NO306209B1 - Fremgangsmåte for fremstilling av isoserinestere under anvendelse av metallalkoksider og <beta>-laktamer, samt fremgangsmåte for fremstilling av et taxan og fremgangsmåte for fremstilling av taxol - Google Patents

Fremgangsmåte for fremstilling av isoserinestere under anvendelse av metallalkoksider og <beta>-laktamer, samt fremgangsmåte for fremstilling av et taxan og fremgangsmåte for fremstilling av taxol

Info

Publication number
NO306209B1
NO306209B1 NO941022A NO941022A NO306209B1 NO 306209 B1 NO306209 B1 NO 306209B1 NO 941022 A NO941022 A NO 941022A NO 941022 A NO941022 A NO 941022A NO 306209 B1 NO306209 B1 NO 306209B1
Authority
NO
Norway
Prior art keywords
beta
deriv
taxane
lactams
preparation
Prior art date
Application number
NO941022A
Other languages
English (en)
Norwegian (no)
Other versions
NO941022L (no
NO941022D0 (no
Inventor
Robert A Holton
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State filed Critical Univ Florida State
Publication of NO941022D0 publication Critical patent/NO941022D0/no
Publication of NO941022L publication Critical patent/NO941022L/no
Publication of NO306209B1 publication Critical patent/NO306209B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/62—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Glass Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
NO941022A 1991-09-23 1994-03-22 Fremgangsmåte for fremstilling av isoserinestere under anvendelse av metallalkoksider og <beta>-laktamer, samt fremgangsmåte for fremstilling av et taxan og fremgangsmåte for fremstilling av taxol NO306209B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76380591A 1991-09-23 1991-09-23
US86295592A 1992-04-03 1992-04-03
US86384992A 1992-04-06 1992-04-06
PCT/US1992/007990 WO1993006079A1 (en) 1991-09-23 1992-09-22 PREPARATION OF SUBSTITUTED ISOSERINE ESTERS USING METAL ALKOXIDES AND β-LACTAMS

Publications (3)

Publication Number Publication Date
NO941022D0 NO941022D0 (no) 1994-03-22
NO941022L NO941022L (no) 1994-05-20
NO306209B1 true NO306209B1 (no) 1999-10-04

Family

ID=29716161

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941022A NO306209B1 (no) 1991-09-23 1994-03-22 Fremgangsmåte for fremstilling av isoserinestere under anvendelse av metallalkoksider og <beta>-laktamer, samt fremgangsmåte for fremstilling av et taxan og fremgangsmåte for fremstilling av taxol

Country Status (16)

Country Link
EP (3) EP0605637B1 (de)
JP (2) JP3469237B2 (de)
KR (1) KR100252493B1 (de)
AT (3) ATE349424T1 (de)
CA (3) CA2098478C (de)
CZ (2) CZ290590B6 (de)
DE (3) DE69233672T2 (de)
DK (3) DK0884314T3 (de)
ES (3) ES2214665T3 (de)
FI (1) FI113046B (de)
GR (1) GR3030329T3 (de)
HU (1) HU226369B1 (de)
NO (1) NO306209B1 (de)
RU (1) RU2128654C1 (de)
SG (2) SG97130A1 (de)
WO (1) WO1993006079A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7074945B2 (en) 1991-09-23 2006-07-11 Florida State University Metal alkoxide taxane derivatives
US5284865A (en) 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US6005138A (en) 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6521660B2 (en) 1991-09-23 2003-02-18 Florida State University 3′-alkyl substituted taxanes and pharmaceutical compositions containing them
US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
HU0203995D0 (en) * 1992-12-23 2003-04-28 Bristol Myers Squibb Co Oxazole derivatives for synthesis of sidechain-bearing taxanes and preparation thereof
US5646176A (en) * 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
ZA94128B (en) * 1993-02-01 1994-08-19 Univ New York State Res Found Process for the preparation of taxane derivatives and betalactam intermediates therefor
TW467896B (en) 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
DK1227093T3 (da) * 1993-03-22 2005-08-29 Univ Florida State Beta-lactamer, der kan anvendes til fremstilling af taxaner med en furyl- eller thienylsubstitueret sidekæde
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
US6201140B1 (en) 1994-07-28 2001-03-13 Bristol-Myers Squibb Company 7-0-ethers of taxane derivatives
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
DE19509697A1 (de) * 1995-03-08 1996-09-12 Schering Ag Neue Borneole, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US6051600A (en) * 1995-09-12 2000-04-18 Mayhew; Eric Liposomal hydrolysis-promoting hydrophobic taxane derivatives
US6107332A (en) 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
DE69715417T2 (de) * 1996-05-08 2003-06-05 Pharmacia & Upjohn Co., Kalamazoo Oxazolidinester
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
JP2003502290A (ja) 1999-05-28 2003-01-21 ブリストル−マイヤーズ スクイブ カンパニー ジアルキルジクロロシランを用いるパクリタキセルの半合成
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
UA75625C2 (en) 2000-12-01 2006-05-15 Biogen Inc Condensed purine derivatives as a1 adenosine receptor antagonists
WO2003047508A2 (en) 2001-11-30 2003-06-12 Bristol-Myers Squibb Company Paclitaxel solvates
PL194032B1 (pl) * 2002-12-19 2007-04-30 Agropharm Sa Sposób wytwarzania półproduktów użytecznych w syntezie paklitakselu
US6956123B2 (en) * 2003-03-17 2005-10-18 Natural Pharmaccuticals, Inc. Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
SV2006002010A (es) 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
WO2006116532A2 (en) 2005-04-28 2006-11-02 University Of Massachusetts Lowell Synthesis of oligo/poly(catechins) and methods of use
EP2276755A4 (de) 2008-03-31 2011-05-04 Univ Florida State Res Found C(10)-ethylester- und c(10)-cyclopropylester-substituierte taxane
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
WO2015153345A1 (en) 2014-04-03 2015-10-08 Invictus Oncology Pvt. Ltd. Supramolecular combinatorial therapeutics

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206221A (en) * 1979-01-03 1980-06-03 The United States Of America As Represented By The Secretary Of Agriculture Cephalomannine and its use in treating leukemic tumors
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene

Also Published As

Publication number Publication date
FI941325L (fi) 1994-05-04
SG52496A1 (en) 1998-09-28
WO1993006079A1 (en) 1993-04-01
DK1193252T3 (da) 2007-04-30
EP1193252B1 (de) 2006-12-27
DE69233672D1 (de) 2007-02-08
EP0605637A1 (de) 1994-07-13
CA2254273C (en) 2003-03-25
CA2418125A1 (en) 1993-03-24
SG97130A1 (en) 2003-07-18
ATE349424T1 (de) 2007-01-15
DE69228756T2 (de) 1999-10-07
ES2214665T3 (es) 2004-09-16
CZ290590B6 (en) 2002-08-14
FI941325A0 (fi) 1994-03-22
EP0884314A2 (de) 1998-12-16
CA2098478C (en) 1999-09-14
CZ287417B6 (cs) 2000-11-15
EP0605637B1 (de) 1999-03-24
JP2004043439A (ja) 2004-02-12
DK0605637T3 (da) 1999-10-11
HU9400830D0 (en) 1994-06-28
NO941022L (no) 1994-05-20
CZ66094A3 (en) 1994-12-15
ATE258171T1 (de) 2004-02-15
DE69233292D1 (de) 2004-02-26
HU226369B1 (en) 2008-09-29
KR100252493B1 (ko) 2000-05-01
HUT71795A (en) 1996-02-28
DE69228756D1 (de) 1999-04-29
EP0884314A3 (de) 2002-05-02
DE69233292T2 (de) 2004-06-09
GR3030329T3 (en) 1999-09-30
EP0884314B1 (de) 2004-01-21
ES2132129T3 (es) 1999-08-16
EP0605637A4 (en) 1994-08-24
EP1193252A2 (de) 2002-04-03
CA2418125C (en) 2007-12-04
CA2098478A1 (en) 1993-03-24
RU2128654C1 (ru) 1999-04-10
ES2277964T3 (es) 2007-08-01
DK0884314T3 (da) 2004-05-24
JP3469237B2 (ja) 2003-11-25
EP1193252A3 (de) 2003-11-05
ATE178060T1 (de) 1999-04-15
NO941022D0 (no) 1994-03-22
DE69233672T2 (de) 2007-10-18
CA2254273A1 (en) 1993-03-24
AU647971B2 (en) 1994-03-31
AU2689092A (en) 1993-04-27
FI113046B (fi) 2004-02-27
JPH07502983A (ja) 1995-03-30

Similar Documents

Publication Publication Date Title
NO941022L (no) Fremstilling av substituerte isoserinestere under anvendelse av metallalkoksider og
DK0559533T3 (da) Fremgangsmåde til fremstilling af beta-lactamderivat og syntetisk mellemprodukt deraf
GB1023220A (en) Production of carboxylic acid amides
ES371463A1 (es) Procedimiento para la preparacion de 2-tio-pirimidin-nucle-osidos.
GB1201631A (en) Novel n-substituted amides
NO970766D0 (no) Fremgangsmåte for fremstilling av taxol og derivater derav
FR2706457B1 (fr) Procédé de préparation d&#39;un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
KR850002101A (ko) 7-옥소-4-티아-1-아자비사이클로[3,2,0]헵트-엔-유도체의 제조방법
SE323078B (de)
ES343838A1 (es) Procedimiento para la obtencion de amidas de acido.
ES394972A1 (es) Procedimiento para la preparacion de nuevos 3 - alcohil - ariloximetilisoxazoles.
ES395419A1 (es) Un procedimiento para la preparacion de derivados del acido6-aminopenicilanico.
ES381402A1 (es) Procedimiento para la obtencion de derivados basicamente sustituidos de la 2,4-(1h,3h)-quinazolindiona.
ES274909A1 (es) Procedimiento para la preparaciën de nuevos derivados de iminodibencilo
ES267692A3 (es) Procedimiento para la obtenciën de amidas de acidos grasos 0,0-dialquil-ditiofosforilicos
ES411562A1 (es) Procedimiento para la produccion de compuestos de cumarina y de cumarinimida.
JPS5519283A (en) Alphaaethynylamino acid and ester
GB1059405A (en) 5,7-substituted-5-norbornene-2,3-dicarboximides and related compounds
EP0229745A3 (en) Substituted o-phthalaldehydes
ES440054A1 (es) Un procedimiento para la preparacion de cefalosporinas.
ES395980A2 (es) Procedimiento para la obtencion de derivados basicamente sustituidos de la 2,4-(1h,3h)-quinazolidiona.
ES354698A1 (es) Un procedimiento de preparacion de las amidas del acido eu-genico o acido 2-hidroxi-3-metoxi-5-alil - benzoico, de sus esteres y de sus eteres.
AR003323A1 (es) Esteres nitricos de derivados del acido 2-(2,6 dihalofenilamino) fenil acetoxiacetico y sus procedimientos de preparacion.
GB887754A (en) Tetracycline amides
ES321373A1 (es) Procedimiento para la preparacion de 4-aril-isoflavanoides

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees