NO20171934A1 - Compositions and methods of treating a neurodegenerative disease - Google Patents

Compositions and methods of treating a neurodegenerative disease Download PDF

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Publication number
NO20171934A1
NO20171934A1 NO20171934A NO20171934A NO20171934A1 NO 20171934 A1 NO20171934 A1 NO 20171934A1 NO 20171934 A NO20171934 A NO 20171934A NO 20171934 A NO20171934 A NO 20171934A NO 20171934 A1 NO20171934 A1 NO 20171934A1
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NO
Norway
Prior art keywords
pharmaceutically acceptable
solvates
hydrates
acceptable salts
composition
Prior art date
Application number
NO20171934A
Other languages
English (en)
Norwegian (no)
Inventor
Lawrence Tim Friedhoff
Kunal KISHNANI
Bryan M Lewis
Stephen Clement Piscitelli
Geetha RAMASWAMY
Shankar Ramaswamy
Melissa Rhodes
Original Assignee
Axovant Sciences Gmbh
Lawrence Tim Friedhoff
Kunal KISHNANI
Bryan M Lewis
Stephen Clement Piscitelli
Geetha RAMASWAMY
Shankar Ramaswamy
Melissa Rhodes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axovant Sciences Gmbh, Lawrence Tim Friedhoff, Kunal KISHNANI, Bryan M Lewis, Stephen Clement Piscitelli, Geetha RAMASWAMY, Shankar Ramaswamy, Melissa Rhodes filed Critical Axovant Sciences Gmbh
Publication of NO20171934A1 publication Critical patent/NO20171934A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20171934A 2015-05-07 2017-12-05 Compositions and methods of treating a neurodegenerative disease NO20171934A1 (en)

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US201562158422P 2015-05-07 2015-05-07
US201562162138P 2015-05-15 2015-05-15
US201562162068P 2015-05-15 2015-05-15
US201562162193P 2015-05-15 2015-05-15
US201562162060P 2015-05-15 2015-05-15
US201562165034P 2015-05-21 2015-05-21
US201562168246P 2015-05-29 2015-05-29
US201562167986P 2015-05-29 2015-05-29
US201562169414P 2015-06-01 2015-06-01
US201562182225P 2015-06-19 2015-06-19
US201562189089P 2015-07-06 2015-07-06
US201562191189P 2015-07-10 2015-07-10
US201562201513P 2015-08-05 2015-08-05
US201562201494P 2015-08-05 2015-08-05
US201562239530P 2015-10-09 2015-10-09
US201562251534P 2015-11-05 2015-11-05
US201562256349P 2015-11-17 2015-11-17
US201562261115P 2015-11-30 2015-11-30
US201662289162P 2016-01-29 2016-01-29
US201662289643P 2016-02-01 2016-02-01
PCT/US2016/031367 WO2016179569A1 (en) 2015-05-07 2016-05-06 Compositions and methods of treating a neurodegenerative disease

Publications (1)

Publication Number Publication Date
NO20171934A1 true NO20171934A1 (en) 2017-12-05

Family

ID=57217933

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20171934A NO20171934A1 (en) 2015-05-07 2017-12-05 Compositions and methods of treating a neurodegenerative disease
NO20171941A NO20171941A1 (en) 2015-05-07 2017-12-05 Methods of treating a neurogenerative disease

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20171941A NO20171941A1 (en) 2015-05-07 2017-12-05 Methods of treating a neurogenerative disease

Country Status (12)

Country Link
US (1) US20160324852A1 (de)
EP (2) EP3291815A4 (de)
JP (2) JP2018515607A (de)
KR (2) KR20180021693A (de)
CN (2) CN107949386A (de)
AU (2) AU2016256923A1 (de)
CA (2) CA2985370A1 (de)
HK (1) HK1245078A1 (de)
IL (2) IL255423A0 (de)
MX (2) MX2017014192A (de)
NO (2) NO20171934A1 (de)
WO (2) WO2016179566A1 (de)

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PL1558582T3 (pl) 2003-07-22 2006-05-31 Arena Pharm Inc Diarylowe i aryloheteroarylowe pochodne mocznika jako modulatory receptora serotoninowego 5-HT2A użyteczne w profilaktyce i w leczeniu zaburzeń związanych z tym receptorem
US9084742B2 (en) 2007-12-12 2015-07-21 Axovant Sciences Ltd. Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-Quinoline
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
HK1245660A1 (zh) 2015-06-12 2018-08-31 Axovant Sciences Gmbh 有用於预防和治疗rem睡眠行为障碍的二芳基脲和芳基脲衍生物
GB201512203D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
TW201720439A (zh) 2015-07-15 2017-06-16 Axovant Sciences Gmbh 用於預防及治療與神經退化性疾病相關的幻覺之作為5-ht2a血清素受體的二芳基及芳基雜芳基脲衍生物
US20210346374A1 (en) * 2016-10-03 2021-11-11 Suven Life Sciences Limited Pharmaceutical compositions of 5-ht6 receptor antagonist
CA3043651A1 (en) 2016-11-15 2018-05-24 H. Lundbeck A/S Agents, uses and methods for the treatment of synucleinopathy
WO2018102824A1 (en) * 2016-12-02 2018-06-07 Axovant Sciences Gmbh Methods for treating neurodegenerative disease
IL270343B2 (en) * 2017-05-24 2025-05-01 H Lundbeck As Combination of a 5-HT6 receptor antagonist and an acetylcholinesterase inhibitor for use in the treatment of Alzheimer's disease in a subpopulation of patients carrying APOE4 alleles
US11484502B2 (en) 2017-06-01 2022-11-01 Eisai R&D Management Co., Ltd. Pharmaceutical composition comprising PDE9 inhibitor
EP3628315A1 (de) * 2018-09-28 2020-04-01 Université de Caen Normandie Kombination aus acetylcholinesterase-inhibitor und 5-ht4-rezeptoragonist als neuroprotektives mittel zur behandlung von neurodegenerativen krankheiten
DK3906927T3 (da) * 2020-05-04 2022-06-20 Bioprojet Pharma Anvendelse af dopamin D3-delagonister til behandling af lidelser i centralnervesystemet
JP2023534190A (ja) * 2020-07-10 2023-08-08 エージンバイオ, インコーポレイテッド GABAAα5アゴニストの多形および認知障害の処置において使用する方法
CN112587534A (zh) * 2020-12-23 2021-04-02 佑嘉(杭州)生物医药科技有限公司 阿伦酸在制备治疗肝纤维化药物中的用途
KR102753583B1 (ko) * 2021-11-11 2025-01-10 의료법인 명지의료재단 Kras 특이적 활성화 t 세포 유도용 항원 조성물
WO2023128900A1 (en) * 2021-12-30 2023-07-06 Pharmactive Ilac Sanayi Ve Ticaret A.S. Pharmaceutical compositions comprising pimavanserin as active ingredient and relevant excipients
US20260049105A1 (en) * 2022-08-18 2026-02-19 Arizona Board Of Regents On Behalf Of The University Of Arizona Selective mc4r ligand for treating obesity and cognitive loss

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
NZ535239A (en) * 2002-03-27 2008-03-28 Glaxo Group Ltd Quinoline derivatives and their use as 5-HT6 ligands
EP2243475B1 (de) * 2005-04-06 2016-01-13 Adamas Pharmaceuticals, Inc. Kombination von Memantin und Donepezil zur Behandlung von Erkrankungen des ZNS
PE20071143A1 (es) * 2006-01-13 2008-01-20 Wyeth Corp Composicion farmaceutica que comprende un inhibidor de acetilcolinesterasa y un antagonista 5-hidroxitriptamina-6
JP2009541423A (ja) * 2006-06-23 2009-11-26 ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ コリンエステラーゼ阻害剤と5‐ht6レセプター親和性の化合物との組合せ
AR061637A1 (es) * 2006-06-26 2008-09-10 Epix Delaware Inc Composiciones y metodos de tratamiento de trastornos del snc
US9084742B2 (en) * 2007-12-12 2015-07-21 Axovant Sciences Ltd. Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-Quinoline
EP2364142B1 (de) * 2008-10-28 2018-01-17 Arena Pharmaceuticals, Inc. Zusammensetzung eines 5-ht2a-serotonin-rezeptor-modulators zur behandlung von damit zusammenhängenden erkrankungen
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Also Published As

Publication number Publication date
JP2018515607A (ja) 2018-06-14
IL255423A0 (en) 2017-12-31
WO2016179566A1 (en) 2016-11-10
JP2018519358A (ja) 2018-07-19
EP3291816A4 (de) 2019-01-02
MX2017014192A (es) 2018-08-01
AU2016258198A1 (en) 2017-11-23
KR20180021693A (ko) 2018-03-05
WO2016179569A1 (en) 2016-11-10
KR20180022661A (ko) 2018-03-06
US20160324852A1 (en) 2016-11-10
CA2985370A1 (en) 2016-11-10
CN107847499A (zh) 2018-03-27
CN107949386A (zh) 2018-04-20
EP3291816A1 (de) 2018-03-14
AU2016256923A1 (en) 2017-11-23
HK1245078A1 (zh) 2018-08-24
MX2017014191A (es) 2018-08-01
EP3291815A1 (de) 2018-03-14
EP3291815A4 (de) 2019-01-16
CA2985366A1 (en) 2016-11-10
NO20171941A1 (en) 2017-12-05
IL255421A0 (en) 2017-12-31

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