NO20092375L - Fremgangsmate for fremstilling av abacavir - Google Patents
Fremgangsmate for fremstilling av abacavirInfo
- Publication number
- NO20092375L NO20092375L NO20092375A NO20092375A NO20092375L NO 20092375 L NO20092375 L NO 20092375L NO 20092375 A NO20092375 A NO 20092375A NO 20092375 A NO20092375 A NO 20092375A NO 20092375 L NO20092375 L NO 20092375L
- Authority
- NO
- Norway
- Prior art keywords
- abacavir
- preparation
- compound
- reacting
- compound obtained
- Prior art date
Links
- MCGSCOLBFJQGHM-SCZZXKLOSA-N abacavir Chemical compound C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1 MCGSCOLBFJQGHM-SCZZXKLOSA-N 0.000 title abstract 3
- 229960004748 abacavir Drugs 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical compound NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Det er beskrevet en fremgangsmåte for fremstilling av abacavir, eller dets salter eller dets solvater som omfatter trinnet med omsetning av en forbindelse (IV) hvor R, er en (C1-C4)-alkylrest med vannfri saltsyre/(C1-C6)-alkohol, og deretter med tri(C1-C4)-alkyl ortoformat, i fravær av vann. Framstillingsprosessen kan omfatte ytterligere trinn ved omsetning av den oppnådde forbindelsen med cyklopropylamin og etterfølgende hydrolyse for å gi abacavir.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87134706P | 2006-12-21 | 2006-12-21 | |
| EP06126797A EP1939196A1 (en) | 2006-12-21 | 2006-12-21 | Process for the preparation of abacavir |
| PCT/EP2007/064371 WO2008074874A1 (en) | 2006-12-21 | 2007-12-20 | Process for the preparation of abacavir |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20092375L true NO20092375L (no) | 2009-07-21 |
Family
ID=37912446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20092375A NO20092375L (no) | 2006-12-21 | 2009-06-22 | Fremgangsmate for fremstilling av abacavir |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8097723B2 (no) |
| EP (2) | EP1939196A1 (no) |
| JP (1) | JP5166438B2 (no) |
| KR (1) | KR20090094025A (no) |
| CN (1) | CN101563346B (no) |
| AT (1) | ATE473979T1 (no) |
| AU (1) | AU2007336195A1 (no) |
| CA (1) | CA2670432A1 (no) |
| DE (1) | DE602007007824D1 (no) |
| ES (1) | ES2348197T3 (no) |
| IL (1) | IL198965A (no) |
| MX (1) | MX2009006231A (no) |
| NO (1) | NO20092375L (no) |
| PL (1) | PL2125814T3 (no) |
| RU (1) | RU2447073C2 (no) |
| SI (1) | SI2125814T1 (no) |
| WO (1) | WO2008074874A1 (no) |
| ZA (1) | ZA200903648B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1905772A1 (en) * | 2006-09-28 | 2008-04-02 | Esteve Quimica, S.A. | Process for the preparation of abacavir |
| EP2085397A1 (en) * | 2008-01-21 | 2009-08-05 | Esteve Quimica, S.A. | Crystalline form of abacavir |
| CA2862006C (en) * | 2012-01-03 | 2016-10-25 | Cellceutix Corporation | Carbocyclic nucleosides and their pharmaceutical use and compositions |
| CN104788451A (zh) * | 2014-01-21 | 2015-07-22 | 浙江九洲药业股份有限公司 | 一种阿巴卡韦的制备方法 |
| CN109239253B (zh) * | 2018-09-21 | 2021-07-09 | 江苏威奇达药业有限公司 | 一种阿巴卡韦的杂质的高效液相检测方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY104575A (en) | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
| GB9402161D0 (en) * | 1994-02-04 | 1994-03-30 | Wellcome Found | Chloropyrimidine intermediates |
| GB0320738D0 (en) * | 2003-09-04 | 2003-10-08 | Glaxo Group Ltd | Novel process |
| EP1905772A1 (en) * | 2006-09-28 | 2008-04-02 | Esteve Quimica, S.A. | Process for the preparation of abacavir |
| WO2008072074A1 (en) * | 2006-12-11 | 2008-06-19 | Aurobindo Pharma Limited | An improved process for the preparation of purine derivative |
| EP2170840A1 (en) * | 2007-06-21 | 2010-04-07 | Aurobindo Pharma Ltd | An improved process for preparing purine derivative |
-
2006
- 2006-12-21 EP EP06126797A patent/EP1939196A1/en not_active Withdrawn
-
2007
- 2007-12-20 SI SI200730377T patent/SI2125814T1/sl unknown
- 2007-12-20 AU AU2007336195A patent/AU2007336195A1/en not_active Abandoned
- 2007-12-20 JP JP2009542076A patent/JP5166438B2/ja not_active Expired - Fee Related
- 2007-12-20 ES ES07857990T patent/ES2348197T3/es active Active
- 2007-12-20 EP EP07857990A patent/EP2125814B1/en active Active
- 2007-12-20 US US12/520,510 patent/US8097723B2/en not_active Expired - Fee Related
- 2007-12-20 KR KR1020097014227A patent/KR20090094025A/ko not_active Withdrawn
- 2007-12-20 PL PL07857990T patent/PL2125814T3/pl unknown
- 2007-12-20 AT AT07857990T patent/ATE473979T1/de not_active IP Right Cessation
- 2007-12-20 ZA ZA200903648A patent/ZA200903648B/xx unknown
- 2007-12-20 RU RU2009128032/04A patent/RU2447073C2/ru not_active IP Right Cessation
- 2007-12-20 CN CN2007800474491A patent/CN101563346B/zh not_active Expired - Fee Related
- 2007-12-20 DE DE602007007824T patent/DE602007007824D1/de active Active
- 2007-12-20 WO PCT/EP2007/064371 patent/WO2008074874A1/en not_active Ceased
- 2007-12-20 MX MX2009006231A patent/MX2009006231A/es active IP Right Grant
- 2007-12-20 CA CA002670432A patent/CA2670432A1/en not_active Abandoned
-
2009
- 2009-05-26 IL IL198965A patent/IL198965A/en not_active IP Right Cessation
- 2009-06-22 NO NO20092375A patent/NO20092375L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101563346A (zh) | 2009-10-21 |
| DE602007007824D1 (de) | 2010-08-26 |
| EP1939196A1 (en) | 2008-07-02 |
| RU2447073C2 (ru) | 2012-04-10 |
| CN101563346B (zh) | 2011-07-27 |
| JP5166438B2 (ja) | 2013-03-21 |
| US20100041883A1 (en) | 2010-02-18 |
| AU2007336195A1 (en) | 2008-06-26 |
| WO2008074874A1 (en) | 2008-06-26 |
| EP2125814A1 (en) | 2009-12-02 |
| EP2125814B1 (en) | 2010-07-14 |
| JP2010513410A (ja) | 2010-04-30 |
| KR20090094025A (ko) | 2009-09-02 |
| IL198965A0 (en) | 2010-02-17 |
| US8097723B2 (en) | 2012-01-17 |
| MX2009006231A (es) | 2009-06-22 |
| ATE473979T1 (de) | 2010-07-15 |
| RU2009128032A (ru) | 2011-01-27 |
| IL198965A (en) | 2012-08-30 |
| CA2670432A1 (en) | 2008-06-26 |
| PL2125814T3 (pl) | 2010-12-31 |
| ZA200903648B (en) | 2010-08-25 |
| SI2125814T1 (sl) | 2010-12-31 |
| ES2348197T3 (es) | 2010-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |