NO20085399L (no) | 2006-05-31 | 2008-12-29 | Regulering av genekspresjon av transformerende vekstfaktor-beta (TGF-β) i levende celler via anvendelse av spesifikke og selektive elektriske og magnetiske felter |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7465546B2 (no) |
| EP (1) | EP2024003A4 (no) |
| JP (1) | JP2009538694A (no) |
| KR (1) | KR20090029749A (no) |
| CN (1) | CN101516435A (no) |
| AU (1) | AU2007255038B2 (no) |
| BR (1) | BRPI0711846A2 (no) |
| CA (1) | CA2653431A1 (no) |
| IL (1) | IL195549A (no) |
| MX (1) | MX2008015123A (no) |
| NO (1) | NO20085399L (no) |
| NZ (1) | NZ573556A (no) |
| RU (1) | RU2008152084A (no) |
| WO (1) | WO2007142901A1 (no) |
| ZA (1) | ZA200810486B (no) |
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| US7599745B2 (en) * | 2000-02-17 | 2009-10-06 | Standen Ltd | Treating a tumor or the like with an electric field |
| US7465546B2 (en) | 2000-02-23 | 2008-12-16 | The Trustees Of The University Of Pennsylvania | Regulation of transforming growth factor-beta (TGF-β) gene expression in living cells via the application of specific and selective electric and electromagnetic fields |
| US7429471B2 (en) * | 2000-02-23 | 2008-09-30 | The Trustees Of The University Of Pennsylvania | Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic signals |
| US7981611B2 (en) * | 2000-02-23 | 2011-07-19 | The Trustees Of The University Of Pennsylvania | Regulation of fibroblastic growth factor-2 (FGF-2) gene expression in living cells with the application of specific and selective electric and electromagnetic fields |
| US8313908B2 (en) * | 2000-02-23 | 2012-11-20 | The Trustees Of The University Of Pennsylvania | Regulation of stem cell gene production with specific and selective electric and electromagnetic fields |
| US7465566B2 (en) * | 2000-02-23 | 2008-12-16 | The Trustees Of The University Of Pennsylvania | Regulation of genes via application of specific and selective electrical and electromagnetic signals |
| US7374916B2 (en) | 2000-02-23 | 2008-05-20 | The Trustees Of The University Of Pennsylvania | Regulation of aggrecan gene expression using specific and selective electrical and electromagnetic signals |
| US7022506B2 (en) * | 2000-02-23 | 2006-04-04 | The Trustees Of The University Of Pennsylvania | Method and device for treating osteoarthritis, cartilage disease, defects and injuries in the human knee |
| US9427598B2 (en) | 2010-10-01 | 2016-08-30 | Rio Grande Neurosciences, Inc. | Method and apparatus for electromagnetic treatment of head, cerebral and neural injury in animals and humans |
| US10350428B2 (en) | 2014-11-04 | 2019-07-16 | Endonovo Therapetics, Inc. | Method and apparatus for electromagnetic treatment of living systems |
| US9433797B2 (en) | 2003-12-05 | 2016-09-06 | Rio Grande Neurosciences, Inc. | Apparatus and method for electromagnetic treatment of neurodegenerative conditions |
| US9656096B2 (en) | 2003-12-05 | 2017-05-23 | Rio Grande Neurosciences, Inc. | Method and apparatus for electromagnetic enhancement of biochemical signaling pathways for therapeutics and prophylaxis in plants, animals and humans |
| US9440089B2 (en) | 2003-12-05 | 2016-09-13 | Rio Grande Neurosciences, Inc. | Apparatus and method for electromagnetic treatment of neurological injury or condition caused by a stroke |
| US8961385B2 (en) | 2003-12-05 | 2015-02-24 | Ivivi Health Sciences, Llc | Devices and method for treatment of degenerative joint diseases with electromagnetic fields |
| US9415233B2 (en) | 2003-12-05 | 2016-08-16 | Rio Grande Neurosciences, Inc. | Apparatus and method for electromagnetic treatment of neurological pain |
| AU2005206794B2 (en) * | 2004-01-12 | 2010-09-16 | The Trustees Of The University Of Pennsylvania | Up-regulation of bone morphogenetic protein (BMP) gene expression in bone cells by electromagnetic signals |
| US8454543B2 (en) | 2004-03-10 | 2013-06-04 | Vision Quest Industries Incorporated | Electrodes for orthotic device |
| US8936560B2 (en) * | 2004-03-10 | 2015-01-20 | Vision Quest Industries Incorporated | Bracing and electrostimulation for arthritis |
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| US20090018613A1 (en) * | 2006-08-02 | 2009-01-15 | Genestim, Llc | Regulation of vascular endothelial growth factor (vegf) gene expression in tissue via the application of electric and/or electromagnetic fields |
| CA2842852C (en) | 2011-07-27 | 2020-07-14 | Vision Quest Industries Incorporated Dba Vq Orthocare | Electrostimulation system |
| US8343027B1 (en) | 2012-01-30 | 2013-01-01 | Ivivi Health Sciences, Llc | Methods and devices for providing electromagnetic treatment in the presence of a metal-containing implant |
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| US20240033509A1 (en) * | 2022-08-01 | 2024-02-01 | BonGenix, LLC | Method and device for stimulating bone growth |
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| AU2005206794B2 (en) | 2004-01-12 | 2010-09-16 | The Trustees Of The University Of Pennsylvania | Up-regulation of bone morphogenetic protein (BMP) gene expression in bone cells by electromagnetic signals |
-
2006
- 2006-05-31 US US11/444,179 patent/US7465546B2/en not_active Expired - Lifetime
-
2007
- 2007-05-29 CA CA002653431A patent/CA2653431A1/en not_active Abandoned
- 2007-05-29 EP EP07777294A patent/EP2024003A4/en not_active Withdrawn
- 2007-05-29 MX MX2008015123A patent/MX2008015123A/es active IP Right Grant
- 2007-05-29 KR KR1020087032071A patent/KR20090029749A/ko not_active Withdrawn
- 2007-05-29 JP JP2009513220A patent/JP2009538694A/ja active Pending
- 2007-05-29 RU RU2008152084/14A patent/RU2008152084A/ru not_active Application Discontinuation
- 2007-05-29 AU AU2007255038A patent/AU2007255038B2/en active Active
- 2007-05-29 BR BRPI0711846-5A patent/BRPI0711846A2/pt not_active Application Discontinuation
- 2007-05-29 WO PCT/US2007/012560 patent/WO2007142901A1/en not_active Ceased
- 2007-05-29 NZ NZ573556A patent/NZ573556A/en unknown
- 2007-05-29 CN CNA2007800202783A patent/CN101516435A/zh active Pending
-
2008
- 2008-11-27 IL IL195549A patent/IL195549A/en active IP Right Grant
- 2008-12-10 ZA ZA200810486A patent/ZA200810486B/xx unknown
- 2008-12-29 NO NO20085399A patent/NO20085399L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL195549A (en) | 2014-05-28 |
| AU2007255038A1 (en) | 2007-12-13 |
| KR20090029749A (ko) | 2009-03-23 |
| EP2024003A1 (en) | 2009-02-18 |
| CN101516435A (zh) | 2009-08-26 |
| CA2653431A1 (en) | 2007-12-13 |
| WO2007142901A1 (en) | 2007-12-13 |
| RU2008152084A (ru) | 2010-07-10 |
| AU2007255038B2 (en) | 2011-03-17 |
| IL195549A0 (en) | 2009-09-01 |
| MX2008015123A (es) | 2009-03-05 |
| EP2024003A4 (en) | 2010-08-04 |
| US7465546B2 (en) | 2008-12-16 |
| BRPI0711846A2 (pt) | 2011-12-13 |
| NZ573556A (en) | 2012-03-30 |
| ZA200810486B (en) | 2009-10-28 |
| JP2009538694A (ja) | 2009-11-12 |
| US20060235473A1 (en) | 2006-10-19 |
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