NO304789B1 - Imidazolforbindelser, farmas÷ytiske preparater som omfatter dem, og anvende av forbindelsene for fremstilling av medikamenter - Google Patents

Imidazolforbindelser, farmas÷ytiske preparater som omfatter dem, og anvende av forbindelsene for fremstilling av medikamenter

Info

Publication number: NO304789B1
Authority: NO; Norway
Prior art keywords: compounds; alkyl; alkoxy; halogen; amino
Prior art date: 1992-12-23

Application number

NO934474A

Other languages

English (en)

Norwegian (no)

Other versions

NO934759D0 (no

NO934759L (no

Inventor

Oskar Axelsson

Dan Peters

Elsebet Istergaard Nielsen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-23

Filing date

1993-12-22

Publication date

1999-02-15

1993-12-22 Application filed by Neurosearch As filed Critical Neurosearch As

1993-12-22 Publication of NO934759D0 publication Critical patent/NO934759D0/no

1994-06-24 Publication of NO934759L publication Critical patent/NO934759L/no

1999-02-15 Publication of NO304789B1 publication Critical patent/NO304789B1/no

Links

150000001875 compounds Chemical class 0.000 title abstract 3
239000003814 drug Substances 0.000 title abstract 2
150000002460 imidazoles Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
206010002660 Anoxia Diseases 0.000 abstract 1
241000976983 Anoxia Species 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010021143 Hypoxia Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
-1 amino, nitro, sulphamoyl Chemical group 0.000 abstract 1
230000007953 anoxia Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
208000028867 ischemia Diseases 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003831 tetrazolyl group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Polyesters Or Polycarbonates (AREA)
Lubricants (AREA)
Epoxy Resins (AREA)

NO934474A 1992-12-23 1993-12-22 Imidazolforbindelser, farmas÷ytiske preparater som omfatter dem, og anvende av forbindelsene for fremstilling av medikamenter NO304789B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK921540A DK154092D0 (da)	1992-12-23	1992-12-23	Imidazolforbindelser, deres fremstilling og anvendelse

Publications (3)

Publication Number	Publication Date
NO934759D0 NO934759D0 (no)	1993-12-22
NO934759L NO934759L (no)	1994-06-24
NO304789B1 true NO304789B1 (no)	1999-02-15

Family

ID=8105880

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO934474A NO304789B1 (no)	1992-12-23	1993-12-22	Imidazolforbindelser, farmas÷ytiske preparater som omfatter dem, og anvende av forbindelsene for fremstilling av medikamenter

Country Status (13)

Country	Link
US (1)	US5441969A (de)
EP (1)	EP0604353B1 (de)
JP (1)	JPH06293742A (de)
KR (1)	KR100310662B1 (de)
AT (1)	ATE167862T1 (de)
AU (1)	AU679697B2 (de)
CA (1)	CA2112081C (de)
DE (1)	DE69319413T2 (de)
DK (1)	DK154092D0 (de)
FI (1)	FI111840B (de)
NO (1)	NO304789B1 (de)
NZ (1)	NZ250477A (de)
ZA (1)	ZA939528B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5496826A (en) *	1994-09-02	1996-03-05	Bristol-Myers Squibb Company	Pharmaceutical methods of using heterocyclic derivatives of N-phenylamides
US5821370A (en) *	1994-10-24	1998-10-13	Eli Lilly And Company	Heterocyclic compounds and their preparation and use
US5891885A (en) *	1996-10-09	1999-04-06	Algos Pharmaceutical Corporation	Method for treating migraine
DE19812059C1 (de) *	1998-03-19	1999-09-23	Wella Ag	Diaminobenzol-Derivate sowie diese Diaminobenzol-Derivate enthaltende Haarfärbemittel
DE69924493T2 (de) *	1998-07-02	2005-09-15	Neurosearch A/S	Kaliumkanal-blockierende mittel
US6194447B1 (en)	1998-07-02	2001-02-27	Neurosearch A/S	Bis (benzimidazole) derivatives serving as potassium blocking agents
US6685951B2 (en)	2001-07-05	2004-02-03	R. T. Alamo Ventures I, Inc.	Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) *	2001-07-05	2003-10-23	R.T. Alamo Ventures I, Llc	Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) *	2001-07-05	2003-01-23	R.T. Alamo Ventures I, Inc.	Sublingual administration of dihydroergotamine for the treatment of migraine
DE10135050A1 (de) *	2001-07-09	2003-02-06	Schering Ag	1-Ary1-2-N-, S- oder O-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate
US6903126B2 (en)	2001-07-09	2005-06-07	Schering Ag	1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
US7482366B2 (en) *	2001-12-21	2009-01-27	X-Ceptor Therapeutics, Inc.	Modulators of LXR
AU2003271548A1 (en) *	2002-10-13	2004-05-04	Neurosearch A/S	Use of skca channel blocking drugs for combating parkinson's disease
DE10342503A1 (de) *	2003-09-12	2005-04-14	Merck Patent Gmbh	Benzyl-Benzimidazolylderivate
JP2008189662A (ja) *	2007-01-12	2008-08-21	New Industry Research Organization	スフィンゴシン１リン酸による神経伝達物質の放出促進機能とその応用
DK2425820T3 (en)	2007-02-11	2015-07-13	Map Pharmaceuticals Inc	A method for the therapeutic administration of DHE in order to enable quick relief of migraine, while minimizing the adverse event profile
DK2734634T3 (da)	2011-07-22	2019-10-21	Univ Chicago	Igf-1 til anvendelse til behandling af migræne
CA2895816C (en)	2012-12-21	2021-02-23	Map Pharmaceuticals, Inc.	8'-hydroxy-dihydroergotamine compounds and compositions
KR101472686B1 (ko) *	2013-07-09	2014-12-16	씨제이헬스케어 주식회사	벤즈이미다졸 유도체의 제조방법
TWI663159B (zh)	2013-12-10	2019-06-21	美商健臻公司	原肌球蛋白相關之激酶（ｔｒｋ）抑制劑
EP3233057A2 (de)	2014-12-18	2017-10-25	Genzyme Corporation	Pharmazeutische formulierungen von inhibitoren der tropomyosin-verwandten kinase (trk)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3928177A1 (de) *	1989-04-08	1991-02-28	Thomae Gmbh Dr K	Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5196444A (en) *	1990-04-27	1993-03-23	Takeda Chemical Industries, Ltd.	1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
NZ239540A (en) *	1990-09-24	1993-11-25	Neurosearch As	1-phenyl benzimidazole derivatives and medicaments
US5210091A (en) *	1991-06-24	1993-05-11	Neurosearch A/S	Imidazole compounds and their use
EP0520200B1 (de) *	1991-06-24	1998-02-18	Neurosearch A/S	Imidazol-Verbindungen, Verfahren zu ihrer Herstellung und ihre Anwendung
US5314903A (en) *	1991-12-03	1994-05-24	Neurosearch A/S	Benzimidazole compounds useful as calcium channel blockers

1992
- 1992-12-23 DK DK921540A patent/DK154092D0/da not_active IP Right Cessation
1993
- 1993-12-06 AU AU52201/93A patent/AU679697B2/en not_active Ceased
- 1993-12-16 NZ NZ250477A patent/NZ250477A/en not_active IP Right Cessation
- 1993-12-20 AT AT93610064T patent/ATE167862T1/de not_active IP Right Cessation
- 1993-12-20 DE DE69319413T patent/DE69319413T2/de not_active Expired - Lifetime
- 1993-12-20 ZA ZA939528A patent/ZA939528B/xx unknown
- 1993-12-20 EP EP93610064A patent/EP0604353B1/de not_active Expired - Lifetime
- 1993-12-21 KR KR1019930028807A patent/KR100310662B1/ko not_active Expired - Fee Related
- 1993-12-21 CA CA002112081A patent/CA2112081C/en not_active Expired - Fee Related
- 1993-12-22 US US08/172,427 patent/US5441969A/en not_active Expired - Lifetime
- 1993-12-22 FI FI935801A patent/FI111840B/fi active
- 1993-12-22 JP JP5324470A patent/JPH06293742A/ja active Pending
- 1993-12-22 NO NO934474A patent/NO304789B1/no unknown

Also Published As

Publication number	Publication date
FI935801L (fi)	1994-06-24
KR940013506A (ko)	1994-07-15
JPH06293742A (ja)	1994-10-21
DE69319413D1 (de)	1998-08-06
FI111840B (fi)	2003-09-30
DK154092D0 (da)	1992-12-23
KR100310662B1 (ko)	2001-12-28
EP0604353B1 (de)	1998-07-01
ATE167862T1 (de)	1998-07-15
DE69319413T2 (de)	1999-01-28
NO934759D0 (no)	1993-12-22
CA2112081C (en)	2005-02-08
ZA939528B (en)	1994-08-08
AU5220193A (en)	1994-07-07
NZ250477A (en)	1995-07-26
FI935801A0 (fi)	1993-12-22
CA2112081A1 (en)	1994-06-24
EP0604353A1 (de)	1994-06-29
US5441969A (en)	1995-08-15
AU679697B2 (en)	1997-07-10
NO934759L (no)	1994-06-24

Publication	Publication Date	Title
NO934759D0 (no)	1993-12-22	Imidazolforbindelser, fremstilling og anvendelse derav
NO303779B1 (no)	1998-08-31	Imidazolforbindelser, anvendelse derav og farmas°ytisk preparat
ATE253546T1 (de)	2003-11-15	Chalcon-derivate und medikamente die diese enthalten
TR28430A (tr)	1996-06-13	N-asetonil benzamidler ve bunlarin fungisid olarak kullanimi.
ATE248824T1 (de)	2003-09-15	Substituierte phenylderivate, ihre herstellung und verwendung
CA2301093A1 (en)	1999-02-25	Fluoropyrazole-biphenylamide fungicides
KR970069985A (ko)	1997-11-07	1,2-디페닐피롤 유도체,그의 제법 및 그의 치료학적 용도
ZA929268B (en)	1993-06-29	Imidazole compounds, their preparation and use.
HU9202047D0 (en)	1992-09-28	Method for producing n-phenyl-thiourea derivatives and pharmaceutical prepartives containing these compounds as active agents
ID23954A (id)	2000-06-08	Tetrahidrogama-karbolin
PT91435A (pt)	1990-03-08	Processo para a preparacao de aril-alquil-aminas e -amidas possuindo propriedades anticonvulsivas e neuroprotectoras e de composicoes farmaceuticas que as contem
BR9304780A (pt)	1994-07-05	Composto, processo para preparar o composto, composição farmacêutica e uso
NO910904L (no)	1991-09-09	Fremgangsmaate for fremstilling av en substituert aminforbindelse.
DE69812028D1 (de)	2003-04-17	Creatine Derivate für Asthma
SE9704770D0 (sv)	1997-12-19	New use
ATE136536T1 (de)	1996-04-15	Derivate von bis(phenyl)äthan
BR9104632A (pt)	1992-06-09	Composto,composicao farmaceutica,aplicacao do referido composto e processo para a preparacao do referido composto
ID23783A (id)	2000-05-11	Anti fungi 2.4.4.-trisubstitusi-1,3-dioksolan
ES8305350A1 (es)	1983-04-01	"un procedimiento para preparar derivados de dialcohilpirazol".
FR2707634B1 (fr)	1995-08-11	Procédé de préparation de N-carbonylarylimines utiles dans la synthèse de taxoïdes thérapeutiquement actifs.
DK0823254T3 (da)	2002-11-04	Hidtil ukendt anvendelse af pyrazolopyridinforbindelser
FI933652A0 (fi)	1993-08-19	Foerfarande foer framstaellning av 1-osubstituerade 3-aminopyrroler
TH40576A (th)	2000-10-03	สารผสมกรองแสงที่เป็นเครื่องสำอาง