NO20092331L - LINGO-bindingsmolekyler og farmasoytisk anvendelse derav - Google Patents

LINGO-bindingsmolekyler og farmasoytisk anvendelse derav

Info

Publication number
NO20092331L
NO20092331L NO20092331A NO20092331A NO20092331L NO 20092331 L NO20092331 L NO 20092331L NO 20092331 A NO20092331 A NO 20092331A NO 20092331 A NO20092331 A NO 20092331A NO 20092331 L NO20092331 L NO 20092331L
Authority
NO
Norway
Prior art keywords
binding molecule
lingo
polynucleotide
binding molecules
pharmaceutical use
Prior art date
Application number
NO20092331A
Other languages
English (en)
Inventor
Josef Prassler
Adrien Walmsley
William Leonard Wishart
Marta Cortes-Cros
Ingo Klagge
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38325542&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20092331(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20092331L publication Critical patent/NO20092331L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Det tilveiebringes et bindingsmolekyl som er i stand til å binde til rotte-, cynomolgus ape- og human LINGO-polypeptidet. Det beskrives videre et polynukleotid som koder et slikt bindingsmolekyl; en ekspresjonsvektor som omfatter nevnte polynukleotid; et ekspresjonssystem som omfatter et polynukleotid i stand til å produsere et bindingsmolekyl; en isolert vertscelle som omfatter et ekspresjonssystem som definert ovenfor; anvendelsen av et slikt bindingsmolekyl som et farmasøytikum, særlig ved behandling for å promotere axonal regenerering/plastisitet; et farmasøytisk preparat omfattende nevnte bindingsmolekyl; samt en fremgangsmåte for behandling av sykdommer assosiert med axonal degenerering og demyelinering.
NO20092331A 2006-11-17 2009-06-17 LINGO-bindingsmolekyler og farmasoytisk anvendelse derav NO20092331L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06124350 2006-11-17
PCT/EP2007/009880 WO2008058736A1 (en) 2006-11-17 2007-11-15 Lingo binding molecules and pharmaceutical use thereof

Publications (1)

Publication Number Publication Date
NO20092331L true NO20092331L (no) 2009-06-17

Family

ID=38325542

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092331A NO20092331L (no) 2006-11-17 2009-06-17 LINGO-bindingsmolekyler og farmasoytisk anvendelse derav

Country Status (27)

Country Link
US (4) US8299221B2 (no)
EP (2) EP2395022A1 (no)
JP (2) JP5647414B2 (no)
KR (1) KR20090078353A (no)
CN (2) CN103351437A (no)
AR (1) AR063829A1 (no)
AT (1) ATE502960T1 (no)
AU (1) AU2007321817A1 (no)
BR (1) BRPI0718406A2 (no)
CA (1) CA2669181A1 (no)
CL (1) CL2007003303A1 (no)
CO (1) CO6180433A2 (no)
CR (1) CR10756A (no)
DE (1) DE602007013445D1 (no)
EC (1) ECSP099332A (no)
ES (1) ES2363622T3 (no)
GT (1) GT200900121A (no)
IL (1) IL198313A0 (no)
MA (1) MA30965B1 (no)
MX (1) MX2009005175A (no)
NO (1) NO20092331L (no)
PE (1) PE20081392A1 (no)
RU (1) RU2009122514A (no)
TN (1) TN2009000190A1 (no)
TW (1) TW200831534A (no)
WO (1) WO2008058736A1 (no)
ZA (1) ZA200902409B (no)

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Also Published As

Publication number Publication date
TN2009000190A1 (en) 2010-10-18
US20130071400A1 (en) 2013-03-21
MA30965B1 (fr) 2009-12-01
CN103351437A (zh) 2013-10-16
GT200900121A (es) 2011-11-11
WO2008058736A1 (en) 2008-05-22
MX2009005175A (es) 2009-08-07
EP2395022A9 (en) 2013-04-24
US20100143362A1 (en) 2010-06-10
JP2013056888A (ja) 2013-03-28
AR063829A1 (es) 2009-02-18
CL2007003303A1 (es) 2008-06-27
EP2395022A1 (en) 2011-12-14
PE20081392A1 (es) 2008-11-12
JP5647414B2 (ja) 2014-12-24
JP2010509906A (ja) 2010-04-02
US20140255415A1 (en) 2014-09-11
CR10756A (es) 2009-06-04
CN101553506B (zh) 2013-08-07
KR20090078353A (ko) 2009-07-17
CO6180433A2 (es) 2010-07-19
CA2669181A1 (en) 2008-05-22
ATE502960T1 (de) 2011-04-15
US8299221B2 (en) 2012-10-30
ES2363622T3 (es) 2011-08-10
IL198313A0 (en) 2011-08-01
CN101553506A (zh) 2009-10-07
EP2084190B1 (en) 2011-03-23
DE602007013445D1 (de) 2011-05-05
BRPI0718406A2 (pt) 2013-12-17
RU2009122514A (ru) 2010-12-27
EP2084190A1 (en) 2009-08-05
AU2007321817A1 (en) 2008-05-22
ZA200902409B (en) 2010-04-28
US20140037639A1 (en) 2014-02-06
TW200831534A (en) 2008-08-01
ECSP099332A (es) 2009-06-30

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