NO304519B1 - Fremstilling av (1)-(-)-2-(aminokarbonyl)-N-(4-amino-2,6-diklorfenyl)-4-[5,5-bis(4-fluorfenyl)pentyl]-1-piperazinacetamid - Google Patents

Fremstilling av (1)-(-)-2-(aminokarbonyl)-N-(4-amino-2,6-diklorfenyl)-4-[5,5-bis(4-fluorfenyl)pentyl]-1-piperazinacetamid Download PDF

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Publication number
NO304519B1
NO304519B1 NO912511A NO912511A NO304519B1 NO 304519 B1 NO304519 B1 NO 304519B1 NO 912511 A NO912511 A NO 912511A NO 912511 A NO912511 A NO 912511A NO 304519 B1 NO304519 B1 NO 304519B1
Authority
NO
Norway
Prior art keywords
formula
bis
fluorophenyl
compound
aminocarbonyl
Prior art date
Application number
NO912511A
Other languages
English (en)
Norwegian (no)
Other versions
NO912511D0 (no
NO912511L (no
Inventor
Herman Van Belle
Willy Joannes Carolu Laerhoven
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO912511D0 publication Critical patent/NO912511D0/no
Publication of NO912511L publication Critical patent/NO912511L/no
Publication of NO304519B1 publication Critical patent/NO304519B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Protection Of Pipes Against Damage, Friction, And Corrosion (AREA)
  • Dicing (AREA)
  • Branch Pipes, Bends, And The Like (AREA)
  • Golf Clubs (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Suspension Of Electric Lines Or Cables (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • External Artificial Organs (AREA)
  • Paper (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
NO912511A 1989-11-22 1991-06-26 Fremstilling av (1)-(-)-2-(aminokarbonyl)-N-(4-amino-2,6-diklorfenyl)-4-[5,5-bis(4-fluorfenyl)pentyl]-1-piperazinacetamid NO304519B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44014289A 1989-11-22 1989-11-22
PCT/EP1990/001985 WO1991007967A2 (en) 1989-11-22 1990-11-19 Method of preventing or limiting reperfusion damage
SG118494A SG118494G (en) 1989-11-22 1994-08-20 Method of preventing or limiting reperfusion damage

Publications (3)

Publication Number Publication Date
NO912511D0 NO912511D0 (no) 1991-06-26
NO912511L NO912511L (no) 1991-08-26
NO304519B1 true NO304519B1 (no) 1999-01-04

Family

ID=26664237

Family Applications (2)

Application Number Title Priority Date Filing Date
NO912511A NO304519B1 (no) 1989-11-22 1991-06-26 Fremstilling av (1)-(-)-2-(aminokarbonyl)-N-(4-amino-2,6-diklorfenyl)-4-[5,5-bis(4-fluorfenyl)pentyl]-1-piperazinacetamid
NO19982078A NO311701B1 (no) 1989-11-22 1998-05-07 Fremgangsmåte for beskyttelse av et donorhjerte for transplantering samt anvendelse av en N-aryl-piperazinalkanamidforbindelse for dette formål

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO19982078A NO311701B1 (no) 1989-11-22 1998-05-07 Fremgangsmåte for beskyttelse av et donorhjerte for transplantering samt anvendelse av en N-aryl-piperazinalkanamidforbindelse for dette formål

Country Status (22)

Country Link
EP (2) EP0577171B1 (de)
JP (1) JP2574585B2 (de)
KR (1) KR0165686B1 (de)
AT (2) ATE213943T1 (de)
AU (1) AU632888B2 (de)
CA (1) CA2044143C (de)
CY (1) CY1869A (de)
DE (2) DE69033926T2 (de)
DK (2) DK0577171T3 (de)
ES (2) ES2053208T3 (de)
FI (1) FI109694B (de)
HK (1) HK115095A (de)
HU (1) HU215847B (de)
IE (1) IE65121B1 (de)
IL (1) IL96390A (de)
NO (2) NO304519B1 (de)
NZ (1) NZ236168A (de)
PT (2) PT95959B (de)
RU (1) RU2093156C1 (de)
SG (1) SG118494G (de)
WO (1) WO1991007967A2 (de)
ZA (1) ZA909345B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9202266D0 (sv) * 1992-07-31 1992-07-31 Kabi Pharmacia Ab Novel piperazine carboxamides
SE9504661D0 (sv) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
US6596706B1 (en) * 1997-11-07 2003-07-22 Daiichi Pharmaceutical Co., Ltd. Piperazine-cyclodextrin complexes
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
SE9904674D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904673D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0001209D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
US6573264B1 (en) * 2000-10-23 2003-06-03 Cv Therapeutics, Inc. Heteroaryl alkyl piperazine derivatives
NZ539828A (en) 2001-05-18 2007-01-26 Astrazeneca Ab 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
US20090018351A1 (en) * 2003-11-12 2009-01-15 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
KR101234421B1 (ko) 2004-08-02 2013-02-18 아스트라제네카 아베 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도
FR2946340B1 (fr) 2009-06-05 2011-06-24 Galderma Res & Dev Nouveaux n-phenyl acetamie, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
KR101900124B1 (ko) 2014-06-25 2018-09-18 전남대학교산학협력단 전복 박리용 조성물
KR101644299B1 (ko) 2014-07-22 2016-08-02 주식회사 엔바이로젠 오미자 및 삼채 추출물을 유효성분으로 포함하는 전복 박리용 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
NZ223847A (en) * 1987-04-01 1989-12-21 Janssen Pharmaceutica Nv Substituted piperazine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
KR0165686B1 (ko) 1999-01-15
CY1869A (en) 1996-04-05
HU215847B (hu) 1999-04-28
ES2173883T3 (es) 2002-11-01
NO982078D0 (no) 1998-05-07
HU9102436D0 (en) 1991-12-30
DE69033926T2 (de) 2002-10-24
JP2574585B2 (ja) 1997-01-22
DE69007471T2 (de) 1994-06-23
ATE213943T1 (de) 2002-03-15
PT95959B (pt) 1998-08-31
FI913433A0 (fi) 1991-07-16
PT102145B (pt) 2002-06-28
NO912511D0 (no) 1991-06-26
DE69007471D1 (de) 1994-04-21
DK0455789T3 (da) 1994-04-05
NO982078L (no) 1991-08-26
ATE102831T1 (de) 1994-04-15
DE69033926D1 (de) 2002-04-11
IL96390A0 (en) 1991-08-16
FI109694B (fi) 2002-09-30
HK115095A (en) 1995-07-21
EP0577171A3 (en) 1994-06-29
IL96390A (en) 1995-06-29
EP0577171A2 (de) 1994-01-05
WO1991007967A2 (en) 1991-06-13
SG118494G (en) 1994-11-25
NZ236168A (en) 1993-05-26
RU2093156C1 (ru) 1997-10-20
PT102145A (pt) 1999-10-29
EP0577171B1 (de) 2002-03-06
ES2053208T3 (es) 1994-07-16
AU632888B2 (en) 1993-01-14
NO311701B1 (no) 2002-01-14
IE65121B1 (en) 1995-10-04
WO1991007967A3 (en) 1991-07-11
CA2044143C (en) 2002-11-19
AU6876391A (en) 1991-06-26
NO912511L (no) 1991-08-26
EP0455789B1 (de) 1994-03-16
CA2044143A1 (en) 1991-05-23
PT95959A (pt) 1991-09-13
EP0455789A1 (de) 1991-11-13
HUT58709A (en) 1992-03-30
KR920700644A (ko) 1992-08-10
ZA909345B (en) 1992-08-26
IE904209A1 (en) 1991-05-22
DK0577171T3 (da) 2002-06-03

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