NO20092393L - Fremgangsmate for fremstilling av 2-amino-4-(4-fluorfenyl)-6-alkylpyrimidin-5-karboksylat - Google Patents
Fremgangsmate for fremstilling av 2-amino-4-(4-fluorfenyl)-6-alkylpyrimidin-5-karboksylatInfo
- Publication number
- NO20092393L NO20092393L NO20092393A NO20092393A NO20092393L NO 20092393 L NO20092393 L NO 20092393L NO 20092393 A NO20092393 A NO 20092393A NO 20092393 A NO20092393 A NO 20092393A NO 20092393 L NO20092393 L NO 20092393L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- preparation
- alkyl
- compound
- alkylpyrimidine
- Prior art date
Links
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- AEKVBBNGWBBYLL-UHFFFAOYSA-N 4-fluorobenzonitrile Chemical compound FC1=CC=C(C#N)C=C1 AEKVBBNGWBBYLL-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Fremgangsmåte for fremstilling av forbindelser med den generelle formel (I), hvori R er hydrogen eller en gruppe med formel -SO2R1, R1 er C1-6alkyl, R2 er hydrogen eller C1-6alkyl, R3 er C1-6alkyl, R4 er C1-6alkyl, karakterisert ved at i et første trinn omsettes en forbindelse med formel (II), hvori R3 og R4 har ovenfor nevnte betydninig, i nærvær av en Lewis-syre med 4-fluorbenzonitril og gir en forbindelse med den generelle formel (III), hvori R3 og R4 har den ovenfor angitte betydning, og i et andre trinn omsettes den oppnådde forbindelse med formel (III) med forbindelsen med formel IV, hvori R og R2 har den ovenfor angitte betydning, og gir sluttproduktet med formel (I).
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99113711 | 1999-07-13 | ||
| EP99120417 | 1999-10-14 | ||
| US18537100P | 2000-02-28 | 2000-02-28 | |
| US18546500P | 2000-02-28 | 2000-02-28 | |
| EP00106303 | 2000-03-23 | ||
| PCT/EP2000/006099 WO2001004100A1 (en) | 1999-07-13 | 2000-06-30 | Process for preparing 2-amino-4-(4-fluorphenyl)-6-alkylpyrimidine-5-carboxylate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20092393L true NO20092393L (no) | 2002-01-11 |
| NO334937B1 NO334937B1 (no) | 2014-07-21 |
Family
ID=27513029
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20020163A NO328103B1 (no) | 1999-07-13 | 2002-01-11 | Fremgangsmate for fremstilling av 2-amino-4-(4-fluorfenyl)-6-alkylpyrimidin-5-karboksylater og mellomprodukter derav |
| NO20092393A NO334937B1 (no) | 1999-07-13 | 2009-06-23 | Fremgangsmåte for fremstilling av N-cyano-N-alkylalkansulfonamider og 4-fenylpyrimidiner samt slike forbindelser |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20020163A NO328103B1 (no) | 1999-07-13 | 2002-01-11 | Fremgangsmate for fremstilling av 2-amino-4-(4-fluorfenyl)-6-alkylpyrimidin-5-karboksylater og mellomprodukter derav |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US6579984B1 (no) |
| EP (1) | EP1194414B1 (no) |
| JP (1) | JP4649813B2 (no) |
| KR (1) | KR100649927B1 (no) |
| CN (1) | CN1164577C (no) |
| AT (1) | ATE307120T1 (no) |
| AU (1) | AU6266600A (no) |
| CA (1) | CA2378782C (no) |
| CZ (1) | CZ304307B6 (no) |
| DE (1) | DE60023296T2 (no) |
| ES (1) | ES2251392T3 (no) |
| HK (1) | HK1046682B (no) |
| HU (1) | HU228303B1 (no) |
| NO (2) | NO328103B1 (no) |
| PL (1) | PL211797B1 (no) |
| SK (1) | SK285993B6 (no) |
| WO (1) | WO2001004100A1 (no) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0003305D0 (en) * | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
| RU2301801C2 (ru) * | 2001-07-13 | 2007-06-27 | АстраЗенека Ю-Кей Лимитед | Способ получения сульфониламинопиримидиновых соединений (варианты), промежуточные продукты и способы их получения |
| KR100888408B1 (ko) * | 2001-07-13 | 2009-03-13 | 아스트라제네카 유케이 리미티드 | 아미노피리미딘 화합물의 제조 방법 |
| GB0218781D0 (en) * | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| DE60330050D1 (de) * | 2002-12-16 | 2009-12-24 | Astrazeneca Uk Ltd | Verfahren zur herstellung von pyrimidinverbindungen |
| GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
| EP2423195A1 (en) | 2010-07-26 | 2012-02-29 | LEK Pharmaceuticals d.d. | Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof |
| EP3915367A1 (en) | 2010-08-18 | 2021-12-01 | BioSplice Therapeutics, Inc. | Diketones and hydroxyketones as catenin signaling pathway activators |
| PE20151721A1 (es) | 2013-02-22 | 2015-12-07 | Samumed Llc | Y-dicetonas como activadores de la ruta de senalizacion de wnt/b-catenina |
| CN103910644B (zh) * | 2014-04-21 | 2015-06-24 | 广西师范大学 | β-烯胺酮酯类化合物及其合成方法和应用 |
| DK3206686T3 (da) | 2014-08-20 | 2019-12-16 | Samumed Llc | Gamma-diketoner til behandling og forebyggelse af ældning af huden og rynker |
| CN110483341A (zh) * | 2019-07-23 | 2019-11-22 | 上海药明康德新药开发有限公司 | 一种1-氰基-n-甲基甲磺酰胺的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4013706A (en) | 1973-11-14 | 1977-03-22 | Sucreries Du Soissonnais Et Compagnie Sucriere | Derivatives of substituted urea, acyl ureas, and sulphonyl ureas, and a process for producing the same |
| DE3717815A1 (de) | 1987-05-27 | 1988-12-15 | Bayer Ag | Fungizide mittel auf basis von substituierten cyanamiden |
| JP2648897B2 (ja) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
| JP3197971B2 (ja) * | 1993-03-01 | 2001-08-13 | 塩野義製薬株式会社 | ５−カルボアルコキシピリミジン誘導体の合成方法 |
-
2000
- 2000-06-30 CZ CZ2002-61A patent/CZ304307B6/cs not_active IP Right Cessation
- 2000-06-30 ES ES00949231T patent/ES2251392T3/es not_active Expired - Lifetime
- 2000-06-30 HK HK02108215.0A patent/HK1046682B/zh not_active IP Right Cessation
- 2000-06-30 CA CA002378782A patent/CA2378782C/en not_active Expired - Lifetime
- 2000-06-30 JP JP2001509711A patent/JP4649813B2/ja not_active Expired - Lifetime
- 2000-06-30 EP EP00949231A patent/EP1194414B1/en not_active Expired - Lifetime
- 2000-06-30 SK SK22-2002A patent/SK285993B6/sk not_active IP Right Cessation
- 2000-06-30 KR KR1020027000488A patent/KR100649927B1/ko not_active Expired - Fee Related
- 2000-06-30 CN CNB008116768A patent/CN1164577C/zh not_active Expired - Lifetime
- 2000-06-30 HU HU0202006A patent/HU228303B1/hu not_active IP Right Cessation
- 2000-06-30 WO PCT/EP2000/006099 patent/WO2001004100A1/en not_active Ceased
- 2000-06-30 US US10/030,077 patent/US6579984B1/en not_active Expired - Lifetime
- 2000-06-30 PL PL353058A patent/PL211797B1/pl unknown
- 2000-06-30 DE DE60023296T patent/DE60023296T2/de not_active Expired - Lifetime
- 2000-06-30 AT AT00949231T patent/ATE307120T1/de active
- 2000-06-30 AU AU62666/00A patent/AU6266600A/en not_active Abandoned
-
2002
- 2002-01-11 NO NO20020163A patent/NO328103B1/no not_active IP Right Cessation
-
2003
- 2003-05-23 US US10/443,797 patent/US6710178B2/en not_active Expired - Lifetime
-
2004
- 2004-03-23 US US10/806,315 patent/US6984757B2/en not_active Expired - Lifetime
-
2009
- 2009-06-23 NO NO20092393A patent/NO334937B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |