NO306342B1 - Syntetiske eksitatoriske aminosyrer, farmasöytisk formulering inneholdende slike aminosyrer samt mellomprodukt - Google Patents

Syntetiske eksitatoriske aminosyrer, farmasöytisk formulering inneholdende slike aminosyrer samt mellomprodukt

Info

Publication number
NO306342B1
NO306342B1 NO953191A NO953191A NO306342B1 NO 306342 B1 NO306342 B1 NO 306342B1 NO 953191 A NO953191 A NO 953191A NO 953191 A NO953191 A NO 953191A NO 306342 B1 NO306342 B1 NO 306342B1
Authority
NO
Norway
Prior art keywords
amino acids
pharmaceutical formulation
formulation containing
synthetic excitatory
synthetic
Prior art date
Application number
NO953191A
Other languages
English (en)
Norwegian (no)
Other versions
NO953191L (no
NO953191D0 (no
Inventor
David Reed Helton
James Allen Monn
Roger Lewis Robey
Darryle Darwin Schoepp
Joseph Patrick Tizzano
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/496,643 external-priority patent/US5750566A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO953191D0 publication Critical patent/NO953191D0/no
Publication of NO953191L publication Critical patent/NO953191L/no
Publication of NO306342B1 publication Critical patent/NO306342B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO953191A 1994-08-12 1995-08-14 Syntetiske eksitatoriske aminosyrer, farmasöytisk formulering inneholdende slike aminosyrer samt mellomprodukt NO306342B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28995794A 1994-08-12 1994-08-12
US33734994A 1994-11-10 1994-11-10
US08/496,643 US5750566A (en) 1994-08-12 1995-06-29 Synthetic excitatory amino acids

Publications (3)

Publication Number Publication Date
NO953191D0 NO953191D0 (no) 1995-08-14
NO953191L NO953191L (no) 1996-02-13
NO306342B1 true NO306342B1 (no) 1999-10-25

Family

ID=27403949

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953191A NO306342B1 (no) 1994-08-12 1995-08-14 Syntetiske eksitatoriske aminosyrer, farmasöytisk formulering inneholdende slike aminosyrer samt mellomprodukt

Country Status (24)

Country Link
US (2) US5925782A (pl)
EP (1) EP0696577B1 (pl)
JP (1) JP2883297B2 (pl)
CN (1) CN1066135C (pl)
AP (1) AP758A (pl)
AT (1) ATE172186T1 (pl)
AU (2) AU692276B2 (pl)
BG (1) BG62728B1 (pl)
CA (1) CA2156024C (pl)
CZ (1) CZ291270B6 (pl)
DE (1) DE69505318T2 (pl)
DK (1) DK0696577T3 (pl)
ES (1) ES2122456T3 (pl)
FI (1) FI114861B (pl)
HU (1) HU223845B1 (pl)
IL (2) IL114910A (pl)
MY (1) MY115977A (pl)
NO (1) NO306342B1 (pl)
NZ (1) NZ272772A (pl)
PL (1) PL182285B1 (pl)
RO (1) RO119147B1 (pl)
SK (1) SK281288B6 (pl)
TW (1) TW438741B (pl)
WO (1) WO1996005175A1 (pl)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118727A (en) * 1995-06-29 2003-01-12 Lilly Co Eli (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid
ZA969485B (en) * 1995-11-16 1998-05-12 Lilly Co Eli Excitatory amino acid receptor antagonists.
WO1997017950A1 (en) 1995-11-16 1997-05-22 Eli Lilly And Company Shoulder prosthesis
US5912248A (en) * 1995-11-16 1999-06-15 Eli Lilly And Company Excitatory amino acid receptor antagonists
GB9605429D0 (en) * 1995-11-16 1996-05-15 Lilly Co Eli Excitatory amino acid receptor antagonists
US5688826A (en) * 1995-11-16 1997-11-18 Eli Lilly And Company Excitatory amino acid derivatives
EA001617B1 (ru) * 1995-11-16 2001-06-25 Эли Лилли Энд Компани Антагонисты рецепторов возбудительной аминокислоты
US6017903A (en) 1996-09-27 2000-01-25 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
US5824662A (en) 1996-09-27 1998-10-20 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
WO1998013046A1 (en) 1996-09-27 1998-04-02 Guilford Pharmaceuticals Inc. Naaladase compositions and methods for treating glutamate abnormality and effecting neuronal activity in animals
EP1014971A1 (en) * 1997-01-29 2000-07-05 Eli Lilly And Company Treatment for premenstrual dysphoric disorder
ZA983930B (en) * 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
US6825211B1 (en) 1997-07-18 2004-11-30 Georgetown University Bicyclic metabotropic glutamate receptor ligands
JP2001515839A (ja) 1997-07-18 2001-09-25 ジョージタウン・ユニバーシティ 二環式向代謝性グルタミン酸受容体リガンド
DK0891978T3 (da) * 1997-07-18 2002-07-01 Hoffmann La Roche 5H-Thiazol(3,2-a)pyrimidinderivativer
JP3727791B2 (ja) * 1998-01-08 2005-12-14 ファイザー・プロダクツ・インク 二環式［３．１．０］ヘキサン及び関連化合物
CN1182105C (zh) 1998-01-28 2004-12-29 大正制药株式会社 含氟氨基酸衍生物
US5933378A (en) * 1998-02-26 1999-08-03 Micron Technology, Inc. Integrated circuit having forced substrate test mode with improved substrate isolation
IL138342A0 (en) * 1998-03-17 2001-10-31 Pfizer Prod Inc Bicyclo[2.2.1] heptanes and related compounds
EP1396273A1 (en) * 1998-03-17 2004-03-10 Pfizer Products Inc. Bicyclo(2.2.1.)heptanes and related compounds
GB9815542D0 (en) * 1998-07-17 1998-09-16 Lilly Co Eli Bicyclohexane derivatives
DE69918136T2 (de) 1998-08-31 2005-07-07 Taisho Pharmaceutical Co., Ltd. 6-Fluorobicyclo[3.1.0]Hexan-Derivate
CH694053A5 (de) * 1998-09-03 2004-06-30 Hoffmann La Roche Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten.
JP4192331B2 (ja) 1999-04-16 2008-12-10 住友化学株式会社 光学活性２−オキソビシクロ［３．１．０］ヘキサン−６−カルボン酸誘導体の製造方法
JP4783967B2 (ja) * 1999-07-21 2011-09-28 大正製薬株式会社 含フッ素アミノ酸誘導体を有効成分とする医薬
GB2355982A (en) * 1999-11-03 2001-05-09 Lilly Co Eli Heterocyclic amino acids
US7256217B2 (en) 2001-01-11 2007-08-14 Eli Lilly And Company Prodrugs of excitatory amino acids
EP1310480A1 (en) * 2001-11-07 2003-05-14 Eli Lilly & Company Prodrugs of excitatory amino acids
WO2002055485A1 (en) 2001-01-11 2002-07-18 Eli Lilly And Company Prodrugs of excitatory amino acids
AU2002353845A1 (en) * 2001-11-23 2003-06-10 Eli Lilly And Company Prodrugs of excitatory amino acids
AU2002361611A1 (en) * 2001-12-21 2003-07-24 Eli Lilly And Company Prodrugs of excitatory amino acids
US7456221B2 (en) 2001-12-21 2008-11-25 Eli Lilly And Company Prodrugs of excitatory amino acids
US20040116489A1 (en) * 2002-02-12 2004-06-17 Massey Steven Marc Synthetic excitatory amino acids
JP4964593B2 (ja) * 2003-09-25 2012-07-04 セノメド バイオサイエンシーズ，エルエルシー 神経学的病状の治療用のテトラヒドロインドロン誘導体
US20050107439A1 (en) * 2003-11-10 2005-05-19 Helton David R. Composition and method for treating emesis
WO2009062134A1 (en) * 2007-11-09 2009-05-14 Cenomed Biosciences, Llc Treatment of post-traumatic stress disorder with tetrahydroindolone arylpiperazine compounds
US20090264443A1 (en) * 2008-04-18 2009-10-22 David Helton Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds
WO2010111080A2 (en) 2009-03-27 2010-09-30 Eli Lilly And Company Optimized treatment of schizophrenia

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3704312A (en) * 1970-10-30 1972-11-28 American Home Prod Bialicyclic amino acids
US3746495A (en) * 1971-06-01 1973-07-17 American Home Prod Anti-ulcer therapy
JP2757960B2 (ja) 1988-10-17 1998-05-25 サントリー株式会社 （２Ｒ，３Ｓ，４Ｓ）−α−（カルボキシシクロプロピル）グリシン
DE69210214T2 (de) 1991-10-18 1996-10-02 Suntory Ltd 2-(2,3-dicarboxycyclopropyl)-glycin und ein verfahren zu ihrer herstellung
GB9325368D0 (en) * 1993-12-10 1994-02-16 Univ Bristol Organic compounds
US5750566A (en) * 1994-08-12 1998-05-12 Eli Lilly And Company Synthetic excitatory amino acids
IL118727A (en) 1995-06-29 2003-01-12 Lilly Co Eli (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid
US5688826A (en) 1995-11-16 1997-11-18 Eli Lilly And Company Excitatory amino acid derivatives

Also Published As

Publication number Publication date
NZ272772A (en) 1997-10-24
JPH08188561A (ja) 1996-07-23
FI953837L (fi) 1996-02-13
NO953191L (no) 1996-02-13
US5925680A (en) 1999-07-20
BG101213A (en) 1998-03-31
SK13397A3 (en) 1997-07-09
CA2156024A1 (en) 1996-02-13
IL114910A0 (en) 1995-12-08
FI114861B (fi) 2005-01-14
RO119147B1 (ro) 2004-04-30
CZ291270B6 (cs) 2003-01-15
DE69505318D1 (de) 1998-11-19
CZ207495A3 (en) 1996-05-15
WO1996005175A1 (en) 1996-02-22
TW438741B (en) 2001-06-07
US5925782A (en) 1999-07-20
CN1123272A (zh) 1996-05-29
HU223845B1 (hu) 2005-02-28
AU2853095A (en) 1996-02-22
AP758A (en) 1999-09-10
CN1066135C (zh) 2001-05-23
ATE172186T1 (de) 1998-10-15
HU9502380D0 (en) 1996-05-28
EP0696577A1 (en) 1996-02-14
AU3325195A (en) 1996-03-07
IL133493A0 (en) 2001-04-30
AU692276B2 (en) 1998-06-04
JP2883297B2 (ja) 1999-04-19
CA2156024C (en) 2004-10-05
PL182285B1 (pl) 2001-12-31
FI953837A0 (fi) 1995-08-14
HUT75524A (en) 1997-05-28
SK281288B6 (sk) 2001-02-12
ES2122456T3 (es) 1998-12-16
DK0696577T3 (da) 1999-06-23
AP9700922A0 (en) 1997-01-31
BG62728B1 (bg) 2000-06-30
PL309972A1 (en) 1996-02-19
IL114910A (en) 2000-06-29
DE69505318T2 (de) 1999-03-25
EP0696577B1 (en) 1998-10-14
NO953191D0 (no) 1995-08-14
HK1013983A1 (en) 1999-09-17
MY115977A (en) 2003-10-31

Similar Documents

Publication Publication Date Title
DK0696577T3 (da) Syntetiske excitatoriske aminosyrer
BR9611367A (pt) Formulação farmacêutic liofilizada estável
BR9607317A (pt) Peptídios e composição farmacêutica
BR9607318A (pt) Peptidos e composição farmacêutica
BR9607851B1 (pt) combinaÇço e formulaÇço farmacÊutica.
FI954978A7 (fi) Modifioidut proteiini- ja peptidilääkeaineet
NO954146D0 (no) Belagte farmasöytiske preparater
FI962589L (fi) 2,4-disulfofenyylibutyylinitroni, sen suolat ja niiden käyttö farmaseuttisina aineina
ZA989740B (en) Cyclic amino acids and derivatives thereof useful as pharmaceutical agents
BR1100329A (pt) Composto e formulação farmacêutica
ATE217787T1 (de) Aerosolformulierungen mit peptiden und proteinen
NO965294D0 (no) Emulsjon, kosmetisk og farmasöytisk preparat inneholdende denne samt anvendelse derav
DK0941056T3 (da) Sphingomyelinasepræparater samt anvendelse deraf
BR9610396A (pt) Formulação farmacêutica
FI945704A7 (fi) Eksitatorisen aminohapporeseptorin antagonisteja
FI950586A0 (fi) Aminohappojohdos
DE69635886D1 (de) Exzitatorisch wirkende Aminosäurederivate
NO963487D0 (no) Isolerte, tyrosinaseavledete peptider, samt anvendelser derav
DK0925273T3 (da) Farmaceutiske præparater indeholdende 4-oxo-butansyrer
TR199600583A2 (tr) Farmasötik aktiviteye sahip -amino asitlerin tolere edilebilirliginin arttirilmasi.
FI973230A0 (fi) Uusi farmaseuttinen formulaatio
FI971085L (fi) Uusia PKA:ta sitovia proteiineja ja näiden käyttömuotoja
BR9606066A (pt) Composto e formulação farmacêutica
NO306672B1 (no) N,N-dietyl-8,8-dipropyl-2-azaspiro[4,5]decan-2-propanamindimaleat, farmasöytisk blanding omfattende forbindelsen samt anvendelse derav
SE9301580D0 (sv) Protein formulation