NO315308B1 - Granulert produkt eller tablett inneholdende et brusende system og en aktivfarmasoytisk substans, samt fremgangsmater til fremstilling derav - Google Patents

Granulert produkt eller tablett inneholdende et brusende system og en aktivfarmasoytisk substans, samt fremgangsmater til fremstilling derav Download PDF

Info

Publication number: NO315308B1
Authority: NO; Norway
Prior art keywords: weight; acid; effervescent; carbonate; tablet
Prior art date: 1994-03-01

Application number

NO19963588A

Other languages

English (en)

Norwegian (no)

Other versions

NO963588L (no

NO963588D0 (no

Inventor

Thomas Gergely

Irmgard Gergely

Stefan Gergely

Original Assignee

Gergely Gerhard

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-01

Filing date

1996-08-28

Publication date

2003-08-18

1994-10-26 Priority claimed from EP94203112A external-priority patent/EP0670160B1/fr

1996-08-28 Application filed by Gergely Gerhard filed Critical Gergely Gerhard

1996-08-28 Publication of NO963588D0 publication Critical patent/NO963588D0/no

1996-10-31 Publication of NO963588L publication Critical patent/NO963588L/no

2003-08-18 Publication of NO315308B1 publication Critical patent/NO315308B1/no

Links

239000003814 drug Substances 0.000 title claims description 24
238000000034 method Methods 0.000 title claims description 20
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 133
239000002253 acid Substances 0.000 claims description 77
239000003826 tablet Substances 0.000 claims description 66
239000000126 substance Substances 0.000 claims description 65
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 50
239000000047 product Substances 0.000 claims description 47
239000000203 mixture Substances 0.000 claims description 46
230000007935 neutral effect Effects 0.000 claims description 43
239000000243 solution Substances 0.000 claims description 41
239000008187 granular material Substances 0.000 claims description 39
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
239000013543 active substance Substances 0.000 claims description 35
239000013078 crystal Substances 0.000 claims description 34
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 32
238000000576 coating method Methods 0.000 claims description 31
239000011248 coating agent Substances 0.000 claims description 30
239000007938 effervescent tablet Substances 0.000 claims description 29
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 28
238000004090 dissolution Methods 0.000 claims description 28
150000007524 organic acids Chemical class 0.000 claims description 28
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 27
238000006243 chemical reaction Methods 0.000 claims description 27
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 26
239000000600 sorbitol Substances 0.000 claims description 26
235000010356 sorbitol Nutrition 0.000 claims description 26
229910000029 sodium carbonate Inorganic materials 0.000 claims description 24
239000007787 solid Substances 0.000 claims description 23
229960001380 cimetidine Drugs 0.000 claims description 20
CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 claims description 20
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 19
229930195725 Mannitol Natural products 0.000 claims description 19
239000003513 alkali Substances 0.000 claims description 19
229960005132 cisapride Drugs 0.000 claims description 19
DCSUBABJRXZOMT-IRLDBZIGSA-N cisapride Chemical compound C([C@@H]([C@@H](CC1)NC(=O)C=2C(=CC(N)=C(Cl)C=2)OC)OC)N1CCCOC1=CC=C(F)C=C1 DCSUBABJRXZOMT-IRLDBZIGSA-N 0.000 claims description 19
DCSUBABJRXZOMT-UHFFFAOYSA-N cisapride Natural products C1CC(NC(=O)C=2C(=CC(N)=C(Cl)C=2)OC)C(OC)CN1CCCOC1=CC=C(F)C=C1 DCSUBABJRXZOMT-UHFFFAOYSA-N 0.000 claims description 19
239000000594 mannitol Substances 0.000 claims description 19
235000010355 mannitol Nutrition 0.000 claims description 19
238000002156 mixing Methods 0.000 claims description 19
238000004519 manufacturing process Methods 0.000 claims description 17
229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 16
235000017557 sodium bicarbonate Nutrition 0.000 claims description 16
238000001035 drying Methods 0.000 claims description 15
239000006260 foam Substances 0.000 claims description 15
239000002245 particle Substances 0.000 claims description 15
238000007792 addition Methods 0.000 claims description 14
239000011230 binding agent Substances 0.000 claims description 14
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 13
239000002518 antifoaming agent Substances 0.000 claims description 13
AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 claims description 11
229940083037 simethicone Drugs 0.000 claims description 11
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 10
230000002209 hydrophobic effect Effects 0.000 claims description 10
HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 claims description 10
235000018342 monosodium citrate Nutrition 0.000 claims description 10
239000002524 monosodium citrate Substances 0.000 claims description 10
OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 9
239000011648 beta-carotene Substances 0.000 claims description 9
TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 9
235000013734 beta-carotene Nutrition 0.000 claims description 9
229960002747 betacarotene Drugs 0.000 claims description 9
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 9
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 9
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 9
OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 9
239000013530 defoamer Substances 0.000 claims description 8
235000003599 food sweetener Nutrition 0.000 claims description 8
239000004094 surface-active agent Substances 0.000 claims description 8
239000003765 sweetening agent Substances 0.000 claims description 8
239000005913 Maltodextrin Substances 0.000 claims description 7
229920002774 Maltodextrin Polymers 0.000 claims description 7
229940035034 maltodextrin Drugs 0.000 claims description 7
238000002844 melting Methods 0.000 claims description 7
230000008018 melting Effects 0.000 claims description 7
229960000620 ranitidine Drugs 0.000 claims description 7
VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 claims description 7
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 6
239000007864 aqueous solution Substances 0.000 claims description 6
150000001720 carbohydrates Chemical class 0.000 claims description 6
235000014633 carbohydrates Nutrition 0.000 claims description 6
239000000416 hydrocolloid Substances 0.000 claims description 6
239000002904 solvent Substances 0.000 claims description 6
239000000725 suspension Substances 0.000 claims description 6
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 5
150000001447 alkali salts Chemical class 0.000 claims description 5
229910000019 calcium carbonate Inorganic materials 0.000 claims description 5
229910002092 carbon dioxide Inorganic materials 0.000 claims description 5
238000002425 crystallisation Methods 0.000 claims description 5
230000008025 crystallization Effects 0.000 claims description 5
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 5
239000011976 maleic acid Substances 0.000 claims description 5
239000000843 powder Substances 0.000 claims description 5
229960001520 ranitidine hydrochloride Drugs 0.000 claims description 5
GGWBHVILAJZWKJ-KJEVSKRMSA-N ranitidine hydrochloride Chemical compound [H+].[Cl-].[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 GGWBHVILAJZWKJ-KJEVSKRMSA-N 0.000 claims description 5
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 5
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
239000000872 buffer Substances 0.000 claims description 4
239000008101 lactose Substances 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 4
238000009736 wetting Methods 0.000 claims description 4
ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 3
239000001569 carbon dioxide Substances 0.000 claims description 3
239000007795 chemical reaction product Substances 0.000 claims description 3
ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 3
239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 3
FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 3
238000010438 heat treatment Methods 0.000 claims description 3
238000002161 passivation Methods 0.000 claims description 3
229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
229920000642 polymer Polymers 0.000 claims description 3
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 2
150000001298 alcohols Chemical class 0.000 claims description 2
238000001704 evaporation Methods 0.000 claims description 2
230000008020 evaporation Effects 0.000 claims description 2
-1 alkali metal salt Chemical class 0.000 claims 5
229910052784 alkaline earth metal Inorganic materials 0.000 claims 5
229910052783 alkali metal Inorganic materials 0.000 claims 4
239000010410 layer Substances 0.000 claims 4
239000000375 suspending agent Substances 0.000 claims 4
229920003169 water-soluble polymer Polymers 0.000 claims 4
CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 claims 2
150000001342 alkaline earth metals Chemical class 0.000 claims 2
229940008099 dimethicone Drugs 0.000 claims 2
235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims 2
239000002798 polar solvent Substances 0.000 claims 2
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
229940122957 Histamine H2 receptor antagonist Drugs 0.000 claims 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 1
239000002671 adjuvant Substances 0.000 claims 1
229910000288 alkali metal carbonate Inorganic materials 0.000 claims 1
150000008041 alkali metal carbonates Chemical class 0.000 claims 1
150000001340 alkali metals Chemical class 0.000 claims 1
235000010323 ascorbic acid Nutrition 0.000 claims 1
229960005070 ascorbic acid Drugs 0.000 claims 1
239000011668 ascorbic acid Substances 0.000 claims 1
239000012928 buffer substance Substances 0.000 claims 1
239000007789 gas Substances 0.000 claims 1
239000011874 heated mixture Substances 0.000 claims 1
235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
239000002344 surface layer Substances 0.000 claims 1
238000003756 stirring Methods 0.000 description 18
229940079593 drug Drugs 0.000 description 16
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 15
230000000694 effects Effects 0.000 description 14
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 13
238000002360 preparation method Methods 0.000 description 13
108010011485 Aspartame Proteins 0.000 description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
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235000010357 aspartame Nutrition 0.000 description 6
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 6
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229910002012 Aerosil® Inorganic materials 0.000 description 5
238000009826 distribution Methods 0.000 description 5
238000005187 foaming Methods 0.000 description 5
ILJOYZVVZZFIKA-UHFFFAOYSA-M sodium;1,1-dioxo-1,2-benzothiazol-3-olate;hydrate Chemical compound O.[Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 ILJOYZVVZZFIKA-UHFFFAOYSA-M 0.000 description 5
239000000945 filler Substances 0.000 description 4
239000001509 sodium citrate Substances 0.000 description 4
APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 4
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
229940069428 antacid Drugs 0.000 description 3
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239000000463 material Substances 0.000 description 3
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
235000011083 sodium citrates Nutrition 0.000 description 3
238000005303 weighing Methods 0.000 description 3
PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 description 2
UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
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239000000853 adhesive Substances 0.000 description 2
230000001070 adhesive effect Effects 0.000 description 2
239000002585 base Substances 0.000 description 2
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
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WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
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229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
229940085605 saccharin sodium Drugs 0.000 description 1
235000019613 sensory perceptions of taste Nutrition 0.000 description 1
238000007873 sieving Methods 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
238000009492 tablet coating Methods 0.000 description 1
239000002700 tablet coating Substances 0.000 description 1
230000035923 taste sensation Effects 0.000 description 1
238000004448 titration Methods 0.000 description 1
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
229940038773 trisodium citrate Drugs 0.000 description 1
238000009827 uniform distribution Methods 0.000 description 1
238000009489 vacuum treatment Methods 0.000 description 1
238000003805 vibration mixing Methods 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent

Landscapes

Health & Medical Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO19963588A 1994-03-01 1996-08-28 Granulert produkt eller tablett inneholdende et brusende system og en aktivfarmasoytisk substans, samt fremgangsmater til fremstilling derav NO315308B1 (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE4406641		1994-03-01
CH87394		1994-03-23
EP94203112A EP0670160B1 (fr)	1994-03-01	1994-10-26	Produit granulaire ou comprimé contenant un système effervescent et un agent actif pharmaceutique, et son procédé de préparation
PCT/EP1995/000650 WO1995023594A1 (fr)	1994-03-01	1995-02-23	Produit ou comprime granulaire contenant un systeme effervescent et un principe actif pharmaceutique, et son procede de preparation

Publications (3)

Publication Number	Publication Date
NO963588D0 NO963588D0 (no)	1996-08-28
NO963588L NO963588L (no)	1996-10-31
NO315308B1 true NO315308B1 (no)	2003-08-18

Family

ID=27172490

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19963588A NO315308B1 (no)	1994-03-01	1996-08-28	Granulert produkt eller tablett inneholdende et brusende system og en aktivfarmasoytisk substans, samt fremgangsmater til fremstilling derav

Country Status (15)

Country	Link
JP (1)	JPH09509669A (fr)
CN (1)	CN1213739C (fr)
AU (1)	AU681256B2 (fr)
BR (1)	BR9506964A (fr)
CA (1)	CA2183952C (fr)
CZ (1)	CZ291710B6 (fr)
DE (1)	DE670160T1 (fr)
FI (1)	FI118033B (fr)
HU (1)	HU228147B1 (fr)
NO (1)	NO315308B1 (fr)
NZ (1)	NZ281228A (fr)
PL (1)	PL181714B1 (fr)
RU (1)	RU2153331C2 (fr)
TW (1)	TW403658B (fr)
WO (1)	WO1995023594A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6489346B1 (en)	1996-01-04	2002-12-03	The Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and method of using same
US5840737A (en)	1996-01-04	1998-11-24	The Curators Of The University Of Missouri	Omeprazole solution and method for using same
US20030070584A1 (en)	2001-05-15	2003-04-17	Cynthia Gulian	Dip coating compositions containing cellulose ethers
US8309118B2 (en)	2001-09-28	2012-11-13	Mcneil-Ppc, Inc.	Film forming compositions containing sucralose
DE10224607B4 (de) *	2002-06-04	2008-03-13	Lts Lohmann Therapie-Systeme Ag	Filmförmige, zerfallsfähige Zubereitungen zur Wirkstofffreisetzung und Verfahren zu deren Herstellung
US7429619B2 (en)	2002-08-02	2008-09-30	Mcneil Consumer Healthcare	Polyacrylic film forming compositions
AU2002350719A1 (en)	2002-11-29	2004-06-23	Janssen Pharmaceutica N.V.	Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
US8993599B2 (en)	2003-07-18	2015-03-31	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en)	2004-05-25	2014-12-09	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
JPWO2006059716A1 (ja) *	2004-12-03	2008-06-05	武田薬品工業株式会社	固形製剤
KR101445671B1 (ko) *	2010-02-26	2014-09-29	도레이 카부시키가이샤	피복 고형 제제
EP2788289B1 (fr) *	2011-12-09	2019-07-31	Merck Patent GmbH	Carbonate de sodium anhydre faiblement poreux
US20150289554A1 (en) *	2012-10-25	2015-10-15	Otc Nutrition Llc	Fast Dissolving Solid Calcium Mineral Supplement Compositions and Processing Making
WO2014095845A1 (fr)	2012-12-19	2014-06-26	Bayer Animal Health Gmbh	Comprimés présentant une appétence améliorée et une stabilité au stockage satisfaisante
CN105670003A (zh) *	2014-11-21	2016-06-15	常州坤宇环保科技有限公司	高吸水树脂防结块剂
EP3318135A1 (fr) *	2016-11-03	2018-05-09	Perfetti Van Melle S.p.A.	Matériau de bonbon effervescent, son procédé de préparation et produits fabriqués à partir de celui-ci
EP4045008A4 (fr) *	2019-10-17	2023-11-15	ISP Investments LLC	Composition d'excipient co-traité effervescent stable et son procédé de préparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU1039170A (en) *	1969-02-24	1971-07-22	Abbott Laboratories	Tableting medium
US4704269A (en) *	1985-06-11	1987-11-03	Hudson Pharmaceutical Corporation	Effervescent antacid and analgesic compositions
CA2023493C (fr) *	1989-08-31	2000-01-04	Masami Moroi	Melange servant a l'administration d'un produit moussant
US5415870A (en) *	1991-07-01	1995-05-16	Gerhard Gergely	Effervescent systems using reaction doping agents

1994
- 1994-10-26 DE DE0670160T patent/DE670160T1/de active Pending
1995
- 1995-02-23 JP JP7522671A patent/JPH09509669A/ja active Pending
- 1995-02-23 CN CN95191882.6A patent/CN1213739C/zh not_active Expired - Fee Related
- 1995-02-23 AU AU18114/95A patent/AU681256B2/en not_active Ceased
- 1995-02-23 CA CA002183952A patent/CA2183952C/fr not_active Expired - Fee Related
- 1995-02-23 NZ NZ281228A patent/NZ281228A/en unknown
- 1995-02-23 HU HU9602380A patent/HU228147B1/hu not_active IP Right Cessation
- 1995-02-23 CZ CZ19962519A patent/CZ291710B6/cs not_active IP Right Cessation
- 1995-02-23 BR BR9506964A patent/BR9506964A/pt not_active Application Discontinuation
- 1995-02-23 RU RU96120083/14A patent/RU2153331C2/ru not_active IP Right Cessation
- 1995-02-23 WO PCT/EP1995/000650 patent/WO1995023594A1/fr not_active Ceased
- 1995-03-01 TW TW084101871A patent/TW403658B/zh not_active IP Right Cessation
1996
- 1996-08-22 PL PL95316113A patent/PL181714B1/pl unknown
- 1996-08-28 NO NO19963588A patent/NO315308B1/no not_active IP Right Cessation
- 1996-08-30 FI FI963385A patent/FI118033B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH09509669A (ja)	1997-09-30
CA2183952C (fr)	2007-01-16
PL316113A1 (en)	1996-12-23
DE670160T1 (de)	1996-03-14
RU2153331C2 (ru)	2000-07-27
CN1213739C (zh)	2005-08-10
NZ281228A (en)	1997-06-24
TW403658B (en)	2000-09-01
HUT75677A (en)	1997-05-28
BR9506964A (pt)	1997-09-09
PL181714B1 (en)	2001-09-28
WO1995023594A1 (fr)	1995-09-08
CN1142182A (zh)	1997-02-05
AU1811495A (en)	1995-09-18
CZ251996A3 (en)	1997-01-15
NO963588L (no)	1996-10-31
FI118033B (fi)	2007-06-15
NO963588D0 (no)	1996-08-28
HU9602380D0 (en)	1996-10-28
CZ291710B6 (cs)	2003-05-14
HU228147B1 (en)	2012-12-28
FI963385A0 (fi)	1996-08-30
FI963385L (fi)	1996-10-30
CA2183952A1 (fr)	1995-09-08
AU681256B2 (en)	1997-08-21

Legal Events

Date	Code	Title	Description
2014-09-22	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
EP0670160B1 (fr)	1999-07-14	Produit granulaire ou comprimé contenant un système effervescent et un agent actif pharmaceutique, et son procédé de préparation
US5792473A (en)	1998-08-11	Granular product or tablet containing an effervescent system and an active pharmaceutical substance, as well as a method for its preparation
EP0501985B1 (fr)	1994-01-26	Comprime pharmaceutique non enrobe a reaction
KR100352881B1 (ko)	2003-01-06	소수성물질의제약학적인고체제형을제조하는방법
US5415870A (en)	1995-05-16	Effervescent systems using reaction doping agents
KR100607395B1 (ko)	2006-08-02	비등성 제형
JP5352474B2 (ja)	2013-11-27	口腔内崩壊錠およびその製造方法
RU2153331C2 (ru)	2000-07-27	Гранулированный продукт или таблетка, содержащие шипучую систему и активное фармацевтическое средство, способы их получения
US20040171669A1 (en)	2004-09-02	Coated granules based on angiotensin-converting enzyme inhibitor
US5776492A (en)	1998-07-07	Rapidly disintegrating medicinal form of tramadol or a tramadol salt
JPH0830005B2 (ja)	1996-03-27	崩壊性錠剤とその製造方法
US9717684B2 (en)	2017-08-01	Stable montelukast solution
US20070154549A1 (en)	2007-07-05	Multiparticulate formulations for oral delivery
JPS61183219A (ja)	1986-08-15	発泡組成物の製造法
US6726928B2 (en)	2004-04-27	Process for preparing solid dosage forms for unpalatable pharmaceuticals
RU96120083A (ru)	1998-11-10	Гранулированный продукт или таблетка, содержащие шипучую систему и активное фармацевтическое средство, а также способ их получения
JP6823539B2 (ja)	2021-02-03	胃内滞留性錠剤
JP2016531161A (ja)	2016-10-06	低ナトリウム発泡性医薬製剤
JP2022184791A (ja)	2022-12-13	オセルタミビルを含む医薬組成物及びその製造方法
WO1986004599A1 (fr)	1986-08-14	Procede de production de compositions moussantes
WO1987003002A1 (fr)	1987-05-21	Procede de production d'une composition moussante