NO315544B1 - Farmasöytisk preparat samt fremstilling derav - Google Patents

Farmasöytisk preparat samt fremstilling derav Download PDF

Info

Publication number: NO315544B1
Authority: NO; Norway
Prior art keywords: weight; cores; preparation according; pharmaceutical; particulate preparation
Prior art date: 1994-06-15

Application number

NO19965381A

Other languages

English (en)

Norwegian (no)

Other versions

NO965381D0 (no

NO965381L (no

Inventor

Thomas Norling

Lone Noergaard Jensen

Jens Hansen

Original Assignee

Dumex Alpharma As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-15

Filing date

1996-12-13

Publication date

2003-09-22

1996-12-13 Application filed by Dumex Alpharma As filed Critical Dumex Alpharma As

1996-12-13 Publication of NO965381D0 publication Critical patent/NO965381D0/no

1997-02-13 Publication of NO965381L publication Critical patent/NO965381L/no

2003-09-22 Publication of NO315544B1 publication Critical patent/NO315544B1/no

Links

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Classifications

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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Inorganic Chemistry (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Mechanical Treatment Of Semiconductor (AREA)
Medicinal Preparation (AREA)

NO19965381A 1994-06-15 1996-12-13 Farmasöytisk preparat samt fremstilling derav NO315544B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK69594		1994-06-15
PCT/DK1995/000240 WO1995034291A1 (fr)	1994-06-15	1995-06-14	Pilules

Publications (3)

Publication Number	Publication Date
NO965381D0 NO965381D0 (no)	1996-12-13
NO965381L NO965381L (no)	1997-02-13
NO315544B1 true NO315544B1 (no)	2003-09-22

Family

ID=8096481

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19965381A NO315544B1 (no)	1994-06-15	1996-12-13	Farmasöytisk preparat samt fremstilling derav

Country Status (12)

Country	Link
EP (1)	EP0765157B1 (fr)
AT (1)	ATE177944T1 (fr)
AU (1)	AU697456B2 (fr)
CA (1)	CA2192086C (fr)
DE (1)	DE69508580T2 (fr)
DK (1)	DK0765157T3 (fr)
ES (1)	ES2131318T3 (fr)
FI (1)	FI118675B (fr)
GR (1)	GR3030256T3 (fr)
NO (1)	NO315544B1 (fr)
NZ (1)	NZ288185A (fr)
WO (1)	WO1995034291A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE1011045A3 (fr) *	1997-03-14	1999-04-06	Ucb Sa	Compositions pharmaceutiques pour la liberation controlee de substances actives.
US6200604B1 (en) *	1998-03-27	2001-03-13	Cima Labs Inc.	Sublingual buccal effervescent
US6974590B2 (en)	1998-03-27	2005-12-13	Cima Labs Inc.	Sublingual buccal effervescent
US6350470B1 (en)	1998-04-29	2002-02-26	Cima Labs Inc.	Effervescent drug delivery system for oral administration
CA2241342C (fr) *	1998-06-15	2000-02-08	Bernard Charles Sherman	Comprimes pharmaceutiques contenant un anti-inflammatoire non steroidien et une prostaglandine
GB9819272D0 (en) *	1998-09-03	1998-10-28	Andaris Ltd	Microparticles
GB0003782D0 (en)	2000-02-17	2000-04-05	Dumex Ltd As	Process
AUPR272901A0 (en) *	2001-01-25	2001-02-22	Gainful Plan Limited	Method of preparing biological materials and preparations produced using same
US20030068356A1 (en)	2001-07-10	2003-04-10	Pather S. Indiran	Sequential drug delivery systems
ITMI20011632A1 (it) *	2001-07-27	2003-01-27	Sanofi Synthelabo	Composizione solida contenente spore di batteri non patogeni del genere bacillus
DE10221726A1 (de) *	2002-05-16	2003-11-27	Sachtleben Chemie Gmbh	Verwendung von Röntgenbaryt als Zusatz-und/oder Hilfsstoff bei der Herstellung von Arzneimitteln, Lebensmitteln und Kosmetika
US9107804B2 (en)	2002-12-10	2015-08-18	Nortec Development Associates, Inc.	Method of preparing biologically active formulations
US7198653B2 (en)	2003-07-31	2007-04-03	Delavau Llc	Calcium carbonate granulation
US7862833B2 (en)	2003-12-31	2011-01-04	Cima Labs, Inc.	Effervescent oral opiate dosage forms and methods of administering opiates
EP1915137B8 (fr)	2005-08-10	2013-09-11	ADD Advanced Drug Delivery Technologies, Ltd.	Préparation orale à libération contrôlée
EP1834634A3 (fr) *	2006-03-08	2007-10-03	Rentschler Pharma GmbH	Composition pharmaceutique en multiple-unité
US9138414B1 (en)	2006-09-15	2015-09-22	Delavau Llc	Calcium supplement having enhanced absorption
EP2598123A1 (fr) *	2010-07-27	2013-06-05	Norgine BV	Compositions
WO2012091040A1 (fr) *	2010-12-27	2012-07-05	富田製薬株式会社	Particule nucléaire de type à désagrégation pour formulation pharmaceutique
US10405568B2 (en) *	2012-11-19	2019-09-10	Tracy L. Lundberg	Flowable food composition with water-holding and lubricating agents
CN117049933B (zh) *	2023-08-11	2025-02-18	西北大学	一种可热塑成型的复合钨系延期药及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2292747A2 (fr) *	1973-09-14	1976-06-25	Gewerk Victor Chem Werke	Procede de preparation de carbonate de calcium de grande finesse et de masse volumique elevee, aisement dispersable
US4096246A (en) *	1976-10-06	1978-06-20	A/S Apothekernes Laboratorium For Specialpraeparater	Zinc bacitracin composition for use as a feed supplement and method for making the same
US4164572A (en) *	1976-10-06	1979-08-14	A/S Apothekernes Laboratorium For Specialpraeparater	Zinc bacitracin composition for use as a feed supplement and method for making the same
JPS5823361B2 (ja) *	1976-10-26	1983-05-14	クミアイ化学工業株式会社	顆粒状農薬の製造法
SE450087B (sv) *	1985-10-11	1987-06-09	Haessle Ab	Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial
DE3900811A1 (de) *	1989-01-13	1990-07-19	Kali Chemie Pharma Gmbh	Neue arzneiform
EP0452862B1 (fr) *	1990-04-18	1995-07-19	Asahi Kasei Kogyo Kabushiki Kaisha	Noyaux des germes sphériques, granules sphériques et procédé de leur préparation
JPH04283520A (ja) *	1991-03-12	1992-10-08	Asahi Chem Ind Co Ltd	球状核および球形顆粒

1995
- 1995-06-14 AU AU27327/95A patent/AU697456B2/en not_active Ceased
- 1995-06-14 CA CA002192086A patent/CA2192086C/fr not_active Expired - Fee Related
- 1995-06-14 DE DE69508580T patent/DE69508580T2/de not_active Expired - Lifetime
- 1995-06-14 EP EP95922430A patent/EP0765157B1/fr not_active Expired - Lifetime
- 1995-06-14 WO PCT/DK1995/000240 patent/WO1995034291A1/fr not_active Ceased
- 1995-06-14 AT AT95922430T patent/ATE177944T1/de active
- 1995-06-14 NZ NZ288185A patent/NZ288185A/en not_active IP Right Cessation
- 1995-06-14 DK DK95922430T patent/DK0765157T3/da active
- 1995-06-14 ES ES95922430T patent/ES2131318T3/es not_active Expired - Lifetime
1996
- 1996-12-13 NO NO19965381A patent/NO315544B1/no not_active IP Right Cessation
- 1996-12-13 FI FI965003A patent/FI118675B/fi not_active IP Right Cessation
1999
- 1999-05-19 GR GR990401349T patent/GR3030256T3/el unknown

Also Published As

Publication number	Publication date
AU697456B2 (en)	1998-10-08
EP0765157A1 (fr)	1997-04-02
FI118675B (fi)	2008-02-15
ES2131318T3 (es)	1999-07-16
WO1995034291A1 (fr)	1995-12-21
CA2192086A1 (fr)	1995-12-21
FI965003A0 (fi)	1996-12-13
DE69508580D1 (en)	1999-04-29
FI965003L (fi)	1996-12-13
DE69508580T2 (de)	1999-09-23
NZ288185A (en)	1998-02-26
DK0765157T3 (da)	1999-10-25
AU2732795A (en)	1996-01-05
EP0765157B1 (fr)	1999-03-24
HK1010335A1 (en)	1999-06-17
NO965381D0 (no)	1996-12-13
ATE177944T1 (de)	1999-04-15
CA2192086C (fr)	2000-01-25
NO965381L (no)	1997-02-13
GR3030256T3 (en)	1999-08-31

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Date	Code	Title	Description
2014-02-03	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
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CN102805733B (zh)	2016-03-09	颗粒制剂及其制造方法
JPH10502629A (ja)	1998-03-10	懸濁液中のモグイステインの制御放出のための薬剤組成物
WO2000023055A1 (fr)	2000-04-27	Systeme d'administration de medicaments par doses pulsees par voie orale
JPH02202A (ja)	1990-01-05	徐放性医薬製剤
EP2934484A1 (fr)	2015-10-28	Nanoparticules stabilisées super saturées pour des médicaments médiocrement solubles
KR20130120989A (ko)	2013-11-05	알코올 저항성 경구 약학 제형
CN106061471A (zh)	2016-10-26	具有持续释放特性并针对乙醇的影响具有抗性的药物或营养组合物
MX2010011409A (es)	2010-12-02	Forma oral solida con perfil de liberacion dual que contiene particulas multiples.
WO2011098194A2 (fr)	2011-08-18	Mini-pastilles pharmaceutiques destinées à la libération prolongée d'acétate de flécaïnide
EP2050438B1 (fr)	2016-10-19	Granulé brut sphérique et son procédé de fabrication
US11786476B2 (en)	2023-10-17	Oral dosage form
US10966928B2 (en)	2021-04-06	Oral dosage form
US8460702B2 (en)	2013-06-11	Pharmaceutical compositions
KR20120135063A (ko)	2012-12-12	입자 제제 및 그 제조 방법
HK1010335B (en)	2000-04-20	Pellets
JP2012250926A (ja)	2012-12-20	粒子製剤