NO317516B1 - Nye indan-l-ol forbindelser, en fremgangsmate for a behandle dem og farmasoytiske forbindelser inneholdende dem - Google Patents

Nye indan-l-ol forbindelser, en fremgangsmate for a behandle dem og farmasoytiske forbindelser inneholdende dem Download PDF

Info

Publication number: NO317516B1
Authority: NO; Norway
Prior art keywords: compounds; formula; dihydro; amino; indanol
Prior art date: 1998-08-21

Application number

NO19994041A

Other languages

English (en)

Norwegian (no)

Other versions

NO994041L (no

NO994041D0 (no

Inventor

Jean-Louis Peglion

Bertrand Goument

Adrian Newman-Tancredi

Mark Millan

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-21

Filing date

1999-08-20

Publication date

2004-11-08

1999-08-20 Application filed by Servier Lab filed Critical Servier Lab

1999-08-20 Publication of NO994041D0 publication Critical patent/NO994041D0/no

2000-02-22 Publication of NO994041L publication Critical patent/NO994041L/no

2004-11-08 Publication of NO317516B1 publication Critical patent/NO317516B1/no

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 57
238000000034 method Methods 0.000 title claims description 13
YIAPLDFPUUJILH-UHFFFAOYSA-N indan-1-ol Chemical class C1=CC=C2C(O)CCC2=C1 YIAPLDFPUUJILH-UHFFFAOYSA-N 0.000 title description 2
239000002253 acid Substances 0.000 claims abstract description 9
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 9
150000003839 salts Chemical class 0.000 claims abstract description 8
125000005843 halogen group Chemical group 0.000 claims abstract description 4
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 3
239000003814 drug Substances 0.000 claims abstract description 3
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125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 3
238000002360 preparation method Methods 0.000 claims description 13
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
208000035475 disorder Diseases 0.000 claims description 7
230000002295 serotoninergic effect Effects 0.000 claims description 7
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
238000011282 treatment Methods 0.000 claims description 6
238000004587 chromatography analysis Methods 0.000 claims description 5
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OWFXIOWLTKNBAP-UHFFFAOYSA-N isoamyl nitrite Chemical compound CC(C)CCON=O OWFXIOWLTKNBAP-UHFFFAOYSA-N 0.000 claims description 3
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239000008298 dragée Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000002526 effect on cardiovascular system Effects 0.000 description 1
230000002500 effect on skin Effects 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
229940012356 eye drops Drugs 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
210000005153 frontal cortex Anatomy 0.000 description 1
239000001530 fumaric acid Substances 0.000 description 1
239000000499 gel Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
210000001320 hippocampus Anatomy 0.000 description 1
238000011534 incubation Methods 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
239000000543 intermediate Substances 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
230000002197 limbic effect Effects 0.000 description 1
238000012417 linear regression Methods 0.000 description 1
239000012280 lithium aluminium hydride Substances 0.000 description 1
-1 lithium aluminum hydride Chemical compound 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
238000004949 mass spectrometry Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
230000036651 mood Effects 0.000 description 1
229940100662 nasal drops Drugs 0.000 description 1
210000005036 nerve Anatomy 0.000 description 1
210000001640 nerve ending Anatomy 0.000 description 1
230000001272 neurogenic effect Effects 0.000 description 1
210000002569 neuron Anatomy 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
239000002674 ointment Substances 0.000 description 1
MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
208000019906 panic disease Diseases 0.000 description 1
229960001779 pargyline Drugs 0.000 description 1
230000008506 pathogenesis Effects 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
BCIIMDOZSUCSEN-UHFFFAOYSA-N piperidin-4-amine Chemical group NC1CCNCC1 BCIIMDOZSUCSEN-UHFFFAOYSA-N 0.000 description 1
LYKMMUBOEFYJQG-UHFFFAOYSA-N piperoxan Chemical compound C1OC2=CC=CC=C2OC1CN1CCCCC1 LYKMMUBOEFYJQG-UHFFFAOYSA-N 0.000 description 1
229910003446 platinum oxide Inorganic materials 0.000 description 1
230000001242 postsynaptic effect Effects 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
229940107700 pyruvic acid Drugs 0.000 description 1
239000002464 receptor antagonist Substances 0.000 description 1
229940044551 receptor antagonist Drugs 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
201000000980 schizophrenia Diseases 0.000 description 1
230000020341 sensory perception of pain Effects 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000012279 sodium borohydride Substances 0.000 description 1
229910000033 sodium borohydride Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000009518 sodium iodide Nutrition 0.000 description 1
239000002904 solvent Substances 0.000 description 1
230000009870 specific binding Effects 0.000 description 1
210000000278 spinal cord Anatomy 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000006190 sub-lingual tablet Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
208000011117 substance-related disease Diseases 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
230000002889 sympathetic effect Effects 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
230000026683 transduction Effects 0.000 description 1
238000010361 transduction Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

NO19994041A 1998-08-21 1999-08-20 Nye indan-l-ol forbindelser, en fremgangsmate for a behandle dem og farmasoytiske forbindelser inneholdende dem NO317516B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9810601A FR2782515B1 (fr)	1998-08-21	1998-08-21	NOUVEAUX DERIVES DE L'INDANE-1-Ol, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT

Publications (3)

Publication Number	Publication Date
NO994041D0 NO994041D0 (no)	1999-08-20
NO994041L NO994041L (no)	2000-02-22
NO317516B1 true NO317516B1 (no)	2004-11-08

Family

ID=9529811

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19994041A NO317516B1 (no)	1998-08-21	1999-08-20	Nye indan-l-ol forbindelser, en fremgangsmate for a behandle dem og farmasoytiske forbindelser inneholdende dem

Country Status (18)

Country	Link
US (1)	US6153625A (pl)
EP (1)	EP0982305B1 (pl)
JP (1)	JP2000072748A (pl)
CN (1)	CN1128144C (pl)
AT (1)	ATE214064T1 (pl)
AU (1)	AU747494B2 (pl)
BR (1)	BR9903867A (pl)
CA (1)	CA2280596A1 (pl)
DE (1)	DE69900961T2 (pl)
DK (1)	DK0982305T3 (pl)
ES (1)	ES2172294T3 (pl)
FR (1)	FR2782515B1 (pl)
HU (1)	HUP9902784A3 (pl)
NO (1)	NO317516B1 (pl)
NZ (1)	NZ337362A (pl)
PL (1)	PL194852B1 (pl)
PT (1)	PT982305E (pl)
ZA (1)	ZA995321B (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0103647D0 (sv) *	2001-11-01	2001-11-01	Astrazeneca Ab	Therapeutic chromone compounds
SE0103646D0 (sv) *	2001-11-01	2001-11-01	Astrazeneca Ab	Therapeutic chroman compounds
NZ526699A (en) *	2001-01-16	2005-03-24	Astrazeneca Ab	8-amino derivatives and their use in treating migraine
MXPA03006250A (es) *	2001-01-16	2003-09-22	Astrazeneca Ab	Compuestos heterociclicos terapeuticos.
BR0206513A (pt) *	2001-01-16	2004-01-06	Astrazeneca Ab	Composição, métodos de tratamento de um ser humano ou animal que sofre de depressão, ansiedade generalizada, distúrbios da alimentação, demência, distúrbio do p nico, distúrbios do sono, distúrbios gastrointestinais, distúrbios motores, distúrbios endócrinos, vasoespasmo e disfunção sexual, uso de qualquer um dos compostos, composição farmacêutica, e, processo para preparar compostos
DE10142661B4 (de) *	2001-08-31	2004-06-09	Aventis Pharma Deutschland Gmbh	Mehrfach substituierte Indan-1-ol-Systeme und ihre Verwendung als Arzneimittel
DE10142667B4 (de) *	2001-08-31	2004-06-09	Aventis Pharma Deutschland Gmbh	C2-substituierte Indan-1-ole und ihre Derivate und ihre Verwendung als Arzneimittel
DE10142662B4 (de) *	2001-08-31	2004-07-08	Aventis Pharma Deutschland Gmbh	Derivate von C2-substituierten Indan-1-ol-Systemen und ihre Verwendung als Arzneimittel
UY29892A1 (es) *	2005-11-04	2007-06-29	Astrazeneca Ab	Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones
CN116283657B (zh) *	2023-02-22	2024-08-20	贵州大学	一种茚酮衍生物及其合成方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2681325B1 (fr) *	1991-09-16	1993-12-17	Fabre Medicament Pierre	Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
GB9318431D0 (en) *	1993-09-06	1993-10-20	Boots Co Plc	Therapeutic agents
FR2761358B1 (fr) *	1997-03-27	1999-05-07	Adir	Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

1998
- 1998-08-21 FR FR9810601A patent/FR2782515B1/fr not_active Expired - Fee Related
1999
- 1999-08-13 US US09/374,161 patent/US6153625A/en not_active Expired - Fee Related
- 1999-08-19 HU HU9902784A patent/HUP9902784A3/hu unknown
- 1999-08-19 JP JP11232097A patent/JP2000072748A/ja active Pending
- 1999-08-20 ZA ZA9905321A patent/ZA995321B/xx unknown
- 1999-08-20 EP EP99402092A patent/EP0982305B1/fr not_active Expired - Lifetime
- 1999-08-20 CA CA002280596A patent/CA2280596A1/fr not_active Abandoned
- 1999-08-20 NO NO19994041A patent/NO317516B1/no unknown
- 1999-08-20 PT PT99402092T patent/PT982305E/pt unknown
- 1999-08-20 DK DK99402092T patent/DK0982305T3/da active
- 1999-08-20 CN CN99119425A patent/CN1128144C/zh not_active Expired - Fee Related
- 1999-08-20 BR BR9903867-6A patent/BR9903867A/pt not_active Application Discontinuation
- 1999-08-20 PL PL335012A patent/PL194852B1/pl not_active IP Right Cessation
- 1999-08-20 DE DE69900961T patent/DE69900961T2/de not_active Expired - Fee Related
- 1999-08-20 AU AU44637/99A patent/AU747494B2/en not_active Ceased
- 1999-08-20 ES ES99402092T patent/ES2172294T3/es not_active Expired - Lifetime
- 1999-08-20 AT AT99402092T patent/ATE214064T1/de not_active IP Right Cessation
- 1999-08-20 NZ NZ337362A patent/NZ337362A/xx unknown

Also Published As

Publication number	Publication date
DE69900961D1 (de)	2002-04-11
CN1128144C (zh)	2003-11-19
ZA995321B (en)	2000-02-22
EP0982305A1 (fr)	2000-03-01
HUP9902784A3 (en)	2001-03-28
EP0982305B1 (fr)	2002-03-06
FR2782515B1 (fr)	2000-09-22
ES2172294T3 (es)	2002-09-16
ATE214064T1 (de)	2002-03-15
NO994041L (no)	2000-02-22
FR2782515A1 (fr)	2000-02-25
CN1250051A (zh)	2000-04-12
NZ337362A (en)	2000-04-28
PL335012A1 (en)	2000-02-28
DE69900961T2 (de)	2002-11-07
DK0982305T3 (da)	2002-06-24
JP2000072748A (ja)	2000-03-07
NO994041D0 (no)	1999-08-20
HUP9902784A2 (hu)	2000-12-28
PL194852B1 (pl)	2007-07-31
AU747494B2 (en)	2002-05-16
PT982305E (pt)	2002-07-31
HK1026212A1 (en)	2000-12-08
US6153625A (en)	2000-11-28
HU9902784D0 (en)	1999-10-28
CA2280596A1 (fr)	2000-02-21
AU4463799A (en)	2000-03-09
BR9903867A (pt)	2000-09-05

Publication	Publication Date	Title
AU731018B2 (en)	2001-03-22	New N-aryl piperidine compounds, a process for their preparation and pharmaceutical compositions containing them
NO176437B (no)	1994-12-27	Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-aminotetralinderivater
CA2090321C (en)	2002-04-09	Therapeutically useful 2-aminotetralin derivatives
AU747494B2 (en)	2002-05-16	New indan-1-ol compounds, a process for their preparation and pharmaceutical compositions containing them
AU725756B2 (en)	2000-10-19	New 2-aminoindan compounds, a process for their preparation and pharmaceutical compositions containing them
NO316693B1 (no)	2004-03-26	Nye indanolforbindelser, fremgangsmate ved deres fremstilling og farmasoytiske sammensetninger inneholdende dem
NO314801B1 (no)	2003-05-26	Nye cyanoindol serotonin-reopptaks-inhibitorforbindelser og farmasöytiske sammensetninger inneholdende dem
JP2007513197A (ja)	2007-05-24	統合失調症の治療のための複素環式置換インダン誘導体および関連化合物
WO2001036428A1 (en)	2001-05-25	Silylated heterocyclic compounds
MXPA06012347A (es)	2007-01-17	Derivados de pirazinilmetil-lactama.
NZ535332A (en)	2006-02-24	New benzoindoline compounds, a process for their preparation and pharmaceutical compositions containing them
HK1014954B (en)	2003-01-10	New n-arylpiperidine compounds, a process for their preparation and pharmaceutical compositions containing them
Paliakov et al.	2007	Improved synthesis of substituted 2-aryl-N-[2-(dimethylamino) ethyl] quinolin-4-amines and their activity as antagonists of immunostimulatory CpG-oligodeoxynucleotides
NO312096B1 (no)	2002-03-18	Nye benzocyklobutanforbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem
HK1026212B (en)	2004-05-14	New indan-1-ol compounds, a process for their preparation and pharmaceutical compositions containing them
MXPA06006033A (en)	2006-10-17	Heterocyclic substituted indane derivatives and related compounds for the treatment of schizophrenia
JP2002519350A (ja)	2002-07-02	６−（４−アリールアルキルピペラジン−１−イル）ベンゾジオキサン及び６−（４−アリールアルキルピペラジン−１−イル）クロマン誘導体：ドーパミン受容体サブタイプ特異的リガンド
HK1029108A1 (en)	2001-03-23	8-azabicyclo 3.2.1) octane-3-methanamine derivatives as ligands of d2 and d3 dopamine and 5ht1a and 5ht2 serotonin receptors
HK1029108B (en)	2002-07-19	8-azabicyclo 3.2.1) octane-3-methanamine derivatives as ligands of d2 and d3 dopamine and 5ht1a and 5ht2 serotonin receptors
HK1014945B (en)	2003-01-17	2-aminoindan compounds, a process for their preparation and pharmaceutical compositions containing them