NO20092729L - Lipasevarianter for farmasoytisk anvendelse - Google Patents
Lipasevarianter for farmasoytisk anvendelseInfo
- Publication number
- NO20092729L NO20092729L NO20092729A NO20092729A NO20092729L NO 20092729 L NO20092729 L NO 20092729L NO 20092729 A NO20092729 A NO 20092729A NO 20092729 A NO20092729 A NO 20092729A NO 20092729 L NO20092729 L NO 20092729L
- Authority
- NO
- Norway
- Prior art keywords
- lipases
- digestive
- improved
- pharmaceutical use
- diabetes
- Prior art date
Links
- 239000004367 Lipase Substances 0.000 title abstract 5
- 102000004882 Lipase Human genes 0.000 title abstract 5
- 108090001060 Lipase Proteins 0.000 title abstract 5
- 235000019421 lipase Nutrition 0.000 title abstract 5
- 241000223258 Thermomyces lanuginosus Species 0.000 abstract 3
- 230000001079 digestive effect Effects 0.000 abstract 3
- 108091005804 Peptidases Proteins 0.000 abstract 2
- 239000004365 Protease Substances 0.000 abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 239000004382 Amylase Substances 0.000 abstract 1
- 102000013142 Amylases Human genes 0.000 abstract 1
- 108010065511 Amylases Proteins 0.000 abstract 1
- 201000003883 Cystic fibrosis Diseases 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 102000057297 Pepsin A Human genes 0.000 abstract 1
- 108090000284 Pepsin A Proteins 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 235000019418 amylase Nutrition 0.000 abstract 1
- 239000003833 bile salt Substances 0.000 abstract 1
- 229940093761 bile salts Drugs 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229940111202 pepsin Drugs 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Detergent Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87119606P | 2006-12-21 | 2006-12-21 | |
| PCT/US2007/087168 WO2008079685A2 (fr) | 2006-12-21 | 2007-12-12 | Variantes lipasiques pour une utilisation pharmaceutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20092729L true NO20092729L (no) | 2009-09-18 |
Family
ID=38043020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20092729A NO20092729L (no) | 2006-12-21 | 2009-07-20 | Lipasevarianter for farmasoytisk anvendelse |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US8273348B2 (fr) |
| EP (6) | EP2099907A2 (fr) |
| JP (1) | JP5406040B2 (fr) |
| KR (1) | KR20090101930A (fr) |
| CN (2) | CN101743308B (fr) |
| AR (1) | AR064494A1 (fr) |
| AU (1) | AU2007337150A1 (fr) |
| BR (1) | BRPI0721103A2 (fr) |
| CA (3) | CA2670643C (fr) |
| IL (1) | IL198893A0 (fr) |
| MX (1) | MX2009006597A (fr) |
| NO (1) | NO20092729L (fr) |
| RU (1) | RU2009128067A (fr) |
| TW (1) | TW200829698A (fr) |
| WO (1) | WO2008079685A2 (fr) |
| ZA (1) | ZA200903598B (fr) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2560613C (fr) | 2004-03-22 | 2015-11-24 | Solvay Pharmaceuticals Gmbh | Compositions pharmaceutiques par voie orale a base de lipases, en particulier de pancreatine, contenant des tensioacitfs |
| PL2278002T3 (pl) | 2005-07-29 | 2017-12-29 | Abbott Laboratories Gmbh | Pankreatyna o zmniejszonej zawartości wirusowej |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| JP5406040B2 (ja) * | 2006-12-21 | 2014-02-05 | ノボザイムス アクティーゼルスカブ | 医薬使用のためのリパーゼ変異体 |
| AR070491A1 (es) * | 2008-02-29 | 2010-04-07 | Novozymes As | Variante de enzima lipolitica con estabilidad aumentada y polinucleotidos que la codifican |
| EP2254996B1 (fr) | 2008-02-29 | 2013-07-17 | DSM IP Assets B.V. | Lipases présentant une spécificité élevée envers les acides gras à chaîne courte et leurs utilisations |
| JP2011513539A (ja) * | 2008-02-29 | 2011-04-28 | ザ プロクター アンド ギャンブル カンパニー | リパーゼを含む洗剤組成物 |
| EP3434764B1 (fr) | 2009-12-09 | 2026-04-08 | The Procter & Gamble Company | Tissu et produits de soins à domicile |
| CN109022518A (zh) | 2011-07-22 | 2018-12-18 | 诺维信北美公司 | 用于预处理纤维素材料和改进其水解的方法 |
| US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
| ES2887576T3 (es) * | 2011-12-29 | 2021-12-23 | Novozymes As | Composiciones detergentes con variantes de lipasa |
| EP4570895A3 (fr) | 2012-02-03 | 2026-01-14 | Novozymes A/S | Variantes de la lipase et polynucléotides les codant |
| EP2834353B1 (fr) | 2012-04-02 | 2017-07-19 | Novozymes A/S | Variantes de la lipase et polynucléotides les codant |
| CN110093330B (zh) * | 2012-10-12 | 2023-11-28 | 丹尼斯科美国公司 | 包含脂解酶变体的组合物和方法 |
| MX392247B (es) * | 2013-05-14 | 2025-03-24 | Novozymes As | Composiciones detergentes. |
| ES2956266T3 (es) * | 2013-07-19 | 2023-12-18 | Danisco Us Inc | Composiciones y procedimientos que comprenden una variante de enzima lipolítica |
| WO2016079305A1 (fr) * | 2014-11-20 | 2016-05-26 | Novozymes A/S | Variants de alicyclobacillus et polynucléotides codant pour ceux-ci |
| EP3227442B1 (fr) * | 2014-12-05 | 2022-02-16 | Novozymes A/S | Variantes de la lipase et polynucléotides les codant |
| CA2965232A1 (fr) * | 2014-12-09 | 2016-06-16 | Novozymes A/S | Variants de lipase et polynucleotides codant pour ces derniers |
| US20180355404A1 (en) | 2015-04-07 | 2018-12-13 | Novozymes A/S | Methods for selecting enzymes having lipase activity |
| CA2987160C (fr) * | 2015-07-01 | 2022-12-13 | Novozymes A/S | Procedes de reduction d'odeur |
| WO2017005640A1 (fr) * | 2015-07-03 | 2017-01-12 | Novozymes A/S | Compositions détergentes présentant une stabilité accrue en présence de sulfites |
| CN109790525A (zh) | 2016-07-18 | 2019-05-21 | 诺维信公司 | 脂肪酶变体、编码其的多核苷酸及其用途 |
| EP3575398A4 (fr) * | 2017-01-30 | 2020-11-11 | Nippon Medical School Foundation | Mutant de protéine de capside de virus adéno-associé (vaa) |
| CN118910005A (zh) * | 2017-09-27 | 2024-11-08 | 诺维信公司 | 脂肪酶变体和包含此类脂肪酶变体的微囊组合物 |
| MX2020003779A (es) * | 2017-09-27 | 2020-08-03 | Procter & Gamble | Composiciones detergentes que comprenden lipasas. |
| US20210071155A1 (en) * | 2018-02-08 | 2021-03-11 | Novozymes A/S | Lipase Variants and Compositions Thereof |
| US12269847B2 (en) * | 2018-08-16 | 2025-04-08 | Donaldson Company, Inc. | Genetically encoded polypeptide for affinity capture and purification of biologics |
| CN111334369B (zh) * | 2020-03-11 | 2022-10-21 | 陕西科技大学 | 一种酶法制备卵磷脂型pufa的方法 |
| JP7741827B2 (ja) * | 2020-06-24 | 2025-09-18 | シリアン アクチェンゲゼルシャフト | 新規リパーゼ酵素 |
| WO2022090361A2 (fr) * | 2020-10-29 | 2022-05-05 | Novozymes A/S | Variants de lipase et compositions comprenant de tels variants de lipase |
| WO2023225459A2 (fr) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions et procédés de prévention, de traitement, de suppression et/ou d'élimination d'infestations et d'infections phytopathogènes |
| CN113846074B (zh) * | 2021-10-20 | 2022-10-21 | 南京林业大学 | 一种疏棉状嗜热丝孢菌脂肪酶突变体g91c及其应用 |
| CN116732002A (zh) * | 2022-03-01 | 2023-09-12 | 中国科学院天津工业生物技术研究所 | 一种耐受表面活性剂的脂肪酶变体及其应用 |
| WO2023247664A2 (fr) * | 2022-06-24 | 2023-12-28 | Novozymes A/S | Variants de lipase et compositions comprenant de tels variants de lipase |
| CN118272341A (zh) * | 2022-12-21 | 2024-07-02 | 丰益(上海)生物技术研发中心有限公司 | 突变的脂肪酶 |
| CN121874156A (zh) * | 2023-12-01 | 2026-04-17 | 青岛蔚蓝生物集团有限公司 | 脂肪酶突变体及其应用 |
| TWI903491B (zh) * | 2024-05-09 | 2025-11-01 | 國立高雄科技大學 | 水體與沉積物通量培養系統 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK173590D0 (da) | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
| DK46693D0 (fr) * | 1993-04-23 | 1993-04-23 | Novo Nordisk As | |
| ES2121786T3 (es) | 1990-09-13 | 1998-12-16 | Novo Nordisk As | Variantes de lipasa. |
| US5869438A (en) | 1990-09-13 | 1999-02-09 | Novo Nordisk A/S | Lipase variants |
| DK0561907T3 (da) | 1990-12-05 | 1999-05-31 | Novo Nordisk As | Proteiner med ændrede epitoper og fremgangsmåder til fremstilling deraf |
| US5914306A (en) | 1991-05-01 | 1999-06-22 | Novo Nordisk A/S | Stabilized enzymes |
| DK39693D0 (da) | 1993-04-02 | 1993-04-02 | Novo Nordisk As | Enzym |
| US5866526A (en) | 1993-10-04 | 1999-02-02 | Novo Nordisk A/S | Enzyme preparation comprising a modified enzyme |
| CA2183431A1 (fr) * | 1994-02-22 | 1995-08-24 | Allan Svendsen | Procede pour preparer un variant d'une enzyme lipolytique |
| AU3924095A (en) | 1994-11-24 | 1996-06-17 | Novo Nordisk A/S | A process for producing polypeptides with reduced allergenicity |
| JPH10510516A (ja) | 1994-12-07 | 1998-10-13 | ノボ ノルディスク アクティーゼルスカブ | アレルゲン性を減らしたポリペプチド |
| ATE210180T1 (de) | 1995-01-26 | 2001-12-15 | Novozymes As | Xylanase beinhaltende futterzusätze für tiere |
| ATE282087T1 (de) | 1995-07-14 | 2004-11-15 | Novozymes As | Modifiziertes enzym mit lipolytischer aktivität |
| WO1997007202A1 (fr) | 1995-08-11 | 1997-02-27 | Novo Nordisk A/S | Nouvelles enzymes lipolytiques |
| US6495357B1 (en) * | 1995-07-14 | 2002-12-17 | Novozyme A/S | Lipolytic enzymes |
| JP2002510963A (ja) | 1997-01-10 | 2002-04-09 | ノボザイムス アクティーゼルスカブ | スキンケア用酵素修飾体 |
| AU740207B2 (en) * | 1997-02-06 | 2001-11-01 | Novozymes A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
| DE69838551T2 (de) | 1997-06-25 | 2008-07-24 | Novozymes A/S | Modifiziertes polypeptid |
| AU3247699A (en) | 1998-02-17 | 1999-09-06 | Novo Nordisk A/S | Lipase variant |
| CN1247776C (zh) * | 1998-02-17 | 2006-03-29 | 诺维信公司 | 脂肪酶变体 |
| JP2002527059A (ja) | 1998-10-13 | 2002-08-27 | ノボザイムス アクティーゼルスカブ | 低められた免疫応答を有する修飾されたポリペプチド |
| ATE263778T1 (de) | 1998-10-30 | 2004-04-15 | Novozymes As | Niedrigallergene proteinvarianten |
| CA2348822A1 (fr) | 1998-10-30 | 2000-05-11 | Novozymes A/S | Proteines glycosylees a allergenicite reduite |
| DK1131416T3 (da) | 1998-11-27 | 2009-10-26 | Novozymes As | Lipolytiske enzymvarianter |
| US7312062B2 (en) * | 1998-11-27 | 2007-12-25 | Novozymes A/S | Lipolytic enzyme variants |
| BR0009012A (pt) | 1999-03-17 | 2001-12-26 | Solvay Pharm Gmbh | Medicamento para o tratamento de diabete |
| EP2278000A1 (fr) * | 1999-03-31 | 2011-01-26 | Novozymes A/S | Variante de lipase |
| KR20010108379A (ko) | 1999-03-31 | 2001-12-07 | 피아 스타르 | 리파제 변이체 |
| CA2395343C (fr) | 2000-02-08 | 2009-06-30 | F. Hoffmann-La Roche Ag | Utilisation de proteases a acidite stable dans l'alimentation animale |
| US7226770B2 (en) | 2000-04-28 | 2007-06-05 | Novozymes A/S | Lipolytic enzyme variant |
| ATE426668T1 (de) * | 2001-01-10 | 2009-04-15 | Novozymes As | Variante eines lipolytischen enzyms |
| AR032392A1 (es) | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
| CN1491278A (zh) | 2001-02-07 | 2004-04-21 | ŵά�Ź�˾ | 脂酶变体 |
| DK2295556T3 (en) | 2002-01-16 | 2015-01-26 | Novozymes As | Lipolytic Enzyme Variants and Method of Preparation thereof. |
| US20060234340A1 (en) | 2003-02-06 | 2006-10-19 | Novozymes A/S | Human heavy chain antibody expression in flamentous fungi |
| DK2270140T3 (en) | 2003-05-09 | 2016-03-14 | Novozymes As | Lipolytic enzyme variants |
| WO2004111216A2 (fr) | 2003-06-19 | 2004-12-23 | Novozymes A/S | Variantes genetiques de la phospholipase |
| EP1639107B1 (fr) | 2003-06-19 | 2013-08-14 | Novozymes A/S | Proteases ameliorees et procedes de production de ces dernieres |
| JP2007535913A (ja) | 2004-01-21 | 2007-12-13 | ノボザイムス アクティーゼルスカブ | ヘテロカリオン菌類又は菌類宿主細胞におけるモノクローナル抗体の生成 |
| CA2560613C (fr) | 2004-03-22 | 2015-11-24 | Solvay Pharmaceuticals Gmbh | Compositions pharmaceutiques par voie orale a base de lipases, en particulier de pancreatine, contenant des tensioacitfs |
| DK1809320T3 (da) | 2004-10-14 | 2010-11-15 | Cystic Fibrosis Foundation The | Præparater indeholdende lipase, protease og amylase til behandling af pankreatisk insufficiens |
| US20080138856A1 (en) | 2005-02-10 | 2008-06-12 | Novozymes A/S | Enzymatic Enantioselective Ester or Amide Hydrolysis or Synthesis |
| EP1896057A2 (fr) | 2005-06-24 | 2008-03-12 | Novozymes A/S | Amylases à usage pharmaceutique |
| CA2612648A1 (fr) * | 2005-06-24 | 2006-12-28 | Novozymes A/S | Lipases a usage pharmaceutique |
| KR20080017039A (ko) | 2005-06-24 | 2008-02-25 | 노보자임스 에이/에스 | 약학적 용도의 프로테아제 |
| WO2007080197A2 (fr) * | 2006-01-16 | 2007-07-19 | Novozymes A/S | Enzymes immobilisees |
| ES2628940T3 (es) * | 2006-01-23 | 2017-08-04 | Novozymes A/S | Variantes de lipasa |
| JP2009523900A (ja) * | 2006-01-23 | 2009-06-25 | ザ プロクター アンド ギャンブル カンパニー | リパーゼと漂白剤触媒を含む組成物 |
| JP5406040B2 (ja) * | 2006-12-21 | 2014-02-05 | ノボザイムス アクティーゼルスカブ | 医薬使用のためのリパーゼ変異体 |
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- 2007-12-12 EP EP10172609.9A patent/EP2261328B1/fr active Active
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