NO300252B1 - Fremgangsmåte for fremstilling av et mikrogranulært preparat - Google Patents

Fremgangsmåte for fremstilling av et mikrogranulært preparat Download PDF

Info

Publication number: NO300252B1
Authority: NO; Norway
Prior art keywords: biologically active; piglets; microgranules; granules; gel
Prior art date: 1986-08-28

Application number

NO881755A

Other languages

English (en)

Norwegian (no)

Other versions

NO881755L (no

NO881755D0 (no

Inventor

Thomas Ko Sai Ying

Original Assignee

Enzacor Pty Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-28

Filing date

1988-04-22

Publication date

1997-05-05

1988-04-22 Application filed by Enzacor Pty Ltd filed Critical Enzacor Pty Ltd

1988-04-22 Publication of NO881755D0 publication Critical patent/NO881755D0/no

1988-06-21 Publication of NO881755L publication Critical patent/NO881755L/no

1994-11-11 Priority to NO944301A priority Critical patent/NO300991B1/no

1997-05-05 Publication of NO300252B1 publication Critical patent/NO300252B1/no

Links

238000002360 preparation method Methods 0.000 title claims abstract description 35
238000000034 method Methods 0.000 title claims abstract description 32
230000008569 process Effects 0.000 title description 2
239000011149 active material Substances 0.000 claims abstract description 38
239000002253 acid Substances 0.000 claims abstract description 12
235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 11
239000000194 fatty acid Substances 0.000 claims abstract description 11
229930195729 fatty acid Natural products 0.000 claims abstract description 11
150000004665 fatty acids Chemical class 0.000 claims abstract description 11
229920000642 polymer Polymers 0.000 claims abstract description 7
239000003513 alkali Substances 0.000 claims abstract description 3
239000004365 Protease Substances 0.000 claims description 28
239000000499 gel Substances 0.000 claims description 28
108010004032 Bromelains Proteins 0.000 claims description 21
AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 19
235000019835 bromelain Nutrition 0.000 claims description 18
238000000576 coating method Methods 0.000 claims description 11
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 10
239000011248 coating agent Substances 0.000 claims description 10
239000011159 matrix material Substances 0.000 claims description 10
229960002477 riboflavin Drugs 0.000 claims description 10
229930182817 methionine Natural products 0.000 claims description 9
235000006109 methionine Nutrition 0.000 claims description 9
235000019192 riboflavin Nutrition 0.000 claims description 9
239000002151 riboflavin Substances 0.000 claims description 9
102000004190 Enzymes Human genes 0.000 claims description 8
108090000790 Enzymes Proteins 0.000 claims description 8
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 8
238000004519 manufacturing process Methods 0.000 claims description 8
108010010803 Gelatin Proteins 0.000 claims description 7
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 7
239000000679 carrageenan Substances 0.000 claims description 7
229920001525 carrageenan Polymers 0.000 claims description 7
229940113118 carrageenan Drugs 0.000 claims description 7
150000001875 compounds Chemical class 0.000 claims description 7
239000008273 gelatin Substances 0.000 claims description 7
229920000159 gelatin Polymers 0.000 claims description 7
235000019322 gelatine Nutrition 0.000 claims description 7
235000011852 gelatine desserts Nutrition 0.000 claims description 7
229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 4
229940081734 cellulose acetate phthalate Drugs 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 4
239000002195 soluble material Substances 0.000 claims description 4
239000011701 zinc Substances 0.000 claims description 4
229930003779 Vitamin B12 Natural products 0.000 claims description 3
235000010443 alginic acid Nutrition 0.000 claims description 3
229920000615 alginic acid Polymers 0.000 claims description 3
239000001913 cellulose Substances 0.000 claims description 3
229920002678 cellulose Polymers 0.000 claims description 3
235000010980 cellulose Nutrition 0.000 claims description 3
AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims description 3
229940088594 vitamin Drugs 0.000 claims description 3
229930003231 vitamin Natural products 0.000 claims description 3
235000013343 vitamin Nutrition 0.000 claims description 3
239000011782 vitamin Substances 0.000 claims description 3
235000019163 vitamin B12 Nutrition 0.000 claims description 3
239000011715 vitamin B12 Substances 0.000 claims description 3
150000001413 amino acids Chemical class 0.000 claims description 2
238000005538 encapsulation Methods 0.000 claims description 2
229940014259 gelatin Drugs 0.000 claims description 2
229910052742 iron Inorganic materials 0.000 claims description 2
229920001490 poly(butyl methacrylate) polymer Polymers 0.000 claims description 2
229910052700 potassium Inorganic materials 0.000 claims description 2
102000004169 proteins and genes Human genes 0.000 claims description 2
108090000623 proteins and genes Proteins 0.000 claims description 2
229920001059 synthetic polymer Polymers 0.000 claims description 2
229960005486 vaccine Drugs 0.000 claims description 2
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
150000007513 acids Chemical class 0.000 claims 1
229940072056 alginate Drugs 0.000 claims 1
229910052751 metal Inorganic materials 0.000 claims 1
239000002184 metal Substances 0.000 claims 1
150000002739 metals Chemical class 0.000 claims 1
239000011591 potassium Substances 0.000 claims 1
229910052725 zinc Inorganic materials 0.000 claims 1
241001465754 Metazoa Species 0.000 abstract description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 18
230000000968 intestinal effect Effects 0.000 abstract description 14
238000011282 treatment Methods 0.000 abstract description 13
239000000463 material Substances 0.000 abstract description 9
235000011389 fruit/vegetable juice Nutrition 0.000 abstract description 5
229920006158 high molecular weight polymer Polymers 0.000 abstract description 4
239000002702 enteric coating Substances 0.000 abstract description 3
238000009505 enteric coating Methods 0.000 abstract description 3
239000008187 granular material Substances 0.000 description 45
239000000243 solution Substances 0.000 description 29
206010012735 Diarrhoea Diseases 0.000 description 25
238000012360 testing method Methods 0.000 description 25
210000004767 rumen Anatomy 0.000 description 13
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
210000002784 stomach Anatomy 0.000 description 12
108091005804 Peptidases Proteins 0.000 description 10
239000012530 fluid Substances 0.000 description 10
108020003175 receptors Proteins 0.000 description 9
102000005962 receptors Human genes 0.000 description 9
239000004677 Nylon Substances 0.000 description 8
239000000853 adhesive Substances 0.000 description 8
229920001778 nylon Polymers 0.000 description 8
SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 7
239000010408 film Substances 0.000 description 7
238000011081 inoculation Methods 0.000 description 7
241000894006 Bacteria Species 0.000 description 6
241000588724 Escherichia coli Species 0.000 description 6
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
230000001070 adhesive effect Effects 0.000 description 6
239000008346 aqueous phase Substances 0.000 description 6
238000003556 assay Methods 0.000 description 6
239000003795 chemical substances by application Substances 0.000 description 6
230000000694 effects Effects 0.000 description 6
210000001035 gastrointestinal tract Anatomy 0.000 description 6
210000000936 intestine Anatomy 0.000 description 6
NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 6
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
102000035195 Peptidases Human genes 0.000 description 5
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 5
230000004888 barrier function Effects 0.000 description 5
208000015181 infectious disease Diseases 0.000 description 5
239000008101 lactose Substances 0.000 description 5
239000002245 particle Substances 0.000 description 5
239000012071 phase Substances 0.000 description 5
235000019419 proteases Nutrition 0.000 description 5
239000007921 spray Substances 0.000 description 5
239000000126 substance Substances 0.000 description 5
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
241000282887 Suidae Species 0.000 description 4
230000002378 acidificating effect Effects 0.000 description 4
230000001580 bacterial effect Effects 0.000 description 4
230000018044 dehydration Effects 0.000 description 4
238000006297 dehydration reaction Methods 0.000 description 4
DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 4
238000002474 experimental method Methods 0.000 description 4
239000004744 fabric Substances 0.000 description 4
239000011148 porous material Substances 0.000 description 4
230000004584 weight gain Effects 0.000 description 4
235000019786 weight gain Nutrition 0.000 description 4
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 3
235000021355 Stearic acid Nutrition 0.000 description 3
238000010521 absorption reaction Methods 0.000 description 3
230000027455 binding Effects 0.000 description 3
230000015556 catabolic process Effects 0.000 description 3
238000010586 diagram Methods 0.000 description 3
210000001198 duodenum Anatomy 0.000 description 3
-1 hydrogen ions Chemical class 0.000 description 3
239000011630 iodine Substances 0.000 description 3
229910052740 iodine Inorganic materials 0.000 description 3
230000007794 irritation Effects 0.000 description 3
239000007788 liquid Substances 0.000 description 3
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 3
208000026775 severe diarrhea Diseases 0.000 description 3
239000002904 solvent Substances 0.000 description 3
239000008117 stearic acid Substances 0.000 description 3
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
239000004470 DL Methionine Substances 0.000 description 2
206010016717 Fistula Diseases 0.000 description 2
102000003886 Glycoproteins Human genes 0.000 description 2
108090000288 Glycoproteins Proteins 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
208000026350 Inborn Genetic disease Diseases 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
238000011887 Necropsy Methods 0.000 description 2
241001494479 Pecora Species 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
241000282849 Ruminantia Species 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
240000008042 Zea mays Species 0.000 description 2
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
235000002017 Zea mays subsp mays Nutrition 0.000 description 2
229960000583 acetic acid Drugs 0.000 description 2
229960001138 acetylsalicylic acid Drugs 0.000 description 2
230000009471 action Effects 0.000 description 2
239000003463 adsorbent Substances 0.000 description 2
239000000783 alginic acid Substances 0.000 description 2
229960001126 alginic acid Drugs 0.000 description 2
150000004781 alginic acids Chemical class 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
229940088710 antibiotic agent Drugs 0.000 description 2
102000005936 beta-Galactosidase Human genes 0.000 description 2
108010005774 beta-Galactosidase Proteins 0.000 description 2
230000004071 biological effect Effects 0.000 description 2
239000006161 blood agar Substances 0.000 description 2
238000009395 breeding Methods 0.000 description 2
230000001488 breeding effect Effects 0.000 description 2
239000011575 calcium Substances 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
239000002775 capsule Substances 0.000 description 2
230000003197 catalytic effect Effects 0.000 description 2
210000004027 cell Anatomy 0.000 description 2
239000008139 complexing agent Substances 0.000 description 2
235000005822 corn Nutrition 0.000 description 2
238000004132 cross linking Methods 0.000 description 2
230000029087 digestion Effects 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
230000002183 duodenal effect Effects 0.000 description 2
230000003890 fistula Effects 0.000 description 2
OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
235000013305 food Nutrition 0.000 description 2
230000002538 fungal effect Effects 0.000 description 2
208000016361 genetic disease Diseases 0.000 description 2
239000012362 glacial acetic acid Substances 0.000 description 2
238000000338 in vitro Methods 0.000 description 2
230000002779 inactivation Effects 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
235000012054 meals Nutrition 0.000 description 2
239000012528 membrane Substances 0.000 description 2
229910021645 metal ion Inorganic materials 0.000 description 2
FFEARJCKVFRZRR-UHFFFAOYSA-N methionine Chemical compound CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 2
235000013336 milk Nutrition 0.000 description 2
239000008267 milk Substances 0.000 description 2
210000004080 milk Anatomy 0.000 description 2
239000000203 mixture Substances 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
239000002953 phosphate buffered saline Substances 0.000 description 2
235000007715 potassium iodide Nutrition 0.000 description 2
239000008213 purified water Substances 0.000 description 2
238000007790 scraping Methods 0.000 description 2
238000003307 slaughter Methods 0.000 description 2
210000000813 small intestine Anatomy 0.000 description 2
208000024891 symptom Diseases 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 description 1
101710128979 23 kDa piroplasm membrane protein Proteins 0.000 description 1
GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
239000005995 Aluminium silicate Substances 0.000 description 1
208000035143 Bacterial infection Diseases 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
244000025254 Cannabis sativa Species 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
229920001661 Chitosan Polymers 0.000 description 1
235000019743 Choline chloride Nutrition 0.000 description 1
108700003861 Dominant Genes Proteins 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
206010014418 Electrolyte imbalance Diseases 0.000 description 1
108010067770 Endopeptidase K Proteins 0.000 description 1
235000019733 Fish meal Nutrition 0.000 description 1
208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
238000012404 In vitro experiment Methods 0.000 description 1
201000010538 Lactose Intolerance Diseases 0.000 description 1
102000004882 Lipase Human genes 0.000 description 1
108090001060 Lipase Proteins 0.000 description 1
239000004367 Lipase Substances 0.000 description 1
OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
240000007594 Oryza sativa Species 0.000 description 1
235000007164 Oryza sativa Nutrition 0.000 description 1
101710177166 Phosphoprotein Proteins 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
101710094326 Ras-related protein R-Ras Proteins 0.000 description 1
241000607142 Salmonella Species 0.000 description 1
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
241000607768 Shigella Species 0.000 description 1
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
240000006394 Sorghum bicolor Species 0.000 description 1
235000011684 Sorghum saccharatum Nutrition 0.000 description 1
235000019764 Soybean Meal Nutrition 0.000 description 1
241000194017 Streptococcus Species 0.000 description 1
108090000787 Subtilisin Proteins 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
239000005864 Sulphur Substances 0.000 description 1
235000009430 Thespesia populnea Nutrition 0.000 description 1
101710157927 Translationally-controlled tumor protein Proteins 0.000 description 1
101710175870 Translationally-controlled tumor protein homolog Proteins 0.000 description 1
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 1
108090000631 Trypsin Proteins 0.000 description 1
102000004142 Trypsin Human genes 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
229930003471 Vitamin B2 Natural products 0.000 description 1
239000005862 Whey Substances 0.000 description 1
102000007544 Whey Proteins Human genes 0.000 description 1
108010046377 Whey Proteins Proteins 0.000 description 1
DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
239000003929 acidic solution Substances 0.000 description 1
229910001413 alkali metal ion Inorganic materials 0.000 description 1
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
235000012211 aluminium silicate Nutrition 0.000 description 1
235000001014 amino acid Nutrition 0.000 description 1
230000002421 anti-septic effect Effects 0.000 description 1
229940064004 antiseptic throat preparations Drugs 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
150000004984 aromatic diamines Chemical class 0.000 description 1
238000000889 atomisation Methods 0.000 description 1
208000022362 bacterial infectious disease Diseases 0.000 description 1
244000052616 bacterial pathogen Species 0.000 description 1
239000011324 bead Substances 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
210000000941 bile Anatomy 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229960002685 biotin Drugs 0.000 description 1
235000020958 biotin Nutrition 0.000 description 1
239000011616 biotin Substances 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
235000010418 carrageenan Nutrition 0.000 description 1
239000004359 castor oil Substances 0.000 description 1
235000019438 castor oil Nutrition 0.000 description 1
230000008859 change Effects 0.000 description 1
SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 description 1
229960003178 choline chloride Drugs 0.000 description 1
210000001072 colon Anatomy 0.000 description 1
230000000112 colonic effect Effects 0.000 description 1
ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
238000012937 correction Methods 0.000 description 1
239000003431 cross linking reagent Substances 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
230000002950 deficient Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
238000004925 denaturation Methods 0.000 description 1
230000036425 denaturation Effects 0.000 description 1
230000008021 deposition Effects 0.000 description 1
229940111685 dibasic potassium phosphate Drugs 0.000 description 1
102000038379 digestive enzymes Human genes 0.000 description 1
108091007734 digestive enzymes Proteins 0.000 description 1
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
229910000397 disodium phosphate Inorganic materials 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
208000001848 dysentery Diseases 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
235000021321 essential mineral Nutrition 0.000 description 1
150000003947 ethylamines Chemical class 0.000 description 1
210000003608 fece Anatomy 0.000 description 1
239000011790 ferrous sulphate Substances 0.000 description 1
235000003891 ferrous sulphate Nutrition 0.000 description 1
239000004467 fishmeal Substances 0.000 description 1
229960000304 folic acid Drugs 0.000 description 1
235000019152 folic acid Nutrition 0.000 description 1
239000011724 folic acid Substances 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
239000007789 gas Substances 0.000 description 1
239000003349 gelling agent Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
230000036541 health Effects 0.000 description 1
230000002949 hemolytic effect Effects 0.000 description 1
NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical class NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229920001477 hydrophilic polymer Polymers 0.000 description 1
238000003018 immunoassay Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
239000002085 irritant Substances 0.000 description 1
231100000021 irritant Toxicity 0.000 description 1
238000002955 isolation Methods 0.000 description 1
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
235000019421 lipase Nutrition 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
RTWNYYOXLSILQN-UHFFFAOYSA-N methanediamine Chemical class NCN RTWNYYOXLSILQN-UHFFFAOYSA-N 0.000 description 1
244000005700 microbiome Species 0.000 description 1
239000004531 microgranule Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
229940111688 monobasic potassium phosphate Drugs 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
235000019799 monosodium phosphate Nutrition 0.000 description 1
210000001711 oxyntic cell Anatomy 0.000 description 1
210000000496 pancreas Anatomy 0.000 description 1
235000015927 pasta Nutrition 0.000 description 1
244000052769 pathogen Species 0.000 description 1
230000035515 penetration Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000008055 phosphate buffer solution Substances 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
235000009566 rice Nutrition 0.000 description 1
229910052701 rubidium Inorganic materials 0.000 description 1
239000011669 selenium Substances 0.000 description 1
229910052711 selenium Inorganic materials 0.000 description 1
238000000926 separation method Methods 0.000 description 1
235000021309 simple sugar Nutrition 0.000 description 1
235000020183 skimmed milk Nutrition 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
239000004455 soybean meal Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
230000001502 supplementing effect Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
239000010409 thin film Substances 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
229940078499 tricalcium phosphate Drugs 0.000 description 1
229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
235000019731 tricalcium phosphate Nutrition 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
230000036269 ulceration Effects 0.000 description 1
210000001835 viscera Anatomy 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
235000019164 vitamin B2 Nutrition 0.000 description 1
239000011716 vitamin B2 Substances 0.000 description 1
235000015099 wheat brans Nutrition 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
239000011686 zinc sulphate Substances 0.000 description 1
235000009529 zinc sulphate Nutrition 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
- A23K40/35—Making capsules specially adapted for ruminants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Food Science & Technology (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Fodder In General (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

NO881755A 1986-08-28 1988-04-22 Fremgangsmåte for fremstilling av et mikrogranulært preparat NO300252B1 (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO944301A NO300991B1 (no)	1986-08-28	1994-11-11	Ikke-terapautisk mikrogranulært preparat

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AUPH771586		1986-08-28
PCT/AU1987/000270 WO1988001506A1 (en)	1986-08-28	1987-08-17	Microgranular preparation useful in the delivery of biologically active materials to the intestinal regions of animals

Publications (3)

Publication Number	Publication Date
NO881755D0 NO881755D0 (no)	1988-04-22
NO881755L NO881755L (no)	1988-06-21
NO300252B1 true NO300252B1 (no)	1997-05-05

Family

ID=3771791

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO881755A NO300252B1 (no)	1986-08-28	1988-04-22	Fremgangsmåte for fremstilling av et mikrogranulært preparat
NO944301A NO300991B1 (no)	1986-08-28	1994-11-11	Ikke-terapautisk mikrogranulært preparat

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO944301A NO300991B1 (no)	1986-08-28	1994-11-11	Ikke-terapautisk mikrogranulært preparat

Country Status (14)

Country	Link
EP (1)	EP0321481B1 (da)
JP (1)	JP2798248B2 (da)
KR (1)	KR950014441B1 (da)
CN (1)	CN1035801C (da)
AT (1)	ATE106242T1 (da)
AU (1)	AU609419B2 (da)
CA (1)	CA1314217C (da)
DE (1)	DE3789965T2 (da)
DK (1)	DK236388A (da)
GR (2)	GR871332B (da)
HK (1)	HK85096A (da)
NO (2)	NO300252B1 (da)
NZ (1)	NZ221575A (da)
WO (1)	WO1988001506A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE90203T1 (de) *	1989-03-17	1993-06-15	Pitman Moore Inc	Kontrollierte, verzoegerte wirkstofffreisetzung von makromolekularen proteinen.
US5077051A (en) *	1990-04-10	1991-12-31	Warner-Lambert Company	Sustained release of active agents from bioadhesive microcapsules
KR930006431B1 (ko) *	1990-10-11	1993-07-16	재단법인 한국화학연구소	약물의 미세캡슐화 방법
SG42846A1 (en) *	1992-06-30	1997-10-17	Cortecs Ltd	Use of enzymes especially bromelain in the treatment of diarrhoea
US5665382A (en) *	1993-02-22	1997-09-09	Vivorx Pharmaceuticals, Inc.	Methods for the preparation of pharmaceutically active agents for in vivo delivery
US6528067B1 (en)	1993-02-22	2003-03-04	American Bioscience, Inc.	Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof
CA2155947C (en) *	1993-02-22	2007-08-21	Mark W. Grinstaff	Methods for in vivo delivery of biologics and compositions useful therefor
US5439686A (en) *	1993-02-22	1995-08-08	Vivorx Pharmaceuticals, Inc.	Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6753006B1 (en)	1993-02-22	2004-06-22	American Bioscience, Inc.	Paclitaxel-containing formulations
US5997904A (en) *	1993-02-22	1999-12-07	American Bioscience, Inc.	Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof
US5916596A (en) *	1993-02-22	1999-06-29	Vivorx Pharmaceuticals, Inc.	Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5650156A (en) *	1993-02-22	1997-07-22	Vivorx Pharmaceuticals, Inc.	Methods for in vivo delivery of nutriceuticals and compositions useful therefor
IT1265092B1 (it) *	1993-05-31	1996-10-30	Giuliani Spa	Preparato per uso come integratore alimentare, o dietetico,a rilascio mirato nel colon
CN1201373A (zh)	1995-11-06	1998-12-09	诺沃挪第克公司	动物饲料添加剂
AU3866397A (en) *	1996-08-20	1998-03-06	Freund Industrial Co. Ltd.	Microspheres containing immunogens, process for producing the same, and method for immunizing animals with the use of the same
WO1998038320A1 (en)	1997-02-25	1998-09-03	Cortecs (Uk) Limited	Component of bromelain
US20020102253A1 (en)	1997-02-25	2002-08-01	Mynott Tracey Lehanne	Component of bromelain
US6932861B2 (en)	2000-11-28	2005-08-23	Fmc Corporation	Edible PGA coating composition
US8877232B2 (en) *	2003-06-20	2014-11-04	Nutrinia Ltd.	Bioactive compounds protection method and compositions containing the same
WO2009026115A1 (en) *	2007-08-17	2009-02-26	Novus International Inc.	Palatable microgranules for acidifying feed rations
PL2538930T3 (pl) *	2010-02-23	2016-11-30		Preparaty do doustnego dostarczania środków adsorbujących do jelita
CN103783323B (zh) *	2014-02-05	2016-05-18	褚旭	一种动物用复合维生素预混料制备方法
EP3193629B1 (en) *	2014-08-25	2023-01-25	Anatara Lifesciences Limited	Anti-diarrhea formulation which avoids antimicrobial resistance
AU2017237164A1 (en)	2016-03-24	2018-10-11	Nutrinia Ltd.	Use of insulin for promoting gastric emptying
US11425924B2 (en) *	2018-01-15	2022-08-30	Glanbia Nutritionals, Ltd.	Composition and method for controlled-release of amino acids
CN109362950B (zh) *	2018-10-08	2022-04-05	杭州康德权饲料有限公司	一种过瘤胃氯化胆碱微胶囊及其制备方法
CN111657395B (zh) *	2020-06-19	2023-06-16	山西农业大学	一种饲料添加剂及其制备方法和一种奶牛饲料

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DD36655A3 (da) *	1964-06-12	1965-11-05
US3803304A (en) *	1965-07-19	1974-04-09	Armour Pharma	Orally administratable pancreatic enzymes and methods of using same
AU501555B2 (en) *	1975-01-14	1979-06-21	Richter, Esdene	Fluid operated device
GB1509866A (en) *	1975-06-10	1978-05-04	Johnson & Johnson	Enteric coated digestive enzyme compositions
AU516072B2 (en) *	1975-06-10	1981-05-14	Johnson & Johnson	Enteric coated digestive enzyme composition
IT1115596B (it) *	1978-03-13	1986-02-03	Bayer Italia Spa	Metodo per la preparazione di microgranuli gastoresistenti ed enterosolubili di sostanze farmaceutiche,in particolare di sostanze proteiche e microgranuli preparati con detto metodo
JPS5867616A (ja) *	1981-10-15	1983-04-22	Tanabe Seiyaku Co Ltd	腸溶性マイクロカプセル
US4447412A (en) *	1983-02-01	1984-05-08	Bilton Gerald L	Enzyme-containing digestive aid compostions
KR940000065B1 (ko) *	1986-08-28	1994-01-05	코 사이 잉 토마스	동물 성장 촉진제

1987
- 1987-08-17 AU AU78585/87A patent/AU609419B2/en not_active Ceased
- 1987-08-17 KR KR1019880700452A patent/KR950014441B1/ko not_active Expired - Fee Related
- 1987-08-17 AT AT87905571T patent/ATE106242T1/de not_active IP Right Cessation
- 1987-08-17 DE DE3789965T patent/DE3789965T2/de not_active Expired - Fee Related
- 1987-08-17 EP EP87905571A patent/EP0321481B1/en not_active Expired - Lifetime
- 1987-08-17 WO PCT/AU1987/000270 patent/WO1988001506A1/en not_active Ceased
- 1987-08-17 JP JP62505093A patent/JP2798248B2/ja not_active Expired - Lifetime
- 1987-08-26 CN CN87106794A patent/CN1035801C/zh not_active Expired - Fee Related
- 1987-08-26 NZ NZ221575A patent/NZ221575A/xx unknown
- 1987-08-27 GR GR871332A patent/GR871332B/el unknown
- 1987-08-27 GR GR871331A patent/GR871331B/el unknown
- 1987-08-27 CA CA000545467A patent/CA1314217C/en not_active Expired - Fee Related
1988
- 1988-04-22 NO NO881755A patent/NO300252B1/no unknown
- 1988-04-28 DK DK236388A patent/DK236388A/da not_active Application Discontinuation
1994
- 1994-11-11 NO NO944301A patent/NO300991B1/no unknown
1996
- 1996-05-16 HK HK85096A patent/HK85096A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0321481A4 (en)	1989-06-26
HK85096A (en)	1996-05-24
GR871332B (en)	1988-01-12
EP0321481B1 (en)	1994-06-01
AU7858587A (en)	1988-03-24
GR871331B (en)	1988-01-12
NZ221575A (en)	1990-03-27
DE3789965T2 (de)	1994-10-13
KR950014441B1 (ko)	1995-11-28
WO1988001506A1 (en)	1988-03-10
NO944301D0 (no)	1994-11-11
NO881755L (no)	1988-06-21
CN1035801C (zh)	1997-09-10
NO300991B1 (no)	1997-09-01
DK236388D0 (da)	1988-04-28
AU609419B2 (en)	1991-05-02
KR880701543A (ko)	1988-11-03
NO881755D0 (no)	1988-04-22
DK236388A (da)	1988-04-28
CN87106794A (zh)	1988-06-29
CA1314217C (en)	1993-03-09
EP0321481A1 (en)	1989-06-28
JP2798248B2 (ja)	1998-09-17
DE3789965D1 (de)	1994-07-07
NO944301L (no)	1988-06-21
JPH02500838A (ja)	1990-03-22
ATE106242T1 (de)	1994-06-15

Publication	Publication Date	Title
US5597564A (en)	1997-01-28	Method of administering a microgranular preparation to the intestinal region of animals
US5356625A (en)	1994-10-18	Microgranular preparation useful in the delivery of biologically active materials to the intestinal regions of animals
AU609419B2 (en)	1991-05-02	Microgranular preparation useful in the delivery of biologically active materials to the intestinal regions of animals
RU2113220C1 (ru)	1998-06-20	Композиция, способ лечения кишечной инфекции, способ неспецифической стимуляции имvунной системы, способ доставки биологически активного материала в верхние отделы тонкого кишечника
JP6081374B2 (ja)	2017-02-15	酸性劣化からの微生物細胞の保護
US5648099A (en)	1997-07-15	Process for microencapsulating cells
Long et al.	2016	Effects of dietary lysozyme levels on growth performance, intestinal morphology, non‐specific immunity and mRNA expression in weanling piglets
US20090053317A1 (en)	2009-02-26	Microparticulate systems for the oral administration of biologically active substances
AU2012210575A1 (en)	2013-08-08	Protection of microbial cells from acidic degradation
EP0319545A1 (en)	1989-06-14	Animal growth promotant.
CN108669298A (zh)	2018-10-19	一种饲用益生菌微胶囊及其制备方法和应用
CN111494601B (zh)	2022-04-22	一种过瘤胃的肠溶性抗菌肽颗粒及制备方法
US3119738A (en)	1964-01-28	Medication for ruminants
CN121101085A (zh)	2025-12-12	一种含发酵原料的哺乳母猪饲料及其制备方法
WO2005123034A2 (en)	2005-12-29	Microparticulate systems for the oral administration of biologically active substances
EP0820306B1 (en)	2002-12-04	Pharmaceutical composition containing pectin and a phospholipid, used as an antidiarrheal and antiulcer agent
ITMI990842A1 (it)	2000-10-22	Microrganismi inattivati comprendenti sostanze solubili e o solubilizzabili ad attivita' farmacologica e o sostanze nutrizionali ad attivita
AU665564B2 (en)	1996-01-11	Therapeutic compositions and methods
CN116784436A (zh)	2023-09-22	一种用于芦丁鸡饲料的凝结芽孢杆菌组合物及其制备方法
CN113694086A (zh)	2021-11-26	益生菌胶囊及其制备方法
Latimer et al.	0	Comparative Immunology Reports