NO305518B1 - Asykliske, fosfonometoksyalkylsubstituerte alkenyl- og alkynyl-purin- og -pyrimidinderivater med antivirusaktivitet - Google Patents

Asykliske, fosfonometoksyalkylsubstituerte alkenyl- og alkynyl-purin- og -pyrimidinderivater med antivirusaktivitet

Info

Publication number: NO305518B1
Authority: NO; Norway
Prior art keywords: azidomethyl; adenine; purine; alkynyl; thymine
Prior art date: 1991-10-11

Application number

NO941275A

Other languages

English (en)

Norwegian (no)

Other versions

NO941275L (no

NO941275D0 (no

Inventor

John C Martin

Joanne J Bronson

Kuo-Long Yu

Original Assignee

Acad Of Science Czech Republic

Rega Stichting

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-11

Filing date

1994-04-08

Publication date

1999-06-14

1994-04-08 Application filed by Acad Of Science Czech Republic, Rega Stichting filed Critical Acad Of Science Czech Republic

1994-04-08 Publication of NO941275D0 publication Critical patent/NO941275D0/no

1994-06-10 Publication of NO941275L publication Critical patent/NO941275L/no

1999-06-14 Publication of NO305518B1 publication Critical patent/NO305518B1/no

Links

-1 alkynyl purine Chemical compound 0.000 title abstract 7
KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 title abstract 3
230000000840 anti-viral effect Effects 0.000 title 1
229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
150000003230 pyrimidines Chemical class 0.000 title 1
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 6
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 6
RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 6
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 4
229930024421 Adenine Natural products 0.000 abstract 4
ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 4
229960000643 adenine Drugs 0.000 abstract 4
229940104302 cytosine Drugs 0.000 abstract 3
229940113082 thymine Drugs 0.000 abstract 3
LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 abstract 2
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 2
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 abstract 2
229940035893 uracil Drugs 0.000 abstract 2
XXJGBENTLXFVFI-UHFFFAOYSA-N 1-amino-methylene Chemical compound N[CH2] XXJGBENTLXFVFI-UHFFFAOYSA-N 0.000 abstract 1
WYDKPTZGVLTYPG-UHFFFAOYSA-N 2,8-diamino-3,7-dihydropurin-6-one Chemical compound N1C(N)=NC(=O)C2=C1N=C(N)N2 WYDKPTZGVLTYPG-UHFFFAOYSA-N 0.000 abstract 1
CRYCZDRIXVHNQB-UHFFFAOYSA-N 2-amino-8-bromo-3,7-dihydropurin-6-one Chemical compound N1C(N)=NC(=O)C2=C1N=C(Br)N2 CRYCZDRIXVHNQB-UHFFFAOYSA-N 0.000 abstract 1
YCFWZXAEOXKNHL-UHFFFAOYSA-N 2-amino-8-chloro-3,7-dihydropurin-6-one Chemical compound N1C(N)=NC(=O)C2=C1N=C(Cl)N2 YCFWZXAEOXKNHL-UHFFFAOYSA-N 0.000 abstract 1
TXGWTBFCLADKKR-UHFFFAOYSA-N 2-amino-8-hydrazinyl-3,7-dihydropurin-6-one Chemical compound N1=C(N)NC(=O)C2=C1N=C(NN)N2 TXGWTBFCLADKKR-UHFFFAOYSA-N 0.000 abstract 1
DJGMEMUXTWZGIC-UHFFFAOYSA-N 2-amino-8-methyl-3,7-dihydropurin-6-one Chemical compound N1C(N)=NC(=O)C2=C1N=C(C)N2 DJGMEMUXTWZGIC-UHFFFAOYSA-N 0.000 abstract 1
MWBWWFOAEOYUST-UHFFFAOYSA-N 2-aminopurine Chemical compound NC1=NC=C2N=CNC2=N1 MWBWWFOAEOYUST-UHFFFAOYSA-N 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
BLXGZIDBSXVMLU-OWOJBTEDSA-N 5-[(e)-2-bromoethenyl]-1h-pyrimidine-2,4-dione Chemical compound Br\C=C\C1=CNC(=O)NC1=O BLXGZIDBSXVMLU-OWOJBTEDSA-N 0.000 abstract 1
LQLQRFGHAALLLE-UHFFFAOYSA-N 5-bromouracil Chemical compound BrC1=CNC(=O)NC1=O LQLQRFGHAALLLE-UHFFFAOYSA-N 0.000 abstract 1
ZRYZBEQILKESAW-UHFFFAOYSA-N 5-ethenyl-1h-pyrimidine-2,4-dione Chemical compound C=CC1=CNC(=O)NC1=O ZRYZBEQILKESAW-UHFFFAOYSA-N 0.000 abstract 1
RHIULBJJKFDJPR-UHFFFAOYSA-N 5-ethyl-1h-pyrimidine-2,4-dione Chemical compound CCC1=CNC(=O)NC1=O RHIULBJJKFDJPR-UHFFFAOYSA-N 0.000 abstract 1
KSNXJLQDQOIRIP-UHFFFAOYSA-N 5-iodouracil Chemical compound IC1=CNC(=O)NC1=O KSNXJLQDQOIRIP-UHFFFAOYSA-N 0.000 abstract 1
JHEKLAXXCHLMNM-UHFFFAOYSA-N 5-propyl-1h-pyrimidine-2,4-dione Chemical compound CCCC1=CNC(=O)NC1=O JHEKLAXXCHLMNM-UHFFFAOYSA-N 0.000 abstract 1
CLGFIVUFZRGQRP-UHFFFAOYSA-N 7,8-dihydro-8-oxoguanine Chemical compound O=C1NC(N)=NC2=C1NC(=O)N2 CLGFIVUFZRGQRP-UHFFFAOYSA-N 0.000 abstract 1
MSSXOMSJDRHRMC-UHFFFAOYSA-N 9H-purine-2,6-diamine Chemical compound NC1=NC(N)=C2NC=NC2=N1 MSSXOMSJDRHRMC-UHFFFAOYSA-N 0.000 abstract 1
UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
150000005690 diesters Chemical class 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
IGFXRKMLLMBKSA-UHFFFAOYSA-N purine Chemical compound N1=C[N]C2=NC=NC2=C1 IGFXRKMLLMBKSA-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
229960003087 tioguanine Drugs 0.000 abstract 1
229940075420 xanthine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

NO941275A 1991-10-11 1994-04-08 Asykliske, fosfonometoksyalkylsubstituerte alkenyl- og alkynyl-purin- og -pyrimidinderivater med antivirusaktivitet NO305518B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US77783591A	1991-10-11	1991-10-11
PCT/US1992/008686 WO1993007157A1 (en)	1991-10-11	1992-10-09	Antiviral acyclic phosphonomethoxyalkyl substituted, alkenyl and alkynyl purine and pyrimidine derivatives

Publications (3)

Publication Number	Publication Date
NO941275D0 NO941275D0 (no)	1994-04-08
NO941275L NO941275L (no)	1994-06-10
NO305518B1 true NO305518B1 (no)	1999-06-14

Family

ID=25111455

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO941275A NO305518B1 (no)	1991-10-11	1994-04-08	Asykliske, fosfonometoksyalkylsubstituerte alkenyl- og alkynyl-purin- og -pyrimidinderivater med antivirusaktivitet

Country Status (14)

Country	Link
US (1)	US5696263A (cs)
EP (1)	EP0630381B1 (cs)
JP (1)	JP3497505B2 (cs)
KR (1)	KR0184530B1 (cs)
AT (1)	ATE151432T1 (cs)
AU (1)	AU661347B2 (cs)
CA (1)	CA2120743C (cs)
CZ (1)	CZ287745B6 (cs)
DE (1)	DE69218968T2 (cs)
HU (1)	HU225970B1 (cs)
IL (1)	IL103410A (cs)
NO (1)	NO305518B1 (cs)
TW (1)	TW371662B (cs)
WO (1)	WO1993007157A1 (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5817647A (en) *	1993-04-01	1998-10-06	Merrell Pharmaceuticals Inc.	Unsaturated acetylene phosphonate derivatives of purines
EP0618214A1 (en) *	1993-04-01	1994-10-05	Merrell Dow Pharmaceuticals Inc.	Unsaturated phosphonate derivatives of purines and pyrimidines
US5798340A (en)	1993-09-17	1998-08-25	Gilead Sciences, Inc.	Nucleotide analogs
IT1270008B (it) *	1994-09-23	1997-04-16	Ist Superiore Sanita	Derivati purinici ed 8-azapurinici atti al trattamento terapeutico dell'aids
US5977061A (en) *	1995-04-21	1999-11-02	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	N6 - substituted nucleotide analagues and their use
US8586781B2 (en)	1998-04-02	2013-11-19	Mbc Pharma, Inc.	Bone targeted therapeutics and methods of making and using the same
US20020119443A1 (en)	2000-07-21	2002-08-29	Gilead Sciences, Inc.	Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
EP1406911B1 (en)	2001-06-29	2016-01-06	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	6-[2-(phosphonomethoxy)alkoxy] pyrimidine derivatives having antiviral activity
NZ543864A (en)	2003-06-16	2009-10-30	Leuven K U Res & Dev	Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
KR101033290B1 (ko)	2004-07-02	2011-05-09	주식회사 엘지생명과학	다이아이소프로필((1-(하이드록시메틸)-사이클로프로필)옥시)메틸포스포네이트의 새로운 제조 방법
FR2908133B1 (fr)	2006-11-08	2012-12-14	Centre Nat Rech Scient	Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
TWI444384B (zh)	2008-02-20	2014-07-11	Gilead Sciences Inc	核苷酸類似物及其在治療惡性腫瘤上的用途
AU2010292500A1 (en) *	2009-08-27	2012-03-15	Epiphany Biosciences, Inc.	Novel nucleoside phosphonates and analogs
WO2013019874A1 (en) *	2011-08-01	2013-02-07	Mbc Pharma, Inc.	Vitamin b6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates
EP3578563B1 (en)	2011-12-22	2021-04-14	Geron Corporation	Guanine analogs as telomerase substrates and telomere length affectors
PT3706762T (pt)	2017-12-07	2024-12-05	Univ Emory	N4-hidroxicitidina e derivados e utilizações antivirais relacionadas com os mesmos

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4556643A (en) *	1982-07-26	1985-12-03	Agracetus	Assay method and probe for polynucleotide sequences
CS233665B1 (en) *	1983-01-06	1985-03-14	Antonin Holy	Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
CA1254525A (en) *	1983-04-13	1989-05-23	Christine L. Brakel	Kit for terminally chemically labeling dna
US5047533A (en) *	1983-05-24	1991-09-10	Sri International	Acyclic purine phosphonate nucleotide analogs
EP0146039A3 (en) *	1983-12-12	1986-08-27	Miles Inc.	Hybridization assay with immobilization of hybrids by antihybrid binding
EP0144913A3 (en) *	1983-12-12	1986-08-20	Miles Inc.	Hybridization assay employing labeled probe and anti-hybrid
CS263952B1 (en) *	1985-04-25	1989-05-12	Holy Antonin	Remedy with antiviral effect
CS264222B1 (en) *	1986-07-18	1989-06-13	Holy Antonin	N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
NZ222553A (en) *	1986-11-18	1991-07-26	Bristol Myers Co	Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions

1992
- 1992-10-09 HU HU9401002A patent/HU225970B1/hu unknown
- 1992-10-09 DE DE69218968T patent/DE69218968T2/de not_active Expired - Lifetime
- 1992-10-09 JP JP50723393A patent/JP3497505B2/ja not_active Expired - Lifetime
- 1992-10-09 EP EP92922088A patent/EP0630381B1/en not_active Expired - Lifetime
- 1992-10-09 AT AT92922088T patent/ATE151432T1/de not_active IP Right Cessation
- 1992-10-09 CZ CZ1994845A patent/CZ287745B6/cs not_active IP Right Cessation
- 1992-10-09 CA CA002120743A patent/CA2120743C/en not_active Expired - Lifetime
- 1992-10-09 KR KR1019940701174A patent/KR0184530B1/ko not_active Expired - Lifetime
- 1992-10-09 AU AU27831/92A patent/AU661347B2/en not_active Expired
- 1992-10-09 WO PCT/US1992/008686 patent/WO1993007157A1/en not_active Ceased
- 1992-10-11 IL IL103410A patent/IL103410A/en not_active IP Right Cessation
1993
- 1993-01-27 TW TW082100500A patent/TW371662B/zh not_active IP Right Cessation
1994
- 1994-04-08 NO NO941275A patent/NO305518B1/no not_active IP Right Cessation
- 1994-12-06 US US08/350,851 patent/US5696263A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69218968D1 (en)	1997-05-15
HU9401002D0 (en)	1994-07-28
EP0630381A1 (en)	1994-12-28
AU661347B2 (en)	1995-07-20
NO941275L (no)	1994-06-10
KR0184530B1 (ko)	1999-05-15
US5696263A (en)	1997-12-09
CA2120743C (en)	2005-03-08
JPH07503453A (ja)	1995-04-13
CZ287745B6 (cs)	2001-01-17
WO1993007157A1 (en)	1993-04-15
HU225970B1 (en)	2008-01-28
EP0630381B1 (en)	1997-04-09
IL103410A (en)	1998-01-04
AU2783192A (en)	1993-05-03
TW371662B (en)	1999-10-11
IL103410A0 (en)	1993-03-15
CZ84594A3 (en)	1995-07-12
ATE151432T1 (de)	1997-04-15
CA2120743A1 (en)	1993-04-15
JP3497505B2 (ja)	2004-02-16
NO941275D0 (no)	1994-04-08
DE69218968T2 (de)	1997-10-09
HUT66770A (en)	1994-12-28
EP0630381A4 (en)	1995-01-04

Legal Events

Date	Code	Title	Description
2012-11-12	MK1K	Patent expired

Publication	Publication Date	Title
NO305518B1 (no)	1999-06-14	Asykliske, fosfonometoksyalkylsubstituerte alkenyl- og alkynyl-purin- og -pyrimidinderivater med antivirusaktivitet
PA8483101A1 (es)	2000-09-29	Compuestos quimicos
NO20033146D0 (no)	2003-07-09	Triazol [4,5-d]pyrimidinderivater og anvendelse av disse som purinergiske reseptorantagonister
MY123650A (en)	2006-05-31	Pharmaceutical compositions comprising a hmg coa reductase inhibitor
HRP20150798T1 (hr)	2015-09-11	Kombinacije pirimidina koje sadrže nnrti s inhibitorima rt
DE60228414D1 (de)	2008-10-02	Pyrrolo 2,3-d pyrimidine und deren verwendung als purinreceptor antagonisten
DK0720604T3 (da)	1998-07-27	Konformationelt låste nukleosidanaloger
ATE282617T1 (de)	2004-12-15	2-hydroxy methylcyclopropylidenmethylpurine als antivirale wirkstoffe
EP0701562A1 (en)	1996-03-20	UNSATURATED PHOSPHONATE DERIVATIVES PURINES AND PYRIMIDINS
JP2002506036A5 (cs)	2006-04-27
MX9303990A (es)	1994-01-31	Tetrazolil (fenoxi y fenoxialquil) piperidinil piridazinas como agentes antivirales.
WO2000016755A3 (en)	2000-05-25	Antiviral combinations of lamivudine and adefovir
KR102378309B1 (ko)	2022-03-24	발가락 교정기
DE60139875D1 (de)	2009-10-22	5-substituierte pyrimidinderivate eines konformatiosfestgelegten nukleosidanalogen
PT86156A (en)	1987-12-01	Process for the preparation of phosphonomethoxyalkylene purine and pyrimidine derivatives and of pharmaceutical compositions containing the same
PT1490368E (pt)	2011-10-24	2,2-bis(hidroximetil)ciclopropilidenometil-purinas e ¿pirimidinas como agentes antivirais
KR960701639A (ko)	1996-03-28	심기능 회복제(heart function restorative)
SU1680040A1 (ru)	1991-09-30	Антискользитель А.Н.Новогрудского
CN2282348Y (zh)	1998-05-27	无后跟健身鞋
KR200223922Y1 (ko)	2001-05-15	뒷바닥보다 앞바닥이 높은신
Harman	2002	A biomechanical power model for world-class 400 metre running
WO2005084205A3 (en)	2005-10-20	Diamino thiazoloindan derivatives and their use
Clercq et al.	1989	Anti-Hiv-1 Activity of 2′, 3′-Dideoxinucleoside Analogues: Structure-Activity Relationship
JP3077185U (ja)	2001-05-11	サンダルまたはスリッパ用取付け健康具
CA2172534A1 (en)	1995-03-30	Conformationally locked nucleoside analogues