NO314454B1 - Farmasöytiske forbindelser og anvendelse av samme for fremstilling av medikament - Google Patents

Farmasöytiske forbindelser og anvendelse av samme for fremstilling av medikament Download PDF

Info

Publication number: NO314454B1
Authority: NO; Norway
Prior art keywords: cryptophysin; mmol; boc; nmr; solution
Prior art date: 1996-08-30

Application number

NO19990833A

Other languages

English (en)

Norwegian (no)

Other versions

NO990833D0 (no

NO990833L (no

Inventor

Rima S Al-Awar

William Joseph Ehlhardt

Subbaraju V Gottumukkala

Michael John Martinelli

Eric D Moher

Richard Elliott Moore

John Edwin Munroe

Bryan Hurst Norman

Vinod F Patel

Chuan Shih

John Eldon Toth

Venkatraghavan Vasudevan

James Edward Ray

Original Assignee

Univ Wayne State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-30

Filing date

1999-02-22

Publication date

2003-03-24

1999-02-22 Application filed by Univ Wayne State filed Critical Univ Wayne State

1999-02-22 Publication of NO990833D0 publication Critical patent/NO990833D0/no

1999-04-26 Publication of NO990833L publication Critical patent/NO990833L/no

2003-03-24 Publication of NO314454B1 publication Critical patent/NO314454B1/no

Links

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VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 86
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239000001257 hydrogen Substances 0.000 claims description 28
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125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 21
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229910052736 halogen Inorganic materials 0.000 claims description 14
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SURQXAFEQWPFPV-UHFFFAOYSA-L iron(2+) sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Fe+2].[O-]S([O-])(=O)=O SURQXAFEQWPFPV-UHFFFAOYSA-L 0.000 description 1
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RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 description 1
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PEECTLLHENGOKU-UHFFFAOYSA-N n,n-dimethylpyridin-4-amine Chemical compound CN(C)C1=CC=NC=C1.CN(C)C1=CC=NC=C1 PEECTLLHENGOKU-UHFFFAOYSA-N 0.000 description 1
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125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
MOYSMPXSEXYEJV-UHFFFAOYSA-M naphthalen-1-ylmethyl(triphenyl)phosphanium;chloride Chemical compound [Cl-].C=1C=CC2=CC=CC=C2C=1C[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 MOYSMPXSEXYEJV-UHFFFAOYSA-M 0.000 description 1
DMALTLZROJLLJW-UHFFFAOYSA-M naphthalen-2-ylmethyl(triphenyl)phosphanium;bromide Chemical compound [Br-].C=1C=C2C=CC=CC2=CC=1C[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 DMALTLZROJLLJW-UHFFFAOYSA-M 0.000 description 1
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XWXYUMMDTVBTOU-UHFFFAOYSA-N nilutamide Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 XWXYUMMDTVBTOU-UHFFFAOYSA-N 0.000 description 1
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WURFKUQACINBSI-UHFFFAOYSA-M ozonide Chemical compound [O]O[O-] WURFKUQACINBSI-UHFFFAOYSA-M 0.000 description 1
125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
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230000000737 periodic effect Effects 0.000 description 1
239000008177 pharmaceutical agent Substances 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
IPNPIHIZVLFAFP-UHFFFAOYSA-N phosphorus tribromide Chemical compound BrP(Br)Br IPNPIHIZVLFAFP-UHFFFAOYSA-N 0.000 description 1
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235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical compound [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 description 1
LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
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239000003755 preservative agent Substances 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
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238000011321 prophylaxis Methods 0.000 description 1
238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
238000010791 quenching Methods 0.000 description 1
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230000009257 reactivity Effects 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
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238000011160 research Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
238000004366 reverse phase liquid chromatography Methods 0.000 description 1
230000000630 rising effect Effects 0.000 description 1
239000012488 sample solution Substances 0.000 description 1
125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
238000000926 separation method Methods 0.000 description 1
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210000002460 smooth muscle Anatomy 0.000 description 1
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URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
239000012279 sodium borohydride Substances 0.000 description 1
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HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
239000001476 sodium potassium tartrate Substances 0.000 description 1
235000011006 sodium potassium tartrate Nutrition 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
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238000013268 sustained release Methods 0.000 description 1
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238000010189 synthetic method Methods 0.000 description 1
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DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
AOCSUUGBCMTKJH-UHFFFAOYSA-N tert-butyl n-(2-aminoethyl)carbamate Chemical compound CC(C)(C)OC(=O)NCCN AOCSUUGBCMTKJH-UHFFFAOYSA-N 0.000 description 1
CWXPZXBSDSIRCS-UHFFFAOYSA-N tert-butyl piperazine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCNCC1 CWXPZXBSDSIRCS-UHFFFAOYSA-N 0.000 description 1
TWRVYXVQOJCHIF-UHFFFAOYSA-N tert-butyl-chloro-methylsilane Chemical compound C[SiH](Cl)C(C)(C)C TWRVYXVQOJCHIF-UHFFFAOYSA-N 0.000 description 1
125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 description 1
229960005353 testolactone Drugs 0.000 description 1
BPEWUONYVDABNZ-DZBHQSCQSA-N testolactone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(OC(=O)CC4)[C@@H]4[C@@H]3CCC2=C1 BPEWUONYVDABNZ-DZBHQSCQSA-N 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
230000002110 toxicologic effect Effects 0.000 description 1
231100000027 toxicology Toxicity 0.000 description 1
238000011277 treatment modality Methods 0.000 description 1
125000004954 trialkylamino group Chemical group 0.000 description 1
125000005208 trialkylammonium group Chemical group 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
125000000025 triisopropylsilyl group Chemical group C(C)(C)[Si](C(C)C)(C(C)C)* 0.000 description 1
JLTRXTDYQLMHGR-UHFFFAOYSA-N trimethylaluminium Chemical compound C[Al](C)C JLTRXTDYQLMHGR-UHFFFAOYSA-N 0.000 description 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
WYGHCXYTLGIJRQ-UHFFFAOYSA-N triphenyl(phenylsulfanylmethyl)phosphanium Chemical compound C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)CSC1=CC=CC=C1 WYGHCXYTLGIJRQ-UHFFFAOYSA-N 0.000 description 1
NBGQQOBCTPJEFE-ZUQRMPMESA-M triphenyl-[(e)-3-phenylprop-2-enyl]phosphanium;chloride Chemical compound [Cl-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C\C=C\C1=CC=CC=C1 NBGQQOBCTPJEFE-ZUQRMPMESA-M 0.000 description 1
LKZOLNNUWQQMDP-UHFFFAOYSA-M triphenyl-[[4-(trifluoromethyl)phenyl]methyl]phosphanium;bromide Chemical compound [Br-].C1=CC(C(F)(F)F)=CC=C1C[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 LKZOLNNUWQQMDP-UHFFFAOYSA-M 0.000 description 1
CMSYDJVRTHCWFP-UHFFFAOYSA-N triphenylphosphane;hydrobromide Chemical compound Br.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 CMSYDJVRTHCWFP-UHFFFAOYSA-N 0.000 description 1
150000003672 ureas Chemical class 0.000 description 1
JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO19990833A 1996-08-30 1999-02-22 Farmasöytiske forbindelser og anvendelse av samme for fremstilling av medikament NO314454B1 (no)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US2581696P	1996-08-30	1996-08-30
US3911397P	1997-02-26	1997-02-26
US3953097P	1997-03-03	1997-03-03
US4002997P	1997-03-04	1997-03-04
PCT/US1997/015240 WO1998008505A1 (fr)	1996-08-30	1997-08-29	Composes pharmaceutiques

Publications (3)

Publication Number	Publication Date
NO990833D0 NO990833D0 (no)	1999-02-22
NO990833L NO990833L (no)	1999-04-26
NO314454B1 true NO314454B1 (no)	2003-03-24

Family

ID=27487441

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19990833A NO314454B1 (no)	1996-08-30	1999-02-22	Farmasöytiske forbindelser og anvendelse av samme for fremstilling av medikament

Country Status (19)

Country	Link
EP (1)	EP0934065B1 (fr)
JP (1)	JP4364944B2 (fr)
CN (1)	CN100356916C (fr)
AT (1)	ATE328592T1 (fr)
AU (1)	AU722492B2 (fr)
BR (1)	BR9711986A (fr)
CA (1)	CA2264063C (fr)
CZ (1)	CZ64599A3 (fr)
DE (1)	DE69736067T9 (fr)
DK (1)	DK0934065T3 (fr)
EA (1)	EA001913B1 (fr)
ES (1)	ES2267149T3 (fr)
IL (1)	IL128610A (fr)
NO (1)	NO314454B1 (fr)
PT (1)	PT934065E (fr)
SI (1)	SI0934065T1 (fr)
TR (1)	TR199901104T2 (fr)
WO (1)	WO1998008505A1 (fr)
YU (1)	YU10899A (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6680311B1 (en)	1996-08-30	2004-01-20	Eli Lilly And Company	Cryptophycin compounds
WO1998009974A1 (fr) *	1996-09-06	1998-03-12	Eli Lilly And Company	Procede et nouveaux intermediaires
KR20010029474A (ko) *	1996-09-06	2001-04-06	피터 지. 스트링거	제약 화합물의 제조 방법
CA2281107A1 (fr) *	1997-02-26	1998-09-03	Eli Lilly And Company	Composes pharmaceutiques a base de tripeptides et de tetrapeptides
IL131162A0 (en) *	1997-02-26	2001-01-28	Lilly Co Eli	Selective epoxidation process for preparing pharmaceutical compounds
EP0870506A1 (fr) *	1997-04-11	1998-10-14	Eli Lilly And Company	Compositions comprenant un dérivé de la cryptophycine associé à un agent de synchronisation ou d'activation pour le traitement du cancer
EP0870510A3 (fr) *	1997-04-11	1999-09-15	Eli Lilly And Company	Combinaison synergique comprenant des dérivés de cryptophycine et des agents microtubules synergisants
EP0870501A1 (fr) *	1997-04-11	1998-10-14	Eli Lilly And Company	Utilisation de dérivés spécifiques de la cryptophycine dans la fabrication d'un médicametn destiné au traitement des mycoses
US6376230B1 (en)	1998-10-16	2002-04-23	Eli Lilly And Company	Stereoselective process for producing intermediates of cryptophycins
US6103913A (en) *	1998-10-16	2000-08-15	Eli Lilly And Company	Process for preparing enollactone derivatives
US6372936B1 (en) *	1999-06-09	2002-04-16	Eli Lilly And Company	Optical resolution of aminoisobobutyric acid
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
US6747021B2 (en)	2000-10-02	2004-06-08	Eli Lilly And Company	Cryptophycin compound
AU2003218110A1 (en)	2002-03-12	2003-09-29	Bristol-Myers Squibb Company	C3-cyano epothilone derivatives
ES2436109T3 (es) *	2006-02-09	2013-12-27	Belrose Pharma Inc.	Conjugados poliméricos de múltiples brazos de 7-etil-10-hidroxicamptotecina para el tratamiento del cáncer de mama, del cáncer colorrectal, del cáncer de páncreas, de ovario y de pulmón
FR2947269B1 (fr)	2009-06-29	2013-01-18	Sanofi Aventis	Nouveaux composes anticancereux
CN107011311A (zh) *	2010-10-22	2017-08-04	斯特拉斯堡大学	用于治疗HSP90相关病状的Pochoxime缀合物
IT201600108581A1 (it) *	2016-10-27	2018-04-27	Navid Sobhani	NUOVE E PIU' POTENTI MOLECOLE PER IL TRATTAMENTO E LA DIAGNOSI DI TUMORI NEUROENDOCRINI (NETs) E DELLE CELLULE STAMINALI DEI NETs
WO2018206635A1 (fr) *	2017-05-10	2018-11-15	Sanofi	Linkers peptidiques et conjugués de cryptophycine, utiles en thérapie, et leur préparation
US11530204B2 (en)	2019-09-30	2022-12-20	The Regents Of The University Of Michigan	Biocatalytic synthesis of cryptophycin anticancer agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4946835A (en) *	1988-07-15	1990-08-07	Merck & Co., Inc.	Antifungal fermentation product and method
US4845086A (en) *	1988-08-09	1989-07-04	Merck & Co., Inc.	Antifungal agent
US4845085A (en) *	1988-08-09	1989-07-04	Merck & Co., Inc.	Antifungal agent
US5194605A (en) *	1989-12-08	1993-03-16	Merck & Co., Inc.	Cyclic renin inhibitors containing 2-substituted (3S,4S)-4-amino-5-cyclohexyl-3-hydroxy pentanoic acid, 2-substituted (3S,4S)-5-cyclohexyl-3,4-di-hydroxy pentanoic acid or 2-substituted (4S,5S)-5-amino-6-cyclohexyl-4-hydroxyhexanoic acid or its analogs
ATE203016T1 (de) *	1993-12-21	2001-07-15	Univ Hawaii	Cryptophycine
US5952298A (en) *	1993-12-21	1999-09-14	The University Of Hawaii	Cryptophycins
DE69633667T2 (de) *	1995-03-07	2006-03-02	University Of Hawaii, Honolulu	Neue synthetische cryptophycine
EP0850057A4 (fr) *	1995-08-30	2001-04-11	Lilly Co Eli	Composes pharmaceutiques
DE69626544T2 (de) *	1995-12-22	2004-01-15	Lilly Co Eli	Arzneistoffe
ATE201018T1 (de) *	1996-02-27	2001-05-15	Lilly Co Eli	Cryptophycinderivate und ihre verwendung als antimikrotubuli mittel

1997
- 1997-08-29 WO PCT/US1997/015240 patent/WO1998008505A1/fr not_active Ceased
- 1997-08-29 DE DE69736067T patent/DE69736067T9/de active Active
- 1997-08-29 TR TR1999/01104T patent/TR199901104T2/xx unknown
- 1997-08-29 CN CNB971990824A patent/CN100356916C/zh not_active Expired - Lifetime
- 1997-08-29 JP JP51195998A patent/JP4364944B2/ja not_active Expired - Lifetime
- 1997-08-29 PT PT97939667T patent/PT934065E/pt unknown
- 1997-08-29 EA EA199900246A patent/EA001913B1/ru not_active IP Right Cessation
- 1997-08-29 EP EP97939667A patent/EP0934065B1/fr not_active Expired - Lifetime
- 1997-08-29 AU AU41701/97A patent/AU722492B2/en not_active Ceased
- 1997-08-29 BR BR9711986A patent/BR9711986A/pt not_active Application Discontinuation
- 1997-08-29 IL IL12861097A patent/IL128610A/en not_active IP Right Cessation
- 1997-08-29 SI SI9730745T patent/SI0934065T1/sl unknown
- 1997-08-29 CA CA002264063A patent/CA2264063C/fr not_active Expired - Fee Related
- 1997-08-29 AT AT97939667T patent/ATE328592T1/de active
- 1997-08-29 YU YU10899A patent/YU10899A/sh unknown
- 1997-08-29 ES ES97939667T patent/ES2267149T3/es not_active Expired - Lifetime
- 1997-08-29 CZ CZ99645A patent/CZ64599A3/cs unknown
- 1997-08-29 DK DK97939667T patent/DK0934065T3/da active
1999
- 1999-02-22 NO NO19990833A patent/NO314454B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0934065A4 (fr)	2000-10-11
CN100356916C (zh)	2007-12-26
NO990833D0 (no)	1999-02-22
NO990833L (no)	1999-04-26
CN1233957A (zh)	1999-11-03
WO1998008505A8 (fr)	1999-08-12
ATE328592T1 (de)	2006-06-15
EA001913B1 (ru)	2001-10-22
DE69736067D1 (en)	2006-07-20
JP2002514175A (ja)	2002-05-14
DK0934065T3 (da)	2006-10-09
SI0934065T1 (sl)	2007-02-28
AU4170197A (en)	1998-03-19
BR9711986A (pt)	1999-08-24
CA2264063A1 (fr)	1998-03-05
CA2264063C (fr)	2007-03-13
AU722492B2 (en)	2000-08-03
HK1025036A1 (en)	2000-11-03
YU10899A (sh)	2002-03-18
CZ64599A3 (cs)	1999-10-13
TR199901104T2 (xx)	1999-07-21
DE69736067T2 (de)	2007-05-10
EP0934065B1 (fr)	2006-06-07
EA199900246A1 (ru)	1999-10-28
IL128610A0 (en)	2001-01-28
ES2267149T3 (es)	2007-03-01
JP4364944B2 (ja)	2009-11-18
WO1998008505A1 (fr)	1998-03-05
PT934065E (pt)	2006-10-31
DE69736067T9 (de)	2007-10-31
EP0934065A1 (fr)	1999-08-11
IL128610A (en)	2004-07-25

Legal Events

Date	Code	Title	Description
2016-03-29	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
US6680311B1 (en)	2004-01-20	Cryptophycin compounds
EP0934065B1 (fr)	2006-06-07	Nouvelles agents antineoplastiques a base des derives de la cryptophycine
CA2796750C (fr)	2017-09-19	Nouveau derive d'acide hydroxamique
LV13120B (en)	2004-03-20	Delta 12, 13-iso-taxol analogs, antineoplastic use and pharmaceutical compositions containing them
WO1998002426A1 (fr)	1998-01-22	Derives de taxane et medicaments les contenant
CA2230540A1 (fr)	1997-03-06	Composes pharmaceutiques
BG63289B1 (bg)	2001-09-28	Нови криптофицини и метод за получаването им
CA2263420A1 (fr)	1998-03-05	Composes pharmaceutiques
EP0923564A1 (fr)	1999-06-23	Composes pharmaceutiques
US20020128185A1 (en)	2002-09-12	Pharmaceutical compounds
MXPA99001825A (en)	2000-01-01	Pharmaceutical compounds
TW533206B (en)	2003-05-21	A novel cryptophycin compound and its pharmaceutical composition
WO2013072766A2 (fr)	2013-05-23	Procédé de fabrication de cabazitaxel et de ses intermédiaires
HK1025036B (en)	2006-09-22	Novel cryptophycin derivatives as anti-neoplastic agents
KR100505779B1 (ko)	2005-08-04	제약 화합물
RU2328492C2 (ru)	2008-07-10	Общий синтез мириапоронов
RU2575129C2 (ru)	2016-02-10	Новое производное гидроксамовой кислоты
MXPA98001604A (en)	1998-10-23	Farmaceuti compounds
AU726730B2 (en)	2000-11-16	Delta 12,13-iso-taxol analogs, antineoplastic use and pharmaceutical compositions containing them
JPH10204073A (ja)	1998-08-04	タキソール誘導体
AU2017377671A1 (en)	2019-07-11	Novel compounds as anti-mycobacterials