NO20091242L - Fremgangsmate for fremstilling av biarylsubstituerte 4-aminosmorsyre eller derivater derav og deres anvendelse ved fremstilling av NEP-inhibitorer - Google Patents

Fremgangsmate for fremstilling av biarylsubstituerte 4-aminosmorsyre eller derivater derav og deres anvendelse ved fremstilling av NEP-inhibitorer

Info

Publication number
NO20091242L
NO20091242L NO20091242A NO20091242A NO20091242L NO 20091242 L NO20091242 L NO 20091242L NO 20091242 A NO20091242 A NO 20091242A NO 20091242 A NO20091242 A NO 20091242A NO 20091242 L NO20091242 L NO 20091242L
Authority
NO
Norway
Prior art keywords
preparation
nep inhibitors
biaryl
derivatives
amino
Prior art date
Application number
NO20091242A
Other languages
English (en)
Other versions
NO341967B1 (no
Inventor
Bernhard Wietfeld
David Hook
Matthias Lotz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37814152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20091242(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20091242L publication Critical patent/NO20091242L/no
Publication of NO341967B1 publication Critical patent/NO341967B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Oppfinnelsen angår en fremgangsmåte for fremstilling av en forbindelse med formel (i) (i) eller salt derav, hvori R1 og R1' er uavhengig hydrogen eller en aminbeskyttende gruppe og R2 er en karboksylgruppe eller en estergruppe, som innbefatter omsetning av en forbindelse med formel (ii) (ii) eller salt derav, hvori R1, R1'og R2 er som definert ovenfor, med hydrogen under nærvær av en overgangsmetallkatalysator og en kiral ligand, hvori overgangsmetallet er valgt fra gruppe 7, 8 eller 9 i det periodiske system. Videre angår oppfinnelsen produkter oppnådd ved nevnte fremgangsmåte og deres anvendelse ved fremstilling av NEP-inhibitorer. Videre angår oppfinnelsen anvendelse av overgangsmetallkatalysator ved fremstilling av NEP-inhibitorer eller prodrug derav.
NO20091242A 2006-09-13 2009-03-25 Fremgangsmåte for fremstilling av biarylsubstituerte 4-aminosmørsyre eller derivater derav og deres anvendelse ved fremstilling av NEP-inhibitorer NO341967B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06120576A EP1903027A1 (en) 2006-09-13 2006-09-13 Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
PCT/EP2007/007913 WO2008031567A1 (en) 2006-09-13 2007-09-11 Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of nep inhibitors

Publications (2)

Publication Number Publication Date
NO20091242L true NO20091242L (no) 2009-03-25
NO341967B1 NO341967B1 (no) 2018-03-05

Family

ID=37814152

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091242A NO341967B1 (no) 2006-09-13 2009-03-25 Fremgangsmåte for fremstilling av biarylsubstituerte 4-aminosmørsyre eller derivater derav og deres anvendelse ved fremstilling av NEP-inhibitorer

Country Status (28)

Country Link
US (2) US20090326066A1 (no)
EP (2) EP1903027A1 (no)
JP (1) JP5455627B2 (no)
KR (1) KR101401118B1 (no)
CN (1) CN101516831B (no)
AU (1) AU2007296889B2 (no)
BR (1) BRPI0716990A2 (no)
CA (1) CA2662393C (no)
CO (1) CO6190550A2 (no)
CY (1) CY1115696T1 (no)
DK (1) DK2066618T3 (no)
ES (1) ES2519446T3 (no)
GT (1) GT200900058A (no)
HR (1) HRP20140984T1 (no)
IL (1) IL196925A (no)
MA (1) MA30724B1 (no)
MX (1) MX2009002746A (no)
MY (1) MY146660A (no)
NO (1) NO341967B1 (no)
NZ (1) NZ574665A (no)
PL (1) PL2066618T3 (no)
PT (1) PT2066618E (no)
RU (1) RU2469019C2 (no)
SG (1) SG177205A1 (no)
SI (1) SI2066618T1 (no)
TN (1) TN2009000077A1 (no)
WO (1) WO2008031567A1 (no)
ZA (1) ZA200900779B (no)

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CA2763565A1 (en) 2009-05-28 2010-12-02 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
PL2435409T3 (pl) 2009-05-28 2015-01-30 Novartis Ag Podstawione pochodne aminopropionowe jako inhibitory neprylizyny
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
ES2550485T3 (es) * 2010-01-22 2015-11-10 Novartis Ag Intermedios de inhibidores de la endopeptidasa neutra y método de preparación de los mismos
PT2609075E (pt) * 2010-08-23 2016-06-03 Novartis Ag Processo para a preparação de intermediários para o fabrico de inibidores da nep
US9085529B2 (en) 2010-08-23 2015-07-21 Novartis Ag Process for the preparation of intermediates useful for the manufacture NEP inhibitors
US8993631B2 (en) 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
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CN105884644B (zh) * 2015-02-15 2020-06-09 深圳信立泰药业股份有限公司 一种中性内肽酶抑制剂盐优势形态及其制备方法
CN106146351B (zh) * 2015-04-03 2020-09-11 博瑞生物医药（苏州）股份有限公司 制备联芳基取代的4-氨基-丁酸或其衍生物的方法
CN106065006B (zh) * 2015-04-22 2020-06-05 深圳信立泰药业股份有限公司 一种中性内肽酶抑制剂盐晶型及其制备方法
CN106187808A (zh) * 2015-05-08 2016-12-07 苏州鹏旭医药科技有限公司 Ahu-377的制备方法、ahu-377中间体及ahu-377中间体的制备方法
CN104860894B (zh) * 2015-06-10 2017-05-17 北京博全健医药科技有限公司 一种抗心衰药lcz696的制备方法
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CN105523964B (zh) * 2015-12-09 2017-05-24 苏州楚凯药业有限公司 一种抗心衰药物中间体的制备方法
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CN106977415B (zh) * 2016-01-15 2021-03-26 广东东阳光药业有限公司 一种沙库必曲的中间体及其制备方法
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JP6944473B2 (ja) 2016-07-05 2021-10-06 ノバルティス アーゲー 初期サクビトリル中間体のための新規な方法
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CN106380421B (zh) * 2016-08-26 2017-12-08 中国科学院上海有机化学研究所 沙库必曲的合成方法
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CN106631903A (zh) * 2016-12-16 2017-05-10 重庆市碚圣医药科技股份有限公司 一种lcz‑696关键中间体的制备方法
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CN107011203B (zh) * 2017-04-28 2019-03-29 江苏阿尔法药业有限公司 一种lcz696中间体ahu-377的制备方法
CN107522628A (zh) * 2017-09-20 2017-12-29 吉尔生化（上海）有限公司 一种l‑3‑（6‑乙酰基‑2‑萘胺基）‑2‑氨基丙酸的合成方法
CN108084058A (zh) * 2017-12-15 2018-05-29 江苏中邦制药有限公司 一种lcz696中间体的制备方法
CN108373423B (zh) * 2018-04-28 2020-10-23 成都苑东生物制药股份有限公司 一种沙库比曲缬沙坦复合物和/或共晶关键中间体沙库比曲钙的制备方法
CN109400504A (zh) * 2018-12-11 2019-03-01 重庆三圣实业股份有限公司 Lcz696中间体非对映异构体的分离纯化方法
CN109503404A (zh) * 2018-12-28 2019-03-22 凯瑞斯德生化(苏州)有限公司 一种lcz-696关键中间体的制备方法
CN111748590B (zh) * 2019-03-29 2024-05-28 弈柯莱(台州)药业有限公司 转氨酶在制备Sacubitril中间体中的应用
CN110128298B (zh) * 2019-06-13 2021-08-03 南京一心和医药科技有限公司 一种沙库巴曲中间体的合成方法
CN112574132B (zh) * 2019-09-30 2024-02-27 广东东阳光药业股份有限公司 一种沙库必曲缬沙坦钠的制备方法
CN113135836A (zh) * 2020-01-20 2021-07-20 鲁南制药集团股份有限公司 一种沙库巴曲钙盐的制备方法
CN113321600B (zh) * 2020-02-28 2024-06-14 四川科伦药物研究院有限公司 制备手性联芳基取代的4-氨基-丁酸及其衍生物的方法
CN113387841A (zh) * 2020-03-13 2021-09-14 凯特立斯（深圳）科技有限公司 一种沙库必曲中间体的合成方法
CN111269148B (zh) * 2020-04-08 2022-02-08 台州职业技术学院 一种沙库比曲中间体的制备方法
JP7064527B2 (ja) * 2020-05-01 2022-05-10 ノバルティス アーゲー サクビトリルカルシウム塩
CN112480179B (zh) * 2020-11-24 2025-11-14 苏州鹏旭医药科技有限公司 一种取代二茂铁基二膦均相催化剂配体
CN112745246A (zh) * 2020-12-30 2021-05-04 重庆市碚圣医药科技股份有限公司 一种沙库必曲中间体的纯化方法
CN119798080B (zh) * 2023-10-11 2025-10-03 杭州科巢生物科技有限公司 一种(r)-5-([1,1′-联苯基]-4-基)-2-甲基-4-氧代戊酸钙盐的制备方法
CN117924111A (zh) * 2023-12-14 2024-04-26 宣城美诺华药业有限公司 一种沙库巴曲缬沙坦钠的制备方法

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Also Published As

Publication number Publication date
JP2010503628A (ja) 2010-02-04
IL196925A0 (en) 2009-11-18
DK2066618T3 (da) 2014-09-22
WO2008031567A1 (en) 2008-03-20
ZA200900779B (en) 2009-12-30
MX2009002746A (es) 2009-03-26
GT200900058A (es) 2010-03-11
NO341967B1 (no) 2018-03-05
KR20090076910A (ko) 2009-07-13
CA2662393C (en) 2015-11-03
CN101516831A (zh) 2009-08-26
EP1903027A1 (en) 2008-03-26
NZ574665A (en) 2012-03-30
RU2009113666A (ru) 2010-10-20
ES2519446T3 (es) 2014-11-07
HK1131381A1 (en) 2010-01-22
IL196925A (en) 2013-10-31
US20130066101A1 (en) 2013-03-14
US8946481B2 (en) 2015-02-03
AU2007296889B2 (en) 2012-03-01
RU2469019C2 (ru) 2012-12-10
CN101516831B (zh) 2013-12-25
PL2066618T3 (pl) 2015-01-30
CY1115696T1 (el) 2017-01-25
SI2066618T1 (sl) 2014-11-28
MA30724B1 (fr) 2009-09-01
CO6190550A2 (es) 2010-08-19
PT2066618E (pt) 2014-09-10
SG177205A1 (en) 2012-01-30
EP2066618A1 (en) 2009-06-10
US20090326066A1 (en) 2009-12-31
EP2066618B1 (en) 2014-07-23
JP5455627B2 (ja) 2014-03-26
TN2009000077A1 (en) 2010-08-19
WO2008031567B1 (en) 2008-05-08
KR101401118B1 (ko) 2014-05-29
MY146660A (en) 2012-09-14
AU2007296889A1 (en) 2008-03-20
CA2662393A1 (en) 2008-03-20
HRP20140984T1 (hr) 2014-12-05
BRPI0716990A2 (pt) 2014-02-04

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