NO302846B1 - Sensor av enzym-elektrodetypen - Google Patents

Sensor av enzym-elektrodetypen Download PDF

Info

Publication number: NO302846B1
Authority: NO; Norway
Prior art keywords: layer; membrane; sensor according; enzyme; sensor
Prior art date: 1987-08-04

Application number

NO883441A

Other languages

English (en)

Norwegian (no)

Other versions

NO883441L (no

NO883441D0 (no

Inventor

Pankaj Maganlal Vadgama

Lian Xiang Tang

Original Assignee

Ici Plc

Lian Xiang Tang

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-04

Filing date

1988-08-03

Publication date

1998-04-27

1988-08-03 Application filed by Ici Plc, Lian Xiang Tang filed Critical Ici Plc

1988-08-03 Publication of NO883441D0 publication Critical patent/NO883441D0/no

1989-02-06 Publication of NO883441L publication Critical patent/NO883441L/no

1998-04-27 Publication of NO302846B1 publication Critical patent/NO302846B1/no

Links

108090000790 Enzymes Proteins 0.000 title claims abstract description 45
102000004190 Enzymes Human genes 0.000 title claims abstract description 45
239000012528 membrane Substances 0.000 claims abstract description 91
239000007788 liquid Substances 0.000 claims abstract description 40
239000011148 porous material Substances 0.000 claims abstract description 35
239000012491 analyte Substances 0.000 claims abstract description 25
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
239000000463 material Substances 0.000 claims description 26
239000000126 substance Substances 0.000 claims description 21
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 18
150000002632 lipids Chemical class 0.000 claims description 8
229920002301 cellulose acetate Polymers 0.000 claims description 7
238000000034 method Methods 0.000 claims description 7
239000004417 polycarbonate Substances 0.000 claims description 7
229920000515 polycarbonate Polymers 0.000 claims description 7
238000006243 chemical reaction Methods 0.000 claims description 5
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 4
229940067606 lecithin Drugs 0.000 claims description 4
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235000014113 dietary fatty acids Nutrition 0.000 claims description 3
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WTTJVINHCBCLGX-UHFFFAOYSA-N (9trans,12cis)-methyl linoleate Natural products CCCCCC=CCC=CCCCCCCCC(=O)OC WTTJVINHCBCLGX-UHFFFAOYSA-N 0.000 claims description 2
LNJCGNRKWOHFFV-UHFFFAOYSA-N 3-(2-hydroxyethylsulfanyl)propanenitrile Chemical compound OCCSCCC#N LNJCGNRKWOHFFV-UHFFFAOYSA-N 0.000 claims description 2
PKIXXJPMNDDDOS-UHFFFAOYSA-N Methyl linoleate Natural products CCCCC=CCCC=CCCCCCCCC(=O)OC PKIXXJPMNDDDOS-UHFFFAOYSA-N 0.000 claims description 2
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239000001913 cellulose Substances 0.000 claims description 2
QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 claims description 2
150000002148 esters Chemical class 0.000 claims description 2
150000004665 fatty acids Chemical class 0.000 claims description 2
150000002576 ketones Chemical class 0.000 claims description 2
QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 claims description 2
229940073769 methyl oleate Drugs 0.000 claims description 2
150000003457 sulfones Chemical class 0.000 claims description 2
229920002319 Poly(methyl acrylate) Polymers 0.000 claims 1
229940074928 isopropyl myristate Drugs 0.000 claims 1
239000002904 solvent Substances 0.000 abstract description 6
229940088598 enzyme Drugs 0.000 description 36
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 23
239000008103 glucose Substances 0.000 description 23
230000004044 response Effects 0.000 description 22
239000000523 sample Substances 0.000 description 13
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 8
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 6
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 6
230000002452 interceptive effect Effects 0.000 description 5
230000035699 permeability Effects 0.000 description 5
102000009027 Albumins Human genes 0.000 description 4
108010088751 Albumins Proteins 0.000 description 4
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
229960005070 ascorbic acid Drugs 0.000 description 4
235000010323 ascorbic acid Nutrition 0.000 description 4
239000011668 ascorbic acid Substances 0.000 description 4
YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 4
DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 4
238000002474 experimental method Methods 0.000 description 4
229960002163 hydrogen peroxide Drugs 0.000 description 4
TYQCGQRIZGCHNB-JLAZNSOCSA-N l-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 description 4
239000000203 mixture Substances 0.000 description 4
108010015776 Glucose oxidase Proteins 0.000 description 3
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical group O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
239000008280 blood Substances 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
239000010408 film Substances 0.000 description 3
235000019420 glucose oxidase Nutrition 0.000 description 3
229910052751 metal Inorganic materials 0.000 description 3
239000002184 metal Substances 0.000 description 3
229910052697 platinum Inorganic materials 0.000 description 3
229920006289 polycarbonate film Polymers 0.000 description 3
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
239000004366 Glucose oxidase Substances 0.000 description 2
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 2
TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 2
MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
238000007598 dipping method Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
239000012530 fluid Substances 0.000 description 2
229940116332 glucose oxidase Drugs 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
229960005489 paracetamol Drugs 0.000 description 2
239000004926 polymethyl methacrylate Substances 0.000 description 2
229910052709 silver Inorganic materials 0.000 description 2
239000004332 silver Substances 0.000 description 2
239000000758 substrate Substances 0.000 description 2
229940116269 uric acid Drugs 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
108010073450 Lactate 2-monooxygenase Proteins 0.000 description 1
239000000020 Nitrocellulose Substances 0.000 description 1
229920005439 Perspex® Polymers 0.000 description 1
108010092464 Urate Oxidase Proteins 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 1
230000001464 adherent effect Effects 0.000 description 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
238000009534 blood test Methods 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
238000006555 catalytic reaction Methods 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
229910010293 ceramic material Inorganic materials 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
239000012470 diluted sample Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
-1 fatty acid ester Chemical class 0.000 description 1
239000011521 glass Substances 0.000 description 1
125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
229920001220 nitrocellulos Polymers 0.000 description 1
150000001282 organosilanes Chemical class 0.000 description 1
229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
239000002861 polymer material Substances 0.000 description 1
239000005373 porous glass Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
239000004627 regenerated cellulose Substances 0.000 description 1
238000011160 research Methods 0.000 description 1
230000006941 response to substance Effects 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000010409 thin film Substances 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/817—Enzyme or microbe electrode

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Fire-Detection Mechanisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Developing Agents For Electrophotography (AREA)
Measuring Fluid Pressure (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Lubrication Of Internal Combustion Engines (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

NO883441A 1987-08-04 1988-08-03 Sensor av enzym-elektrodetypen NO302846B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878718430A GB8718430D0 (en)	1987-08-04	1987-08-04	Sensor

Publications (3)

Publication Number	Publication Date
NO883441D0 NO883441D0 (no)	1988-08-03
NO883441L NO883441L (no)	1989-02-06
NO302846B1 true NO302846B1 (no)	1998-04-27

Family

ID=10621794

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO883441A NO302846B1 (no)	1987-08-04	1988-08-03	Sensor av enzym-elektrodetypen

Country Status (16)

Country	Link
US (1)	US4919767A (da)
EP (1)	EP0302661B1 (da)
JP (1)	JP2614277B2 (da)
AT (1)	ATE118543T1 (da)
AU (1)	AU608875B2 (da)
CA (1)	CA1290015C (da)
DE (1)	DE3853029T2 (da)
DK (1)	DK170656B1 (da)
ES (1)	ES2070852T3 (da)
FI (1)	FI91331C (da)
GB (1)	GB8718430D0 (da)
IE (1)	IE67374B1 (da)
IL (1)	IL87263A (da)
NO (1)	NO302846B1 (da)
NZ (1)	NZ225672A (da)
PT (1)	PT88183B (da)

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JPH04278450A (ja) *	1991-03-04	1992-10-05	Adam Heller	バイオセンサー及び分析物を分析する方法
GB9226840D0 (en) *	1992-12-23	1993-02-17	Unilever Plc	Improvements in or relating to electrochemical reactions
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DE69634802T2 (de) *	1995-11-08	2006-03-16	Hypoguard Ltd., Woodbridge	Biosensoren mit membran
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US20060091006A1 (en) *	1999-11-04	2006-05-04	Yi Wang	Analyte sensor with insertion monitor, and methods
WO2001090733A1 (en)	2000-05-23	2001-11-29	Radiometer Medical A/S	A sensor membrane, a method for the preparation thereof, a sensor and a layered membrane structure for such sensor
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EP1397068A2 (en)	2001-04-02	2004-03-17	Therasense, Inc.	Blood glucose tracking apparatus and methods
CN100439513C (zh) *	2002-05-16	2008-12-03	霍夫曼-拉罗奇有限公司	含有非再生酶-辅酶复合体的方法和试剂体系
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US9572534B2 (en)	2010-06-29	2017-02-21	Abbott Diabetes Care Inc.	Devices, systems and methods for on-skin or on-body mounting of medical devices
US8613703B2 (en)	2007-05-31	2013-12-24	Abbott Diabetes Care Inc.	Insertion devices and methods
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1988
- 1988-07-27 IE IE230388A patent/IE67374B1/en not_active IP Right Cessation
- 1988-07-28 AT AT88306938T patent/ATE118543T1/de not_active IP Right Cessation
- 1988-07-28 DE DE3853029T patent/DE3853029T2/de not_active Expired - Fee Related
- 1988-07-28 EP EP88306938A patent/EP0302661B1/en not_active Expired - Lifetime
- 1988-07-28 ES ES88306938T patent/ES2070852T3/es not_active Expired - Lifetime
- 1988-07-29 IL IL87263A patent/IL87263A/xx unknown
- 1988-08-02 FI FI883622A patent/FI91331C/fi not_active IP Right Cessation
- 1988-08-03 DK DK433588A patent/DK170656B1/da not_active IP Right Cessation
- 1988-08-03 NO NO883441A patent/NO302846B1/no unknown
- 1988-08-03 NZ NZ225672A patent/NZ225672A/xx unknown
- 1988-08-03 PT PT88183A patent/PT88183B/pt not_active IP Right Cessation
- 1988-08-03 AU AU20355/88A patent/AU608875B2/en not_active Ceased
- 1988-08-04 CA CA000573855A patent/CA1290015C/en not_active Expired - Lifetime
- 1988-08-04 US US07/228,153 patent/US4919767A/en not_active Expired - Fee Related
- 1988-08-04 JP JP63195277A patent/JP2614277B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI883622A0 (fi)	1988-08-02
DK433588D0 (da)	1988-08-03
PT88183B (pt)	1994-09-30
DK170656B1 (da)	1995-11-20
AU2035588A (en)	1989-02-09
IE67374B1 (en)	1996-03-20
CA1290015C (en)	1991-10-01
IE882303L (en)	1989-02-04
NO883441L (no)	1989-02-06
IL87263A (en)	1992-08-18
IL87263A0 (en)	1988-12-30
DE3853029T2 (de)	1995-08-24
NO883441D0 (no)	1988-08-03
DE3853029D1 (de)	1995-03-23
AU608875B2 (en)	1991-04-18
FI91331C (fi)	1994-06-10
PT88183A (pt)	1989-06-30
ATE118543T1 (de)	1995-03-15
FI883622L (fi)	1989-02-05
EP0302661A1 (en)	1989-02-08
GB8718430D0 (en)	1987-09-09
FI91331B (fi)	1994-02-28
EP0302661B1 (en)	1995-02-15
NZ225672A (en)	1991-01-29
US4919767A (en)	1990-04-24
DK433588A (da)	1989-02-05
JPH01131446A (ja)	1989-05-24
JP2614277B2 (ja)	1997-05-28
ES2070852T3 (es)	1995-06-16

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