NO301589B1 - 4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, anvendelse derav og legemidler som inneholder forbindelsene - Google Patents

4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, anvendelse derav og legemidler som inneholder forbindelsene

Info

Publication number: NO301589B1
Authority: NO; Norway
Prior art keywords: compounds; ureido; pyrimidine; amino; carboxylic acid
Prior art date: 1992-02-22

Application number

NO930596A

Other languages

English (en)

Norwegian (no)

Other versions

NO930596D0 (no

NO930596L (no

Inventor

Klaus-Dieter Kampe

Ernold Granzer

Michael Leineweber

Gerhard Rackur

Hans Georg Boeger

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-22

Filing date

1993-02-19

Publication date

1997-11-17

1993-02-19 Application filed by Hoechst Ag filed Critical Hoechst Ag

1993-02-19 Publication of NO930596D0 publication Critical patent/NO930596D0/no

1993-08-23 Publication of NO930596L publication Critical patent/NO930596L/no

1997-11-17 Publication of NO301589B1 publication Critical patent/NO301589B1/no

Links

150000001875 compounds Chemical class 0.000 title abstract 5
SHGZREYDEWHPDB-UHFFFAOYSA-N 4-amino-2-(carbamoylamino)pyrimidine-5-carboxamide Chemical class NC(=O)NC1=NC=C(C(N)=O)C(N)=N1 SHGZREYDEWHPDB-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 2
102000000853 LDL receptors Human genes 0.000 abstract 1
108010001831 LDL receptors Proteins 0.000 abstract 1
230000002440 hepatic effect Effects 0.000 abstract 1
230000037356 lipid metabolism Effects 0.000 abstract 1
230000000638 stimulation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Obesity (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO930596A 1992-02-22 1993-02-19 4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, anvendelse derav og legemidler som inneholder forbindelsene NO301589B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4205484		1992-02-22

Publications (3)

Publication Number	Publication Date
NO930596D0 NO930596D0 (no)	1993-02-19
NO930596L NO930596L (no)	1993-08-23
NO301589B1 true NO301589B1 (no)	1997-11-17

Family

ID=6452364

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO930596A NO301589B1 (no)	1992-02-22	1993-02-19	4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, anvendelse derav og legemidler som inneholder forbindelsene

Country Status (16)

Country	Link
US (1)	US5571816A (fr)
EP (1)	EP0557879B1 (fr)
JP (1)	JP2726790B2 (fr)
AT (1)	ATE147384T1 (fr)
AU (2)	AU658266B2 (fr)
CA (1)	CA2089954C (fr)
DE (1)	DE59305012D1 (fr)
DK (1)	DK0557879T3 (fr)
ES (1)	ES2098570T3 (fr)
FI (1)	FI105029B (fr)
GR (1)	GR3022889T3 (fr)
HU (2)	HU213212B (fr)
IL (1)	IL104791A (fr)
NO (1)	NO301589B1 (fr)
NZ (2)	NZ264752A (fr)
ZA (1)	ZA931182B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0557877T3 (da) *	1992-02-22	1998-04-27	Hoechst Ag	Opløselige salte af 4-amino-2-(4,4-dimethyl-imidazolidin-2-on-l-yl)-pyrimidin-5-carboxylsyre-eN-methyl-N-(3-trifluormethyl-phenyl)-amide,fremgangsmådetil deres fremstilling, deres anvendelse som lægemidler og udgangsprodukter
DE19625089A1 (de) *	1996-06-24	1998-01-02	Hoechst Ag	4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19625088A1 (de) *	1996-06-24	1998-01-02	Hoechst Ag	4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
JPH10265464A (ja) *	1997-03-24	1998-10-06	Sumitomo Pharmaceut Co Ltd	Ｌｄｌ受容体遺伝子発現増強剤
DK0869121T3 (da) *	1997-04-04	2004-09-20	Aventis Pharma Gmbh	Hypolipidæmiske propanolaminderivater
DE19845403B4 (de) *	1998-10-02	2005-02-10	Aventis Pharma Deutschland Gmbh	Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19845406C2 (de) *	1998-10-02	2001-10-18	Aventis Pharma Gmbh	Substituierte 1,3-Diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)- propanolderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19845405C2 (de) *	1998-10-02	2000-07-13	Aventis Pharma Gmbh	Arylsubstituierte Propanolaminderivate und deren Verwendung
US7087597B1 (en)	1999-10-12	2006-08-08	Takeda Pharmaceutical Company Limited	Pyrimidine 5-carboxamide compounds, process for producing the same and use thereof
KR100566188B1 (ko) *	1999-11-27	2006-03-29	동화약품공업주식회사	신규의 5-피리미딘카르복스아미드 유도체 및 그를포함하는 약학적 조성물
KR100566189B1 (ko) *	1999-12-29	2006-03-29	동화약품공업주식회사	신규의 5-피리미딘카르복스아미드 유도체 및 그를포함하는 약학적 조성물
JP5557832B2 (ja) *	2008-03-18	2014-07-23	メルク・シャープ・アンド・ドーム・コーポレーション	置換４−ヒドロキシピリジン−５−カルボキサミド
JP2011057661A (ja) *	2009-08-14	2011-03-24	Bayer Cropscience Ag	殺虫性カルボキサミド類

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2853220A1 (de) *	1978-12-09	1980-07-03	Hoechst Ag	Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung
DE3522940A1 (de) *	1985-06-27	1987-01-08	Hoechst Ag	4-amino-2-(imidazolidin-2-on-1-yl)-pyrimidin-5-carbonsaeure-(n-(3-trifluormethyl-phenyl)-amide) zur antithrombotischen prophylaxe und behandlung sowie ihre verwendung zur herstellung von antithrombotisch wirksamen arzneimitteln
DK0557877T3 (da) *	1992-02-22	1998-04-27	Hoechst Ag	Opløselige salte af 4-amino-2-(4,4-dimethyl-imidazolidin-2-on-l-yl)-pyrimidin-5-carboxylsyre-eN-methyl-N-(3-trifluormethyl-phenyl)-amide,fremgangsmådetil deres fremstilling, deres anvendelse som lægemidler og udgangsprodukter

1993
- 1993-02-17 DK DK93102453.3T patent/DK0557879T3/da active
- 1993-02-17 DE DE59305012T patent/DE59305012D1/de not_active Expired - Fee Related
- 1993-02-17 EP EP93102453A patent/EP0557879B1/fr not_active Expired - Lifetime
- 1993-02-17 ES ES93102453T patent/ES2098570T3/es not_active Expired - Lifetime
- 1993-02-17 AT AT93102453T patent/ATE147384T1/de not_active IP Right Cessation
- 1993-02-18 FI FI930717A patent/FI105029B/fi active
- 1993-02-19 ZA ZA931182A patent/ZA931182B/xx unknown
- 1993-02-19 IL IL104791A patent/IL104791A/xx not_active IP Right Cessation
- 1993-02-19 NZ NZ264752A patent/NZ264752A/en unknown
- 1993-02-19 NZ NZ245936A patent/NZ245936A/en unknown
- 1993-02-19 HU HU9300458A patent/HU213212B/hu not_active IP Right Cessation
- 1993-02-19 AU AU33762/93A patent/AU658266B2/en not_active Ceased
- 1993-02-19 NO NO930596A patent/NO301589B1/no not_active IP Right Cessation
- 1993-02-19 JP JP5053227A patent/JP2726790B2/ja not_active Expired - Lifetime
- 1993-02-19 CA CA002089954A patent/CA2089954C/fr not_active Expired - Fee Related
1995
- 1995-01-19 AU AU10290/95A patent/AU669462B2/en not_active Ceased
- 1995-04-20 HU HU9501122A patent/HUT70638A/hu unknown
- 1995-08-16 US US08/515,882 patent/US5571816A/en not_active Expired - Fee Related
1997
- 1997-03-24 GR GR970400571T patent/GR3022889T3/el unknown

Also Published As

Publication number	Publication date
ATE147384T1 (de)	1997-01-15
HUT70638A (en)	1995-10-30
GR3022889T3 (en)	1997-06-30
EP0557879B1 (fr)	1997-01-08
FI105029B (fi)	2000-05-31
HU213212B (en)	1997-03-28
AU669462B2 (en)	1996-06-06
JP2726790B2 (ja)	1998-03-11
IL104791A0 (en)	1993-06-10
FI930717A7 (fi)	1993-08-23
CA2089954A1 (fr)	1993-08-23
CA2089954C (fr)	2002-03-26
HUT63409A (en)	1993-08-30
DK0557879T3 (da)	1997-06-16
ZA931182B (en)	1993-09-16
ES2098570T3 (es)	1997-05-01
NO930596D0 (no)	1993-02-19
IL104791A (en)	1997-11-20
AU3376293A (en)	1993-08-26
NZ245936A (en)	1995-10-26
DE59305012D1 (de)	1997-02-20
EP0557879A1 (fr)	1993-09-01
HU9501122D0 (en)	1995-06-28
AU658266B2 (en)	1995-04-06
AU1029095A (en)	1995-04-06
US5571816A (en)	1996-11-05
NZ264752A (en)	1995-10-26
JPH0641120A (ja)	1994-02-15
HU9300458D0 (en)	1993-05-28
NO930596L (no)	1993-08-23
FI930717A0 (fi)	1993-02-18

Legal Events

Date	Code	Title	Description
2003-09-29	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN AUGUST 2003

Publication	Publication Date	Title
TW257753B (fr)	1995-09-21
ATE175201T1 (de)	1999-01-15	Mono-n-substituierte 1,4,7,10- tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
NO301589B1 (no)	1997-11-17	4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, anvendelse derav og legemidler som inneholder forbindelsene
ATE122042T1 (de)	1995-05-15	Pyrazoloisoquinoline-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
CS235488A2 (en)	1990-02-12	Method of new dihydropyridinamides production
EP0521393A3 (en)	1993-07-14	Diclofenac salt, a method for the preparation thereof and pharmaceutical compositions containing it
EG15762A (en)	1986-12-30	Substituted hydroxy-malonic acid diamides,a process for their preparation,and their use as pest combating agents
IL65217A (en)	1985-11-29	N-(2,2,2-trifluoroethyl)-n-alkyl-azolyloxyacetic acid amides,their preparation and their use as herbicides
DE3861271D1 (de)	1991-01-24	Basisch substituierte benzofurancarbonsaeureamide, verfahren zu ihrer herstellung und sie enthaltende therapeutische mittel.
HU9601701D0 (en)	1996-08-28	Aromatic hydroxamic acid compounds, process for producing them and their use
MA21913A1 (fr)	1991-04-01	Procede de preparation de derives amino-oligohydroxy inhibiteurs de la renine .
GR3025235T3 (en)	1998-02-27	Soluble salts of 4-amino-2-(4,4-dimethyl-imidazolidin-2-on-1-yl)-pyrimidin-5-carboxylic acid N-methyl-N-(3-trifluoromethyl-phenyl)-amide, process for their preparation, their use as medicine and initial products
DE59307401D1 (de)	1997-10-30	Alpha-Aryl-alpha-hydroxy-beta-imidazolinylpropionsäureamide
MX9206997A (es)	1993-06-01	Procedimiento para la preparacion de derivados de trifluorobenceno.
NO933465D0 (no)	1993-09-28	Legemidler inneholdende 1,5,6,7-tetrahydro -4- indazol -4- on-derivater, nye 1,5,6,7 - tetrahydro -4- indazol -4- on-derivater, og fremgangsmaate for deres fremstilling
SU1162187A1 (ru)	1997-03-20	N-(N-АНИЗИЛ- β -ОКСИЭТИЛ)-4-ЭТОКСИКАРБОНИЛ-1,2,3,6-ТЕТРАГИДРОПИРИДИН В КАЧЕСТВЕ ПОЛУПРОДУКТА ДЛЯ СИНТЕЗА 1,2,3,6-ТЕТРАГИДРОИЗОНИКОТИНОВОЙ КИСЛОТЫ