NO311604B1 - Blanding for biomaterial og fremgangsmåte for fremstilling derav - Google Patents

Blanding for biomaterial og fremgangsmåte for fremstilling derav Download PDF

Info

Publication number: NO311604B1
Authority: NO; Norway
Prior art keywords: mixture; polymer; liquid phase; sterile; stated
Prior art date: 1995-08-07

Application number

NO19980504A

Other languages

English (en)

Norwegian (no)

Other versions

NO980504D0 (no

NO980504L (no

Inventor

Guy Daculsi

Pierre Weiss

Anne Dupraz

Mieczyslam Lapkowski

Original Assignee

Centre Nat Rech Scient

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-07

Filing date

1998-02-05

Publication date

2001-12-17

1998-02-05 Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient

1998-02-05 Publication of NO980504D0 publication Critical patent/NO980504D0/no

1998-04-06 Publication of NO980504L publication Critical patent/NO980504L/no

2001-12-17 Publication of NO311604B1 publication Critical patent/NO311604B1/no

Links

239000000203 mixture Substances 0.000 title claims abstract description 78
239000012620 biological material Substances 0.000 title claims abstract description 12
238000002360 preparation method Methods 0.000 title claims description 4
238000000034 method Methods 0.000 title claims description 3
230000008569 process Effects 0.000 title description 2
239000007791 liquid phase Substances 0.000 claims abstract description 21
239000012071 phase Substances 0.000 claims abstract description 19
239000001506 calcium phosphate Substances 0.000 claims abstract description 18
239000002245 particle Substances 0.000 claims abstract description 13
229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 11
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 11
239000007864 aqueous solution Substances 0.000 claims abstract description 9
229910000391 tricalcium phosphate Inorganic materials 0.000 claims abstract description 9
229940078499 tricalcium phosphate Drugs 0.000 claims abstract description 9
229920000249 biocompatible polymer Polymers 0.000 claims abstract description 8
238000006467 substitution reaction Methods 0.000 claims abstract description 6
229920000642 polymer Polymers 0.000 claims description 45
239000011575 calcium Substances 0.000 claims description 8
229920002678 cellulose Polymers 0.000 claims description 8
239000001913 cellulose Substances 0.000 claims description 8
230000015572 biosynthetic process Effects 0.000 claims description 7
230000001954 sterilising effect Effects 0.000 claims description 7
229920003086 cellulose ether Polymers 0.000 claims description 6
PSKMQMATIKSZEV-UHFFFAOYSA-H calcium titanium(4+) diphosphate Chemical compound [Ca+2].[Ti+4].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O PSKMQMATIKSZEV-UHFFFAOYSA-H 0.000 claims description 5
238000002513 implantation Methods 0.000 claims description 5
238000004519 manufacturing process Methods 0.000 claims description 5
238000002156 mixing Methods 0.000 claims description 5
238000004659 sterilization and disinfection Methods 0.000 claims description 5
239000010936 titanium Substances 0.000 claims description 5
229910052783 alkali metal Inorganic materials 0.000 claims description 4
150000001340 alkali metals Chemical class 0.000 claims description 4
150000001875 compounds Chemical class 0.000 claims description 4
125000000524 functional group Chemical group 0.000 claims description 4
239000004593 Epoxy Substances 0.000 claims description 3
239000003125 aqueous solvent Substances 0.000 claims description 3
239000012298 atmosphere Substances 0.000 claims description 3
239000000843 powder Substances 0.000 claims description 3
229920002907 Guar gum Polymers 0.000 claims description 2
ANUVOLVNLJAALL-UHFFFAOYSA-N N.O[SiH3] Chemical compound N.O[SiH3] ANUVOLVNLJAALL-UHFFFAOYSA-N 0.000 claims description 2
229920002472 Starch Polymers 0.000 claims description 2
125000000217 alkyl group Chemical group 0.000 claims description 2
238000006266 etherification reaction Methods 0.000 claims description 2
239000000665 guar gum Substances 0.000 claims description 2
235000010417 guar gum Nutrition 0.000 claims description 2
229960002154 guar gum Drugs 0.000 claims description 2
125000005843 halogen group Chemical group 0.000 claims description 2
125000001183 hydrocarbyl group Chemical group 0.000 claims description 2
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
239000002243 precursor Substances 0.000 claims description 2
239000008107 starch Substances 0.000 claims description 2
235000019698 starch Nutrition 0.000 claims description 2
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract description 13
229910019142 PO4 Inorganic materials 0.000 abstract description 2
230000000694 effects Effects 0.000 abstract description 2
235000019731 tricalcium phosphate Nutrition 0.000 abstract description 2
235000011010 calcium phosphates Nutrition 0.000 description 9
238000004132 cross linking Methods 0.000 description 9
239000000463 material Substances 0.000 description 9
210000001519 tissue Anatomy 0.000 description 8
229910000389 calcium phosphate Inorganic materials 0.000 description 7
239000000945 filler Substances 0.000 description 7
239000012764 mineral filler Substances 0.000 description 7
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 6
239000004354 Hydroxyethyl cellulose Substances 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
210000004027 cell Anatomy 0.000 description 6
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 6
238000002347 injection Methods 0.000 description 6
239000007924 injection Substances 0.000 description 6
BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 5
229910000077 silane Inorganic materials 0.000 description 5
238000001356 surgical procedure Methods 0.000 description 5
231100000331 toxic Toxicity 0.000 description 5
230000002588 toxic effect Effects 0.000 description 5
230000008859 change Effects 0.000 description 4
238000006243 chemical reaction Methods 0.000 description 4
239000000499 gel Substances 0.000 description 4
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 4
SCPYDCQAZCOKTP-UHFFFAOYSA-N silanol Chemical compound [SiH3]O SCPYDCQAZCOKTP-UHFFFAOYSA-N 0.000 description 4
125000005372 silanol group Chemical group 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
239000007853 buffer solution Substances 0.000 description 3
238000001727 in vivo Methods 0.000 description 3
230000000399 orthopedic effect Effects 0.000 description 3
BPSIOYPQMFLKFR-UHFFFAOYSA-N trimethoxy-[3-(oxiran-2-ylmethoxy)propyl]silane Chemical compound CO[Si](OC)(OC)CCCOCC1CO1 BPSIOYPQMFLKFR-UHFFFAOYSA-N 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
239000013060 biological fluid Substances 0.000 description 2
230000033558 biomineral tissue development Effects 0.000 description 2
239000006227 byproduct Substances 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
239000000919 ceramic Substances 0.000 description 2
239000002131 composite material Substances 0.000 description 2
238000009833 condensation Methods 0.000 description 2
230000005494 condensation Effects 0.000 description 2
231100000433 cytotoxic Toxicity 0.000 description 2
230000001472 cytotoxic effect Effects 0.000 description 2
239000002270 dispersing agent Substances 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
210000002950 fibroblast Anatomy 0.000 description 2
150000004676 glycans Chemical class 0.000 description 2
239000008187 granular material Substances 0.000 description 2
239000000017 hydrogel Substances 0.000 description 2
239000011159 matrix material Substances 0.000 description 2
-1 phosphocalcium Chemical compound 0.000 description 2
229920001282 polysaccharide Polymers 0.000 description 2
239000005017 polysaccharide Substances 0.000 description 2
239000000047 product Substances 0.000 description 2
238000011160 research Methods 0.000 description 2
238000000518 rheometry Methods 0.000 description 2
230000037390 scarring Effects 0.000 description 2
229910052710 silicon Inorganic materials 0.000 description 2
239000010703 silicon Substances 0.000 description 2
239000000243 solution Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
UDHXJZHVNHGCEC-UHFFFAOYSA-N Chlorophacinone Chemical compound C1=CC(Cl)=CC=C1C(C=1C=CC=CC=1)C(=O)C1C(=O)C2=CC=CC=C2C1=O UDHXJZHVNHGCEC-UHFFFAOYSA-N 0.000 description 1
241000766026 Coregonus nasus Species 0.000 description 1
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
241000124236 Lentula Species 0.000 description 1
241000906034 Orthops Species 0.000 description 1
230000009471 action Effects 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
238000013459 approach Methods 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
208000037873 arthrodesis Diseases 0.000 description 1
239000002585 base Substances 0.000 description 1
229920005601 base polymer Polymers 0.000 description 1
230000008901 benefit Effects 0.000 description 1
239000005312 bioglass Substances 0.000 description 1
239000003364 biologic glue Substances 0.000 description 1
210000000988 bone and bone Anatomy 0.000 description 1
239000000316 bone substitute Substances 0.000 description 1
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
239000000920 calcium hydroxide Substances 0.000 description 1
229910001861 calcium hydroxide Inorganic materials 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
239000004568 cement Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
230000008602 contraction Effects 0.000 description 1
239000011243 crosslinked material Substances 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
230000008021 deposition Effects 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
150000002118 epoxides Chemical class 0.000 description 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
238000011049 filling Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
238000007306 functionalization reaction Methods 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
239000007943 implant Substances 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000010954 inorganic particle Substances 0.000 description 1
229920000554 ionomer Polymers 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000007788 liquid Substances 0.000 description 1
210000004705 lumbosacral region Anatomy 0.000 description 1
238000003760 magnetic stirring Methods 0.000 description 1
210000001595 mastoid Anatomy 0.000 description 1
238000005259 measurement Methods 0.000 description 1
229910001463 metal phosphate Inorganic materials 0.000 description 1
ARYZCSRUUPFYMY-UHFFFAOYSA-N methoxysilane Chemical group CO[SiH3] ARYZCSRUUPFYMY-UHFFFAOYSA-N 0.000 description 1
239000011707 mineral Substances 0.000 description 1
239000002557 mineral fiber Substances 0.000 description 1
239000012299 nitrogen atmosphere Substances 0.000 description 1
231100001083 no cytotoxicity Toxicity 0.000 description 1
150000003961 organosilicon compounds Chemical class 0.000 description 1
230000020477 pH reduction Effects 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
238000010992 reflux Methods 0.000 description 1
230000008439 repair process Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
239000000565 sealant Substances 0.000 description 1
150000004756 silanes Chemical class 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
231100000820 toxicity test Toxicity 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oral & Maxillofacial Surgery (AREA)
Transplantation (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Dermatology (AREA)
Medicinal Chemistry (AREA)
Inorganic Chemistry (AREA)
Engineering & Computer Science (AREA)
Composite Materials (AREA)
Materials Engineering (AREA)
Materials For Medical Uses (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Prostheses (AREA)
Medicinal Preparation (AREA)
Compositions Of Macromolecular Compounds (AREA)

NO19980504A 1995-08-07 1998-02-05 Blanding for biomaterial og fremgangsmåte for fremstilling derav NO311604B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9509582A FR2737663B1 (fr)	1995-08-07	1995-08-07	Composition pour bio-materiau, procede de preparation
PCT/FR1996/001196 WO1997005911A1 (fr)	1995-08-07	1996-07-29	Composition pour bio-materiau, procede de preparation

Publications (3)

Publication Number	Publication Date
NO980504D0 NO980504D0 (no)	1998-02-05
NO980504L NO980504L (no)	1998-04-06
NO311604B1 true NO311604B1 (no)	2001-12-17

Family

ID=9481764

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19980504A NO311604B1 (no)	1995-08-07	1998-02-05	Blanding for biomaterial og fremgangsmåte for fremstilling derav

Country Status (14)

Country	Link
US (1)	US6001394A (de)
EP (1)	EP0843562B1 (de)
JP (1)	JP3597541B2 (de)
AT (1)	ATE214292T1 (de)
AU (1)	AU707039B2 (de)
CA (1)	CA2226304C (de)
DE (1)	DE69619830T2 (de)
DK (1)	DK0843562T3 (de)
ES (1)	ES2173306T3 (de)
FR (1)	FR2737663B1 (de)
NO (1)	NO311604B1 (de)
PT (1)	PT843562E (de)
WO (1)	WO1997005911A1 (de)
ZA (1)	ZA966635B (de)

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JP3806061B2 (ja) *	2002-05-21	2006-08-09	富士通株式会社	金属修飾アパタイト含有膜の形成方法、これに用いられるコーティング液、および金属修飾アパタイト含有膜で被覆された部位を有する電子機器
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FR2850282B1 (fr)	2003-01-27	2007-04-06	Jerome Asius	Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
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US8226715B2 (en)	2003-06-30	2012-07-24	Depuy Mitek, Inc.	Scaffold for connective tissue repair
US10583220B2 (en)	2003-08-11	2020-03-10	DePuy Synthes Products, Inc.	Method and apparatus for resurfacing an articular surface
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US7316822B2 (en)	2003-11-26	2008-01-08	Ethicon, Inc.	Conformable tissue repair implant capable of injection delivery
US7901461B2 (en)	2003-12-05	2011-03-08	Ethicon, Inc.	Viable tissue repair implants and methods of use
EP1701672A4 (de)	2003-12-19	2011-04-27	Osteotech Inc	Aus gewebe erhaltenes maschengeflecht für die orthopädische regeneration
US8012210B2 (en)	2004-01-16	2011-09-06	Warsaw Orthopedic, Inc.	Implant frames for use with settable materials and related methods of use
FR2865939B1 (fr) *	2004-02-06	2007-08-31	Biomatlante	Utilisation de polymeres organiques silanises pour creation de revetement bioactif, pour implant ou prothese
US11395865B2 (en)	2004-02-09	2022-07-26	DePuy Synthes Products, Inc.	Scaffolds with viable tissue
US8137686B2 (en)	2004-04-20	2012-03-20	Depuy Mitek, Inc.	Nonwoven tissue scaffold
US8221780B2 (en)	2004-04-20	2012-07-17	Depuy Mitek, Inc.	Nonwoven tissue scaffold
US8657881B2 (en)	2004-04-20	2014-02-25	Depuy Mitek, Llc	Meniscal repair scaffold
US7621963B2 (en) *	2005-04-13	2009-11-24	Ebi, Llc	Composite bone graft material
US20060233849A1 (en) *	2005-04-13	2006-10-19	Simon Bruce J	Composite bone graft material
DE102005024296B4 (de) *	2005-05-19	2007-02-01	Bundesanstalt für Materialforschung und -Prüfung (BAM)	Resorbierbarer, biokompatibler Formkörper und Verfahren zur Herstellung
AU2007207429A1 (en)	2006-01-19	2007-07-26	Warsaw Orthopedic, Inc.	Injectable and moldable bone substitute materials
CA2637606C (en)	2006-01-19	2013-03-19	Osteotech, Inc.	Porous osteoimplant
FR2913199B1 (fr) *	2007-03-01	2009-05-08	Biomatlante Sarl	Composition granulaire deshydratee et ses applications biomedicales.
US10010649B2 (en) *	2007-05-04	2018-07-03	Ascendia Ab	Method and means for culturing osteoblastic cells
EP2254610A4 (de) *	2008-02-22	2013-07-31	Dermal Technologies Llc	Zusammensetzungen zur gewebeverstärkung
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FR2936801A1 (fr) *	2008-10-03	2010-04-09	Centre Nat Rech Scient	Procede de silanisation de polysaccharides.
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NL8402534A (nl) *	1984-08-17	1986-03-17	Gerrit Johannes Brinks	Materiaal, geschikt voor toepassing als implantatiemateriaal bij mens en dier ter vervanging van afwezig botweefsel, alsmede werkwijze ter bereiding van het materiaal.
JP2877840B2 (ja) *	1989-06-08	1999-04-05	三金工業株式会社	生体硬組織用セメント材料
JP2621622B2 (ja) *	1990-09-27	1997-06-18	三菱マテリアル株式会社	水硬性リン酸カルシウムセメント
DE69214005T2 (de) *	1991-05-01	1997-05-15	Chichibu Onoda Cement Corp	Erhärtende Zusammensetzungen zur Verwendung in der Medizin oder Zahnheilkunde
FR2715853B1 (fr) *	1994-02-08	1996-04-26	Centre Nat Rech Scient	Composition pour bio-matériau; procédé de préparation.
JP3011006U (ja)	1994-02-15	1995-05-16	恵美子高木	水分吸収体付き立体裁断ドライハーブ入り和紙マスク

1995
- 1995-08-07 FR FR9509582A patent/FR2737663B1/fr not_active Expired - Fee Related
1996
- 1996-07-29 JP JP50793097A patent/JP3597541B2/ja not_active Expired - Lifetime
- 1996-07-29 US US09/011,215 patent/US6001394A/en not_active Expired - Lifetime
- 1996-07-29 EP EP96927103A patent/EP0843562B1/de not_active Expired - Lifetime
- 1996-07-29 DK DK96927103T patent/DK0843562T3/da active
- 1996-07-29 WO PCT/FR1996/001196 patent/WO1997005911A1/fr not_active Ceased
- 1996-07-29 AT AT96927103T patent/ATE214292T1/de active
- 1996-07-29 CA CA002226304A patent/CA2226304C/fr not_active Expired - Lifetime
- 1996-07-29 ES ES96927103T patent/ES2173306T3/es not_active Expired - Lifetime
- 1996-07-29 AU AU67042/96A patent/AU707039B2/en not_active Expired
- 1996-07-29 DE DE69619830T patent/DE69619830T2/de not_active Expired - Lifetime
- 1996-07-29 PT PT96927103T patent/PT843562E/pt unknown
- 1996-08-05 ZA ZA9606635A patent/ZA966635B/xx unknown
1998
- 1998-02-05 NO NO19980504A patent/NO311604B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0843562B1 (de)	2002-03-13
JPH11510076A (ja)	1999-09-07
EP0843562A1 (de)	1998-05-27
NO980504D0 (no)	1998-02-05
NO980504L (no)	1998-04-06
AU707039B2 (en)	1999-07-01
CA2226304A1 (fr)	1997-02-20
FR2737663B1 (fr)	1997-10-03
DE69619830D1 (de)	2002-04-18
DE69619830T2 (de)	2002-09-12
ZA966635B (en)	1998-02-05
AU6704296A (en)	1997-03-05
FR2737663A1 (fr)	1997-02-14
PT843562E (pt)	2002-08-30
DK0843562T3 (da)	2002-05-21
ATE214292T1 (de)	2002-03-15
ES2173306T3 (es)	2002-10-16
JP3597541B2 (ja)	2004-12-08
CA2226304C (fr)	2007-01-09
WO1997005911A1 (fr)	1997-02-20
US6001394A (en)	1999-12-14

Legal Events

Date	Code	Title	Description
2016-08-08	MK1K	Patent expired

Publication	Publication Date	Title
NO311604B1 (no)	2001-12-17	Blanding for biomaterial og fremgangsmåte for fremstilling derav
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