NO20090862L - 2-fenyl-indoler som prostaglandin D2-reseptorantagonister - Google Patents

2-fenyl-indoler som prostaglandin D2-reseptorantagonister

Info

Publication number: NO20090862L
Authority: NO; Norway
Prior art keywords: urticari; itching; inflammation; allergic; diseases
Prior art date: 2006-07-25

Application number

NO20090862A

Other languages

English (en)

Norwegian (no)

Inventor

Zhaoxia Yang

Stephan Reiling

Thaddeus R Nieduzak

Rose M Mathew

Sharon Jackson

Keith J Harris

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-25

Filing date

2009-02-24

Publication date

2009-02-24

2009-02-24 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2009-02-24 Publication of NO20090862L publication Critical patent/NO20090862L/no

Links

KLLLJCACIRKBDT-UHFFFAOYSA-N 2-phenyl-1H-indole Chemical class N1C2=CC=CC=C2C=C1C1=CC=CC=C1 KLLLJCACIRKBDT-UHFFFAOYSA-N 0.000 title 1
102000009389 Prostaglandin D receptors Human genes 0.000 title 1
108050000258 Prostaglandin D receptors Proteins 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
201000004624 Dermatitis Diseases 0.000 abstract 2
206010061218 Inflammation Diseases 0.000 abstract 2
208000003251 Pruritus Diseases 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000035475 disorder Diseases 0.000 abstract 2
230000004054 inflammatory process Effects 0.000 abstract 2
230000007803 itching Effects 0.000 abstract 2
206010002198 Anaphylactic reaction Diseases 0.000 abstract 1
206010006482 Bronchospasm Diseases 0.000 abstract 1
208000002177 Cataract Diseases 0.000 abstract 1
206010008190 Cerebrovascular accident Diseases 0.000 abstract 1
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
206010009900 Colitis ulcerative Diseases 0.000 abstract 1
206010010744 Conjunctivitis allergic Diseases 0.000 abstract 1
206010012438 Dermatitis atopic Diseases 0.000 abstract 1
208000004262 Food Hypersensitivity Diseases 0.000 abstract 1
206010016946 Food allergy Diseases 0.000 abstract 1
102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 abstract 1
101000988802 Homo sapiens Hematopoietic prostaglandin D synthase Proteins 0.000 abstract 1
206010063837 Reperfusion injury Diseases 0.000 abstract 1
206010039085 Rhinitis allergic Diseases 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
201000008736 Systemic mastocytosis Diseases 0.000 abstract 1
201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
208000002205 allergic conjunctivitis Diseases 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
201000010105 allergic rhinitis Diseases 0.000 abstract 1
230000036783 anaphylactic response Effects 0.000 abstract 1
208000003455 anaphylaxis Diseases 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
208000024998 atopic conjunctivitis Diseases 0.000 abstract 1
201000008937 atopic dermatitis Diseases 0.000 abstract 1
208000010668 atopic eczema Diseases 0.000 abstract 1
206010006451 bronchitis Diseases 0.000 abstract 1
230000007885 bronchoconstriction Effects 0.000 abstract 1
230000020411 cell activation Effects 0.000 abstract 1
208000026106 cerebrovascular disease Diseases 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
235000020932 food allergy Nutrition 0.000 abstract 1
210000003630 histaminocyte Anatomy 0.000 abstract 1
208000030603 inherited susceptibility to asthma Diseases 0.000 abstract 1
230000000302 ischemic effect Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
208000008423 pleurisy Diseases 0.000 abstract 1
BHMBVRSPMRCCGG-OUTUXVNYSA-N prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 abstract 1
BHMBVRSPMRCCGG-UHFFFAOYSA-N prostaglandine D2 Natural products CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O BHMBVRSPMRCCGG-UHFFFAOYSA-N 0.000 abstract 1
230000002207 retinal effect Effects 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
238000007790 scraping Methods 0.000 abstract 1
230000035939 shock Effects 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Immunology (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Otolaryngology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

NO20090862A 2006-07-25 2009-02-24 2-fenyl-indoler som prostaglandin D2-reseptorantagonister NO20090862L (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US82030106P	2006-07-25	2006-07-25
US82029906P	2006-07-25	2006-07-25
US82030206P	2006-07-25	2006-07-25
PCT/US2007/073945 WO2008014186A1 (fr)	2006-07-25	2007-07-20	2-phényl-indoles en tant qu'antagonistes du récepteur de la prostaglandine d2

Publications (1)

Publication Number	Publication Date
NO20090862L true NO20090862L (no)	2009-02-24

Family

ID=38610820

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20090862A NO20090862L (no)	2006-07-25	2009-02-24	2-fenyl-indoler som prostaglandin D2-reseptorantagonister

Country Status (25)

Country	Link
US (1)	US20090176804A1 (fr)
EP (1)	EP2066628B1 (fr)
JP (1)	JP2009544721A (fr)
KR (1)	KR20090039735A (fr)
AR (1)	AR062051A1 (fr)
AT (1)	ATE485270T1 (fr)
AU (1)	AU2007276885A1 (fr)
BR (1)	BRPI0714554A2 (fr)
CA (1)	CA2659055A1 (fr)
CL (1)	CL2007002163A1 (fr)
CO (1)	CO6190511A2 (fr)
CR (1)	CR10577A (fr)
DE (1)	DE602007010010D1 (fr)
DK (1)	DK2066628T3 (fr)
EC (1)	ECSP099087A (fr)
GT (1)	GT200900016A (fr)
IL (1)	IL196587A0 (fr)
MA (1)	MA30643B1 (fr)
MX (1)	MX2009000830A (fr)
NO (1)	NO20090862L (fr)
PE (1)	PE20080549A1 (fr)
PT (1)	PT2066628E (fr)
TN (1)	TNSN08515A1 (fr)
TW (1)	TW200821286A (fr)
WO (1)	WO2008014186A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPWO2009072576A1 (ja) *	2007-12-04	2011-04-28	サッポロビール株式会社	骨形成促進剤
MX2011005120A (es) *	2008-11-17	2011-05-30	Hoffmann La Roche	Acidos naftilaceticos.
WO2011117798A1 (fr)	2010-03-22	2011-09-29	Actelion Pharmaceuticals Ltd	Dérivés de 3-(hétéroarylamino)-1,2,3,4-tétrahydro-9h-carbazole et leur utilisation comme modulateurs du récepteur de la prostaglandine d2
MY165623A (en)	2011-04-14	2018-04-18	Idorsia Pharmaceuticals Ltd	7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators
ES2690782T3 (es)	2012-10-24	2018-11-22	Nyu Winthrop Hospital	Biomarcador no invasivo para identificar sujetos en riesgo de parto prematuro
JP2015089886A (ja) *	2013-11-06	2015-05-11	国立大学法人名古屋大学	嵩高い置換基を有する化合物を用いた植物成長調整剤
HRP20181555T1 (hr)	2014-03-17	2018-11-30	Idorsia Pharmaceuticals Ltd	Derivati azaindol-octene kiseline i njihova uporaba kao modulatora receptora prostaglandina d2
RU2016140708A (ru)	2014-03-18	2018-04-18	Идорсиа Фармасьютиклз Лтд	Производные азаиндол уксусной кислоты и их применение в качестве модуляторов рецептора простагландина d2
PL3350179T3 (pl)	2015-09-15	2021-08-02	Idorsia Pharmaceuticals Ltd	Krystaliczne postacie
CN111094988A (zh)	2017-09-13	2020-05-01	普罗根尼蒂公司	先兆子痫生物标志物及相关系统和方法
WO2019166632A1 (fr)	2018-03-02	2019-09-06	Inflazome Limited	Nouveaux composés
EP3759090A1 (fr)	2018-03-02	2021-01-06	Inflazome Limited	Nouveaux composés
WO2019166633A1 (fr)	2018-03-02	2019-09-06	Inflazome Limited	Dérivés de sulfonamide utilisés en tant qu'inhibiteurs de nlrp3
WO2019166627A1 (fr)	2018-03-02	2019-09-06	Inflazome Limited	Nouveaux composés
US11884645B2 (en)	2018-03-02	2024-01-30	Inflazome Limited	Sulfonyl acetamides as NLRP3 inhibitors
JP7455762B2 (ja) *	2018-05-09	2024-03-26	グルソックス・バイオテック・アーベー	選択的なＮｏｘ阻害活性を有する新規のスルホンアミド誘導体
EP4070113A4 (fr)	2019-12-04	2023-12-20	Biora Therapeutics, Inc.	Évaluation de la prééclampsie à l'aide de dosages du facteur de croissance placentaire libre et dissocié
CN111333516B (zh) *	2020-04-14	2022-09-06	国药集团化学试剂有限公司	一种2-氯-5-溴硝基苯的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DOP2006000016A (es) *	2005-01-26	2006-07-31	Aventis Pharma Inc	2-fenil-indoles como antagonistas del receptor de la prostaglandina d2.

2007
- 2007-07-20 DK DK07799729.4T patent/DK2066628T3/da active
- 2007-07-20 WO PCT/US2007/073945 patent/WO2008014186A1/fr not_active Ceased
- 2007-07-20 BR BRPI0714554-3A patent/BRPI0714554A2/pt not_active IP Right Cessation
- 2007-07-20 MX MX2009000830A patent/MX2009000830A/es active IP Right Grant
- 2007-07-20 AU AU2007276885A patent/AU2007276885A1/en not_active Abandoned
- 2007-07-20 JP JP2009521914A patent/JP2009544721A/ja not_active Abandoned
- 2007-07-20 CA CA002659055A patent/CA2659055A1/fr not_active Abandoned
- 2007-07-20 DE DE602007010010T patent/DE602007010010D1/de active Active
- 2007-07-20 PT PT07799729T patent/PT2066628E/pt unknown
- 2007-07-20 EP EP07799729A patent/EP2066628B1/fr active Active
- 2007-07-20 AT AT07799729T patent/ATE485270T1/de active
- 2007-07-20 KR KR1020097001687A patent/KR20090039735A/ko not_active Abandoned
- 2007-07-23 PE PE2007000951A patent/PE20080549A1/es not_active Application Discontinuation
- 2007-07-24 CL CL200702163A patent/CL2007002163A1/es unknown
- 2007-07-24 AR ARP070103291A patent/AR062051A1/es not_active Application Discontinuation
- 2007-07-25 TW TW096127005A patent/TW200821286A/zh unknown
2008
- 2008-12-12 TN TNP2008000515A patent/TNSN08515A1/en unknown
2009
- 2009-01-15 CO CO09002745A patent/CO6190511A2/es not_active Application Discontinuation
- 2009-01-19 IL IL196587A patent/IL196587A0/en unknown
- 2009-01-21 CR CR10577A patent/CR10577A/es not_active Application Discontinuation
- 2009-01-22 US US12/357,725 patent/US20090176804A1/en not_active Abandoned
- 2009-01-23 EC EC2009009087A patent/ECSP099087A/es unknown
- 2009-01-23 GT GT200900016A patent/GT200900016A/es unknown
- 2009-02-13 MA MA31635A patent/MA30643B1/fr unknown
- 2009-02-24 NO NO20090862A patent/NO20090862L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
MA30643B1 (fr)	2009-08-03
AR062051A1 (es)	2008-08-10
MX2009000830A (es)	2009-02-03
CR10577A (es)	2009-03-20
US20090176804A1 (en)	2009-07-09
PE20080549A1 (es)	2008-06-20
IL196587A0 (en)	2009-11-18
DE602007010010D1 (de)	2010-12-02
PT2066628E (pt)	2010-12-31
EP2066628A1 (fr)	2009-06-10
EP2066628B1 (fr)	2010-10-20
JP2009544721A (ja)	2009-12-17
AU2007276885A1 (en)	2008-01-31
CA2659055A1 (fr)	2008-01-31
ATE485270T1 (de)	2010-11-15
ECSP099087A (es)	2009-02-27
KR20090039735A (ko)	2009-04-22
TW200821286A (en)	2008-05-16
CL2007002163A1 (es)	2008-02-08
BRPI0714554A2 (pt)	2013-05-07
GT200900016A (es)	2010-10-13
CO6190511A2 (es)	2010-08-19
DK2066628T3 (da)	2011-02-07
TNSN08515A1 (en)	2010-04-14
WO2008014186A1 (fr)	2008-01-31

Legal Events

Date	Code	Title	Description
2013-03-11	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20090862L (no)	2009-02-24	2-fenyl-indoler som prostaglandin D2-reseptorantagonister
NO20072440L (no)	2007-07-03	2,6-substituert-4-monosubstituertamino-pyrimidin som prostaglanding D2 reseptor antagonister
NO20084291L (no)	2008-11-11	2,6-substituert-4-monosubstituert aminopyridin som prostaglandin D2 reseptor-antagonister
NO20024281L (no)	2002-11-08	Indolderivater, fremgangsmÕte for fremstilling av de samme og anvendelse derav
TNSN08131A1 (en)	2009-07-14	Dihydrogen phosphate salt of a prostaglandin d2 receptor antagonist
TNSN07251A1 (en)	2008-12-31	2-phenyl-indoles as prostaglandin d2 receptor antagonists
NO20070321L (no)	2007-03-12	Pyridazin-3(2H)-on-derivater og deres anvendelse som PDE4-inhibitorer
NO20070319L (no)	2007-03-06	Nye pyridazin-3(2H)-on-derivater og deres anvendelse som PDE4-inhibitorer
NO20090139L (no)	2009-03-05	Substituted phenyl acetic acids as DP-2 antagonists
NO20090138L (no)	2009-03-05	Substituted phenyl acetic acids as DP-2 antagonists
EP1486491A4 (fr)	2006-02-15	Composes d'acide carboxylique et medicaments renfermant les composes comme principe actif
MX2009003100A (es)	2009-05-11	Inhibidores de fosfodiesterasa tipo iv.
WO2007114848A3 (fr)	2009-01-29	Composés chimiques
NO20084564L (no)	2008-12-02	Stramme "Constrained" forbindelser som CGRP-reseptor antagonister
NO20061207L (no)	2006-06-19	Karboksylsyreforbindelser og medisinske preparater inneholdende de samme som den aktive bestanddel
TW200635932A (en)	2006-10-16	New pyridothienopyrimidine derivatives
WO2006085212A3 (fr)	2006-10-19	Inhibiteurs de la phosphodiesterase de type iv
UA95303C2 (en)	2011-07-25	2-phenyl-indoles as prostaglandin d2 receptor antagonists
DOP2009000009A (es)	2009-02-15	2-fenilindoles como antagonistas del receptor de la prostaglandina d2
WO2008035316A3 (fr)	2008-11-27	Inhibiteurs de phosphodiestérase
WO2007046022A3 (fr)	2008-10-23	Inhibiteurs de phosphodiesterase de type-iv
UY30505A1 (es)	2008-02-29	Fenilindoles como antagonistas del receptor de la prostaglandina d2