NO312933B1 - Preserverende opplösning, anvendelse derav og fremgangsmåte for preservering - Google Patents

Preserverende opplösning, anvendelse derav og fremgangsmåte for preservering Download PDF

Info

Publication number: NO312933B1
Authority: NO; Norway
Prior art keywords: preservation solution; preservation; dextran; calcium; nitroglycerin
Prior art date: 1995-12-15

Application number

NO19982721A

Other languages

English (en)

Norwegian (no)

Other versions

NO982721D0 (no

NO982721L (no

Inventor

Stig Steen

Original Assignee

Xenodevice Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-15

Filing date

1998-06-12

Publication date

2002-07-22

1998-06-12 Application filed by Xenodevice Ab filed Critical Xenodevice Ab

1998-06-12 Publication of NO982721D0 publication Critical patent/NO982721D0/no

1998-08-14 Publication of NO982721L publication Critical patent/NO982721L/no

2002-07-22 Publication of NO312933B1 publication Critical patent/NO312933B1/no

Links

238000000034 method Methods 0.000 title claims abstract description 8
238000004321 preservation Methods 0.000 title claims description 29
239000003755 preservative agent Substances 0.000 title description 2
230000002335 preservative effect Effects 0.000 title description 2
239000003761 preservation solution Substances 0.000 claims abstract description 75
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 33
239000011575 calcium Substances 0.000 claims abstract description 33
229910052791 calcium Inorganic materials 0.000 claims abstract description 33
210000000056 organ Anatomy 0.000 claims abstract description 30
SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims abstract description 29
239000000006 Nitroglycerin Substances 0.000 claims abstract description 29
229960003711 glyceryl trinitrate Drugs 0.000 claims abstract description 29
241001465754 Metazoa Species 0.000 claims abstract description 15
239000000243 solution Substances 0.000 claims description 44
210000004204 blood vessel Anatomy 0.000 claims description 28
FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims description 23
229920002307 Dextran Polymers 0.000 claims description 15
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 12
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 12
239000011591 potassium Substances 0.000 claims description 12
229910052700 potassium Inorganic materials 0.000 claims description 12
230000007774 longterm Effects 0.000 claims description 11
229960002897 heparin Drugs 0.000 claims description 10
229920000669 heparin Polymers 0.000 claims description 10
210000002216 heart Anatomy 0.000 claims description 9
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 8
229940119744 dextran 40 Drugs 0.000 claims description 8
239000011777 magnesium Substances 0.000 claims description 8
229910052749 magnesium Inorganic materials 0.000 claims description 8
239000011734 sodium Substances 0.000 claims description 8
229910052708 sodium Inorganic materials 0.000 claims description 8
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
230000003115 biocidal effect Effects 0.000 claims description 6
239000000872 buffer Substances 0.000 claims description 6
239000008103 glucose Substances 0.000 claims description 6
239000003242 anti bacterial agent Substances 0.000 claims description 5
230000002016 colloidosmotic effect Effects 0.000 claims description 5
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 4
239000002357 osmotic agent Substances 0.000 claims description 4
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 4
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
239000000460 chlorine Substances 0.000 claims description 3
229910052801 chlorine Inorganic materials 0.000 claims description 3
229940087051 fragmin Drugs 0.000 claims description 3
210000004072 lung Anatomy 0.000 claims description 3
239000008363 phosphate buffer Substances 0.000 claims description 3
FZWBNHMXJMCXLU-UHFFFAOYSA-N 2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OCC(O)C(O)C(O)C(O)C=O)O1 FZWBNHMXJMCXLU-UHFFFAOYSA-N 0.000 claims description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
229940119743 dextran 70 Drugs 0.000 claims description 2
239000003055 low molecular weight heparin Substances 0.000 claims description 2
235000019371 penicillin G benzathine Nutrition 0.000 claims description 2
229940056360 penicillin g Drugs 0.000 claims description 2
229940127215 low-molecular weight heparin Drugs 0.000 claims 1
210000001519 tissue Anatomy 0.000 description 17
239000008280 blood Substances 0.000 description 14
210000004369 blood Anatomy 0.000 description 13
230000006870 function Effects 0.000 description 11
230000000694 effects Effects 0.000 description 8
210000003038 endothelium Anatomy 0.000 description 8
238000011160 research Methods 0.000 description 8
230000002792 vascular Effects 0.000 description 8
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
238000001356 surgical procedure Methods 0.000 description 7
210000004351 coronary vessel Anatomy 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
239000003792 electrolyte Substances 0.000 description 5
230000008753 endothelial function Effects 0.000 description 5
239000004615 ingredient Substances 0.000 description 5
230000003834 intracellular effect Effects 0.000 description 5
238000003860 storage Methods 0.000 description 5
210000003462 vein Anatomy 0.000 description 5
210000004027 cell Anatomy 0.000 description 4
210000000170 cell membrane Anatomy 0.000 description 4
206010020718 hyperplasia Diseases 0.000 description 4
239000001301 oxygen Substances 0.000 description 4
229910052760 oxygen Inorganic materials 0.000 description 4
XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 description 4
239000002504 physiological saline solution Substances 0.000 description 4
239000000126 substance Substances 0.000 description 4
238000002054 transplantation Methods 0.000 description 4
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
230000009286 beneficial effect Effects 0.000 description 3
229940041984 dextran 1 Drugs 0.000 description 3
210000003989 endothelium vascular Anatomy 0.000 description 3
210000000265 leukocyte Anatomy 0.000 description 3
239000000203 mixture Substances 0.000 description 3
231100000331 toxic Toxicity 0.000 description 3
230000002588 toxic effect Effects 0.000 description 3
229930008281 A03AD01 - Papaverine Natural products 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
229920002306 Glycocalyx Polymers 0.000 description 2
MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
239000008156 Ringer's lactate solution Substances 0.000 description 2
206010047163 Vasospasm Diseases 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
239000013543 active substance Substances 0.000 description 2
208000003455 anaphylaxis Diseases 0.000 description 2
210000000709 aorta Anatomy 0.000 description 2
YEESUBCSWGVPCE-UHFFFAOYSA-N azanylidyneoxidanium iron(2+) pentacyanide Chemical group [Fe++].[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.N#[O+] YEESUBCSWGVPCE-UHFFFAOYSA-N 0.000 description 2
230000017531 blood circulation Effects 0.000 description 2
ZEWYCNBZMPELPF-UHFFFAOYSA-J calcium;potassium;sodium;2-hydroxypropanoic acid;sodium;tetrachloride Chemical compound [Na].[Na+].[Cl-].[Cl-].[Cl-].[Cl-].[K+].[Ca+2].CC(O)C(O)=O ZEWYCNBZMPELPF-UHFFFAOYSA-J 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
238000002316 cosmetic surgery Methods 0.000 description 2
229960004969 dalteparin Drugs 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
230000002542 deteriorative effect Effects 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
239000012530 fluid Substances 0.000 description 2
210000004517 glycocalyx Anatomy 0.000 description 2
125000001183 hydrocarbyl group Chemical group 0.000 description 2
210000003734 kidney Anatomy 0.000 description 2
239000007788 liquid Substances 0.000 description 2
230000004060 metabolic process Effects 0.000 description 2
230000004220 muscle function Effects 0.000 description 2
229960002460 nitroprusside Drugs 0.000 description 2
230000003204 osmotic effect Effects 0.000 description 2
229960001789 papaverine Drugs 0.000 description 2
230000002093 peripheral effect Effects 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
239000010452 phosphate Substances 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
230000010410 reperfusion Effects 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
210000002460 smooth muscle Anatomy 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000000758 substrate Substances 0.000 description 2
238000007631 vascular surgery Methods 0.000 description 2
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
206010021143 Hypoxia Diseases 0.000 description 1
208000007536 Thrombosis Diseases 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
230000002411 adverse Effects 0.000 description 1
210000001557 animal structure Anatomy 0.000 description 1
210000003423 ankle Anatomy 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
210000000601 blood cell Anatomy 0.000 description 1
210000001772 blood platelet Anatomy 0.000 description 1
210000001601 blood-air barrier Anatomy 0.000 description 1
210000000481 breast Anatomy 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
230000003139 buffering effect Effects 0.000 description 1
238000007675 cardiac surgery Methods 0.000 description 1
210000002421 cell wall Anatomy 0.000 description 1
230000015271 coagulation Effects 0.000 description 1
238000005345 coagulation Methods 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
230000008602 contraction Effects 0.000 description 1
230000008094 contradictory effect Effects 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000000593 degrading effect Effects 0.000 description 1
230000001066 destructive effect Effects 0.000 description 1
-1 dextran 1 Chemical compound 0.000 description 1
XEYBHCRIKKKOSS-UHFFFAOYSA-N disodium;azanylidyneoxidanium;iron(2+);pentacyanide Chemical compound [Na+].[Na+].[Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].[O+]#N XEYBHCRIKKKOSS-UHFFFAOYSA-N 0.000 description 1
210000002889 endothelial cell Anatomy 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
210000003191 femoral vein Anatomy 0.000 description 1
210000002683 foot Anatomy 0.000 description 1
210000004013 groin Anatomy 0.000 description 1
210000003709 heart valve Anatomy 0.000 description 1
230000002727 hyperosmolar Effects 0.000 description 1
208000018875 hypoxemia Diseases 0.000 description 1
210000003090 iliac artery Anatomy 0.000 description 1
230000036039 immunity Effects 0.000 description 1
238000002513 implantation Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
208000028867 ischemia Diseases 0.000 description 1
210000002414 leg Anatomy 0.000 description 1
238000005259 measurement Methods 0.000 description 1
210000000663 muscle cell Anatomy 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000000162 organ preservation solution Substances 0.000 description 1
231100000614 poison Toxicity 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
230000002685 pulmonary effect Effects 0.000 description 1
238000002278 reconstructive surgery Methods 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
229940083618 sodium nitroprusside Drugs 0.000 description 1
241000894007 species Species 0.000 description 1
210000001562 sternum Anatomy 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
238000012360 testing method Methods 0.000 description 1
239000003440 toxic substance Substances 0.000 description 1
210000000689 upper leg Anatomy 0.000 description 1
210000003556 vascular endothelial cell Anatomy 0.000 description 1
230000000304 vasodilatating effect Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/124—Disinfecting agents, e.g. antimicrobials
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients

Landscapes

Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Dentistry (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Environmental Sciences (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Investigating Or Analysing Biological Materials (AREA)
Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)

NO19982721A 1995-12-15 1998-06-12 Preserverende opplösning, anvendelse derav og fremgangsmåte for preservering NO312933B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9504505A SE505499C2 (sv)	1995-12-15	1995-12-15	Förvaringslösning för organ och vävnad eller delar därav från människor och djur innehållande kalcium och nitroglycerin, användning därav samt förfarande för förvaring därmed
PCT/SE1996/001664 WO1997022244A1 (en)	1995-12-15	1996-12-16	Preservation solution

Publications (3)

Publication Number	Publication Date
NO982721D0 NO982721D0 (no)	1998-06-12
NO982721L NO982721L (no)	1998-08-14
NO312933B1 true NO312933B1 (no)	2002-07-22

Family

ID=20400616

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19982721A NO312933B1 (no)	1995-12-15	1998-06-12	Preserverende opplösning, anvendelse derav og fremgangsmåte for preservering

Country Status (17)

Country	Link
EP (1)	EP0977480B1 (cs)
JP (1)	JP2000514780A (cs)
CN (1)	CN1147225C (cs)
AT (1)	ATE225125T1 (cs)
AU (1)	AU695722B2 (cs)
BR (1)	BR9612128A (cs)
CZ (1)	CZ185098A3 (cs)
DE (1)	DE69624150T2 (cs)
ES (1)	ES2179960T3 (cs)
HU (1)	HUP9900112A3 (cs)
IL (1)	IL124927A (cs)
MX (1)	MX9804817A (cs)
NO (1)	NO312933B1 (cs)
PL (1)	PL186303B1 (cs)
PT (1)	PT977480E (cs)
SE (1)	SE505499C2 (cs)
WO (1)	WO1997022244A1 (cs)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2793651B1 (fr) *	1999-05-18	2003-05-16	Cair L G L	Solution aqueuse de conservation de tissus et d'organes
CA2427765C (en)	2000-11-03	2012-01-24	Vitrolife Ab	Evaluation and preservation solution
CN103931605B (zh)	2004-10-07	2015-11-18	特兰斯迈迪茨公司	用于活体外器官护理的系统和方法
US8304181B2 (en)	2004-10-07	2012-11-06	Transmedics, Inc.	Method for ex-vivo organ care and for using lactate as an indication of donor organ status
US12010987B2 (en)	2004-10-07	2024-06-18	Transmedics, Inc.	Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US9078428B2 (en)	2005-06-28	2015-07-14	Transmedics, Inc.	Systems, methods, compositions and solutions for perfusing an organ
US9457179B2 (en)	2007-03-20	2016-10-04	Transmedics, Inc.	Systems for monitoring and applying electrical currents in an organ perfusion system
CN100448351C (zh) *	2007-07-12	2009-01-07	江苏省原子医学研究所	一种标本防腐固定液
DE102007047040A1 (de) *	2007-10-01	2009-04-16	Fresenius Kabi Deutschland Gmbh	Transparentes Kältegel
US8420380B2 (en)	2008-01-31	2013-04-16	Transmedics, Inc.	Systems and methods for ex vivo lung care
GB201020300D0 (en) *	2010-11-30	2011-01-12	Vitrolife Sweden Ab	Product
US20130011823A1 (en)	2011-04-14	2013-01-10	Hassanein Waleed H	Organ care solution for ex-vivo machine perfusion of donor lungs
JP2017518301A (ja)	2014-06-02	2017-07-06	トランスメディクス，インク．Ｔｒａｎｓｍｅｄｉｃｓ，Ｉｎｃ．	ｅｘ−ｖｉｖｏでの臓器管理システム
CA3155169A1 (en)	2014-12-12	2016-06-16	Tevosol, Inc.	Apparatus and method for organ perfusion
CA2997267A1 (en)	2015-09-09	2017-03-16	Transmedics, Inc.	Aortic cannula for ex vivo organ care system
ES2968062T3 (es)	2016-05-30	2024-05-07	Transmedics Inc	Aparato y método de ventilación pulmonar ex vivo con presión exterior variable
SI3448149T1 (sl) *	2017-01-17	2019-12-31	Xvivo Perfusion Ab	Raztopine za konzerviranje in/ali perfuzijo organa
CN111264516B (zh) *	2020-02-20	2020-10-30	科瑞百奥泰州生物技术有限公司	一种血管无冰晶冷冻保存液及血管保存方法
CN111700063B (zh) *	2020-06-29	2021-03-30	广州瑞铂茵健康科技有限公司	一种脐带标本的保存方法
WO2022144186A1 (en) *	2021-01-04	2022-07-07	Xvivo Perfusion Ab	Lipid layer preservation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3705874A1 (de) *	1987-02-24	1988-09-01	Laevosan Gmbh & Co Kg	Darmspuelloesung
US5082831A (en) *	1989-12-05	1992-01-21	Cryovita Laboratories, Inc.	Total body washout solution and method of use
US5145771A (en) *	1990-04-12	1992-09-08	The University Of North Carolina At Chapel Hill	Rinse solution for organs and tissues
RU1836905C (ru) *	1991-01-09	1993-08-30	Нижегородский научно-исследовательский институт травматологии и ортопедии	Способ консервировани деминерализованных костных трансплантантов
CA2066374C (en) *	1991-04-19	2002-01-29	Paul E. Segall	Solution for perfusing primates
US5370989A (en) *	1992-04-03	1994-12-06	The Trustees Of Columbia University In The City Of New York	Solution for prolonged organ preservation
JP3253131B2 (ja) *	1992-07-24	2002-02-04	洋巳和田	移植臓器用溶液
US5407428A (en) *	1993-06-04	1995-04-18	Biotime, Inc.	Solutions for use as plasma expanders and substitutes
AU4526996A (en) *	1994-12-28	1996-07-19	Biotime, Inc.	Plasma expanders and blood substitutes

1995
- 1995-12-15 SE SE9504505A patent/SE505499C2/sv not_active IP Right Cessation
1996
- 1996-12-16 CZ CZ981850A patent/CZ185098A3/cs unknown
- 1996-12-16 BR BR9612128-9A patent/BR9612128A/pt not_active Application Discontinuation
- 1996-12-16 AT AT96942712T patent/ATE225125T1/de not_active IP Right Cessation
- 1996-12-16 ES ES96942712T patent/ES2179960T3/es not_active Expired - Lifetime
- 1996-12-16 WO PCT/SE1996/001664 patent/WO1997022244A1/en not_active Ceased
- 1996-12-16 JP JP09522709A patent/JP2000514780A/ja not_active Ceased
- 1996-12-16 IL IL12492796A patent/IL124927A/xx not_active IP Right Cessation
- 1996-12-16 AU AU11559/97A patent/AU695722B2/en not_active Ceased
- 1996-12-16 HU HU9900112A patent/HUP9900112A3/hu unknown
- 1996-12-16 PT PT96942712T patent/PT977480E/pt unknown
- 1996-12-16 PL PL96327335A patent/PL186303B1/pl not_active IP Right Cessation
- 1996-12-16 DE DE69624150T patent/DE69624150T2/de not_active Expired - Lifetime
- 1996-12-16 EP EP96942712A patent/EP0977480B1/en not_active Expired - Lifetime
- 1996-12-16 CN CNB961996811A patent/CN1147225C/zh not_active Expired - Fee Related
1998
- 1998-06-12 NO NO19982721A patent/NO312933B1/no unknown
- 1998-06-15 MX MX9804817A patent/MX9804817A/es not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE225125T1 (de)	2002-10-15
AU1155997A (en)	1997-07-14
WO1997022244A1 (en)	1997-06-26
SE9504505D0 (sv)	1995-12-15
EP0977480B1 (en)	2002-10-02
IL124927A (en)	2003-06-24
PL327335A1 (en)	1998-12-07
MX9804817A (es)	1998-12-31
DE69624150D1 (de)	2002-11-07
CZ185098A3 (cs)	1998-10-14
CN1147225C (zh)	2004-04-28
HUP9900112A3 (en)	2001-04-28
NO982721D0 (no)	1998-06-12
BR9612128A (pt)	1999-12-28
AU695722B2 (en)	1998-08-20
ES2179960T3 (es)	2003-02-01
NO982721L (no)	1998-08-14
JP2000514780A (ja)	2000-11-07
PT977480E (pt)	2003-02-28
EP0977480A1 (en)	2000-02-09
SE505499C2 (sv)	1997-09-08
IL124927A0 (en)	1999-01-26
SE9504505L (sv)	1997-06-16
CN1207647A (zh)	1999-02-10
DE69624150T2 (de)	2003-03-06
HUP9900112A2 (hu)	2000-10-28
PL186303B1 (pl)	2003-12-31

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