NO316310B1 - Anvendelse av en TNF-inhibitor til fremstilling av et medikament - Google Patents
Anvendelse av en TNF-inhibitor til fremstilling av et medikament Download PDFInfo
- Publication number
- NO316310B1 NO316310B1 NO19932610A NO932610A NO316310B1 NO 316310 B1 NO316310 B1 NO 316310B1 NO 19932610 A NO19932610 A NO 19932610A NO 932610 A NO932610 A NO 932610A NO 316310 B1 NO316310 B1 NO 316310B1
- Authority
- NO
- Norway
- Prior art keywords
- tnf
- inhibitor
- tnf inhibitor
- kda
- hours
- Prior art date
Links
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 title claims abstract description 169
- 239000002451 tumor necrosis factor inhibitor Substances 0.000 title claims abstract description 169
- 239000003814 drug Substances 0.000 title claims description 6
- 229940079593 drug Drugs 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title description 3
- 238000000034 method Methods 0.000 claims abstract description 41
- 108020004511 Recombinant DNA Proteins 0.000 claims abstract description 8
- 238000004519 manufacturing process Methods 0.000 claims abstract description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims description 37
- 239000000203 mixture Substances 0.000 claims description 33
- 239000002202 Polyethylene glycol Substances 0.000 claims description 29
- 239000003112 inhibitor Substances 0.000 claims description 29
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 17
- 238000009472 formulation Methods 0.000 claims description 16
- 239000012634 fragment Substances 0.000 claims description 13
- 238000007920 subcutaneous administration Methods 0.000 claims description 13
- 238000001802 infusion Methods 0.000 claims description 9
- 238000001990 intravenous administration Methods 0.000 claims description 7
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 5
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims description 2
- 206010003256 Arthritis gonococcal Diseases 0.000 claims description 2
- 208000033464 Reiter syndrome Diseases 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims description 2
- 201000008482 osteoarthritis Diseases 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 208000002574 reactive arthritis Diseases 0.000 claims description 2
- 208000025722 ankylosing spondylitis 2 Diseases 0.000 claims 1
- 229920006158 high molecular weight polymer Polymers 0.000 claims 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 1
- 239000002861 polymer material Substances 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract description 38
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 38
- 230000001404 mediated effect Effects 0.000 abstract description 35
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 121
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 119
- 239000007924 injection Substances 0.000 description 52
- 238000002347 injection Methods 0.000 description 52
- 108090000623 proteins and genes Proteins 0.000 description 45
- 235000018102 proteins Nutrition 0.000 description 41
- 102000004169 proteins and genes Human genes 0.000 description 41
- 102000004127 Cytokines Human genes 0.000 description 40
- 108090000695 Cytokines Proteins 0.000 description 40
- 241000699670 Mus sp. Species 0.000 description 36
- 241000700159 Rattus Species 0.000 description 36
- 238000002474 experimental method Methods 0.000 description 31
- 238000011282 treatment Methods 0.000 description 30
- 206010040070 Septic Shock Diseases 0.000 description 29
- 230000036303 septic shock Effects 0.000 description 29
- 206010003246 arthritis Diseases 0.000 description 28
- 230000000694 effects Effects 0.000 description 28
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 26
- 108091006086 inhibitor proteins Proteins 0.000 description 21
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 20
- 230000036760 body temperature Effects 0.000 description 17
- 150000001875 compounds Chemical class 0.000 description 17
- 239000002158 endotoxin Substances 0.000 description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
- 210000004027 cell Anatomy 0.000 description 14
- 230000037396 body weight Effects 0.000 description 13
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 13
- 210000000440 neutrophil Anatomy 0.000 description 13
- 239000002953 phosphate buffered saline Substances 0.000 description 13
- 241001465754 Metazoa Species 0.000 description 12
- 230000002631 hypothermal effect Effects 0.000 description 12
- 210000003423 ankle Anatomy 0.000 description 11
- 230000002401 inhibitory effect Effects 0.000 description 11
- 239000011780 sodium chloride Substances 0.000 description 10
- 230000001154 acute effect Effects 0.000 description 9
- 210000001503 joint Anatomy 0.000 description 9
- 210000004072 lung Anatomy 0.000 description 9
- 239000012530 fluid Substances 0.000 description 8
- 230000035939 shock Effects 0.000 description 8
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 7
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 7
- 238000010171 animal model Methods 0.000 description 7
- 230000004941 influx Effects 0.000 description 7
- 239000007928 intraperitoneal injection Substances 0.000 description 7
- 206010039073 rheumatoid arthritis Diseases 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 6
- 208000005069 pulmonary fibrosis Diseases 0.000 description 6
- 230000007420 reactivation Effects 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 241000894007 species Species 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 206010040047 Sepsis Diseases 0.000 description 5
- 125000000539 amino acid group Chemical group 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000001143 conditioned effect Effects 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 210000002950 fibroblast Anatomy 0.000 description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 239000000543 intermediate Substances 0.000 description 5
- 210000000936 intestine Anatomy 0.000 description 5
- 230000001665 lethal effect Effects 0.000 description 5
- 210000000265 leukocyte Anatomy 0.000 description 5
- 230000007170 pathology Effects 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 4
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 4
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 4
- 206010028851 Necrosis Diseases 0.000 description 4
- 210000000544 articulatio talocruralis Anatomy 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 210000002421 cell wall Anatomy 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 230000034994 death Effects 0.000 description 4
- 231100000517 death Toxicity 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 230000002757 inflammatory effect Effects 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 238000010253 intravenous injection Methods 0.000 description 4
- 230000017074 necrotic cell death Effects 0.000 description 4
- 230000003448 neutrophilic effect Effects 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 238000010254 subcutaneous injection Methods 0.000 description 4
- 239000007929 subcutaneous injection Substances 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 208000011580 syndromic disease Diseases 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 238000011870 unpaired t-test Methods 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 206010009900 Colitis ulcerative Diseases 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 102000000589 Interleukin-1 Human genes 0.000 description 3
- 108010002352 Interleukin-1 Proteins 0.000 description 3
- 208000004852 Lung Injury Diseases 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 102000016611 Proteoglycans Human genes 0.000 description 3
- 108010067787 Proteoglycans Proteins 0.000 description 3
- 108700012920 TNF Proteins 0.000 description 3
- 206010069363 Traumatic lung injury Diseases 0.000 description 3
- 201000006704 Ulcerative Colitis Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 210000000845 cartilage Anatomy 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 210000002889 endothelial cell Anatomy 0.000 description 3
- 231100000518 lethal Toxicity 0.000 description 3
- 229920006008 lipopolysaccharide Polymers 0.000 description 3
- 231100000515 lung injury Toxicity 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 208000013223 septicemia Diseases 0.000 description 3
- 210000001179 synovial fluid Anatomy 0.000 description 3
- 210000002437 synoviocyte Anatomy 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 210000003437 trachea Anatomy 0.000 description 3
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 2
- 206010001889 Alveolitis Diseases 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 208000011231 Crohn disease Diseases 0.000 description 2
- 206010060902 Diffuse alveolar damage Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 206010024264 Lethargy Diseases 0.000 description 2
- 206010040799 Skin atrophy Diseases 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 210000001132 alveolar macrophage Anatomy 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000002917 arthritic effect Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 102000023732 binding proteins Human genes 0.000 description 2
- 108091008324 binding proteins Proteins 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 235000018417 cysteine Nutrition 0.000 description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000000921 elemental analysis Methods 0.000 description 2
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 description 2
- 102000057041 human TNF Human genes 0.000 description 2
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000028709 inflammatory response Effects 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 230000018276 interleukin-1 production Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 229920003192 poly(bis maleimide) Polymers 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 238000009163 protein therapy Methods 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 239000002464 receptor antagonist Substances 0.000 description 2
- 229940044551 receptor antagonist Drugs 0.000 description 2
- 230000010410 reperfusion Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 239000000829 suppository Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 208000008203 tachypnea Diseases 0.000 description 2
- 206010043089 tachypnoea Diseases 0.000 description 2
- 210000004876 tela submucosa Anatomy 0.000 description 2
- 238000011285 therapeutic regimen Methods 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 1
- XQUPVDVFXZDTLT-UHFFFAOYSA-N 1-[4-[[4-(2,5-dioxopyrrol-1-yl)phenyl]methyl]phenyl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1C(C=C1)=CC=C1CC1=CC=C(N2C(C=CC2=O)=O)C=C1 XQUPVDVFXZDTLT-UHFFFAOYSA-N 0.000 description 1
- NHJVRSWLHSJWIN-UHFFFAOYSA-N 2,4,6-trinitrobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O NHJVRSWLHSJWIN-UHFFFAOYSA-N 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 208000013824 Acidemia Diseases 0.000 description 1
- 208000010444 Acidosis Diseases 0.000 description 1
- 208000017612 Acute Hemorrhagic Pancreatitis Diseases 0.000 description 1
- 102000011767 Acute-Phase Proteins Human genes 0.000 description 1
- 108010062271 Acute-Phase Proteins Proteins 0.000 description 1
- 206010053555 Arthritis bacterial Diseases 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 108010006654 Bleomycin Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 208000006386 Bone Resorption Diseases 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 206010008531 Chills Diseases 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 206010011703 Cyanosis Diseases 0.000 description 1
- 102000018832 Cytochromes Human genes 0.000 description 1
- 108010052832 Cytochromes Proteins 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 239000012981 Hank's balanced salt solution Substances 0.000 description 1
- 206010056328 Hepatic ischaemia Diseases 0.000 description 1
- 206010020843 Hyperthermia Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 208000004575 Infectious Arthritis Diseases 0.000 description 1
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 1
- 206010023203 Joint destruction Diseases 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 108010013563 Lipoprotein Lipase Proteins 0.000 description 1
- 102100022119 Lipoprotein lipase Human genes 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 102000004083 Lymphotoxin-alpha Human genes 0.000 description 1
- 108090000542 Lymphotoxin-alpha Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000003797 Neuropeptides Human genes 0.000 description 1
- 108090000189 Neuropeptides Proteins 0.000 description 1
- 206010033650 Pancreatitis haemorrhagic Diseases 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 241000276498 Pollachius virens Species 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 206010037423 Pulmonary oedema Diseases 0.000 description 1
- 101100046535 Rattus norvegicus Tnf gene Proteins 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 241000219061 Rheum Species 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 239000012505 Superdex™ Substances 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 238000012084 abdominal surgery Methods 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000026816 acute arthritis Diseases 0.000 description 1
- 206010069351 acute lung injury Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 1
- 230000008382 alveolar damage Effects 0.000 description 1
- 210000002821 alveolar epithelial cell Anatomy 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008952 bacterial invasion Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 229960001561 bleomycin Drugs 0.000 description 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000001601 blood-air barrier Anatomy 0.000 description 1
- 230000024279 bone resorption Effects 0.000 description 1
- 239000007975 buffered saline Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004534 cecum Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
- 229960002986 dinoprostone Drugs 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 208000009190 disseminated intravascular coagulation Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002497 edematous effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 231100000284 endotoxic Toxicity 0.000 description 1
- 230000002346 endotoxic effect Effects 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940079360 enema for constipation Drugs 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 210000000224 granular leucocyte Anatomy 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 210000003547 hepatic macrophage Anatomy 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 1
- 230000036031 hyperthermia Effects 0.000 description 1
- 210000003016 hypothalamus Anatomy 0.000 description 1
- 230000036044 hypoxaemia Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 229960002725 isoflurane Drugs 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 238000002350 laparotomy Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 230000023404 leukocyte cell-cell adhesion Effects 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- 150000002617 leukotrienes Chemical class 0.000 description 1
- 238000011694 lewis rat Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 231100000516 lung damage Toxicity 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical class O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 210000003622 mature neutrocyte Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 125000002073 methionyl group Chemical group 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100001160 nonlethal Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000007523 nucleic acids Chemical group 0.000 description 1
- 210000004409 osteocyte Anatomy 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 230000006320 pegylation Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 210000003456 pulmonary alveoli Anatomy 0.000 description 1
- 208000005333 pulmonary edema Diseases 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000006215 rectal suppository Substances 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 238000011808 rodent model Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 201000001223 septic arthritis Diseases 0.000 description 1
- 230000009919 sequestration Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 238000012385 systemic delivery Methods 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 238000012384 transportation and delivery Methods 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64434591A | 1991-01-18 | 1991-01-18 | |
| PCT/US1992/000432 WO1992013095A1 (en) | 1991-01-18 | 1992-01-17 | Methods for treating tumor necrosis factor mediated diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO932610D0 NO932610D0 (no) | 1993-07-19 |
| NO932610L NO932610L (no) | 1993-09-09 |
| NO316310B1 true NO316310B1 (no) | 2004-01-12 |
Family
ID=24584497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19932610A NO316310B1 (no) | 1991-01-18 | 1993-07-19 | Anvendelse av en TNF-inhibitor til fremstilling av et medikament |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0567566B2 (de) |
| JP (2) | JP2864434B2 (de) |
| KR (1) | KR100234520B1 (de) |
| AT (1) | ATE190629T1 (de) |
| AU (2) | AU1235692A (de) |
| CA (1) | CA2100329C (de) |
| DE (1) | DE69230789T3 (de) |
| DK (1) | DK0567566T4 (de) |
| ES (1) | ES2145744T5 (de) |
| GE (1) | GEP20002142B (de) |
| GR (1) | GR3033327T3 (de) |
| NO (1) | NO316310B1 (de) |
| RU (1) | RU2166955C2 (de) |
| SG (1) | SG63617A1 (de) |
| WO (1) | WO1992013095A1 (de) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5512544A (en) * | 1987-09-13 | 1996-04-30 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising an anticytokine |
| IL98078A0 (en) * | 1991-05-07 | 1992-06-21 | Yeda Res & Dev | Pharmaceutical compositions comprising an anticytokyne |
| US6221675B1 (en) | 1989-04-21 | 2001-04-24 | Amgen, Inc. | TNF receptors, TNF binding proteins and DNAs coding for them |
| DK0393438T3 (da) * | 1989-04-21 | 2005-05-30 | Amgen Inc | TNF-receptor, TNF-bindende proteiner og DNAér, der koder herfor |
| US7264944B1 (en) | 1989-04-21 | 2007-09-04 | Amgen Inc. | TNF receptors, TNF binding proteins and DNAs coding for them |
| IL95031A (en) | 1989-07-18 | 2007-03-08 | Amgen Inc | Method for the production of a human recombinant tumor necrosis factor inhibitor |
| US6143866A (en) * | 1989-07-18 | 2000-11-07 | Amgen, Inc. | Tumor necrosis factor (TNF) inhibitor and method for obtaining the same |
| US20030225254A1 (en) | 1989-08-07 | 2003-12-04 | Rathjen Deborah Ann | Tumour necrosis factor binding ligands |
| JP3443119B2 (ja) | 1989-08-07 | 2003-09-02 | ペプテック リミテッド | 腫瘍壊死因子結合リガンド |
| DE59010908D1 (de) | 1989-09-12 | 2000-08-10 | Hoffmann La Roche | TNF-bindende Proteine |
| US5656272A (en) * | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
| US7192584B2 (en) | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
| US6284471B1 (en) | 1991-03-18 | 2001-09-04 | New York University Medical Center | Anti-TNFa antibodies and assays employing anti-TNFa antibodies |
| US5698195A (en) * | 1991-03-18 | 1997-12-16 | New York University Medical Center | Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies |
| US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| EP0611302B1 (de) * | 1991-10-15 | 2000-03-29 | MULLARKEY, Michael F. | Rezeptoren zur Behandlung von Entzündungen vom verzögerten Typ |
| EP0639079B1 (de) * | 1992-04-30 | 2000-01-12 | Amgen Inc. | Methoden zur Behandlung von Interleukin- 1 und - Tumor - Nekrose - Faktor - verursachten Krankheiten |
| EP0620739A4 (en) * | 1992-09-15 | 1997-01-15 | Immunex Corp | Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists. |
| US5457129A (en) * | 1993-05-17 | 1995-10-10 | Research Development Foundation | Inhibition of nitric oxide production by retinoic acid |
| US5446090A (en) * | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| CA2139385C (en) * | 1994-02-04 | 2001-12-25 | Gottfried Alber | Products containing g-csf and tnf binding protein |
| US5629384A (en) * | 1994-05-17 | 1997-05-13 | Consiglio Nazionale Delle Ricerche | Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| ES2171547T3 (es) * | 1995-07-14 | 2002-09-16 | Applied Research Systems | Receptor de tnf y hormona esteroidica dhea en terapia combinada. |
| US7012060B1 (en) | 1995-07-14 | 2006-03-14 | Applied Research Systems Ars Holding N.V. | TNF receptor and steroid hormone in a combined therapy |
| TW555765B (en) | 1996-07-09 | 2003-10-01 | Amgen Inc | Low molecular weight soluble tumor necrosis factor type-I and type-II proteins |
| DK0942740T3 (da) | 1996-12-06 | 2003-12-15 | Amgen Inc | Kombinationsterapi under anvendelse af et TFN-bindende protein til behandling af TFN-medierede sygdomme |
| CA2273852C (en) | 1996-12-06 | 2009-09-29 | Amgen Inc. | Combination therapy using an il-1 inhibitor for treating il-1 mediated diseases |
| US6419919B2 (en) * | 1997-11-07 | 2002-07-16 | John D. Mountz | Method for the augmentation of gene expression |
| ATE259829T1 (de) * | 1998-10-20 | 2004-03-15 | Vlaams Interuniv Inst Biotech | Verwendung eines zytokine-produzierenden lactococcus stammes zur behandlung von kolitis |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US20040220103A1 (en) | 1999-04-19 | 2004-11-04 | Immunex Corporation | Soluble tumor necrosis factor receptor treatment of medical disorders |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| AU4541101A (en) | 2000-03-02 | 2001-09-12 | Xencor Inc | Design and discovery of protein based tnf-alpha variants for the treatment of tnf-alpha related disorders |
| UA81743C2 (uk) | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
| CA2451955C (en) | 2001-06-26 | 2015-09-29 | Abgenix, Inc. | Antibodies to opgl |
| TWI327597B (en) | 2001-08-01 | 2010-07-21 | Centocor Inc | Anti-tnf antibodies, compositions, methods and uses |
| US7585840B2 (en) | 2002-04-10 | 2009-09-08 | Merck Serono S.A. | Use of osteoprotegerin for the treatment and/or prevention of fibrotic disease |
| AU2003240754B2 (en) | 2002-04-10 | 2009-02-26 | Merck Serono Sa | Use of osteoprotegerin for the prevention and/or treatment of fibrosis/sclerosis |
| US9028822B2 (en) | 2002-06-28 | 2015-05-12 | Domantis Limited | Antagonists against TNFR1 and methods of use therefor |
| US7279155B2 (en) | 2002-10-08 | 2007-10-09 | Ares Trading S.A. | Method of treatment using a cytokine able to bind IL-18BP to inhibit the activity of a second cytokine |
| US7892563B2 (en) | 2003-05-20 | 2011-02-22 | Wyeth Holdings Corporation | Methods for treatment of severe acute respiratory syndrome (SARS) |
| US7482376B2 (en) * | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
| IL161672A0 (en) | 2004-04-29 | 2004-09-27 | Yeda Res & Dev | Compositions and methods for therapy of chemotherapy-induced neuropathy |
| IL161673A0 (en) | 2004-04-29 | 2004-09-27 | Applied Research Systems | Compositions and methods for therapy of chemotherapy-induced neuropathy |
| EP1879611B1 (de) | 2005-04-26 | 2011-10-26 | Merck Serono SA | Insp163-polypeptide und -polynukleotide für die behandlung oder vorbeugung von lungenkrebs |
| ES2385639T3 (es) | 2005-06-03 | 2012-07-27 | Ares Trading S.A. | Producción de una proteína de unión a IL-18 recombinante |
| AU2006256763B2 (en) | 2005-06-10 | 2012-08-02 | Ares Trading S.A. | Process for the purification of IL-18 binding protein |
| BRPI0613042A2 (pt) | 2005-07-15 | 2010-12-14 | Serono Lab | inibidores de jnk para o tratamento de endometriose |
| KR20080044836A (ko) | 2005-07-15 | 2008-05-21 | 라보라뚜와르 세로노 에스. 에이. | 자궁내막증 치료용 ｊｎｋ 억제제 |
| DK1917276T3 (en) | 2005-08-26 | 2018-05-07 | Ares Trading Sa | Process for Preparation of Glycosylated Interferon Beta |
| JP2009507003A (ja) | 2005-09-01 | 2009-02-19 | アレス トレーディング ソシエテ アノニム | 視神経炎の治療 |
| JP2009513689A (ja) | 2005-10-31 | 2009-04-02 | ラボラトワール セローノ ソシエテ アノニム | 神経学的疾患の治療、及び／又は予防のためのｓｄｆ−１の使用 |
| US8795668B2 (en) * | 2005-12-23 | 2014-08-05 | The Regents Of The University Of Michigan | Methods for treating pulmonary fibrosis |
| IL173104A0 (en) | 2006-01-12 | 2006-06-11 | Yeda Res & Dev | Siva and ubiquintination |
| CA2649810A1 (en) | 2006-05-24 | 2007-11-29 | Laboratoires Serono S.A. | Cladribine regimen for treating multiple sclerosis |
| US7833527B2 (en) | 2006-10-02 | 2010-11-16 | Amgen Inc. | Methods of treating psoriasis using IL-17 Receptor A antibodies |
| AU2008208837A1 (en) | 2007-01-26 | 2008-07-31 | Merck Serono S.A. | Purification of Fc-TACT fusion proteins using the oilbody technology |
| EP2203465A1 (de) | 2007-10-22 | 2010-07-07 | Merck Serono S.A. | Verfahren zu reinigung eines fc enthaltenden proteins |
| US8415291B2 (en) | 2008-10-31 | 2013-04-09 | Centocor Ortho Biotech Inc. | Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses |
| AU2010231575B2 (en) | 2009-03-30 | 2013-09-12 | Edimer Biotech S.A. | Preparation of isolated agonist anti-EDAR monoclonal antibodies |
| TW201117824A (en) | 2009-10-12 | 2011-06-01 | Amgen Inc | Use of IL-17 receptor a antigen binding proteins |
| SI3295957T1 (sl) | 2010-01-15 | 2020-02-28 | Kirin-Amgen, Inc. | Formulacija protitelesa proti IL-17RA in terapevtski režim za zdravljenje luskavice |
| WO2011145085A2 (en) | 2010-05-21 | 2011-11-24 | Procognia (Israel) Ltd | Novel antibodies and methods of use for the treatment and diagnosis of cancer |
| US9597325B2 (en) | 2010-10-13 | 2017-03-21 | Trustees Of Boston University | Inhibitors of late SV40 factor (LSF) as cancer chemotherapeutics |
| US20140234330A1 (en) | 2011-07-22 | 2014-08-21 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
| US9827252B2 (en) | 2012-03-16 | 2017-11-28 | Children's Medical Center Corporation | Calmodulin inhibitors for the treatment of ribosomal disorders and ribosomapathies |
| JP6280031B2 (ja) | 2012-03-29 | 2018-02-14 | 中外製薬株式会社 | 抗ｌａｍｐ５抗体およびその利用 |
| PT3041864T (pt) | 2013-09-05 | 2021-10-26 | Ab2 Bio Sa | Proteína de ligação a il-18 (il-18bp) em doenças inflamatórias |
| JP6596014B2 (ja) | 2014-03-31 | 2019-10-23 | アムジェン ケー・エー，インコーポレイテッド | 爪および頭皮乾癬の治療方法 |
| UA128752C2 (uk) | 2015-03-05 | 2024-10-16 | Аб2 Біо Са | Фармацевтична композиція для лікування асоційованого з il-18 захворювання або порушення |
| US10465003B2 (en) | 2016-02-05 | 2019-11-05 | Janssen Biotech, Inc. | Anti-TNF antibodies, compositions, methods and use for the treatment or prevention of type 1 diabetes |
| EP4427760A3 (de) | 2016-07-13 | 2024-11-13 | Children's Medical Center, Corp. | Calmodulin-inhibitoren, chk2-inhibitoren und rsk-inhibitoren zur behandlung von ribosomalen erkrankungen und ribosomapathien |
| JP2020506916A (ja) | 2017-01-30 | 2020-03-05 | ヤンセン バイオテツク，インコーポレーテツド | 活動性乾癬性関節炎の治療のための抗ｔｎｆ抗体、組成物、及び方法 |
| EP3579871A4 (de) | 2017-02-07 | 2021-07-21 | Janssen Biotech, Inc. | Anti-tnf-antikörper, zusammensetzungen und verfahren zur behandlung von aktivem morbus bechterew |
| CN119097635A (zh) | 2017-11-24 | 2024-12-10 | 默克专利股份公司 | 用于治疗进展型形式的多发性硬化症的克拉屈滨疗法 |
| US11780911B2 (en) | 2019-05-23 | 2023-10-10 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha |
| WO2021224432A1 (en) | 2020-05-06 | 2021-11-11 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) in respiratory diseases |
| MX2022014430A (es) | 2020-05-21 | 2023-02-22 | Janssen Biotech Inc | Método para tratar la enfermedad inflamatoria del intestino con una terapia de combinación de anticuerpos para il-23 y tnf alfa. |
| EP3943097A1 (de) | 2020-07-24 | 2022-01-26 | AB2 Bio SA | Car-t-zelltherapie |
| US20240226284A1 (en) | 2020-09-10 | 2024-07-11 | Merck Patent Gmbh | Novel treatment regimen for the treatment of autoimmune disorders |
| CA3244428A1 (en) | 2022-03-04 | 2023-09-07 | Ab2 Bio Sa | IL-18 BINDING PROTEIN (IL-18BP) IN THE TREATMENT OF VEXAS SYNDROME |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1283046C (en) * | 1986-05-29 | 1991-04-16 | Nandini Katre | Tumor necrosis factor formulation |
| IL83878A (en) * | 1987-09-13 | 1995-07-31 | Yeda Res & Dev | Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it |
| GB8807803D0 (en) * | 1988-03-31 | 1988-05-05 | Glaxo Group Ltd | Biochemical product |
| SU1671310A1 (ru) * | 1989-01-30 | 1991-08-23 | Всесоюзный Научно-Исследовательский Институт Экспериментальной Ветеринарии Им.Я.Р.Коваленко | Способ профилактики вирусных заболеваний птиц |
| DK0393438T3 (da) * | 1989-04-21 | 2005-05-30 | Amgen Inc | TNF-receptor, TNF-bindende proteiner og DNAér, der koder herfor |
| DE3922089A1 (de) * | 1989-05-09 | 1990-12-13 | Basf Ag | Neue proteine und ihre herstellung |
| IL95031A (en) * | 1989-07-18 | 2007-03-08 | Amgen Inc | Method for the production of a human recombinant tumor necrosis factor inhibitor |
| GEP20033082B (en) * | 1991-03-15 | 2003-10-27 | Amgen Inc | Pegylation of Polypeptides |
-
1992
- 1992-01-17 AU AU12356/92A patent/AU1235692A/en not_active Abandoned
- 1992-01-17 WO PCT/US1992/000432 patent/WO1992013095A1/en not_active Ceased
- 1992-01-17 GE GEAP19922664A patent/GEP20002142B/en unknown
- 1992-01-17 RU RU93051522/14A patent/RU2166955C2/ru active
- 1992-01-17 KR KR1019930702129A patent/KR100234520B1/ko not_active Expired - Lifetime
- 1992-01-17 CA CA002100329A patent/CA2100329C/en not_active Expired - Lifetime
- 1992-01-17 SG SG1996007283A patent/SG63617A1/en unknown
- 1992-01-17 DK DK92904429T patent/DK0567566T4/da active
- 1992-01-17 JP JP4504597A patent/JP2864434B2/ja not_active Expired - Lifetime
- 1992-01-17 EP EP92904429A patent/EP0567566B2/de not_active Expired - Lifetime
- 1992-01-17 AT AT92904429T patent/ATE190629T1/de not_active IP Right Cessation
- 1992-01-17 DE DE69230789T patent/DE69230789T3/de not_active Expired - Lifetime
- 1992-01-17 ES ES92904429T patent/ES2145744T5/es not_active Expired - Lifetime
-
1993
- 1993-07-19 NO NO19932610A patent/NO316310B1/no not_active IP Right Cessation
-
1996
- 1996-02-02 AU AU42288/96A patent/AU702466B2/en not_active Withdrawn - After Issue
-
1998
- 1998-09-10 JP JP29598898A patent/JP3210629B2/ja not_active Expired - Lifetime
-
2000
- 2000-04-26 GR GR20000401011T patent/GR3033327T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69230789D1 (de) | 2000-04-20 |
| JP2864434B2 (ja) | 1999-03-03 |
| EP0567566A4 (en) | 1994-10-05 |
| WO1992013095A1 (en) | 1992-08-06 |
| ES2145744T3 (es) | 2000-07-16 |
| KR100234520B1 (ko) | 1999-12-15 |
| EP0567566B2 (de) | 2007-07-04 |
| AU4228896A (en) | 1996-04-18 |
| NO932610D0 (no) | 1993-07-19 |
| DE69230789T3 (de) | 2007-10-31 |
| JPH06506446A (ja) | 1994-07-21 |
| JP3210629B2 (ja) | 2001-09-17 |
| ATE190629T1 (de) | 2000-04-15 |
| CA2100329C (en) | 2009-09-29 |
| CA2100329A1 (en) | 1992-07-19 |
| RU2166955C2 (ru) | 2001-05-20 |
| JPH11199505A (ja) | 1999-07-27 |
| SG63617A1 (en) | 1999-03-30 |
| EP0567566B1 (de) | 2000-03-15 |
| ES2145744T5 (es) | 2008-02-01 |
| AU1235692A (en) | 1992-08-27 |
| GR3033327T3 (en) | 2000-09-29 |
| DE69230789T2 (de) | 2000-08-31 |
| DK0567566T4 (da) | 2007-10-22 |
| EP0567566A1 (de) | 1993-11-03 |
| DK0567566T3 (da) | 2000-07-31 |
| AU702466B2 (en) | 1999-02-25 |
| GEP20002142B (en) | 2000-06-25 |
| NO932610L (no) | 1993-09-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU702466B2 (en) | Methods for treating tumor necrosis factor mediated diseases | |
| AU672606B2 (en) | Methods for treating interleukin-1 and tumor necrosis factor mediated diseases | |
| Palladino Jr et al. | Characterization of the antitumor activities of human tumor necrosis factor-alpha and the comparison with other cytokines: induction of tumor-specific immunity. | |
| KR101510941B1 (ko) | 신규한 펩타이드 및 이의 용도 | |
| KR101989201B1 (ko) | 항염증 조성물 | |
| CN113286604A (zh) | 治疗炎症性疾病的蛋白质 | |
| US20130017226A1 (en) | TNF-A and TWEAK Dual Antagonist for the Prophylaxis and Treatment of Autoimmune Diseases | |
| JAMES et al. | Tumour necrosis factor (TNF) as a mediator of macrophage helminthotoxic activity | |
| RU2524630C2 (ru) | Применение apl пептида для лечения воспалительной болезни кишечника и диабета типа 1 | |
| JP3030386B2 (ja) | 抗ガン剤 | |
| CN104628870A (zh) | 一种人IL12Rβ1-CHR蛋白及其Fc融合蛋白 | |
| Tracey et al. | Studies of cachexia in parasitic infection | |
| KR20210070910A (ko) | 펩타이드 또는 이의 혼합물을 유효성분으로 함유하는 베체트병 또는 류마티스 관절염 예방 또는 치료용 약학조성물 | |
| US6255283B1 (en) | Use of proteins extractable from animal organs for the preparation of medicaments for the treatment of pathological conditions characterized by hyperproduction of tumor necrosis factor (TNF) | |
| AU784768B2 (en) | Methods for treating cytokine mediated diseases | |
| CN112057623A (zh) | 一种磷脂酰丝氨酸在制备治疗炎症性肠病药物中的应用 | |
| US20220241374A1 (en) | Treatment of non-alcoholic steatohepatitis | |
| CA3230014A1 (en) | Fusion protein of interleukin-2 and application thereof in ibd | |
| CN113583098A (zh) | 一种来源于真菌的环状拟肽及其制备方法和应用 | |
| JP2008094746A (ja) | 炎症性疾患の治療又は予防剤 | |
| JP2006315988A (ja) | ケモカイン産生誘導効果を有する血管新生阻害物質 | |
| BEUTLER et al. | LYMPHOKINES, VOL. 14 | |
| Tracey et al. | Cachectin/TNF: A mediator of lethal endotoxemia | |
| Bond | The production and characterization of a putative anti-idiotypic antibody to tumor necrosis factor-α | |
| CN109954131A (zh) | 一种肿瘤坏死因子相关凋亡诱导配体拮抗剂作为脓毒血症治疗药物的应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |