NO306346B1 - N-substituerte azabicykloalkanderivater, anvendelse derav og farmasöytisk preparat - Google Patents

N-substituerte azabicykloalkanderivater, anvendelse derav og farmasöytisk preparat

Info

Publication number
NO306346B1
NO306346B1 NO962286A NO962286A NO306346B1 NO 306346 B1 NO306346 B1 NO 306346B1 NO 962286 A NO962286 A NO 962286A NO 962286 A NO962286 A NO 962286A NO 306346 B1 NO306346 B1 NO 306346B1
Authority
NO
Norway
Prior art keywords
pharmaceutical preparation
pct
azabicycloalkane derivatives
substituted
substituted azabicycloalkane
Prior art date
Application number
NO962286A
Other languages
English (en)
Norwegian (no)
Other versions
NO962286D0 (no
NO962286L (no
Inventor
Gerd Steiner
Rainer Munschauer
Liliane Unger
Hans-Juergen Teschendorf
Thomas Hoeger
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of NO962286D0 publication Critical patent/NO962286D0/no
Publication of NO962286L publication Critical patent/NO962286L/no
Publication of NO306346B1 publication Critical patent/NO306346B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Ink Jet (AREA)
NO962286A 1993-12-04 1996-06-03 N-substituerte azabicykloalkanderivater, anvendelse derav og farmasöytisk preparat NO306346B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4341403A DE4341403A1 (de) 1993-12-04 1993-12-04 N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
PCT/EP1994/003913 WO1995015327A1 (fr) 1993-12-04 1994-11-26 Derives d'azabicycloalcane n-substitue utilises comme neuroleptiques asf

Publications (3)

Publication Number Publication Date
NO962286D0 NO962286D0 (no) 1996-06-03
NO962286L NO962286L (no) 1996-06-03
NO306346B1 true NO306346B1 (no) 1999-10-25

Family

ID=6504205

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962286A NO306346B1 (no) 1993-12-04 1996-06-03 N-substituerte azabicykloalkanderivater, anvendelse derav og farmasöytisk preparat

Country Status (13)

Country Link
US (1) US5703091A (fr)
EP (1) EP0731802B1 (fr)
JP (1) JP3935201B2 (fr)
AT (1) ATE194620T1 (fr)
AU (1) AU680583B2 (fr)
BR (1) BR9408246A (fr)
DE (2) DE4341403A1 (fr)
ES (1) ES2148476T3 (fr)
FI (1) FI113644B (fr)
IL (1) IL111861A (fr)
NO (1) NO306346B1 (fr)
TW (1) TW285667B (fr)
WO (1) WO1995015327A1 (fr)

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DE19848521A1 (de) * 1998-10-21 2000-04-27 Basf Ag Verfahren zur Herstellung von (+)-exo-6-Phenyl-3-azabicyclo-[3.2.0]heptanen
DE19854147A1 (de) * 1998-11-24 2000-05-25 Basf Ag Verwendung von N-substituierten Azabicycloalkan-Derivaten zur Verwendung bei der Bekämpfung der Cocainsucht
TWI244481B (en) 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
GB9912411D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912410D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912415D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912413D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912417D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912416D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
JP2003512355A (ja) 1999-10-15 2003-04-02 デュポン ファーマシューティカルズ カンパニー ケモカイン受容体活性のモジュレータとしての二環式および三環式アミン
US6784200B2 (en) * 2000-10-13 2004-08-31 Bristol-Myers Squibb Pharma Company Bicyclic and tricyclic amines as modulators of chemokine receptor activity
GB0015562D0 (en) * 2000-06-23 2000-08-16 Pfizer Ltd Heterocycles
SE0100326D0 (sv) 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
MXPA03008109A (es) * 2001-03-07 2003-12-12 Pfizer Prod Inc Moduladores de la actividad de receptores de quimiocinas.
CA2495589A1 (fr) * 2002-08-14 2004-02-26 Abbott Laboratories Composes azabicycliques comme agents actifs du systeme nerveux central
JP2006501236A (ja) * 2002-08-23 2006-01-12 ランバクシー ラボラトリーズ リミテッド ムスカリン性レセプター拮抗薬としてのフルオロおよびスルホニルアミノ含有３，６−二置換アザビシクロ（３．１．０）ヘキサン誘導体
US7232835B2 (en) * 2002-12-10 2007-06-19 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo derivatives as muscarinic receptor antagonists
FR2866647B1 (fr) * 2004-02-20 2006-10-27 Servier Lab Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DK1761542T3 (da) 2004-06-09 2008-04-28 Hoffmann La Roche Octahydropyrrolo[3,4-C] pyrrolderivater og anvendelsen deraf som antivirusmidler
GB0507602D0 (en) * 2005-04-14 2005-05-18 Glaxo Group Ltd Compounds
US7665658B2 (en) 2005-06-07 2010-02-23 First Data Corporation Dynamic aggregation of payment transactions
ES2433135T3 (es) 2006-04-28 2013-12-09 Laboratorios Del Dr. Esteve, S.A. Compuestos biciclicos de tetrahidropirrol
EP1849771A1 (fr) * 2006-04-28 2007-10-31 Laboratorios Del Dr. Esteve, S.A. Derives bicyclic de Tetrahydopyrrole
EP1849772A1 (fr) 2006-04-28 2007-10-31 Laboratorios Del Dr. Esteve, S.A. Dérivés bicyclic de Tetrahydopyrrole
GB0625198D0 (en) 2006-12-18 2007-01-24 Glaxo Group Ltd Chemical compounds
GB0809479D0 (en) * 2008-05-23 2008-07-02 Glaxo Group Ltd Novel compounds
CA2812526A1 (fr) 2010-05-06 2011-11-10 Vertex Pharmaceuticals Incorporated Amides de chromene heterocyclique-piperidine spirocyclique utiles comme modulateurs des canaux ioniques
BR112013007566A2 (pt) 2010-09-28 2016-08-02 Panacea Biotec Ltd novos compostos bicíclicos
EP2642998B1 (fr) 2010-11-24 2020-09-16 The Trustees of Columbia University in the City of New York Antagoniste rbp4 non rétinoïde pour le traitement de la dégénérescence maculaire liée à l'âge et de la maladie de stargardt
BR112013019211A2 (pt) 2011-02-02 2021-07-06 Vertex Pharma amidas de piperidina espirocíclicas de pirrolopirazina como moduladores de canais de íon
CN103443105A (zh) 2011-02-18 2013-12-11 沃泰克斯药物股份有限公司 作为离子通道调节剂的苯并二氢吡喃-螺环哌啶酰胺
US8828996B2 (en) 2011-03-14 2014-09-09 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels
WO2013166037A1 (fr) 2012-05-01 2013-11-07 The Trustees Of Columbia University In The City Of New York Antagonistes non rétinoïdes pour le traitement de troubles oculaires
ES2700541T3 (es) 2013-03-14 2019-02-18 Univ Columbia Octahidrociclopentapirroles, su preparación y uso
US9938291B2 (en) 2013-03-14 2018-04-10 The Trustess Of Columbia University In The City Of New York N-alkyl-2-phenoxyethanamines, their preparation and use
WO2014151936A1 (fr) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles, leur préparation et leur utilisation
WO2014152013A1 (fr) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York 4-phénylpipéridines, leur préparation et leur utilisation
EP3461827B1 (fr) 2013-09-26 2022-02-23 Cadent Therapeutics, Inc. Modulateurs de nrb2, à base d'octahydro-cyclopenta[c]pyrrole, à modulation négative sélective
DK4036094T3 (da) 2014-04-30 2026-03-23 Univ Columbia Erstattede 4-fenylpiperidiner, deres fremstilling og anvendelse
JO3579B1 (ar) 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
EP3331886B1 (fr) 2015-08-05 2020-07-15 Indivior UK Limited Antagonistes du récepteur d3 de la dopamine ayant un fragment bicyclo
WO2018021447A1 (fr) * 2016-07-28 2018-02-01 塩野義製薬株式会社 Composé cyclique condensé contenant de l'azote ayant un effet antagoniste du récepteur de la dopamine d3
BR112020014875A2 (pt) 2018-01-26 2020-12-08 Shionogi & Co., Ltd. Composto cíclico condensado tendo antagonismo de receptor de dopamina d3
BR112020015712A2 (pt) 2018-02-05 2020-12-08 Alkermes, Inc. Compostos para tratamento de dor
SMT202400265T1 (it) 2018-11-14 2024-07-09 Janssen Pharmaceutica Nv Metodi di sintesi migliorati per realizzare composti eterociclici fusi come modulatori del recettore per l'oressina
US11274082B2 (en) 2019-05-31 2022-03-15 Ikena Oncology, Inc. Tead inhibitors and uses thereof
WO2020243423A1 (fr) 2019-05-31 2020-12-03 Ikena Oncology, Inc. Inhibiteurs de tead et leurs utilisations
EP4010325A1 (fr) 2019-08-07 2022-06-15 Janssen Pharmaceutica NV Procédés synthétiques améliorés pour la fabrication de composés de (2h-1,2,3-triazol-2-yl)phényle utilisés comme modulateurs des récepteurs de l'orexine
CN114957087A (zh) * 2022-04-13 2022-08-30 湖南复瑞生物医药技术有限责任公司 一种帕罗韦德中间体制备方法

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NL110185C (fr) * 1958-04-22
NO154582C (no) * 1978-10-20 1986-11-05 Ferrosan Ab Analogifremgangsmaate for fremstilling av terapeutisk aktive difenyl-dibutylpiperazinkarboksamider.
US4435419A (en) * 1981-07-01 1984-03-06 American Cyanamid Company Method of treating depression using azabicyclohexanes
US4605655A (en) * 1984-03-06 1986-08-12 Bristol-Myers Company Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
EP0190472B1 (fr) * 1984-12-21 1989-07-12 Duphar International Research B.V Médicaments à activité antipsychotique
US4994460A (en) * 1989-06-01 1991-02-19 Bristol-Myers Squibb Co. Agents for treatment of brain ischemia
US5055470A (en) * 1989-06-01 1991-10-08 Bristol-Myers Squibb Co. Method of treatment of ischemia in brain
DE4112353A1 (de) * 1991-04-16 1992-10-22 Basf Ag 1,3,4-trisubstituierte piperidin-derivate, ihre herstellung und verwendung
US5216018A (en) * 1992-02-14 1993-06-01 Du Pont Merck Pharmaceutical Company Hydroisoindolines and hydroisoquinolines as psychotropic
US5532243A (en) * 1992-02-14 1996-07-02 The Dupont Merck Pharmaceutical Company Antipsychotic nitrogen-containing bicyclic compounds
DE4243287A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
DE4219973A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung

Also Published As

Publication number Publication date
EP0731802A1 (fr) 1996-09-18
FI962324A0 (fi) 1996-06-03
IL111861A (en) 1999-08-17
ES2148476T3 (es) 2000-10-16
ATE194620T1 (de) 2000-07-15
TW285667B (fr) 1996-09-11
EP0731802B1 (fr) 2000-07-12
JPH09506346A (ja) 1997-06-24
DE4341403A1 (de) 1995-06-08
WO1995015327A1 (fr) 1995-06-08
US5703091A (en) 1997-12-30
AU1240395A (en) 1995-06-19
DE69425273T2 (de) 2001-01-18
BR9408246A (pt) 1997-05-27
AU680583B2 (en) 1997-07-31
JP3935201B2 (ja) 2007-06-20
FI113644B (fi) 2004-05-31
DE69425273D1 (de) 2000-08-17
NO962286D0 (no) 1996-06-03
FI962324L (fi) 1996-06-03
IL111861A0 (en) 1995-03-15
NO962286L (no) 1996-06-03

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Legal Events

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