NO20090138L - Substituted phenyl acetic acids as DP-2 antagonists - Google Patents

Substituted phenyl acetic acids as DP-2 antagonists

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Publication number
NO20090138L
NO20090138L NO20090138A NO20090138A NO20090138L NO 20090138 L NO20090138 L NO 20090138L NO 20090138 A NO20090138 A NO 20090138A NO 20090138 A NO20090138 A NO 20090138A NO 20090138 L NO20090138 L NO 20090138L
Authority
NO
Norway
Prior art keywords
antagonists
substituted phenyl
acetic acids
phenyl acetic
processes
Prior art date
Application number
NO20090138A
Other languages
Norwegian (no)
Inventor
Amy Oliver
Nataly Hawthorn
Thomas Dudler
Mark Reed
Eugene Thorsett
Kerry Fowler
Francine Farouz
Fuqiang Ruan
Danwen Huang
Joshua Odingo
Musong Kim
Angela Judkins
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of NO20090138L publication Critical patent/NO20090138L/en

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  • Obesity (AREA)
  • AIDS & HIV (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)

Abstract

Substituerte fenyleddiksyreforbindelser med formel I, farmasøytiske sammensetninger, fremgangsmåter for deres fremstilling og fremgangsmåter, er tilveiebrakt som er anvendelige ved behandling og hindring av forstyrrelser eller tilstander som responderer på DP-2-reseptormodulering, særlig inflammatoriske og immunrelaterte forstyrrelser og tilstander, slik som astma, allergisk rinitt og atopisk dermatitt.Substituted phenylacetic acid compounds of formula I, pharmaceutical compositions, processes for their preparation and processes are provided which are useful in the treatment and prevention of disorders or conditions responsive to DP-2 receptor modulation, especially inflammatory and immune-related disorders and conditions, such as allergic rhinitis and atopic dermatitis.

NO20090138A 2006-06-09 2009-01-09 Substituted phenyl acetic acids as DP-2 antagonists NO20090138L (en)

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY149934A (en) 2006-08-21 2013-10-31 Array Biopharma Inc 4-substituted phenoxyphenylacetic acid derivatives
JP5543354B2 (en) * 2007-10-19 2014-07-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Gamma-secretase amine binding regulator
EA017907B1 (en) * 2007-10-19 2013-04-30 Янссен Фармацевтика Н.В. AMIDE LINKED MODULATORS OF γ-SECRETASE
WO2009052334A1 (en) * 2007-10-19 2009-04-23 Janssen Pharmaceutica, N.V. Carbon linked modulators of y-secretase
AU2011261375B2 (en) 2010-06-04 2016-09-22 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
EP2590944B1 (en) 2010-07-05 2015-09-30 Actelion Pharmaceuticals Ltd. 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
HK1199259A1 (en) 2011-08-15 2015-06-26 Intermune, Inc. Lysophosphatidic acid receptor antagonists
JP6097765B2 (en) 2011-12-21 2017-03-15 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
WO2014006585A1 (en) 2012-07-05 2014-01-09 Actelion Pharmaceuticals Ltd 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
CN102757339A (en) * 2012-08-01 2012-10-31 北京联本医药化学技术有限公司 Improved preparation method of 4-(2-carboxybenzyloxy) phenylacetic acid
AU2014262764B2 (en) 2013-05-07 2018-11-15 The Regents Of The University Of California Radiomitigating pharmaceutical formulations
CN112300120B (en) * 2019-07-31 2023-04-14 北京四环制药有限公司 Compound for preparing balsalavir or derivatives thereof, preparation method and application thereof
JP2023503926A (en) * 2019-11-22 2023-02-01 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア TASPASE1 inhibitors and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200505523B (en) * 2002-12-20 2006-09-27 Amgen Inc Asthma and allergic inflammation modulators
DE60303238T2 (en) * 2003-04-25 2006-09-14 Actimis Pharmaceuticals, Inc., La Jolla Pyrimidine-acetic acid derivatives suitable for the treatment of CRTH2-related diseases
SE0302811D0 (en) * 2003-10-23 2003-10-23 Astrazeneca Ab Novel compounds
AR048523A1 (en) * 2004-04-07 2006-05-03 Kalypsys Inc COMPOUNDS WITH ARIL SULFONAMIDE AND SULFONYL STRUCTURE AS PPAR MODULATORS AND METHODS TO TREAT METABOLIC DISORDERS
JP2008534678A (en) * 2005-04-04 2008-08-28 アストラゼネカ・アクチエボラーグ Novel diazaspiroalkanes and their use for the treatment of CCR8 mediated diseases
JP4324221B2 (en) * 2005-08-26 2009-09-02 株式会社医薬分子設計研究所 Derivatives having PPAR agonist activity
US20080269240A1 (en) * 2005-09-22 2008-10-30 Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan Novel Adenine Compound

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CN101490024A (en) 2009-07-22
JP2009539880A (en) 2009-11-19
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